Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65630 products of "Quinazoline and Quinoline Derivatives"
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7-(4-Bromobutoxy)-3,4-dihydroquinolin-2-one
CAS:Controlled Product<p>Impurity Aripiprazole Bromobutoxyquinoline Impurity<br>Stability Hygroscopic<br>Applications An impurity in the synthesis of Aripiprazole (A771000). A degradation product in Aripiprazole tablets. Aripiprazole Bromobutoxyquinoline Impurity<br>References Reddy, G.V.R., et al.: Eur. J. Chem., 1, 20 (2010),<br></p>Formula:C13H16BrNO2Color and Shape:White To Off-WhiteMolecular weight:298.18R 84852
CAS:<p>Applications R 84852 is an impurity of paliperidone (P141000), a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br>References Solanki, P.V., et. al.: ACS Sustainable Chem. Eng., 1, 243 (2013)<br></p>Formula:C23H28FN3O4Color and Shape:NeatMolecular weight:429.48Levosimendan
CAS:<p>Applications Bioactive enantiomer of racemate, Simendan. Positive inotropic agent with vasodilating activity. Cardiotonic.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995), Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996),<br></p>Formula:C14H12N6OColor and Shape:Yellow To Dark YellowMolecular weight:280.283,7-Dihydro-3-methyl-1,7-bis(5-oxohexyl)-1H-purine-2,6-dione
CAS:Formula:C18H26N4O4Color and Shape:NeatMolecular weight:362.42Tazarotenic Acid
CAS:Controlled Product<p>Applications Tazarotenic acid is the major active metabolite of Tazarotene (T010050).<br>References Nagpal, S., et al.: J. Biol. Chem., 270, 923 (1995), Madhu, C., et al.: J. Pharm. Sci., 86, 972 (1997), Attar, M., et al.: Drug Metab. Dispos., 31, 476 (2003),<br></p>Formula:C19H17NO2SColor and Shape:NeatMolecular weight:323.41ent-Tadalafil
CAS:Controlled Product<p>Impurity Tadalafil EP Impurity B<br>Applications Tadalafil (T004500) analog. Tadalafil Impurity (6S,12aS)<br>References Daugan, A., et al.: J. Med. Chem., 46, 4533 (2003), Jiang, W., et al.: Bioorg. Med. Chem., 12, 1505 (2004),<br></p>Formula:C22H19N3O4Color and Shape:NeatMolecular weight:389.40Nuarimol
CAS:<p>Applications Nuarimol is used in the preparation of difluoroethyl-containing heterocyclic compounds useful as antiviral agents and fungicides. Also used as a substance in the modelling inhibition of avian aromatase by azole pesticides.<br>References Fan, Z., et al.: Faming Zhuanli Shenqing (2016), CN 105503708 A 20160420; Saxena, A. K., et al.: SAR and QSAR in Environmental Research, 26, 757 (2015)<br></p>Formula:C17H12ClFN2OColor and Shape:White To Light YellowMolecular weight:314.74(3R,4R)-1-Nitroso Tofacitinib
Formula:C13H18N6OColor and Shape:White To Off-WhiteMolecular weight:274.322N-(2-Amino-4-thiazolyl)acetyl Mirabegron
CAS:Formula:C26H28N6O3S2Color and Shape:NeatMolecular weight:536.669N-Nitroso-Atomoxetine
Controlled ProductFormula:C17H20N2O2Color and Shape:Off WhiteMolecular weight:284.353rac-trans-Ketoconazole
CAS:Controlled Product<p>Impurity Ketoconazole EP Impurity C<br>Applications rac-trans-Ketoconazole (Ketoconazole EP Impurity C) is a Ketoconazole (K186000) analog. The trans isomer of Ketoconazole.<br>References Kan, P.B., et al.: J. Steroid Biochem., 23, 1023 (1985),<br></p>Formula:C26H28Cl2N4O4Color and Shape:Off-WhiteMolecular weight:531.43Tazarotene Thiochromane Dimer
