Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65580 products of "Quinazoline and Quinoline Derivatives"
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Niclosamide
CAS:Controlled Product<p>Applications Niclosamide is used as an anthelmintic drug (Cestodes).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Loftsson, T., et al.: J. Pharm. Sci., 85, 1017 (1996), Malik, N., et al.: Anti. Cancer Drugs, 10, 767 (1999), El-Sayed, M., et al.: Pharm. Res., 18, 23 (2001),<br></p>Formula:C13H8Cl2N2O4Color and Shape:NeatMolecular weight:327.121-Chloro Dihydro Dutasteride
CAS:<p>Impurity Dutasteride EP Impurity F<br>Applications 1-Chloro Dihydro Dutasteride (Dutateride EP Impurity F) is a 3-oxo-4-aza-5α-androstene-17β-carboxylic acid derivative and an impurity of Dutasteride (D735000).<br></p>Formula:C27H31ClF6N2O2Color and Shape:NeatMolecular weight:564.99L-2-Aminobutyric Acid Methyl Ester Hydrochloride
CAS:Controlled Product<p>Applications Intermediate in the preparation of Ergonovine (E597800) derivatives.<br>References Beck, H., et al.: Bioorg. Med. Chem. Lett., 18, 1037 (2008),<br></p>Formula:C5H12ClNO2Color and Shape:NeatMolecular weight:153.614-Defluoro 2-Fluoro Flunarizine Dihydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 4-Defluoro 2-Fluoro Flunarizine Dihydrochloride is an impurity of Flunarizine(F455200, Dihydrochloride), which is a calcium channel blocker. Flunarizine is a fluorinated derivative of Cinnarizine and a vasodilator (cerebral and peripheral).<br>References Desmedt, L.K., et al.: Arzneim.-Forsch., 25, 1408 (1975), Godfraind, T., et al.: Eur. J. Pharmacol., 53, 273 (1979), Nihard, P., et al.: Angiology, 33, 37 (1982), Holmes, B., et al.: Drugs, 27, 6 (1984)<br></p>Formula:C26H26F2N2HClColor and Shape:White SolidMolecular weight:404.4923646Nordeprenyl (>90%)
CAS:Controlled Product<p>Applications A metabolite of Deprenyl.<br>References Yoshida, T., et al.: Xenobiotica, 17, 957 (1987), Meeker, J., et al.: J. Anal. Toxicol., 14, 330 (1990), Heinonen, E., et al.: Clin. Pharm. Ther., 56, 742 (1994), Szoko, E., et al.: Int. J. Pharm. Adv., 1, 320 (1996),<br></p>Formula:C12H15NPurity:>90%Color and Shape:NeatMolecular weight:173.253-Dimethylaminopropyl-2-benzylaminobenzoate Hydrochloride
CAS:Formula:C19H24N2O2·ClHColor and Shape:NeatMolecular weight:348.8710,11-Dihydro-10-hydroxy Carbamazepine-d3
CAS:Controlled Product<p>Applications A labelled metabolite of Oxcarbazepine (O869250).<br>References Burkhart, C., et al.: Clin. Exp. Allergy, 32, 1635 (2002), Pearce, R., et al.: Drug Metab. Dispos., 30, 1170 (2002), Naisbitt, D., et al.: Mol. Pharmacol., 63, 732 (2003), Farrell, J., et al.: Br. J. Clin. Pharmacol., 57, 690 (2004),<br></p>Formula:C152H3H11N2O2Color and Shape:Off WhiteMolecular weight:257.302-[3-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-oxopropyl]benzoic Acid Methyl Ester
CAS:Controlled Product<p>Applications An intermediate in the synthesis of Montelukast.<br>References Labelle, M., et al.: Bioorg. Med. Chem. Lett., 4, 463 (1994), Roberge, C., et al.: J. Ferment. Bioeng., 81, 530 (1996), Shafiee, A., et al.: App. Microbiol. Biotechnol., 49, 709 (1998),<br></p>Formula:C28H22ClNO3Color and Shape:NeatMolecular weight:455.93Vortioxetine Sulfone
CAS:<p>Applications Vortioxetine Sulfone is a derivative of Vortioxetine (V766000), a multimodal serotonergic agent that inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT (1,2,3).<br>References Paunovic, A. et al.: ACS Chem. Biol., 12, 132 (2017);<br></p>Formula:C18H22N2O2SColor and Shape:NeatMolecular weight:330.44ORM-15341
CAS:<p>Applications ORM-15341 is a metabolite of Darolutamide. Darolutamide is a potent androgen receptor antagonist with strong efficacy in prostate cancer models.<br>References Sugawara, T., et al.: Int. J. Cancer, 145, 1382 (2019); Yu, J., et al.: Eur. J. Med. Chem., 182, 111608 (2019)<br></p>Formula:C19H17ClN6O2Color and Shape:NeatMolecular weight:396.836-O-α-D-Maltosyl-β-cyclodextrin
