Benzodiazepine Derivatives

Applications Controlled substance (depressant). Anxiolytic. Labelled Bromazepam.
References Schwartz, M.A., et al.: J. Pharm. Sci., 62, 1776 (1973), Chalmers, P., et al.: Anesthesia, 39, 370 (1984), Hassan, M.M., et al.: Anal. Profiles Drug Subs., 16, 1 (1987),

Applications 2-(2-Acetylhydrazino)-7-chloro-5-phenyl-3H-1,4-benzodiazepine is an impurity of Alprazolam (A575650.
References Hester, J.B., et al.: J. Org. Chem., 44, 2688, (1979); Anjaneyulu, Y., et al.: Asian. J. Chem., 19, 3375 (2007);

Impurity Clonazepam EP Impurity A
Applications 2-Amino-5-nitro-2'-chlorobenzophenone (Clonazepam EP Impurity A) is an impurity of Clonazepam (C587080).

Applications Flunitrazepam is used as an hypnotic. This is a controlled substance (depressant).
References Sternbach, L.H., et al.: J. Med. Chem., 6, 261 (1963), Eidelberg, E., et al.: Neurology, 5, 223 (1965), Caplan, Y., et al.: J. Anal. Toxicol., 25, 396 (2001), Wood, M., et al.: Forensic Sci. Int., 150, 227 (2005),

Impurity Clonazepam EP Impurity B
Applications 3-Amino-4-(2-chlorophenyl)-6-nitro-2(1H)-quinolinone (Clonazepam EP Impurity B) is an impurity of Clonazepam (C587080), antiepileptic agent with anxiolytic and antimanic properties.
References Mayer, W., et al.: Pharmazie, 29, 700 (1974), Blum, et al.: Arzneim.-Forsch., 23, 377 (1973), Winslow, W.C., et al.: Anal. Profiles Drug Subs., 6, 61 (1977)

Applications The major metabolite of Clonazepam (C587080).
References Clark, D., et al.: Drugs, 29, 342 (1985), Colmenero, J., et al.: Antimicrob. Agents Chemother., 38, 2798 (1994), Grant, D., et al.: Pharmacology, 61, 204 (2000), Negrusz, A., et al.: Anal. Bioanal. Chem., 376, 1198 (2003),

Applications A metabolite of Diazepam; but has a much weaker anticonvulsant effect.
References Hara, T., et al.: J. Med. Chem., 21, 263 (1978),

Applications Controlled substance (depressant). Anxiolytic.
References Sethy, V.H., et al.: Arch. Pharmacol., 301, 157 (1978), Fawcett, J.A., et al.: Pharmacotherapy, 2, 242 (1982),

Applications Controlled substance (depressant). Anxiolytic.
References Schwartz, M.A., et al.: J. Pharm. Sci., 62, 1776 (1973), Chalmers, P., et al.: Anesthesia, 39, 370 (1984), Hassan, M.M., et al.: Anal. Profiles Drug Subs., 16, 1 (1987),

Applications Intermediate in the preparation of Alprazolam impurities.
References Hanawa, T., et al.: Drug Dev. Ind. Pharm., 26, 1199 (2000), Cheng, P., et al.: Bioorg. Med. Chem. Lett., 18, 3787 (2008),

Applications N-Desmethyl Clobazam is an impurity of Clobazam (C582500), which is a benzodiazepine, psychotherapeutic agent. Clobazam (CLB) has proven efficacy against multiple seizure types and is an anxiolytic, anticonvulsant and controlled substance (depressant).
References Gastaut, H., et al.: Epilepsia, 20, 437 (1979), Guberman, A., et al.: Can J. Neurol. Sci., 17, 311 (1990), Munn, R., et al.: Pediatr. Neurol. 9, 465 (1993)

Applications Flumazenil carboxylic acid is a derivative of Flumazenil (F500450), a benzodiazepine antagonist that can prevent or abolish (at the receptor level) the effects of a benzodiazepine.
References Brogden, R. & Goa, K.: Drugs, 35, 448 (1988); Klotz, U. & Kanto, J.: Clin. Pharmacokinet., 14, 1 (1988)

Applications Benzodiazepine psychotherapeutic agent. Clobazam (CLB) has proven efficacy against multiple seizure types. An anxiolytic; anticonvulsant. Controlled substance (depressant).
References Gastaut, H., et al.: Epilepsia, 20, 437 (1979), Guberman, A., et al.: Can J. Neurol. Sci., 17, 311 (1990), Munn, R., et al.: Pediatr. Neurol. 9, 465 (1993)

Applications An impurity of Alprazolam (A575650).
References Nudelman, N., et al.: J. Pharm. Sci., 91, 1274 (2002), Marin, A., et al.: Anal. Chem., 77, 471 (2005),

Applications Controlled substance (depressant). Anxiolytic.
References Sethy, V.H., et al.: Arch. Pharmacol., 301, 157 (1978), Fawcett, J.A., et al.: Pharmacotherapy, 2, 242 (1982),