CAS:<p>Applications Tazarotene Thiochromane DImer is an impurity of Tazarotene (T010050), an acetylenic retinoid prodrug converted to the active metabolite, Tazarotenic acid, with selective affinity for retinoic acid receptors RARβ and RARγ.<br>References Tang-Liu, D.D.-S., et al.: Clin. Pharmacokinet., 37, 273 (1999), Roeder, A., et al.: Skin Pharmacol. Physiol., 17, 111 (2004),<br></p>Formula:C26H26S2Color and Shape:NeatMolecular weight:402.6146Valsartan Ethyl Ester
CAS:Controlled Product<p>Applications Valsartan Ethyl Ester is an impurity of Valsartan (V095750), a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993); Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>Formula:C26H33N5O3Color and Shape:White To Light BeigeMolecular weight:463.57Cobicistat
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Cobicistat is a HIV protease inhibitor and has been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations.<br>References Von, H., Exp. Rev. Clin. Pharmacol., 5, 557 (2012); Lepist, E.I., et al.: Antimicrob. Agent. Chemother., 56, 5409 (2012); Orr, S.T.M., et al.: J. Med. Chem., 55, 4896 (2012);<br></p>Formula:C40H53N7O5S2Color and Shape:NeatMolecular weight:776.025-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic Acid
CAS:Controlled Product<p>Applications 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic Acid is useful for the synthesis of 5-Bromo-7-azaindolin-2-one derivatives which possesses in vitro activity against selected cancer cell lines.<br>References Zhang, J., et al.: Molecules, 21, 1674-1683 (2016);<br></p>Formula:C8H9NO3Color and Shape:NeatMolecular weight:167.16(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol
CAS:<p>Stability Hygroscopic<br>Applications (3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol was used to preapare AZD6140 as an orally active reversible P2Y12 receptor antagonist for prevention of thrombosis.<br>References Zhang, H., et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012);<br></p>Formula:C8H15NO3Color and Shape:NeatMolecular weight:173.213-Hydroxy Imiquimod
CAS:Controlled Product<p>Applications 4-Amino-β-methyl-1H-imidazo[4,5-c]quinoline-1-propanol, is an aryl ether substituted imidazoquinolines, which can be used in the design of immunomodulating agents for use as vaccine adjuvants and anticancer treatments.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shi, C., et al.: ACS Med. Chem. Lett., 3, 501 (2012);<br></p>Formula:C14H16N4OColor and Shape:NeatMolecular weight:256.3cis-Tadalafil
CAS:Controlled Product<p>Impurity Tadalafil EP Impurity A<br>Applications The (6R)-cis-enantiomer of Tadalafil (T004500). Tadalafil Impurity (6R,12aS)<br>References Aldridge, J., et al.: Br. Med. J., 318, 669 (1999), Daugan, A., et al.: J. Med. Chem., 46, 4533 (2003), Vredenbregt, M., et al.: J. Pharm. Biomed. Anal., 40, 840 (2006),<br></p>Formula:C22H19N3O4Color and Shape:Off-WhiteMolecular weight:389.404-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-iodo-2-methoxy-benzamide
CAS:<p>Impurity Amisulpride EP Impurity C<br>Applications 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-iodo-2-methoxy-benzamide is an impurity of Amisulpride (A633250), an antipsychotic. Amisulpride is a dopamine receptor antagonist. (Amisulpride EP Impurity C). Dopamine imaging agent<br>References Protais, P., et al.: Neuropharmacol., 24, 861 (1985), Perrault, G., et al.: J. Pharmacol. Exp. Ther., 280, 73 (1997),<br></p>Formula:C15H22IN3O2Color and Shape:NeatMolecular weight:403.26(S)-Lisinopril Dimer
