Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65497 products of "Quinazoline and Quinoline Derivatives"
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2-{[4-methyl-5-(thiophen-2-yl)-4h-1,2,4-triazol-3-yl]sulfanyl}acetic acid
CAS:Purity:95+%Molecular weight:255.3099976(4R-cis)-6-Chloromethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester
CAS:Controlled Product<p>Applications A HMG-CoA reductase inhibitor intermediate.<br>References Hummel, W., et al.: J. Microbiol. Methods, 9, 201 (1989), Jendralla, H., et al.: J. Med. Chem., 34, 2962 (1991), Vicenzi, J., et al.: Enzyme Microb. Technol., 20, 494 ( 1997),<br></p>Formula:C13H23ClO4Color and Shape:NeatMolecular weight:278.77Ethylenediamine P-Toluenesulfonate
CAS:Controlled Product<p>Impurity Xylometazoline EP Impurity E<br>Stability Hygroscopic<br>Applications Ethylenediamine P-Toluenesulfonate is a reactant used in the synthesis of antitumor agents. Also is an impurity of Xylometazoline (X749950), a vasoconstrictor involved in signal transduction, also used as a nasal decongestant. May be used in treatments involving ischemic injury due to the ability to shift energy metabolism from mitochondrial to glycolysis (2).<br>References 1. Fliri, A. et al.: J. Med. Chem. 2009 Dec 24;52(24):8038-46.2. Gohil, V. et al.: Nat Biotechnol. 2010 Mar;28(3):249-55.<br></p>Formula:C7H8O3S·C2H8N2Color and Shape:NeatMolecular weight:232.2999Despiperazine Amino Norfloxacin
CAS:Controlled ProductFormula:C12H11FN2O3Color and Shape:NeatMolecular weight:250.228-tert-butyl-4-(thiophene-2-carbonyl)-1-oxa-4-azaspiro[4.5]decane-3-carboxylic acid
CAS:Purity:95.0%Molecular weight:351.45999145507815-(p-Methylphenyl)-5-phenylhydantoin
CAS:<p>Applications An antibody agent.<br>References Rowell, F. J., et al.: Immunochemistry, 13, 891 (1976),<br></p>Formula:C16H14N2O2Color and Shape:NeatMolecular weight:266.293-(3-([1,1'-biphenyl]-4-yl)-1-phenyl-1h-pyrazol-4-yl)acrylic acid
CAS:Purity:97%Molecular weight:366.423’-[3-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)propyl] Domperidone(Domperidone Impurity E) (>90%)
CAS:Formula:C32H34ClN7O3Purity:>90%Color and Shape:White To Off-WhiteMolecular weight:600.114-(4-ethoxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-1,2,4-triazole-5-thione
CAS:Purity:97%Molecular weight:298.35998535156252-(8-Chlorodibenzo[b,d]furan-1-yl)-4,6-diphenyl-1,3,5-triazine
CAS:Purity:98%Molecular weight:433.8999938964844Alogliptin Benzoate
CAS:<p>Applications Alogliptin Benzoate is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Alogliptin Benzoate is used in the treatment of type 2 diabetes.<br>References Wang, Y., et. al.: Drugs Future, 33, 7 (2008); Lynn, F., et al.: Diabetes, 50, 1004 (2001); Trumper, A., et al.: J. Endocrinol., 174, 233 (2002); Vollmer, K., et al.: J. Clin. Endocrinol. Metab., 94, 1379 (2009)<br></p>Formula:C18H21N5O2·C7H6O2Color and Shape:NeatMolecular weight:461.51Asenapine N-Oxide
CAS:Controlled Product<p>Applications A metabolite of Asenapine (A788000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ven der Wildenberg, H.M., et al.: Arzneim.-Forsch., 40, 540 (1990),<br></p>Formula:C17H16ClNO2Color and Shape:NeatMolecular weight:301.773-Methoxy-4-nitro-1H-pyrazole-5-carboxylic acid
CAS:Formula:C5H5N3O5Purity:95.0%Color and Shape:SolidMolecular weight:187.111Astemizole
CAS:Controlled Product<p>Applications Nonsedating-type histamine H1-receptor antagonist. Potential for combination therapy with antivancer drugs such as doxorubicin in resistant leukemia. Antihistaminic.<br>References Wauquier, A., et al.: Eur. J. Pharmacol., 72, 245 (1981), Laduron, P.M., et al.: Mol. Pharmacol., 21, 294 (1982), Richards, D.M., et al.: Drugs, 28, 38 (1984), Al-Obaid, A.M., et al.: Anal. Profiles Drug Subs., 20, 173 (1991), Ishikawa, M., et al.: Biol. Pharm. Bull., 23, 112 (2000),<br></p>Formula:C28H31FN4OColor and Shape:White To Off-WhiteMolecular weight:458.576-(methylsulfonyl)-N-(pyridin-3-ylmethyl)benzo[d]thiazol-2-amine
