Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65573 products of "Quinazoline and Quinoline Derivatives"
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Fingolimod
CAS:Controlled Product<p>Applications Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Formula:C19H33NO2Color and Shape:NeatMolecular weight:307.47(S)-4,5,6,7-Tetrahydro-N2,N6-propionyl-2,6-benzothiazolediamine
CAS:Controlled Product<p>Applications Pramipexole derivative.<br></p>Formula:C13H19N3O2SColor and Shape:NeatMolecular weight:281.37(5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone
CAS:Controlled Product<p>Applications (5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone is an intermediate used in the synthesis of dronedarone hydrochloride (I), a class III antiarrhythmia drug for the prevention of cardiac arrhythmias such as atrial fibrillation.<br>References Mali, A. C., et al.: Org. Proc. Res. Dev., 17, 863 (2013)<br></p>Formula:C30H42N2O3Color and Shape:NeatMolecular weight:478.67Quinoline Yellow (Technical Grade)
CAS:<p>Stability Hygroscopic<br>Applications Quinoline yellow, is a yellow powder used in lipstick, lotion, soap, shampoo, bubble bath, ingested drugs, and applied drugs applications.<br></p>Formula:C18H9NNa2O8S2Color and Shape:NeatMolecular weight:477.38Stiripentol-d9
CAS:Controlled Product<p>Applications An labelled epilepsy drug. It has been used as co-therapy for treatment of epilepsy. It inhibits the enzymes responsible for metabolism of other anti-convulsant agents.<br>References Laurie, D., et al.: J. Neurosci., 12, 4151 (1992), Smith, A., et al.: J. Pharmacol. Exp. Therap., 311, 601 (2004), Trojnar, M., et al.: Pharm. Rep., 57, 154 (2005), Drafts, B., et al.: J. Pharm. Exp. Ther., 318, 1094 (2006), Picton, A., et al.: Brain Res., 1165, 40 (2007),<br></p>Formula:C14H9D9O3Color and Shape:White SolidMolecular weight:243.355-Amino-2-bromo-pyridine-4-carbonitrile
CAS:Purity:98+%Color and Shape:SolidMolecular weight:198.02299499511725-Amino-1-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-3-methyl-1H-pyrazole-4-carbonitrile
Purity:95.0%Molecular weight:256.26501464843754-(2-Oxo-1,2,3,4-tetrahydroquinolin-6-yl)oxy Cilostazol (>85%)
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications An impurity of Cilostazol (C441500) which is a potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Has antimitogeni, antithrombotic, vasodilatory and cardiotonic properties in vivo.<br>References Suri, A., et al.: J. Clin. Pharmacol., 38, 144 (1998), Park, S.-W., et al.: Am. J. Cardiol., 84, 511 (1999), Tsuchikane, E., et al.: Circulation, 100, 21 (1999),<br></p>Formula:C29H34N6O4Purity:>85%Color and Shape:NeatMolecular weight:530.626-(4-methoxyphenyl)-3-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidine
CAS:Purity:95.0%Molecular weight:307.36999511718751-[[3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]4-hydroxyphenyl]methyl 2-Butanedioic Acid Ester (>90%)
<p>Impurity Fesoterodine Impurity 6;<br>Applications 1-[[3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]4-hydroxyphenyl]methyl 2-Butanedioic Acid Ester is derived from (R)-Fesoterodine Fumarate (F321300), which is a muscarinic receptor antagonist for the treatment of Lower Urininary Tract Symptoms (LUTS). It is very similar to Tolterodine (T535800).<br>References Rogers, D., et al.: Pharmacotherapy, 20, 1092 (2000), Praharaj, S., et al.: J. Psychopharmacology, 19, 426 (2005),<br></p>Formula:C26H35NO5Purity:>90%Color and Shape:NeatMolecular weight:441.562-((2-Oxo-2-(thiophen-2-yl)ethyl)thio)-4,6-di(thiophen-2-yl)nicotinonitrile
