Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65630 products of "Quinazoline and Quinoline Derivatives"
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(6,7-Dimethyl-3-phenyl-quinoxalin-2-yl)-phenyl-methanone
Purity:95.0%Molecular weight:338.41000366210944’-Hydroxy Toremifene (~8% E isomer)
CAS:Controlled Product<p>Applications 4’-Hydroxy Toremifene is a metabolite of Toremifene (T547500).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jones, R.M. et al.: Biomed. Chrom., 16, 361 (2002);<br></p>Formula:C26H28ClNO2Color and Shape:NeatMolecular weight:421.964-Phenyl-2-(pyridin-3-yl)thiazole
CAS:Purity:95.0%Color and Shape:Liquid, No data available.Molecular weight:238.30999755859375Dehydroxy Mirabegron Hydrochloride Salt
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Dehydroxy Mirabegron is an impurity of Mirabegron (M364900), potent bladder relaxant and reagent for diabetes remedy. It can also be used to effectively identify impurity generated during Mirabegron synthesis, so as to control the quality.<br>References Zhang, F., et.al., Faming Zhuanli Shenqing, 15, (2014);<br></p>Formula:C21H24N4OS·(HCl)Color and Shape:NeatMolecular weight:380.51 + (36.46)Benzocaine-d4
CAS:Controlled Product<p>Applications Labelled Benzocaine (B202970). Benzocaine is used as an anesthetic (local).<br>References Ali, S.L., et al.: Anal. Profiles Drug Subs., 12, 73 (1983),<br></p>Formula:C92H4H7NO2Color and Shape:NeatMolecular weight:169.21Ramelteon
CAS:Controlled Product<p>Applications Melatonin MT1/MT2 receptor agonist. Sedative, hypnotic.<br>References Yukuhiro, N., et al.: Brain Res., 59, 1027 (2004), Cajochen, C., et al.: Curr. Opin. Invest. Drugs, 6, 114 (2005), Kato, K., et al.: Neuropharmacology, 48, 301 (2005),<br></p>Formula:C16H21NO2Color and Shape:NeatMolecular weight:259.34Fluconazole N-Oxide
CAS:Controlled ProductFormula:C13H12F2N6O2Color and Shape:Off WhiteMolecular weight:322.27Tezacaftor
CAS:<p>Applications Tezacaftor is used as a combination therapy with Ivacaftor for the treatment of patients with cystic fibrosis.<br>References Rowe, S. M., et al.: N. Engl. J. Med., 377, 2024 (2017); Dhooghe, B., et al.: Exp. Opin. Investig. Drugs, 25, 423 (2016)<br></p>Formula:C26H27F3N2O6Color and Shape:White To Light YellowMolecular weight:520.5(2-methoxyethyl)(2-thienylmethyl)amine hydrochloride
CAS:Formula:C8H14ClNOSColor and Shape:SolidMolecular weight:207.723-(2,4-dimethylphenyl)-2-sulfanylidene-1,2,3,4-tetrahydroquinazolin-4-one
CAS:Purity:98%Molecular weight:282.3599853515625cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl p-Tolylsulfonate
CAS:<p>Impurity Ketoconazole EP Impurity E<br>Applications cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl p-Tolylsulfonate (Ketoconazole EP Impurity E) is an intermediate in the synthesis of the drug Ketoconazole (K186000).<br>References McManus, O., et al.: Biochemistry, 32, 6128 (1993), Olesen, S., et al.: Eur. J. Pharmacol., 251, 53 (1994), Assano, M., et al.: J. Pharm. Exp. Ther., 275, 775 (1995), Hewawasam, P., et al.: J. Med. Chem., 45, 1487 (2002),<br></p>Formula:C21H20Cl2N2O5SColor and Shape:NeatMolecular weight:483.367-(4-Chlorobutoxy)-3,4-dihydro-2(1H)-quinolinone
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 7-(4-Chlorobutoxy)-3,4-dihydro-2(1H)-quinolinone is used in the synthesis of aripiprazole, an antipsychotic oral drug used in the treatment of Schizophrenia.<br>References Bonacorsi, S. et al.: J. Label. Comp. Radiopharm., 49, 1 (2006); Morita, Seiji; K. et al.: Tetrahedron, 54, 4811 (1998);<br></p>Formula:C13H16ClNO2Color and Shape:Off-WhiteMolecular weight:253.725-Chloro-Vortioxetine Hydrobromide