CAS:<p>Applications 6-O-α-D-Maltosyl-β-cyclodextrin is an additive to improve the solubility of quetiapine.<br>References Ogawa, N., et. al.: Chem. Pharm. Bull., 31, 809 (2013)<br></p>Formula:C54H90O45Color and Shape:White PowderMolecular weight:1459.267-Nitro-4-(pyridin-2-ylmethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
CAS:Purity:95+%Molecular weight:285.2590026855469Ref: 10-F608382
1gTo inquire2gTo inquire5gTo inquire10gTo inquire100mgTo inquire250mgTo inquire500mgTo inquireRamelteon Metabolite M-II-d3 (mixture of R and S at the hydroxy position)
CAS:Controlled Product<p>Applications The major metabolite of Ramelteon in serum (M-II).<br>References Karim, A., et al.: J. Clin. Pharmacol., 44, 1210 (2004), Prescott, E., et al.: Drug Metab. Rev., 36, 203 (2004), Kato, K., et al.: Neuropharmacology, 48, 301 (2005), Karim, A., et al.: J. Clin. Pharmacol., 46, 140 (2006),<br></p>Formula:C16D3H18NO3Color and Shape:NeatMolecular weight:278.36Amido Methyl Meloxicam (Meloxicam Impurity)
CAS:Controlled Product<p>Applications Amido Methyl Meloxicam is an impurity of Meloxicam (M216100).<br>References Lazer, E., et al.: J. Med. Chem., 40, 980 (1997),<br></p>Formula:C15H15N3O4S2Color and Shape:NeatMolecular weight:365.434-Bromo-1-ethyl-1 H -pyrazole-3-carboxylic acid methyl ester
CAS:Formula:C7H9BrN2O2Purity:96%Color and Shape:SolidMolecular weight:233.065(±)-Bifonazole
CAS:<p>Applications (±)-Bifonazole acts as an anti-fungal agent used in the treatment of skin diseases. Causes an increase in Ca2+ concentration and triggers cell death in PC3 human prostate cancer cells.<br>References Cheng, J. et al.: J. Recep. Sign. Transduct., 34, 493 (2014); Chen, Z. et al.: Mol. Pharm., 12, 590 (2015);<br></p>Formula:C22H18N2Color and Shape:NeatMolecular weight:310.39trans-4-[[(2-Amino-5-bromophenyl)methyl]amino]-cyclohexanol
CAS:<p>Applications trans-4-[[(2-Amino-5-bromophenyl)methyl]amino]-cyclohexanol is an impurity of Ambroxol (A575900), a bronchosecretolytic drug and a metabolite of Bromohexine.<br>References Jauch, R., et al.: Arzneim-Forsch., 13, 474 (1963)<br></p>Formula:C13H19BrN2OColor and Shape:NeatMolecular weight:299.21Tadalafil Ketolactam (>90%)
CAS:Controlled Product<p>Stability Hygroscopic, Unstable in Solution<br>Applications Tadalafil Ketolactam is a Tadalafil (T004500) impurity.<br></p>Formula:C22H19N3O6Purity:>90%Color and Shape:NeatMolecular weight:421.4028Ibrutinib
CAS:Controlled Product<p>Applications Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.<br>References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)<br></p>Formula:C25H24N6O2Color and Shape:Off-WhiteMolecular weight:440.504-(2-Nitroanilino)pyridine
CAS:Controlled Product<p>Impurity Droperidol Impurity 4<br>Applications 4-(2-Nitroanilino)pyridine can be used to increase the yield of 4-(2-Aminoanilino)pyridine (A583160) dihydrochloride by hydrogenation in the presence of a Ni-Cr catalyst. Droperidol Impurity 4.<br>References Avots, A., et al.: U.S.S.R., SU 1318592 A1 19870623<br></p>Formula:C11H9N3O2Color and Shape:NeatMolecular weight:215.208(4R-cis)-6-Chloromethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester
CAS:Controlled Product<p>Applications A HMG-CoA reductase inhibitor intermediate.<br>References Hummel, W., et al.: J. Microbiol. Methods, 9, 201 (1989), Jendralla, H., et al.: J. Med. Chem., 34, 2962 (1991), Vicenzi, J., et al.: Enzyme Microb. Technol., 20, 494 ( 1997),<br></p>Formula:C13H23ClO4Color and Shape:NeatMolecular weight:278.77(S)-Naproxen Ethyl Ester
