Organic Phosphates and Phosphonates

Applications Fenthion Sulfoxide is the sulfoxide anlogue and metabolite of the organothiophosphate insecticide Fenthion (F278000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wallnoefer, P. et al.: Pflanzensch.-Nach., 29, 236 (1976); Minelli, E.V. et al.: J. Agric. Food. Chem., 44, 936 (1996);

Stability Hygroscopic
Applications Amifostine Thiol is a metabolite of Amifostine (A576810) which provides normal cells with selective protection against the toxic effects of cancer chemotherapy and radiation treatment.
References Satge, J., et al.: Eur. J. Med. Chem., 24, 48 (1989); Geary, R.S., et al.: Biopharm. Drug Dispos., 12, 261 (1991); Brown, D.Q., et al. Pharmacol. Ther., 39, 159 (1988); Capizzi, R.L., et al.: Cancer, 72, 3495 (1993); Treskes, M., et al.: Cancer Chemother. Pharmacol., 33, 93 (1993)

Stability Moisture Sensitive
Applications Phoxim is an organophosphate insecticide. It is an analogous dimethyl ester and an organothiophosphate acaricide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lu, Y., et al.: Nature, 487, 362 (2012); Jokanovic, M., et al.: Arch. Toxicol., 70, 119 (1995); Wang, W., et al.: Pest. Biochem. Physiol., 84, 180 (2006)

Stability Hygroscopic
Applications Isotope labelled Parathion-methyl is an derivative of Parathion (P192220), an organophosphate insecticide used on cotton, rice and fruit trees. Cannabis testing.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sykes, M., et al.: J. Agri. Food. Chem., 61, 4205 (2013); Sipes, N.S., et al.: Chem. Res. Toxicol., 26, 878 (2013);

Applications Disalicylimide is an impurity of Deferasirox (D228650), an orally active tridentate iron chelator.
References Hershko, C., et al.: Blood, 97, 1115 (2001), Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003), Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003),

Applications It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.This compound is suitable for aldehyde dehydrogenase (ALDH) related research.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999),

Stability Very Hygroscopic
Applications The major metabolite of herbicidal Glufosinate (G596950).

Stability Hygroscopic
Applications Used as a herbicide.
References Abbas, H., et al.: J. Agric. Food Chem., 50, 5246

Pravastatin lactone is a prodrug of pravastatin that is hydrolyzed in vivo to its active form. It is used for the treatment of bowel disease and has been shown to have concentration-time curves that are linear and dose-dependent. Pravastatin lactone has an acidic pH, which may be due to the presence of carboxyl groups on the molecule. This drug also inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, which is an enzyme that catalyzes the conversion of HMG CoA to mevalonate in order to produce cholesterol. Pravastatin lactone also suppresses the production of fatty acids by inhibiting their synthesis at the level of acetyl-coenzyme A (acetyl-CoA). The drug has not shown any evidence of toxicity when administered to rats at doses up to 10 mg/kg body weight per day