Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65630 products of "Quinazoline and Quinoline Derivatives"
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1,1’-Methylene Bis[Theobromine]
CAS:Controlled ProductFormula:C15H16N8O4Color and Shape:NeatMolecular weight:372.346-Hydroxy-2-[6-[N-(tert-butoxycarbonyl)-N-methylamino]pyridin-3-yl]quinoline
CAS:Purity:98%Molecular weight:351.406005859375Leflunomide-d4
CAS:Controlled Product<p>Applications An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases.This compound is suitable for dihydroorotate dehydrogenase (DHODH) related research.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Vrenken, T., et al.: J. Hepatol., 49, 799 (2008), Mazzucco, G., et al.: Clin. Nephrol., 70, 163 (2008), Davies, M., et al.: J. Med. Chem., 52, 2683 (2009),<br></p>Formula:C12D4H5F3N2O2Color and Shape:NeatMolecular weight:274.23N-Nitroso Propafenone (2,2,3,3,3-Propyl-D5)
Controlled ProductFormula:C21D5H21N2O4Color and Shape:NeatMolecular weight:375.4731,1'-[(1-Methylethyl)imino]bis[3-(1-naphthalenyloxy)-2-propanol
CAS:<p>Applications 1,1'-[(1-Methylethyl)imino]bis[3-(1-naphthalenyloxy)-2-propanol is an impurity of Propranolol (P831800), an β−Adrenergic blocker used as a antihypertensive and antilanginal agent.<br>References Helboe, P., et al.: J. Chromatography., 245, 229 (1982); Helboe, P., et al.: J. Chromatography., 245, 229 (1982);<br></p>Formula:C29H33NO4Color and Shape:Off-White To BeigeMolecular weight:459.58rac-cis-7-Hydroxy Pramipexole
CAS:Controlled Product<p>Impurity Pramipexole Related Compound G<br>Applications Pramipexole derivative used for the preparation of (S)-Pramipexole via resolution of 2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole derivatives.<br>References Validation of a column liquid chromatographic method for the analysis of pramipexole and its 5 impurities. Journal of AOAC International (2010), 93(4), 1102-1112. Gegoe, Csaba Lehel; Fejes, Imre; Garaczi, Sandor; Kovacs, Imre; Lukacs, Ferenc; Majercsik, Orsolya; Schneider, Geza. Process for preparation of (S)-pramipexole via resolution of 2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole derivatives. Eur. Pat. Appl. (2008), 26pp. CODEN: EPXXDW EP 1878731<br></p>Formula:C10H17N3OSColor and Shape:NeatMolecular weight:227.33O-Des(2-dimethylaminoethyl)-O-methyl Itopride
CAS:Controlled Product<p>Applications O-Des(2-dimethylaminoethyl)-O-methyl Itopride is an impurity of Itopride (I931500, HCl); a dopamine D2-receptor antagonist with anticholinesterase activity. Also gastroprokinetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Iwanaga, Y., et al; Jpn. J. Pharmacol., 56, 261 (1991); Mushiroda, T., et al.: Drug Metab. Dispos., 28, 1231 (2000)<br></p>Formula:C17H19NO4Color and Shape:Off-WhiteMolecular weight:301.34rac-Desmethyl Irinotecan Hydrochloride
CAS:Controlled Product<p>Impurity Irinotecan Related Compound C<br>Stability Hygroscopic<br>Applications Desmethyl Irinotecan Hydrochloride is an impurity in the synthesis of Irinotecan Hydrochloride (I767500), a DNA topoisomerase inhibitor.<br>References Kunimoto, T., et al.: Cancer Res., 47, 5944 (1987), Shimada, Y., et al.: J. Clin. Oncol., 11, 909 (1993);<br></p>Formula:C32H36N4O6·ClHColor and Shape:Light Yellow To YellowMolecular weight:609.113-(4-Methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline
CAS:Controlled Product<p>Applications Intermediate in the preparation of Nilotinib.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhang, G., et al.: Bioorg. Med. Chem. Lett., 19, 6691 (2009), Seeliger, M., et al.: Cancer Res., 69, 2384 (2009),<br></p>Formula:C11H10F3N3Color and Shape:NeatMolecular weight:241.21(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)methanol
CAS:Formula:C12H18BNO3Purity:96.0%Color and Shape:SolidMolecular weight:235.09O-Desmorpholinopropyl Gefitinib
CAS:<p>Applications A metabolite of Gefitinib.<br>References Ranson, M., et al.: J. Clin. Oncology, 20, 2240 (2002); Mendelsohn, J., et al.: J. Clin. Oncology, 21, 2787 (2003); McKillop, D., et al.: Xenobiotica, 10, 917 (2004);<br></p>Formula:C15H11ClFN3O2Color and Shape:NeatMolecular weight:319.72(2E)-3-[3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-N-(pyridin-3-ylmethyl)prop-2-enamide
CAS:Molecular weight:398.44100952148442-Mercaptobenzimidazole