CAS:<p>Impurity Naproxen EP Impurity F<br>Applications Naproxen (N377520) ethyl derivative. Naproxen impurity.<br>References Haddock, R., et al.: Xenobiotica, 14, 327 (1984), Jeremy, J., et al.: Drugs, 40, 53 (1990), Wadhwa, L., et al.: Int. J. Pharm., 118, 31 (1995),<br></p>Formula:C16H18O3Color and Shape:NeatMolecular weight:258.311-Phenyl-1,2-propanediol (Mixture of Diastereomers)
CAS:Controlled Product<p>Applications 1-Phenyl-1,2-propanediol is a reagent in pharmaceutical chemistry, used in the synthesis of nor(pseudo)ephedrine related compounds.<br>References Sehl, T. et al.: Green Chem., 16, 3341 (2014); Moorthy, J. et al.: J. Org. Chem., 76, 9593 (2011);<br></p>Formula:C9H12O2Color and Shape:NeatMolecular weight:152.19(S)-O-Desmethyl Naproxen
CAS:Controlled Product<p>Applications A metabolite of Naproxen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rettie, A., et al.: Chem. Res. Toxicol., 5, 54 (1992), Tracy, T., et al.: Biochem. Pharmacol., 52, 1305 (1996), Bonnabry, P., et al.: Eur. J. Clin. Pharmacol., 49, 305 (1996), Rao, S., et al.: J. Med. Chem., 43, 2789 (2000), Hutzler, J., et al.: Drug Metab. Dispos., 29, 1029 (2001),<br></p>Formula:C13H12O3Color and Shape:WhiteMolecular weight:216.23Des(methoxycarbonyl) Febantel
CAS:Controlled Product<p>Applications Febantel (F227000) impurity. Anthelmintic.<br>References Wollweber, H., et al.: Arzneim.-Forsch., 34, 531 (1984),<br></p>Formula:C18H20N4O4SColor and Shape:NeatMolecular weight:388.44Asenapine N-β-D-Glucuronide Trifluoroacetic Acid Salt (Mixture of Diastereomers)
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Asenapine N-β-D-Glucuronide is a metabolite of Asenapine (A788000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C23H25ClNO7·C2F3O2Color and Shape:NeatMolecular weight:575.92N-Dehydroxyzileuton
CAS:Controlled Product<p>Applications N-Dehydroxyzileuton is a pharmacologically inactive metabolite of Zileuton (Z420000), an inhibitor of 5-lipoxygenase that is used to treat patients with asthma.<br>References Awni, W., et al.: Clin. Pharm., 29, 62 (1995); Machinist, J., et al.: Clin. Pharm., 29, 34 (1995); Remko, M., et al.: Phys. Chem. Chem. Phys., 2, 2511 (2000);<br></p>Formula:C11H12N2OSColor and Shape:NeatMolecular weight:220.29N-Desmethyl Danofloxacin
CAS:<p>Applications A metabolite of Danofloxacin.<br>References Kiely, J.S., et al.: J. Med. Chem., 43, 656 (1991)<br></p>Formula:C18H18FN3O3Color and Shape:NeatMolecular weight:343.353-Hydroxy-2-pyrone
CAS:Controlled Product<p>Applications 3-Hydroxy-2-pyrone<br></p>Formula:C5H4O3Color and Shape:NeatMolecular weight:112.08N-(2-Hydroxyethyl)-P,P-bisaziridinyl Thiophosphamide
CAS:Controlled ProductFormula:C6H14N3OPSColor and Shape:NeatMolecular weight:207.23[4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]phenyl]cyclopropylmethanone
CAS:Controlled Product<p>Applications [4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]phenyl]cyclopropylmethanone is an impurity of Haloperidol (H103700), an antidyskinetic; antipsychotic.<br>References Janicki, C.A., et al.: Anal. Profiles Drug Subs., 9, 341 (1980); Beresford, R., et al.: Drugs, 33, 31 (1987)<br></p>Formula:C21H22ClNO2Color and Shape:NeatMolecular weight:355.86Roflumilast-d4
CAS:Controlled Product<p>Applications Labelled selective phosphodiesterase 4(PDE4) inhibitor. Antiasthmatic; in treatment of chronic obstructive pulmonary disease.<br>References Hatzelmann, A., et al.: J. Pharmacol. Exp. Ther., 297, 267 (2001), Schmidt, B.M.W., et al.: J. Allergy Clin. Immunol., 108, 530 (2001), Timmer, W., et al.: J. Clin. Pharmacol., 42, 297 (2002), Rabe, K.F., et al.: Lancet, 366, 563 (2005),<br></p>Formula:C17D4H10Cl2F2N2O3Color and Shape:NeatMolecular weight:407.23Anastrozole Diamide
