Flavonoids and Polyphenols

<p>Applications Triclosan is used as bactericide and preservative for cosmetic and detergent compositions (1). Broadly used as an antiseptic and disinfectant (2).This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Lindström, A. et al.: Environ. Sci. Technol. 2002 Jun 1;36(11):2322-9. 2. Ruszkiewicz, J. et al.: J. Toxicol. Environ. Health B. Crit. Rev. 2017;20(2):104-117.<br></p>

<p>Applications Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol<br>References Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987), O'Dell, T.J., et al.: Nature, 353, 588 (1991), Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1992), Platanias, L.C., et al.: J. Biol. Chem., 267, 24053 (1992), Yoshida, H., et al.: Biochim. Biophys. Acta, 1137, 321 (1992), Uckun, F.M., et al.: Science, 267, 886 (1995)Merck Index 12th ed. 43952. Huang, R.Q.; Fang, M.J.; Dillon, G.H., Mol. Brain Res. 67: 177-183 (1999)<br></p>

<p>Applications Isotope labelled Triclosan is used as bactericide and preservative for cosmetic and detergent compositions (1). Broadly used as an antiseptic and disinfectant (2). This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Lindström, A. et al.: Environ. Sci. Technol. 2002 Jun 1;36(11):2322-9. 2. Ruszkiewicz, J. et al.: J. Toxicol. Environ. Health B. Crit. Rev. 2017;20(2):104-117.<br></p>

<p>Applications Bisdemethoxycurcumin is one of the three major forms of curcuminoids found in the rhizomes of turmeric. Bisdemethoxycurcumin displays antioxidant, anti-inflammatory as well as chemotherapeutic activity. Bisdemethoxycurcumin acts as an inhibitor of human pancreatic α-amylase, a target for type-2 diabetes .<br>References Ponnusamy, S. et al.: Food Chem., 135, 2638 (2012); Hung, C.-M. et al.: J. Agric. Food. Chem., 60, 8427 (2012); Jayaprakasha, G.K. et al.: Food Chem., 98, 720 (2006);<br></p>

<p>Applications A protected caffeine metabolite with high antioxidant activity. It is a very sensitive biomarker for the consumption of relatively small amount of coffee.<br>References Buchanan, C., et al.: J. Sci. Food Agric., 71, 459 (1996), Andreasen, M., et al.: J. Agric. Food Chem., 49, 5679 (2001), Poquet, L., et al.: Drug Metab. Dispos., 36, 190 (2008),<br></p>

<p>M04091 - (S)-(+)-Rolipram</p>

<p>Applications A major component of green coffee the extracts of which promote weight loss in overweight and obese people. Chlorogenic Acid is an important intermediate in lignin biosynthesis. Chlorogenic Acid is an antioxidant and an inhibitor of the tumor promoting activity of phorbol ester. It has protective effect against streptozotocin-nicotinamide generated oxidative stress induced diabetes and may also protect against cardiovascular disease.<br>References Chem. and Eng. News p. 20 April 15, 2013; Karthikesan, K. et al.: J. Func. Foods, 2, 134 (2010); Lincoln, W.M. et al.: Clin. Exp. Phamacol. Physiol., 27, 152 (2000); Gamborg, O.L. et al.: Can. J. Biochem., 45, 1451 (1967);<br></p>

<p>Applications A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.Curcumin is currently being examined as a possible therapeutic for the treatment of Alzheimers disease. Neuroprotective. Dyes and metabolites.<br>References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007), Chem. and Eng. News 90(31), 44 (2012)<br></p>