CAS:Purity:95.0%Molecular weight:319.3999938964844Vildagliptin Racemic
CAS:<p>Applications Vildagliptin Racemic is an impurity of Vildagliptin (V305000),a class of oral anti-hyperglycemic agents that inhibit dipeptidyl peptidase 4 (DPP-4), which can act as a serine exopeptidase. Aside from their use in type 2 diabetes, gliptins have positive cardiovascular and anti-inflammtatory effects. Antidiabetic.<br>References Ahren, B., et al.: J. Clin. Endocrinol. Metab., 89, 2078 (2004), Ahren, B., et al.: Diabetes Care, 27, 2874 (2004), Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 5, 1094 (2004),<br></p>Formula:C17H25N3O2Color and Shape:NeatMolecular weight:303.3992-(3,4-Dimethylbenzoyl)-5-(1,3-dioxolan-2-yl)thiophene
CAS:Purity:97.0%Molecular weight:288.35998535156254-methoxy-N-(pyridin-3-ylmethyl)-1,3-benzothiazol-2-amine
CAS:Purity:95.0%Molecular weight:271.33999633789063-methyl-1-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-1H-pyrazol-5-amine
CAS:Purity:95.0%Molecular weight:291.31799316406251-[3-(Trifluoromethyl)pyridin-2-yl]piperazine hydrochloride
CAS:Purity:97.0%Molecular weight:267.67999267578125Mitotane-13C6
CAS:Controlled Product<p>Applications Mitotane-13C6 is the isotope labelled analogue of Mitotane (M372500), an antineoplastic and adrenolytic agent.<br>References Das, S., and Thomas, P.: Endocrinology, 140, 1953 (1999), Andersen, A., et al.: Ther. Drug. Monit., 21, 355 (1999), Leblond, V.S., and Hontela, T.: Toxicol. Appl. Pharmacol., 157, 16 (1999)<br></p>Formula:C6C8H10Cl4Color and Shape:Light YellowMolecular weight:326.02-Chloro Phenothiazine
CAS:Controlled Product<p>Impurity Chlorpromazine EP Impurity E<br>Applications Metabolite of Chloropromazine<br>References Motohashi, N., et al.: Anticancer Res., 17, 4403 (1997), Azuine, M., et al.: Pharmacol. Res., 49, 161 (2004), Touil, F., et al.: J. Pharm. Biomed. Anal., 40, 822 (2006),<br></p>Formula:C12H8ClNSColor and Shape:GreyMolecular weight:233.72N-(3-Chloro-4-(((2-(methylamino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide
CAS:Purity:98.0%Molecular weight:418.8999938964844Nizatidine-d3
CAS:Controlled Product<p>Applications Labelled Nizatidine. Histamine H2-receptor antagonist related to Ranitidine (R120000). Antiulcerative.<br>References Callaghan, J.T., et al.: Clin. Pharmacol. Ther., 37, 162 (1985), Secor, J.W., et al.: Br. J. Clin. Pharmacol., 20, 710 (1985), Knadler, M.P., et al.: Drug Metab. Dispos., 14, 175 (1986), Wozniak, T.J., et al.: Anal. Profiles Drug Subs., 19, 397(1990)<br></p>Formula:C12D3H18N5O2S2Color and Shape:Light Yellow SolidMolecular weight:334.48Demethylpiperazinyl 7-Desoxo 7-Thioxosildenafil Sulfonic Acid
CAS:Controlled ProductFormula:C17H20N4O4S2Color and Shape:Off White SolidMolecular weight:408.50Carisoprodol
CAS:Controlled Product<p>Applications Muscle relaxant (skeletal).<br>References Musso, D., et al.: J. Med. Chem. 46, 399 (2003), Newman, P., et al.: Eur. J. Clin. Pharm., 23, 31 (1982).<br></p>Formula:C12H24N2O4Color and Shape:White To Off-WhiteMolecular weight:260.33Reserpine-d9
CAS:Controlled Product<p>Applications Labelled Reserpine (R144600). An indole alkaloid found in Rauwolfia serpentina. Inhibits vesicular uptake of catecholamines and serotonin. Reserpine is reasonably anticipated to be a human carcinogen. Antihypertensive.<br>References Muller, J.M., et al.: Experientia, 8, 338 (1952), Schirmer, R.E., et al.: Anal. Profiles Drug Subs., 4, 384 (1975), Diener, R.M., et al.: Toxicol. Pathol., 8, 1 (1980),<br></p>Formula:C332H9H31N2O9Color and Shape:NeatMolecular weight:617.733-(1,3-benzodioxol-5-yl)-1H-pyrazole hydrochloride
CAS:Purity:95.0%Molecular weight:224.63999938964844N-(4-Pyridin-2-yl-thiazol-2-yl)benzene-1,4-diamine
CAS:Color and Shape:SolidMolecular weight:268.3399963378906rac-Naproxen-13C,d3