CAS:Controlled Product<p>Impurity Anastrozole Diamide Impurity<br>Applications Anastrozole Diamide is a derivative of Anastrozole (A637425), an aromatase inhibitor. Used as an antineoplastic. Anastrozole Diamide Impurity<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>Formula:C17H23N5O2Color and Shape:WhiteMolecular weight:329.40Lodenafil Carbonate
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Lodenafil carbonate is a new PDE-5 inhibitor used for oral therapy in erectile dysfunction.<br>References Rosen, R., et al.: Urology, 49, 822 (1997), Chew, K., et al.: J. Sex Med., 5, 928 (2008), Teixeira, C., et al.: Eur. J. Pharmacol., 591, 189 (2008),<br></p>Formula:C47H62N12O11S2Color and Shape:NeatMolecular weight:1035.20Desfluoro Fluvoxketone
CAS:Controlled Product<p>Applications Desfluoro Fluvoxamine intermediate.<br></p>Formula:C13H16F2O2Color and Shape:NeatMolecular weight:242.26Topiramate
CAS:<p>Applications Used as an anticonvulsant.<br>References Maryanoff, B.E., et al.: J. Med. Chem., 30, 880 (1987); Bialer, M.: Clin. Pharmacokinet., 24(6), 441-52 (1993)<br></p>Formula:C12H21NO8SColor and Shape:White To Off-WhiteMolecular weight:339.36(2R)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile
CAS:Controlled Product<p>Applications (2R)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile, can be used in the synthesis of 1-[[(3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine, and Vildagliptin (C363780), which are potent, selective, and orally bioavailable dipeptidyl peptidase IV Inhibitor with Antihyperglycemic properties, that might be used for the treatment of type 2 diabetes.<br>References Singh, S.K., et al.: Beil. J. Org. Chem., 4, 20 (2008); Villhauer, E. B., et al.: J. Med. Chem., 46, 2774 (2003);<br></p>Formula:C7H9ClN2OColor and Shape:NeatMolecular weight:172.614-Bromo Riluzole
CAS:Controlled Product<p>Applications 4-Bromo Riluzole is an impurity of Riluzole (R510000); a benzothiazole derivative that is used to treat amyotrophic lateral sclerosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahamed, A., et al.: J. Pharm. Res., 3, 1028 (2010); Satyanarayana, B., et al.: ARKIVOC, no vol., 109 (2008)<br></p>Formula:C8H4BrF3N2OSColor and Shape:NeatMolecular weight:313.09N,O-Bis(trimethylsilyl)trifluoroacetamide (~90%)
CAS:Controlled Product<p>Applications Used as a reactant in the preparation of pyrimidinone ribosides and analogs that show anti-tumor properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Driscoll, J.S. et al.: J. Med. Chem., 34, 3280 (1991); Pan, L. et al.: J. Pharm. Biomed. Anal., 52, 589 (2010);<br></p>Formula:C8H18F3NOSi2Purity:~90%Color and Shape:Colourless To Light YellowMolecular weight:257.40Ethionamide-d3
CAS:Controlled Product<p>Applications Ethionamide-d3 is the isotope labelled analogue of Ethionamide (E890420), a antibacterial (tuberculostatic) agent.<br>References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),<br></p>Formula:C8H7D3N2SColor and Shape:NeatMolecular weight:169.26Bisnortilidine
CAS:Controlled Product<p>Applications A metabolite of Tilidine (T440300(M)), which is a controlled substance (opiate) and a analgesic. Tilidine is used in clinical trial in comparison with Nefopam. Tilidine is one of the most widely used narcotics in Germany and Belgium.<br>References Hengy, H., et al.: J. Pharm. Sci., 67, 1765 (1978); Cordonnier, J., et al.: J. Anal. Toxicol., 11, 144 (1987); Hajda, J., et al.: J. Clin. Pharmacol., 42, 1257 (2002); Vollmer, K.-O., et al.: Arzneim.-Forsch., 20, 990 (1970); Abeloos, J., et al.: Acta Anaesthesiol. Belg., 34, 283 (1983); Van Cauwenberge, H., et al.: Int. J. Clin. Pharmacol. Res., 12, 1 (1992)<br></p>Formula:C15H19NO2Color and Shape:NeatMolecular weight:245.32
![2-[3-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-oxopropyl]benzoic Acid Methyl Ester](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FC380010.webp&w=3840&q=75)
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