CAS:Controlled Product<p>Applications 5-Chloro-Vortioxetine is an impurity of Vortioxetine (V766000), a multimodal serotonergic agent. Vortioxetine inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT.<br>References Bang-Andersen, B., et al.: J. Med. Chem., 54, 3206 (2011); Mørk, A., et al.: J. Pharmacol. Exp. Ther., 340, 666 (2012); Mørk, A., et al.: Pharmacol. Biochem. Behav. 105C, 41 (2013)<br></p>Formula:C18H22BrClN2SColor and Shape:NeatMolecular weight:413.86-chloro-2-(3-hydroxyphenyl)quinoline-4-carboxylic acid
CAS:Purity:95.0%Molecular weight:299.7099914550781Rivaroxaban Pseudodimer
CAS:<p>Applications Rivaroxaban Pseudodimer is an impurity of Rivaroxaban (R538000), a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formula:C38H36Cl2N6O10S2Color and Shape:NeatMolecular weight:871.76Roflumilast
CAS:<p>Applications Roflumilast is a selective phosphodiesterase 4(PDE4) inhibitor. Antiasthmatic; used in treatment of chronic obstructive pulmonary disease.<br>References Hatzelmann, A., et al.: J. Pharmacol. Exp. Ther., 297, 267 (2001); Schmidt, B.M.W., et al.: J. Allergy Clin. Immunol., 108, 530 (2001); Timmer, W., et al.: J. Clin. Pharmacol., 42, 297 (2002); Rabe, K.F., et al.: Lancet, 366, 563 (2005);<br></p>Formula:C17H14Cl2F2N2O3Color and Shape:NeatMolecular weight:403.213,7-Dimethyl-quinoxaline-2-carboxylic acid benzyl ester
Purity:95.0%Molecular weight:292.33801269531256-CHLORO-1-(6-FLUOROPYRIDIN-2-YL)-1H-PYRAZOLO[4,3-C]PYRIDINE
CAS:Purity:95.0%Molecular weight:248.649993896484388-methyl-2-(2-methylphenyl)quinoline-4-carboxylic acid
CAS:Purity:95.0%Molecular weight:277.3229980468755-chloro-4-methyl-N-(pyridin-2-ylmethyl)-1,3-benzothiazol-2-amine
CAS:Purity:95.0%Molecular weight:289.7799987792969Metaraminol Bitartrate
CAS:Controlled Product<p>Applications Metaraminol Bitartrate is a vasopressor comparable to ephedrine used in the maintenance of arterial pressure during spinal anesthesia. Also used in the treatment of hypotension while under the effect of anaesthesia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ngan, K. et al.: Anesthes., 95, 307 (2001); Critchley, L. et al.: Br. J. Anaesth., 76, 734 (1996);<br></p>Formula:C9H13NO2·C4H6O6Color and Shape:WhiteMolecular weight:317.29Daprodustat
CAS:<p>Applications Daprodustat is a novel HIF (Hypoxia inducible factor)-prolyl hydroxylase inhibitor.<br>References Olson, E., et al.: Vasc. Med., 19, 473 (2014);<br></p>Formula:C19H27N3O6Color and Shape:Off-WhiteMolecular weight:393.433-(3,5-Dimethyl-pyrazol-1-yl)-benzoic acid
CAS:Formula:C12H12N2O2Purity:95.0%Color and Shape:SolidMolecular weight:216.245-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is used as a reagent in the synthesis of N-(2-acylaminobenzyl or 2-acylaminoheterocyclylmethyl)thiophene-2-carboxamide derivatives as antithrombotics. It is also used as a reagent in the synthesis of diamide derivatives as FXa inhibitors. 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is an intermediate for Edoxaban (E555520).<br>References Mochizuki, A., et al.: Jpn. Kokai Tokkyo Koho. JP 2010120852 A 20100603. Jun 3, 2010; Mochizuki, A., et al.: PCT Int. Appl. WO 2008123017 A1 20081016. Oct 16, 2008<br></p>Formula:C8H11ClN2O2SColor and Shape:Light BrownMolecular weight:234.72,7-Bis(pyridin-4-ylmethyl)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone
CAS:Purity:95%Molecular weight:448.437988281252,5-Bis(2,2,2-trifluoroethoxy)benzoic Acid
CAS:Controlled Product<p>Impurity Flecainide EP Impurity D<br>Applications Flecainide Acetate Impurity D.<br>References Banitt, E., et al.: J. Med. Chem., 18, 1130 (1975),<br></p>Formula:C11H8F6O4Color and Shape:White To Off-WhiteMolecular weight:318.174-Bromo-1-chloro-6-methoxyisoquinoline