CAS:Controlled Product<p>Applications Labelled Naproxen. An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Harrison, I.T., et al.: J. Med. Chem., 13, 203 (1970)<br></p>Formula:CC132H3H11O3Color and Shape:NeatMolecular weight:234.27Cimetidine Amide Dihydrochloride
CAS:Controlled Product<p>Impurity Cimetidine EP Impurity C<br>Applications Cimetidine Amide Dihydrochloride (Cimetidine EP Impurity C) is an impurity of Cimetidine.<br>References Durant, G.J., et al.: J. Med. Chem., 18, 830 (1975), Pounder, R.E., et al.: Br. Med. J., 2, 307 (1975),<br></p>Formula:C10H18N6OS·2ClHColor and Shape:White To Off-WhiteMolecular weight:343.28Thiourea
CAS:Controlled Product<p>Applications Thiourea is used in biochemistry to increase the solubility (and resolution) of membrane proteins in two-dimensional electrophoresis. Thiourea is also used to treat thyrotoxicosis, a hypermetabolic clinical syndrome that is induced by multiple causes (Graves’ disease, hyperthyroidism, etc.).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jabbour, S.: Am. J. Clin. Dermatol., 4, 315 (2003); Himsworth, H.: Lancet, 242, 465 (1943); Rabilloud, T., et al.: Electrophoresis, 19, 758 (1998)<br></p>Formula:CH4N2SColor and Shape:WhiteMolecular weight:76.125-chloro-2-(1H-pyrazol-5-yl)aniline
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:193.6300048828125N-(4-((4-Chloro-6-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)thio)phenyl)cyclopropanecarboxamide
CAS:Purity:95.0%Molecular weight:400.890014648437522-Hydroxy Mifepristone-d6
CAS:Controlled Product<p>Applications A labelled metabolite of Mifepristone.<br>References Heikinheimo, O., et al.: J. Steroid Biochem., 26, 279 (1987), Brogden, R., et al.: Drugs, 45, 384 (1993), Shi, Y., et al.: Contraception, 48, 133 (1993), Jang, G., et al.: Biochem. Pharmacol., 52, 753 (1996), Gainer, E., et al.: Steroids, 68, 1005 (2003),<br></p>Formula:C29H29D6NO3Color and Shape:NeatMolecular weight:451.63Saxagliptin Hydrochloride
CAS:Controlled Product<p>Applications Saxagliptin is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once daily dosing.<br>References Feng, J., et al.: J. Med. Chem., 50, 2297 (2007), Rosenstock, J., et al.: Diabetes Obes. Metab., 10, 376 (2008), Thomas, L., et al.: J. Pharmacol. Exp. Ther., 325, 175 (2008),<br></p>Formula:C18H25N3O2·ClHColor and Shape:NeatMolecular weight:351.873’-Amino-2’-Hydroxy-[1,1’]biphenyl-3-carboxylic Acid
CAS:Controlled Product<p>Applications 3’-Amino-2’-Hydroxy-[1,1’]Biphenyl-3-carboxylic Acid is used in the synthesis of monoethanolamine salts. A hydrazine cleavage product from Eltrombopag (E508000), an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia<br>References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),<br></p>Formula:C13H11NO3Color and Shape:NeatMolecular weight:229.231(3-Methoxypyridin-4-yl)boronic acid hydrate
CAS:Formula:C6H10BNO4Purity:95.0%Color and Shape:SolidMolecular weight:170.96Cloperastine Fendizoate
CAS:<p>Stability Hygroscopic<br>Applications Cloperastine fendizoate is used in the treatment of chronic non-productive cough. Antitussive. it is the salt of Cloperastine (CAS:3703-76-2)<br>References Aliprandi, P. et al.: Clin. Drug Invest. 22, 209 (2002)<br></p>Formula:C20H24ClNO·C20H14O4Color and Shape:White To Off-WhiteMolecular weight:648.19Sitagliptin Phosphate
CAS:Controlled Product<p>Applications Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.<br>References Kim, D., et al.: J. Med. Chem. 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005), Bergman, A., et al: Clin. Ther. 28, 55 (2006)<br></p>Formula:C16H15F6N5O·H3O4PColor and Shape:NeatMolecular weight:505.314-Amino Fluconazole Bromide
CAS:<p>Impurity Fluconazole EP Impurity I<br>Applications 4-Amino Fluconazole Bromide (Fluconazole EP Impurity I) is an impurity of Fluconazole (F421000), which is used as an antifungal.<br>References Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985)<br></p>Formula:C13H14F2N7O·BrColor and Shape:NeatMolecular weight:402.20
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