Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65624 products of "Quinazoline and Quinoline Derivatives"
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11-Keto Oxcarbazepine
CAS:Controlled Product<p>Stability Unstable in Solution<br>Applications A keto impurity of the anticonvulsant Oxcarbazepine (O869250).<br></p>Formula:C15H10N2O3Color and Shape:NeatMolecular weight:266.25N,N’-Bis[Des(5-chloro-2-carvoxythienyl) Rivaroxaban] Urea
CAS:Controlled ProductFormula:C29H32N6O9Color and Shape:WhiteMolecular weight:608.60Indomethacin Diamide
CAS:Controlled Product<p>Applications Indomethacin Diamide is an impurity of Indomethacin (I641000), an non-steroidal anti-inflammatory drug commonly used in the treatment of fever, pain and swelling.<br>References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)<br></p>Formula:C33H27Cl2N3O5Color and Shape:NeatMolecular weight:616.491-Amino-imidazolidine-2,4-dione
CAS:<p>Applications 1-Amino-imidazolidine-2,4-dione (cas# 6301-02-6) is a useful research chemical.<br></p>Formula:C3H5N3O2Color and Shape:NeatMolecular weight:115.095-Imino-N,4-bis(4-phenyl)-4,5-dihydro Riluzole
Controlled ProductFormula:C16H10F6N4O2SColor and Shape:NeatMolecular weight:436.33Cinitapride Tartrate
CAS:<p>Applications Cinitapride Tartrate is the salt analogue of Cinitapride (C441990), a novel prokinetic benzamide-stimulating gastrointestinal motility agent and antiucer agent. It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors.<br>References Alarcon de la Lastra, C. et al.: Pharmacol, 54, 193 (1997); Robert, M. et al.: Drug Metab. Disp., 35, 1149 (2007); Alarcon de la Lastra, C. et al.: Inflam. Res., 47, 131 (1998)<br></p>Formula:C21H30N4O4·C4H6O6Color and Shape:NeatMolecular weight:552.574-Fluorobenzoic acid
CAS:Controlled Product<p>Applications 4-Fluorobenzoic acid<br></p>Formula:C7H5FO2Color and Shape:NeatMolecular weight:140.111-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine
CAS:Controlled Product<p>Applications 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine is an intermediate used to prepare nonracemic γ-bicyclic heteroarylpiperazine- and heteroarylpiperidine-substituted prolinylthiazolidines as selective and orally active dipeptidylpeptidase 4 inhibitors for use as antidiabetic agents.<br>References Yoshida, T., et al.: Bioorg. Med. Chem., 20, 5705 (2012)<br></p>Formula:C14H18N4Color and Shape:NeatMolecular weight:242.32Maropitant Citrate Salt
CAS:<p>Applications Maropitant is a neurokinin type 1 (NK-1) receptor antagonist. Recent studies show that Maropitant decreased the anesthetic requirements during visceral stimulation of the ovary and ovarian ligament in dogs.<br>References Boscan, P. et al.: Am. J. Vet. Res., 72, 1576 (2011);<br></p>Formula:C32H40N2O·C6H8O7Color and Shape:Off White SolidMolecular weight:660.8N4-(4-methoxyphenyl)-N6-(pyridin-2-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
CAS:Purity:95.0%Molecular weight:347.3819885253906Benzhydrol
CAS:<p>Impurity Diphenhydramine EP Impurity D<br>Applications Intermediate in the preparation of Modafinil (M482500).<br>References Kumar, C., et al.: Eur. J. Med. Chem., 44, 1223 (2009),<br></p>Formula:C13H12OColor and Shape:WhiteMolecular weight:184.23Fluralaner-13C2,15N,D2
CAS:Controlled ProductFormula:C2C20D2H15Cl2F615NN2O3Color and Shape:Off-WhiteMolecular weight:561.2764'-[(2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-Biphenyl]-2-carbonitrile
CAS:Controlled Product<p>Impurity Irbesartan Cyano Impurity<br>Applications A butyldiazaspirononenone derivative used in the preparation of acetylcholinesterase inhibitors. An impurity found in Irbesartan (I751000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kavitha, C.V. et al.: Bioorg. Med. Chem., 15, 7391 (2007);<br></p>Formula:C25H27N3OColor and Shape:NeatMolecular weight:385.5010-(Pyridin-3-yl)-2,3,6,7-tetrahydro-1H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11(5H)-one