CAS:Controlled Product<p>Applications (S)-Lisinopril (L468985) impurity. Lisinopril Impurity G (Dimer Impurity)<br></p>Formula:C42H60N6O9Color and Shape:WhiteMolecular weight:792.96Maraviroc-d6
CAS:Controlled Product<p>Applications Potent, non-competitive CCR5 receptor antagonist; inhibits binding of HIV viral coat protein gp120. Antiviral.<br>References Fumero, E., et al.: Clin. Microbiol. Infect., 9, 1077 (2003), Walker, D.K., et al.: Drug Metab. Dispos., 33, 587 (2005), Wood, A., et al.: Prog. Med. Chem., 43, 239 (2005),<br></p>Formula:C29D6H35F2N5OColor and Shape:NeatMolecular weight:519.70Dechloro-Rivaroxaban
CAS:Controlled Product<p>Applications Dechloro-Rivaroxaban is an impurity of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formula:C19H19N3O5SColor and Shape:NeatMolecular weight:401.444-Nitro Lenalidomide
CAS:Controlled Product<p>Impurity Lenalidomide impurity<br>Applications Lenalidomide (L328000) analog. Lenalidomide impurity; Lenalidomide intermediate.<br>References Hashimoto, Y., et al.: Bioorg. Med. Chem., 10, 461 (2002),<br></p>Formula:C13H11N3O5Color and Shape:NeatMolecular weight:289.241-Acetyl-4-(4-hydroxyphenyl)piperazine
CAS:Controlled Product<p>Applications 1-Acetyl-4-(4-hydroxyphenyl)piperazine is an intermediate used to prepare Ketoconazole (K186000) which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo.<br>References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)<br></p>Formula:C12H16N2O2Color and Shape:WhiteMolecular weight:220.272-(4-Hydroxybenzyl)-N,5-bis-(4-fluorophenyl)-5-hydroxypentanamide
CAS:<p>Applications 2-(4-Hydroxybenzyl)-N,5-bis-(4-fluorophenyl)-5-hydroxypentanamide is an ring-opened impurity of Ezetimibe (E975000).<br>References Raman, B. et al.: J. Pharmac. Biomed. Anal., 52, 73 (2010);<br></p>Formula:C24H23F2NO3Color and Shape:WhiteMolecular weight:411.44(1-[[2-[(2-Aminophenyl)amino]-5-methyl-3-thienyl]carbonyl]-4-methyl-piperazine
CAS:Controlled Product<p>Applications 1-[[2-[(2-Aminophenyl)amino]-5-methyl-3-thienyl]carbonyl]-4-methyl-piperazine is an impurity of Olanzapine (O253750), a serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity.<br>References Moore, N.A., et al.: Curr. Opin Invest. Drugs, 2, 281 (1993), Baldwin, D.S. and Montgomery, S.A.: Int. Clin. Psychopharmacol., 10, 239 (1995), Tohen, M., et al.: Am. J. Psychiatry, 156, 702 (1999)<br></p>Formula:C17H22N4OSColor and Shape:NeatMolecular weight:330.45Thioacetic Acid
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications Thiacetic Acid is a commonly used reagent in organic synthesis for the introduction of thiol groups in molecules.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chapman, J.H. et al.: J. Chem. Soc., 579 (1950); Hoque, A., et al.: Bioorg. Med. Chem. Lett., 22, 6770 (2012)<br></p>Formula:C2H4OSColor and Shape:NeatMolecular weight:76.12Ethyl 4-Acetamidobenzoate
CAS:Controlled Product<p>Applications Ethyl 4-acetamidobenzoate is a reagent that is used in the synthesis of DAMPA-d3, which is a labeleld antitumor agent.<br>References Martinelli, J.E., et al.: J. Med. Chem., 22, 869 (1979);<br></p>Formula:C11H13NO3Color and Shape:Off-WhiteMolecular weight:207.235-Nitro-2-furfuraldazine
CAS:Controlled Product<p>Impurity Nitrofurazone USP Related Compound A<br>Applications 5-Nitro-2-furfuraldazine is an impurity in the synthesis of Nitrofurazone (N493880), anti-infective (topical). Antimicrobial. Nitrofurazone USP Related Compound A<br>References Morris, et al.: Cancer Res., 29, 2145 (1969), Sanderson, H., et al.: Toxicol. Lett., 144, 383 (2003),<br></p>Formula:C10H6N4O6Color and Shape:NeatMolecular weight:278.178(3’S)-ent-Ezetimibe