CAS:Purity:98.0%Molecular weight:424.57000732421875Phthalic Hydrazide
CAS:<p>Applications Phthalic Hydrazide is a reagent in the synthesis in various pyrazolophthalazine derivatives.<br>References Rezaei, S.et al.: Tetra. Lett., 53, 5123 (2012);<br></p>Formula:C8H6N2O2Color and Shape:NeatMolecular weight:162.15O-Desethyl Dapagliflozin tetraacetate)
CAS:<p>Applications Empagliflozin Tetraacetate is an Empagliflozin (E521510) impurity and is a reagent used to design and synthesize nitric oxide releasing derivatives of dapagliflozin which has potential antidiabetic and antithrombotic agents.<br>References Zheng, L., et al.: Bioorg. Med. Chem., 26, 3947 (2018)<br></p>Formula:C27H29ClO10Color and Shape:White To Off-WhiteMolecular weight:548.97Dechloro Trazodone
CAS:Controlled Product<p>Impurity Trazodone Deschloro Impurity<br>Stability Hygroscopic<br>Applications A Trazodone (T718500) impurity. An antipsychotic with potential use as a schizophrenia agent. Trazodone impurity B.<br>References Pai, N. et al.: J. Chem Pharmaceut. Res., 2, 458 (2010); Silvestrini, B., et al.: Eur. J. Pharmacol., 12, 231 (1970); Brogden, R.N., et al.: Drugs, 21, 401 (1981);<br></p>Formula:C19H23N5OColor and Shape:NeatMolecular weight:337.42N-Benzylpyridin-2-amine
CAS:Formula:C12H12N2Purity:95.0%Color and Shape:SolidMolecular weight:184.242Methyl 4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)benzoate
CAS:Purity:95.0%Molecular weight:356.3850097656255-Benzo[1,3]dioxol-5-yl-1 H -pyrazole-3-carboxylic acid methyl ester
CAS:Molecular weight:246.22200012207032-METHOXY-4-(5-(PYRIDIN-4-YL)-1H-BENZO[D]IMIDAZOL-1-YL)PHENOL
CAS:Purity:95.0%Molecular weight:317.34799194335946-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-1-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butyl]-3,4-dihydro-2(1H)-quinolinone
CAS:Controlled Product<p>Impurity Cilostazol USP Related Compound C<br>Applications 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-1-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butyl]-3,4-dihydro-2(1H)-quinolinone, is an impurity of Cilostazol (C441500), a potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake.<br>References Suri, A., et al.: J. Clin. Pharmacol., 38, 144 (1998), Park, S.-W., et al.: Am. J. Cardiol., 84, 511 (1999), Tsuchikane, E., et al.: Circulation, 100, 21 (1999);<br></p>Formula:C31H45N9O2Color and Shape:NeatMolecular weight:575.75Rafoxanide
CAS:<p>Applications Rafoxanide is a thyroid hormone receptor.<br>References Bernal, J., et al.: Vitam. Horm., 71, 95 (2005), Fujimoto, N., et al.: J. Endocrinol., 181, 77 (2005), Hamers, T., et al.: Toxicol. Sci., 92, 157 (2006), Jugan, M., et al.: Biochem. Pharmacol., 79, 939 (2010),<br></p>Formula:C19H11Cl2I2NO3Color and Shape:WhiteMolecular weight:626.01Depropylamino Chloro Propafenone
CAS:<p>Impurity Propafenone EP Impurity E; Propafenone BP Impurity E; Propafenone USP Impurity E<br>Applications Depropylamino Chloro Propafenone (Propafenone EP Impurity E; Propafenone BP Impurity E; Propafenone USP Impurity E) is an impurity of Propafenone (D288655).<br>References Hollmann, M., et al.: Arzneim.-Forsch., 33, 763 (1983); Bryson, H. M., et al.:Drugs, 45, 85 (1993);<br></p>Formula:C18H19ClO3Color and Shape:NeatMolecular weight:318.79Deferiprone-d3 3-O-β-D-Glucuronide Sodium Salt