CAS:Controlled Product<p>Impurity Rabeprazole EP Impurity F<br>Applications An antidegradant, protecting rubber from oxidation. An intermediate in the synthesis of Rabeprazole (R070500)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Beheshti, A., et al.: J. Food Sci., 75, C135 (2010), Rohrig, U., et al.: J. Med. Chem., 53, 1172 (2010),<br></p>Formula:C7H6N2SColor and Shape:NeatMolecular weight:150.203-AMINO-5-(TRIFLUOROMETHYL)PYRAZOLE HYDROCHLORIDE
CAS:Formula:C4H5ClF3N3Purity:≥95%Color and Shape:SolidMolecular weight:187.55S-Amisulpride
CAS:Controlled Product<p>Applications S-Amisulpride is an isomer of the antipsychotic Amisulpride (A633250). S-Amisulpride has been shown to produce a maximal increase in prolactin level similar to that of the racemic form of Amisulpride.<br>References Protais, P., et al.: Neuropharmacol., 24, 861 (1985); Perrault, G., et al.: J. Pharmacol. Exp. Ther., 280, 73 (1997); Marchese, G., et. al.: Eur. J. Pharmacol., 448, 263 (2002)<br></p>Formula:C17H27N3O4SColor and Shape:NeatMolecular weight:369.48Risperidone-d4
CAS:Controlled Product<p>Applications A deuterated version of Risperidone (R525000), a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jannssen, P.A.J., et al.: J. Pharmacol. Exp. Ther., 244, 685 (1988), Gelders, Y.G., et al.: Pharmacopsychiatry, 23, 206 (1990), Green, B.: Curr. Med. Res. Opin., 16, 57 (2000)<br></p>Formula:C232H4H23FN4O2Color and Shape:BeigeMolecular weight:414.514-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate
CAS:Purity:97.0%Molecular weight:361.760009765625Lansoprazole
CAS:<p>Applications Used as a gastric proton pump inhibitor. An antiulcerative. May limit the severity of tuberculosis (see Chem. and Eng. News. p. 28 July 20 (2018)).<br>References Figgitt, D., et al.: Drugs, 60, 925 (2000), Katsuki, H., et al.: Eur. J. Clin. Pharmacol., 57, 709 (2001), Barradell, L.B., et al.: Drugs, 44, 225 (1992), Kim, K., et al.: Clin. Pharmacol. Ther., 72, 90 (2002), Niioka, T., et al.: Ther. Drug Monit., 28, 321 (2006), Chem. and Eng. News. p. 28 July 20 (2018)<br></p>Formula:C16H14F3N3O2SColor and Shape:White To Light BeigeMolecular weight:369.36N-[[(5S)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-acetamide
CAS:Controlled Product<p>Applications N-[[(5S)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-acetamide is an impurity of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formula:C16H19N3O5Color and Shape:NeatMolecular weight:333.34(S)-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide
CAS:Purity:98%Molecular weight:401.440002441406252-(2-Ethoxyphenyl)quinoline-4-carboxylic acid
CAS:Color and Shape:SolidMolecular weight:293.3219909667969rac Efavirenz-d4
CAS:Controlled ProductFormula:C14H5D4ClF3NO2Color and Shape:NeatMolecular weight:319.701-(4-Fluorophenyl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1H-pyrazole-4-carbaldehyde
CAS:Molecular weight:324.3110046386719ETHYL 5-AMINO-1-(QUINOXALIN-2-YL)-1H-PYRAZOLE-4-CARBOXYLATE
CAS:Purity:95.0%Molecular weight:283.2909851074219Ref: 10-F601461
1gTo inquire2gTo inquire5gTo inquire10gTo inquire100mgTo inquire250mgTo inquire500mgTo inquire6-Hydroxy Ondansetron
CAS:<p>Applications A metabolite of Ondansetron.<br>References Colthup, P., et al.: J. Pharm. Sci., 80, 868 (1991), Miyauchi, S., et al.: Pharm. Res.,10, 434 (1993), Ekins, S., et al.: Drug Metab. Dispos., 23, 1274 (1995), Worboys, P., et al.: Xenobiotica, 26, 897 (1996),<br></p>Formula:C18H19N3O2Color and Shape:Off-White To Light BrownMolecular weight:309.362Ethionamide Sulfoxide
CAS:Controlled Product<p>Applications The major metabolite of Ethionamide.<br>References Rivera-Marrero, C., et al.: Microb. Pathog., 25, 307 (1998), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Cole, S., et al.: Nature, 409, 1007 (2001), Liang, X., et al.: Bacteriology, 183, 843 (2001),<br></p>Formula:C8H10N2OSColor and Shape:NeatMolecular weight:182.24Ketoconazole-d3
CAS:Controlled Product<p>Applications Ketoconazole-d3 is the labeled analogue of Ketoconazole (K186000), which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986); Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989); Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988); Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)<br></p>Formula:C26H25D3Cl2N4O4Color and Shape:NeatMolecular weight:534.45[3-(1H-Pyrazol-1-yl)phenyl]methylamine
CAS:Formula:C10H11N3Purity:95%Color and Shape:LiquidMolecular weight:173.219Valsartan Methyl Ester
CAS:Controlled Product<p>Impurity Valsartan USP Related Compound E<br>Applications Valsartan Methyl Ester (Valsartan USP Related Compound E) is an analog of Valsartan (V095750), is a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>Formula:C25H31N5O3Color and Shape:NeatMolecular weight:449.552-[3-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-oxopropyl]benzoic Acid Methyl Ester