CAS:<p>Applications An enantiomeric impurity of Ezetimibe (E975005), an antihyperlipoproteinemic and cholesterol absorption inhibitor.<br></p>Formula:C24H21F2NO3Color and Shape:WhiteMolecular weight:409.43Tert-Butyl 2-(pyridin-4-yl)acetate
CAS:Purity:95.0%Color and Shape:LiquidMolecular weight:193.24600219726562Fingolimod Palmitate Amide
CAS:Controlled Product<p>Applications Fingolimod Palmitate Amide is an impurity of Fingolimod (F805000, HCl salt), a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Formula:C35H63NO3Color and Shape:NeatMolecular weight:545.88Quinfamide
CAS:Controlled Product<p>Applications Quinfamide is an anti-amebic agent used to treat tropical parasitic infections.<br>References Slighter, R., et al.: Parasitol., 81, 157 (1980), Parthasarathy, P., et al.: Eur. J. Med. Chem., 28, 195 (1993), Padilla, N., et al.: Clin. Drug Invest., 20, 89 (2000),<br></p>Formula:C16H13Cl2NO4Color and Shape:White To Light BeigeMolecular weight:354.185''''-Methyl-apixaban
CAS:Controlled Product<p>Impurity Apixaban<br>Applications Analytical standard impurity of drug.<br></p>Formula:C26H27N5O4Color and Shape:NeatMolecular weight:473.524Lomerizine Dihydrochloride
CAS:Controlled Product<p>Applications A diphenylpiperazine calcium channel blocker. A selective cerebral vasodilator. Antimigraine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kanazawa, T., et al.: J. Cardiovasc. Pharmacol., 16, 430 (1990), Hara, H., et al.: Arch. Int. Pharmacodyn, 304, 206 (1990), Danielisova, V., et al.: Neurochem. Res., 19, 1503 (1994)<br></p>Formula:C27H30F2N2O3·2ClHColor and Shape:NeatMolecular weight:541.461-[4-[(1,2,3,4-Tetrahydro-2-oxo-7-quinolinyl)oxy]butyl] Aripiprazole
CAS:<p>Impurity Aripiprazole Impurity 4<br>Applications 1-[4-[(1,2,3,4-Tetrahydro-2-oxo-7-quinolinyl)oxy]butyl] Aripiprazole is a synthetic impurity of the drug aripiprazole (A771000). Aripiprazole is a novel atypical antipsychotic drug used in the treatment of schizophrenia. Aripiprazole Impurity 4<br>References Filijovic, N. D., et al.: Acta Chromatogr., 26, 13 (2014)<br></p>Formula:C36H42Cl2N4O4Color and Shape:White To Off-WhiteMolecular weight:665.649Captopril-d3
CAS:Controlled Product<p>Applications Orally active angiotensin-converting enzyme (ACE) inhibitor.<br>References Rubin, B., et al.: Eur. J Pharmacol., 51, 377 (1978),<br></p>Formula:C9D3H12NO3SColor and Shape:White SolidMolecular weight:220.30Omeprazole-d3 Sulfide
CAS:Controlled ProductFormula:C172H3H16N3O2SColor and Shape:NeatMolecular weight:332.44ent-Levobunolol Hydrochloride (R-Bunolol Hydrochloride)
CAS:Controlled Product<p>Applications A non-selective ß-adrenoceptor antagonist used as an anticonvulsant. The enantiomer of Levobunolol (L335000).<br>References Kaplan, H.R., et al.: Eur. J. Pharm., 16, 237 (1971), DiCarlo,F.J., et al.: Clin. Pharm. Ther., 22, 858 (1977)<br></p>Formula:C17H25NO3·ClHColor and Shape:NeatMolecular weight:327.85Nilotinib N-Oxide
CAS:Controlled Product<p>Applications A metabolite of Nilotinib (N465300). It is a COVID19-related research product.<br></p>Formula:C28H22F3N7O2Color and Shape:NeatMolecular weight:545.52(Z)-Thiothixene-d8
CAS:Controlled ProductFormula:C23H21D8N3O2S2Color and Shape:NeatMolecular weight:451.67Aripiprazole N1-Oxide