CAS:Purity:98%Molecular weight:318.3760070800781O3-Desethyl Apremilast
CAS:Controlled ProductFormula:C20H20N2O7SColor and Shape:NeatMolecular weight:432.454’-Bromomethyl-2-cyanobiphenyl
CAS:Controlled Product<p>Impurity Irbesartan Bromo Nitrile Impurity<br>Applications Halogenated benzonitrile used in protein-binding studies of quinoxaline angiotensin II receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References KIm, Y.S., et al.: Bioorg. Med. Chem., 3, 2667 (1993),<br></p>Formula:C14H10BrNColor and Shape:NeatMolecular weight:272.147-(1-ethyl-5-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid
CAS:Purity:95.0%Molecular weight:271.2799987792969N-Desmethyl Imatinib Dimesylate
Controlled Product<p>Stability Hygroscopic<br>Applications N-Desmethyl Imatinib Dimesylate is a by-product of the synthesis of N-Desmethyl Imatinib Mesylate (D292345), a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.<br>References Schindler, T., et al.: Science, 289, 1938 (2000); Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001)<br></p>Formula:C28H29N7O•C3H8O2SColor and Shape:NeatMolecular weight:479.582108161-(4-Fluorophenyl)-4-(4-(pyridin-2-yl)piperazin-1-yl)butan-1-one
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:327.403015136718752-Amino-2-[2-(4-hexylphenyl)ethyl]-1,3-propanediol
CAS:Controlled ProductFormula:C17H29NO2Color and Shape:NeatMolecular weight:279.42Nizatidine Sulfoxide
CAS:Controlled ProductFormula:C12H21N5O3S2Color and Shape:NeatMolecular weight:347.463,4-Dehydro Cilostazol-d11
CAS:Controlled Product<p>Applications A labelled metabolite of Cilostazol.<br></p>Formula:C20H14D11N5O2Color and Shape:NeatMolecular weight:378.51D-Tryptophan Methyl Ester Hydrochloride
CAS:Controlled Product<p>Applications Intermediate for the synthesis of Tryptophan derivatives.<br>References Deveau, A., et al.: Bioorg. Med. Chem. Lett., 18, 3522 (2008),<br></p>Formula:C12H14N2O2·ClHColor and Shape:White To Off-WhiteMolecular weight:254.71Phenylbutazone-d9
CAS:Controlled ProductFormula:C192H9H11N2O2Color and Shape:White To Light BrownMolecular weight:317.43N-Demethyl Ivabradine Hydrochloride
CAS:Controlled ProductFormula:C26H34N2O5·ClHColor and Shape:NeatMolecular weight:491.02N-Desmethyl Clozapine-d8
CAS:Controlled Product<p>Applications A major labelled metabolite of clozapine. A potent and selective 5-HT2C serotonin receptor antogonist.<br>References Kuoppamaki, M. et al.: Eur. J. Pharm. Mol. Pharm. Sect., 245, 179 (1993), Olessen, O.V., et al.: J. Chromatog., 622, 39 (1993), Pirmohamed, M., et al.: J. Pharmacol. Exp. Ther., 272, 984 (1995)<br></p>Formula:C172H8H9ClN4Color and Shape:Light YellowMolecular weight:320.85Cabozantinib L-Malate Salt
CAS:Controlled Product<p>Applications Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis.<br>References Camp, R., et al.: Cancer, 86, 2259 (1999), Morello, S., et al.: J. Cell Physiol., 189, 285 (2001), Zhang, Y., et al.: Oncogene, 21, 217 (2002), Wells, S., et al.: J. Clin. Oncol., 28, 767 (2010),<br></p>Formula:C28H24FN3O5·C4H6O5Color and Shape:NeatMolecular weight:635.59Nifedipine-d6
CAS:Controlled Product<p>Applications Used as an antihypertensive and antianginal. A labelled dihydorpyridine calcium channel blocker.<br>References Ali, S.L., et al.: Anal. Profiles Drug Subs., 18, 221 (1989), Soons, P.A., et al.: J. Pharm. Biomed. Anal., 9, 475 (1991), Brown, M.J., et al.: Lancet, 356, 366 (2000),<br></p>Formula:C172H6H12N2O6Color and Shape:YellowMolecular weight:352.37Deschloro Aripiprazole
