Organic Phosphates and Phosphonates

Stability Hygroscopic
Applications A major biodegradation product of Malathion (M111000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kim, Y. et al.: Chemosphere, 60, 1349 (2005); Yoshii, K. et al.: J. Health Sci., 54, 535 (2008); Hayasaka, M. et al.: Jap. J. Forensic Toxicol., 12, 15 (1994);

Applications Malathion (Diethyl-d10) is used as one of the substances for the clean-up step in post-harvest pesticide residue analysis.
References Ucles, A., et al.: Talanta, 144, 51 (2015)

Applications Amifostine Trihydrate is a widely used cytoprotective and radio-protective agent.
References Adibhatla K.S., et al. Novel method of manufacture of high purity Amifostine trihydrate. Indian Pat. Appl. IN 2005CH01592 A 20080125. Jan 25, 2008

Applications Deferasirox Methyl Ester is a derivative of Deferasirox (D228650); an orally active tridentate iron chelator.
References Hershko, C., et al.: Blood, 97, 1115 (2001); Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003); Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003)

Applications Alendronic Acid-d6 Sodium Salt is a labelled salt analogue of Alendronic Acid (A521250), a bisphosphonate used as a bone reabsoption inhibitor.
References Wang, X.M., et al.: Clin. J. Dent. Res., 3, 26 (2000); Woo, T., et al.: Best Pract. Res. Clin. Rheumatol., 15, 469 (2001); Benford, H.L., et al.: Bone, 28, 465 (2001)

Impurity Milrinone Impurity 12
Applications 5-Decyano 5-Carboxymilrinone (Milrinone Impurity 12) is an impurity of Milrinone (M344680), a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.
References Alousi, A.A., et al.: J. Cardiovasc Pharmacol., 5, 792 (1983); Maskin, C.S., et al.: Circulation, 67, 1065 (1983); Sinoway, L.S., et al.: J. Am. Coll. Cardiol., 2, 327 (1983); Baim, D.S., et al.: N. Engl. J. Med., 309, 748 (1983)

Applications Angiotensin-converting enzyme ACE inhibitor. A prodrug that is de-esterified to the active inhibitor, the sulfhydryl group containing metabolite, Zofenoprilat.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gorren, A., et al.: Biochem. J., 331, 801 (1998), Subissi, A., et al.: Cardivascular Drug Reviews, 17, 2 (1999), Marchand, C., et al.: Mol. Pharmacol., 64, 600 (2003), Maurin, C., et al.: J. Med. Chem., 47, 5583 (2004),

Applications An impurity arising in the synthesis of zoledronic acid (Z623500).

Stability Hygroscopic
Applications Butafosfan, a component of Catosal, is licensed for the treatment of metabolic disorders or as a tonic in swine. It reduces the stress-induced cortisol (C696302, d4 labelled) response after mixing of unfamiliar pigs. It can also increase milk production in Holstein cows in combination with cyanocobalamin.
References De Groot, J., et al.: J. Vet. Pharmacol. Ther., 26, 222 (2003); Pereira, R., et al.: Animal, 7, 1143 (2013)

Applications A biphosphonate bone resorption inhibitor.
References Green, J.R., et al.: J. Bone Min. Res., 9, 745 (1994), Risser, F., et al.: J. Pharm. Biomed. Anal., 15, 1877 (1997), Body, J.J., Cancer, 80, 1699 (1997),

Applications (4S)-4-(Phenylthio)-L-proline is an impurity of Zofenopril (Z587000).
References Krapcho, J., et al.: J. Med. Chem., 31, 1148 (1988),

Stability Moisture Sensitive
Applications A major biodegradation product of Malathion (M111000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kim, Y. et al.: Chemosphere, 60, 1349 (2005); Yoshii, K. et al.: J. Health Sci., 54, 535 (2008); Hayasaka, M. et al.: Jap. J. Forensic Toxicol., 12, 15 (1994);

Applications A metabolite of the anti-tumor drug Ifosfamide (I265000). An impurity of Cyclophosphamide (C988580).
References Gilard, V. et al.: J. Med. Chem., 42, 2542 (1999); Seligman, A.M. et al.: Cancer Chemother. Rep., 59, 233 (1975);

Applications A labelled metabolite of Cyclophosphamide (CPA) (C988580).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Takamizawa, A., et al.: J. Med. Chem., 18, 376 (1975), Jones, R.J., et al.: J. Hematother., 1, 343 (1992), Biggs, D., et al.: Prog. Clin. Biol. Res., 389, 9 (1994),

Applications Dichlorvos-d6 is a deuterated analogue of Dichlorvos a Cholinesterase inhibitor. Anthelmintic, insecticide. Used as a standard for Pesticide detection. Also used in Cannabis testing.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969), Reuber, M.D., et al.: Clin. Toxicol., 18, 47 (1981),

Applications It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.This compound is suitable for aldehyde dehydrogenase (ALDH) related research.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999),