CAS:Controlled Product<p>Stability Very Hygroscopic<br>Applications A labelled metabolite of Deferiprone (D474000).<br>References Choudhury, R., et al.: Drug Metab. Dispos., 23, 314 (1995);<br></p>Formula:C13H13D3NNaO8Color and Shape:Off-White To Light BeigeMolecular weight:340.28Gabapentin-d6 Hydrochloride
CAS:Controlled Product<p>Applications Gabapentin Hydrochloride is a salt analogue of Gabapentin-d6 (G117253), a labelled amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant.<br>References Vollmer, K.O. et al.: Arzneim.-Forsch., 36, 830 (1986); Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)<br></p>Formula:C9H11D6NO2·HClColor and Shape:NeatMolecular weight:213.732,7-Bis(pyridin-4-ylmethyl)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone
CAS:Purity:95%Molecular weight:448.43798828125De-4-fluoro 5-Fluoro Chidamide
CAS:<p>Applications De-5-fluoro 4-Fluorochidamide is an analogue of Chidamide (CAS 743420-02-0), a hitsone deacetylase inhibitor (HDACI) that enhances gemcitabine (G305000) cytotoxicity in pancreatic cancer cells.<br>References Qiao, Z., et. al.: Biochem. Bioph. Res. Co., 434, 95 (2013)<br></p>Formula:C22H19FN4O2Color and Shape:Off White PowderMolecular weight:390.41Aripiprazole N4-Oxide
CAS:Controlled Product<p>Impurity Aripiprazole Impurity 9<br>Applications Aripiprazole N4-Oxide is a metabolite of anti-psychotic drug, Aripiprazole (A771000). Aripiprazole Impurity 9<br>References Rowley, M., et al.: J. Med. Chem., 44, 477 ( 2001), Ozdemir, V., et al.: Curr. Opin. Invest Drugs 2002, 3, 113,,,4) Jordan, S; European Journal Pharmacol 2002, 441, 137<br></p>Formula:C23H27Cl2N3O3Color and Shape:NeatMolecular weight:464.385,5-Diphenyl Hydantoin Sodium
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 5,5-Diphenyl Hydantoin Sodium salt reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na+, K+, and Ca2+ channels.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Faucette, S., et al.: J. Pharmacol. Exp. Ther., 320, 72 (2007), Guo, D., et al.: J. Biol. Chem., 282, 36766 (2007), Merrell, M., et al.: Drug Metab. Dispos., 36, 1716 (2008),<br></p>Formula:C15H11N2O2·NaColor and Shape:NeatMolecular weight:274.251-Hydroxycyclopentyl 2-chlorophenyl Ketone
CAS:Controlled ProductFormula:C12H13ClO2Color and Shape:Colourless To Light YellowMolecular weight:224.68Flubendazole
CAS:<p>Applications An anthelmintic.<br>References Thienpont, D., et al.: Arzneimittel-Forsch., 28, 605 (1978), Vanparijs, O., et al.: Vet. Parasitol, 5, 237 (1979),<br></p>Formula:C16H12FN3O3Color and Shape:ColourlessMolecular weight:313.284-fluoro-N-(pyridin-2-ylmethyl)-1,3-benzothiazol-2-amine
CAS:Purity:95.0%Molecular weight:259.299987792968752,3,4-Trimethoxybenzaldehyde
CAS:Controlled Product<p>Applications 2,3,4-Trimethoxybenzaldehyde is a trimethoxylated aromatic aldehyde. 2,3,4-Trimethoxybenzaldehyde is an impurity of the anti-anginal drug Trimetazidine (T795610).<br>References Medenica, M.B. et al.: J. Chrom. Sci., 46, 430 (2008);<br></p>Formula:C10H12O4Color and Shape:Off-WhiteMolecular weight:196.202,3-Diphenyl-5-(thiophen-2-yl)-2H-tetrazol-3-ium chloride
CAS:Purity:98%Molecular weight:340.82998657226563-[1-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2,5-dimethyl-1H-pyrrol-3-yl]-3-oxopropanenitrile