CAS:Controlled Product<p>Impurity Aripiprazole EP Impurity F<br>Stability Hygroscopic<br>Applications Aripiprazole N1-Oxide (Aripiprazole EP Impurity F) is a metabolite of anti-psychotic drug, Aripiprazole (A771000).<br>References Rowley, M., et al.: J. Med. Chem., 44, 477 ( 2001), Ozdemir, V., et al.: Curr. Opin. Invest Drugs 2002, 3, 113,,,4) Jordan, S; European Journal Pharmacol 2002, 441, 137<br></p>Formula:C23H27Cl2N3O3Color and Shape:NeatMolecular weight:464.38Depropylamino Chloro Propafenone
CAS:<p>Impurity Propafenone EP Impurity E; Propafenone BP Impurity E; Propafenone USP Impurity E<br>Applications Depropylamino Chloro Propafenone (Propafenone EP Impurity E; Propafenone BP Impurity E; Propafenone USP Impurity E) is an impurity of Propafenone (D288655).<br>References Hollmann, M., et al.: Arzneim.-Forsch., 33, 763 (1983); Bryson, H. M., et al.:Drugs, 45, 85 (1993);<br></p>Formula:C18H19ClO3Color and Shape:NeatMolecular weight:318.79Dechloro Trazodone
CAS:Controlled Product<p>Impurity Trazodone Deschloro Impurity<br>Stability Hygroscopic<br>Applications A Trazodone (T718500) impurity. An antipsychotic with potential use as a schizophrenia agent. Trazodone impurity B.<br>References Pai, N. et al.: J. Chem Pharmaceut. Res., 2, 458 (2010); Silvestrini, B., et al.: Eur. J. Pharmacol., 12, 231 (1970); Brogden, R.N., et al.: Drugs, 21, 401 (1981);<br></p>Formula:C19H23N5OColor and Shape:NeatMolecular weight:337.42Phthalic Hydrazide
CAS:<p>Applications Phthalic Hydrazide is a reagent in the synthesis in various pyrazolophthalazine derivatives.<br>References Rezaei, S.et al.: Tetra. Lett., 53, 5123 (2012);<br></p>Formula:C8H6N2O2Color and Shape:NeatMolecular weight:162.151-[[3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]4-hydroxyphenyl]methyl 2-Butanedioic Acid Ester (>90%)
<p>Impurity Fesoterodine Impurity 6;<br>Applications 1-[[3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]4-hydroxyphenyl]methyl 2-Butanedioic Acid Ester is derived from (R)-Fesoterodine Fumarate (F321300), which is a muscarinic receptor antagonist for the treatment of Lower Urininary Tract Symptoms (LUTS). It is very similar to Tolterodine (T535800).<br>References Rogers, D., et al.: Pharmacotherapy, 20, 1092 (2000), Praharaj, S., et al.: J. Psychopharmacology, 19, 426 (2005),<br></p>Formula:C26H35NO5Purity:>90%Color and Shape:NeatMolecular weight:441.56Nateglinide-d5
CAS:Controlled Product<p>Applications A labelled version of Nateglinide, an amino-acid derivative that stimulates insulin secretion which is used as an antidiabetic.<br>References Shinkai, H., et al.: J. Med. Chem., 32, 1436 (1989), Sato, Y., et al.: Diabetes Res. Clin. Pract., 12, 53 (1991), Vicent, D., et al.: J. Clin. Invest., 111, 1373 (2003), Ceriello, A., et al.: Diabet. Med., 21, 171 (2004),<br></p>Formula:C192H5H22NO3Color and Shape:NeatMolecular weight:322.45Tropicamide
CAS:<p>Applications Ophthalmic anticholinergic. Mydriatic.<br>References Blessel, K.W., et al.: Anal. Profiles Drug Subs., 3, 565 (1974), Krapivinsky, G., et al.: J. Biol. Chem., 270, 29059 (1995), Bedingfield, J., et al.: Eur. J. Pharmacol., 309, 71 (1996), Jin, W., et al.: Biochemistry, 38, 14294 (1999), Kew, J., et al.: Pharmacol. Ther., 104, 233 ( 2004), Bertaso, F., et al.: J. Neurochem., 99, 288 (2006),<br></p>Formula:C17H20N2O2Color and Shape:NeatMolecular weight:284.35
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