CAS:Purity:97%Color and Shape:SolidMolecular weight:272.5299988Benzocaine
CAS:Controlled Product<p>Applications Benzocaine is used as an anesthetic (local).<br>References Kholod, Y., et al.: Environ. Sci. Technol., 43, 9208 (2009), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Perez-Garrido, Alfonso; Helguera, A., et al.: J. Pharm. Sci., 98, 4557 (2009), Onoue, S., et al.: J. Pharm. Sci., 98, 3647 (2009),<br></p>Formula:C9H11NO2Color and Shape:NeatMolecular weight:165.19Latrepirdine dihydrochloride
CAS:Latrepirdine dihydrochloride (Dimebolin dihydrochloride) is an orally active, and neuroactive antagonist of multiple drug targets.Formula:C21H25N3·2HClPurity:98.45%Color and Shape:SolidMolecular weight:392.37N-Nitroso-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-L-valine Methyl Ester-d8
Formula:C20H13D8N3O3Color and Shape:NeatApixaban Dimer
CAS:Controlled Product<p>Applications Apixaban Dimer is an impurity compound of Apixaban (A726700). Apixaban is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful in the prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Luettgen, J. M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);<br></p>Formula:C40H34N10O6Color and Shape:NeatMolecular weight:750.782-Pyrrolidin-1-ylquinolin-8-ol
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:214.26800537109375Propoxyphenyl Thioaildenafil
CAS:Controlled Product<p>Applications Propoxyphenyl Thioaildenafil is an analogue of Thioaildenafil (T344365). Propoxyphenyl Thioaildenafil is a phosphodiesterase-5 inhibitor (PDE-5) that has been found in health supplements.<br>References Kee, C., Ge, X., Koh, H., Low, M.: J. Pharmaceut. Biomed., 70, 265 (2012)<br></p>Formula:C24H34N6O3S2Color and Shape:NeatMolecular weight:518.74,7-dimethoxy-N-(pyridin-2-ylmethyl)benzo[d]thiazol-2-amine
CAS:Purity:95.0%Molecular weight:301.35998535156255-Aminothiophene-2-carbonitrile
CAS:Formula:C5H4N2SPurity:98%Color and Shape:SolidMolecular weight:124.161-[3-(4-tert-Butylbenzoyl)propyl]-4-hydroxypiperidine
CAS:Controlled ProductFormula:C19H29NO2Color and Shape:WhiteMolecular weight:303.447-Hydroxy Chlorpromazine Hydrochloride
CAS:<p>Impurity Chlorpromazine 7-Hydroxy Impurity<br>Stability Hygroscopic<br>Applications 7-Hydroxychlorpromazine is the 7-hydroxy analogue and a major metabolite of the atypical antipsychotic Chlorpromazine (C424750).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jori, A. et al.: Int. J. Neuropharmacol., 5, 435 (1966); Shavit, S. et al.: Comm. Psychopharmacol., 4, 495 (1980);<br></p>Formula:C17H19ClN2OS·HClColor and Shape:White To Light PurpleMolecular weight:371.32Tolvaptan-d7
CAS:Controlled Product<p>Applications Labelled Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),<br></p>Formula:C26H18D7ClN2O3Color and Shape:NeatMolecular weight:455.98[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]methanol
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:268.2909851074219(5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone
CAS:Controlled Product<p>Applications (5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone is an intermediate used in the synthesis of dronedarone hydrochloride (I), a class III antiarrhythmia drug for the prevention of cardiac arrhythmias such as atrial fibrillation.<br>References Mali, A. C., et al.: Org. Proc. Res. Dev., 17, 863 (2013)<br></p>Formula:C30H42N2O3Color and Shape:NeatMolecular weight:478.67
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