CAS:Controlled Product<p>Impurity Aripiprazole EP Impurity C<br>Applications Deschloroaripiprazole (Aripiprazole EP Impurity C) is a derivative of Aripiprazole (A771000), a dopamine D2 receptor agonist. Antipsychotic.<br>References Chen, X. et al.: J. Med. Chem., 55, 7141 (2012); Canive, J.M., et al.: Psychopharmacol. Bull., 34, 101 (1998), Oshiro, Y., et al.: J. Med. Chem., 41, 658 (1998),<br></p>Formula:C23H28ClN3O2Color and Shape:Off-WhiteMolecular weight:413.94Sertindole
CAS:Controlled Product<p>Applications Antipsychotic used in the treatment of schizophrenia.<br>References Nourian, Z., et al.: Eur. J. Pharmacol., 596, 32 (2008), Karczewski, J., et al.: Biochem. Pharmacol., 77, 1602 (2009), Isoherranen, N., et al.: Chem. Res. Toxicol., 22, 294 (2009), Goetghebeur, P., et al.: Psychopharmacol., 202, 287 (2009),<br></p>Formula:C24H26ClFN4OColor and Shape:NeatMolecular weight:440.94Cilostazol-d11
CAS:Controlled Product<p>Applications A potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Has antimitogeni, antithrombotic, vasodilatory and cardiotonic properties in vivo. Also affects lipid levels in vivo.<br>References Suri, A., et al.: J. Clin. Pharmacol., 38, 144 (1998), Park, S.-W., et al.: Am. J. Cardiol., 84, 511 (1999), Tsuchikane, E., et al.: Circulation, 100, 21 (1999),<br></p>Formula:C20H16D11N5O2Color and Shape:NeatMolecular weight:380.52Cyamemazine
CAS:<p>Applications Cyamemazine is an anxiolytic antipsychotic, which reduces ethanol withdrawal symptoms.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Robinson, et al.: J. Pharm. Pharmacol., 18, 19 (1966), Miller, L., et al.: J. Pharmacol. Exp. Ther., 246, 170 (1988), Podhorna, J., et al.: Curr. Pharm. Des., 8, 23 (2002), Hameg, A., et al.: Biochem. Pharmacol., 65, 435 (2003),<br></p>Formula:C19H21N3SColor and Shape:Green YellowMolecular weight:323.468-(2,3-Dichlorophenyl)-8-aza-5-azoniaspiro[4.5]decane Bromide
CAS:Controlled Product<p>Impurity Aripiprazole Impurity 12<br>Applications 8-(2,3-Dichlorophenyl)-8-aza-5-azoniaspiro[4.5]decane Bromide is an intermediate used in the preparation of Aripiprazole (A771000), a selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity. Antipsychotic. Aripiprazole Impurity 12<br>References Canive, J.M., et al.: Psychopharmacol. Bull., 34, 101 (1998), Oshiro, Y., et al.: J. Med. Chem., 41, 658 (1998),<br></p>Formula:C14H19Cl2N2·BrColor and Shape:NeatMolecular weight:366.12N-Formyl Varenicline
CAS:Controlled Product<p>Applications A metabolite of Varenicline. Metabolite M5.<br>References Dow, J., et al.: Drug Metab. Dispos., 22, 738 (1994), Toide, K., et al.: Biochem. Pharmacol., 67, 1269 (2004), Coe, J., et al.: J. Med. Chem., 48, 3474 (2005), Doll, R., et al.: Br. J. Cancer, 92, 426 (2005),<br></p>Formula:C14H13N3OColor and Shape:NeatMolecular weight:239.27Ticagrelor Sulfoxide (Mixture of Diastereomers)
CAS:Controlled Product<p>Applications Ticagrelor Sulfoxide is an impurity of ticagrelor (T437700). Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Formula:C23H28F2N6O5SColor and Shape:NeatMolecular weight:538.57Macitentan
CAS:Controlled Product<p>Applications Macitentan, is an orally active endothelin receptor antagonist used for pulmonary arterial hypertension.<br>References Emoto, N. Ensho to Men'eki, 20, 487 (2012);<br></p>Formula:C19H20Br2N6O4SColor and Shape:White To Off-WhiteMolecular weight:588.27Quizalofop
CAS:<p> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C17H13ClN2O4Color and Shape:Off-White To Light YellowMolecular weight:344.75
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![8-(2,3-Dichlorophenyl)-8-aza-5-azoniaspiro[4.5]decane Bromide](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FD436070.webp&w=3840&q=75)