CAS:Controlled Product<p>Applications An intermediate in the synthesis of Montelukast.<br>References Labelle, M., et al.: Bioorg. Med. Chem. Lett., 4, 463 (1994), Roberge, C., et al.: J. Ferment. Bioeng., 81, 530 (1996), Shafiee, A., et al.: App. Microbiol. Biotechnol., 49, 709 (1998),<br></p>Formula:C28H22ClNO3Color and Shape:NeatMolecular weight:455.93Nitisinone
CAS:<p>Applications Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I.<br>References Lindstedt, S., et al.: Lancet, 340, 813 (1992), Ellis, M.K., et al.: Toxicol. Appl. Pharmacol., 133, 12 (1995), Lock, E.A., et al.: J. Inherited Metab. Dis., 21, 498 (1998),<br></p>Formula:C14H10F3NO5Color and Shape:NeatMolecular weight:329.23(4R-cis)-6-Chloromethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester
CAS:Controlled Product<p>Applications A HMG-CoA reductase inhibitor intermediate.<br>References Hummel, W., et al.: J. Microbiol. Methods, 9, 201 (1989), Jendralla, H., et al.: J. Med. Chem., 34, 2962 (1991), Vicenzi, J., et al.: Enzyme Microb. Technol., 20, 494 ( 1997),<br></p>Formula:C13H23ClO4Color and Shape:NeatMolecular weight:278.77O-Desmethyl Gefitinib
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A major metabolite of Gefitinib.<br>References Ranson, M., et al.: J. Clin. Oncology, 20, 2240 (2002), Mendelsohn, J., et al.: J. Clin. Oncology, 21, 2787 (2003), McKillop, D., et al.: Xenobiotica, 10, 917 (2004),<br></p>Formula:C21H22ClFN4O3Color and Shape:YellowMolecular weight:432.88Plerixafor
CAS:<p>Stability Hygroscopic<br>Applications Plerixafor is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM). Selective CXCR4 antagonist.<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>Formula:C28H54N8Color and Shape:Off White PowderMolecular weight:502.78Ivacaftor (4-tertbutyl-d9) (Major)
CAS:Controlled ProductFormula:C24H19D9N2O3Color and Shape:NeatMolecular weight:401.55Retigabine
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A new experimental anticonvulsant drug. Anxiolytic.<br>References Dailey, J.W.; et al.: Neuroscience Lett., 195, 77 (1995), Korsgaard, M.P.G., et al.: J. Pharmacol. Exp. Ther., 314, 1, 282 (2005),<br></p>Formula:C16H18FN3O2Color and Shape:NeatMolecular weight:303.332-(2-Chlorophenyl)-2-(methylamino)-6-(thiophen-2-ylmethylidene)cyclohexan-1-one
CAS:Purity:98%Molecular weight:331.86N-Nitroso Clonidine
CAS:Controlled ProductFormula:C9H8Cl2N4OColor and Shape:NeatMolecular weight:259.09Vildagliptin Lactam
CAS:<p>Impurity Rac-Vildagliptin Impurity F<br>Applications Vildagliptin Lactam is an impurity of Vildagliptin (V305000). Glyptins are class of oral anti-hyperglycemic agents that inhibit dipeptidyl peptidase 4 (DPP-4), which can act as a serine exopeptidase. ASide from there use in type 2 diabetes, gliptins have positive cardiovascular and anti-inflammtatory effects. Antidiabetic.<br>References Ahren, B., et al.: J. Clin. Endocrinol. Metab., 89, 2078 (2004), Ahren, B., et al.: Diabetes Care, 27, 2874 (2004), Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 5, 1094 (2004),<br></p>Formula:C17H24N2O3Color and Shape:Off-WhiteMolecular weight:304.38
![1,1’-Methylene Bis[Theobromine]](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FM303945.webp&w=3840&q=75)
![6-Hydroxy-2-[6-[N-(tert-butoxycarbonyl)-N-methylamino]pyridin-3-yl]quinoline](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F10%2Fthumb-webp%2FF601133.webp&w=3840&q=75)
![1,1'-[(1-Methylethyl)imino]bis[3-(1-naphthalenyloxy)-2-propanol](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FM304925.webp&w=3840&q=75)
![(2E)-3-[3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-N-(pyridin-3-ylmethyl)prop-2-enamide](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F10%2Fthumb-webp%2FF094180.webp&w=3840&q=75)
![N-[[(5S)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-acetamide](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FO870195.webp&w=3840&q=75)
![1-(4-Fluorophenyl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1H-pyrazole-4-carbaldehyde](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F10%2Fthumb-webp%2FF493980.webp&w=3840&q=75)
![[3-(1H-Pyrazol-1-yl)phenyl]methylamine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F10%2Fthumb-webp%2FF065384.webp&w=3840&q=75)
![2-[3-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-oxopropyl]benzoic Acid Methyl Ester](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FC380010.webp&w=3840&q=75)