CAS:Purity:98%Molecular weight:348.40600585937511-(4-Ethyl-1-piperazinyl)-dibenzo[b,f][1,4]thiazepine Dihydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 11-(4-Ethyl-1-piperazinyl)-dibenzo[b,f][1,4]thiazepine is an impurity of Quetiapine hemifumarate (Q510000), a dibenzothiazepine antipsychotic medication used in the treatment of schizophrenia.<br>References Kumar, K., et al.: Org. Chem.: An Indian Journal, 8, 164 (2012); Raju, I., et al.: Chromatographia, 70, 545 (2009)<br></p>Formula:C19H23Cl2N3SColor and Shape:NeatMolecular weight:396.384,4'-Difluorobenzophenone
CAS:Controlled ProductFormula:C13H8F2OColor and Shape:NeatMolecular weight:218.20cis-Ambroxol Hydrochloride
CAS:<p>Stability Hygroscopic<br>Applications cis-Ambroxol Hydrochloride is a cis isomer of Ambroxol Hydrochloride (A575900 ), a metabolite of Bromohexine. Ambroxol Hydrochloride is a bronchosecretolytic drug.<br>References Jauch, R., et al.: Arzneim-Forsch., 13, 474 (1963)<br></p>Formula:C13H18Br2N2O·x(HCl)Color and Shape:NeatMolecular weight:378.10 + x(36.46)Etomidate Hydrochloride
CAS:Controlled Product<p>Applications (cas# 53188-20-8) is a useful research chemical.<br></p>Formula:C14H17ClN2O2Color and Shape:NeatMolecular weight:280.75(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid
CAS:Controlled Product<p>Applications (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid has been used as a reactant for the preparation of dipeptidyl peptidase-4 (DPP4) inhibitors for the treatment of type 2 diabetes, such as sitagliptin.<br>References Kim, H.J., et. al.: Bioorg. Med. Chem. Lett., 22, 5545 (2012)<br></p>Formula:C15H18F3NO4Color and Shape:NeatMolecular weight:333.304-(4-Fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridine Hydrochloride
CAS:Controlled Product<p>Impurity Paroxetine EP Impurity G<br>Applications 4-(4-Fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridine Hydrochloride (Paroxetine EP Impurity G) is the active metabolite of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (M325910), N-Methyl-4-phenylpyridinium (MPP+), selectively destroys the dopaminergic neurons and induces the symptoms of Parkinson's disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gerlach, M., et al.: Eur. J. Pharmacol., 208, 273 (1991), Tipton, K., et al.: J. Neurochem., 61, 1191 (1993), Wimalasena, D., et al.: J. Biol. Chem., 279, 15298 (2004),<br></p>Formula:C12H14FN·ClHColor and Shape:Light YellowMolecular weight:227.713,4-Bis(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)benzamide
CAS:Purity:98%Molecular weight:407.29000854492193-Aminopiperidine-2,6-dione Hydrochloride
CAS:Controlled Product<p>Applications 3-Aminopiperidine-2,6-dione hydrochloride is a reagent for preparing lenalidomide that can induce ubiquitination and degradation of CK1α in del(5q) MDS. It can also be used to prepare phthalimide conjugates that can promote ligand-dependent target protein degradation.<br>References Kronke, J., et al.: Nature 523, 183 (2015); Liu C., et al.: Faming Zhuanli Shenqing CN 105348257 A 20160224 (2016); Rao, R., et al. : PCT Int. Appl. WO 2016024286 A2 20160218 (2016)<br></p>Formula:C5H8N2O2·ClHColor and Shape:Off-WhiteMolecular weight:164.590(3-Chloro-5-trifluoromethyl-pyridin-2-yloxy)-acetic acid ethyl ester
CAS:Purity:95.0%Molecular weight:283.6300048828125
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