Organic Phosphates and Phosphonates

Ranelic acid chelates metals; its strontium salt treats osteoporosis, boosting bone density.

Impurity Captopril EP Impurity D
Stability Hygroscopic
Applications 3-Bromo-2-methylpropionic Acid (Captopril EP Impurity D) is used in the preparation of captopril selenium analogs as antioxidants and ACE inhibitors used as antihypertensive drugs.
References Bhuyan, B. et al.: Org. Biomol. Chem., 9, 1356 (2011);

Stability Very Hygroscopic
Applications The active metabolite of Zofenopril, an ACE inhibitor.
References Cushman, D., et al.: Br. J. Clin. Pharmacol., 28, 115S (1989), Kelly, J., et al.: Clin. Pharmacokinet., 19, 177 (1990), Liu, X., et al.: Cardiv. Drugs Ther., 6, 437 (1992), Marzo, A., et al.: Arzneim.- Forsch., 49, 992 (1999), Subissi, A., et al.: Cardiv. Drug Rev., 17, 2 (1999),

Applications Cyclophosphamide-d8 H2O [bis(2-chloroethyl-d4)] is a useful isotopically labeled compound of Cyclophosphamide Monohydrate (C988580)

Stability Moisture Sensitive
Applications Diethyl (Ethoxycarbonyl)phosphonate is an impurity in the synthesis of Foscarnet (F727400), an inhibitor of viral DNA polymerase and reverse transcriptase. Foscarnet is used as an antiviral.
References Helgstrand, E., et al.: Science, 201, 819 (1978), Reno, J.M., et al.: Antimicrob. Agents Chemother., 13, 188, (1978), Alenius, S., et al.: Arch. Virol., 60, 197 (1979),

Applications Labelled orally active tridentate iron chelator.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hershko, C., et al.: Blood, 97, 1115 (2001), Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003), Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003),

Applications 3-(Methylnitrosamine)propionaldehyde (MNPA) was detected for the 1st time in the saliva of betel quid chewers and is a potent carcinogen. It exhibits higher cytotoxicity than Nitrosoguvacine (NGC), Nitrosoguvacoline (NG) and 3-(Methylnitrosamino)propionitrile (MNPN).
References Bartsch, H., et al.: Mutat. Res., 250, 103 (1991), Su, T., et al.: Drug Metab. Dispos., 24, 884 (1996), Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001),

Applications A labelled metabolite of Pravastatin (P702000), a competitive inhibitor of HMG-CoA reductase.
References Serizawa, N., et al.: J. Antibiot., 36, 604 (1983), White, H.D, et al.: N. Engl. J. Med., 343, 317 (2000)

Applications Reagent used for Horner-Emmons modification.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hediger, M., et al.: Bioorg. Med. Chem., 12, 4995 (2004), Kim, J., et al.: Nat., 452, 239 (2008),

Stability Hygroscopic
Applications Isotope labelled Aldophosphamide Semicarbazone is a major metabolite of cyclophosphamide (C988580), a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.This compound is suitable for aldehyde dehydrogenase (ALDH) related research.
References Struck, R.F., et al.: Cancer. Rsch., 34, 2933 (1947); Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999),

Applications Aldophosphamide Semicarbazone is a major metabolite of cyclophosphamide (C988580), a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.This compound is suitable for aldehyde dehydrogenase (ALDH) related research.
References Struck, R.F., et al.: Cancer. Rsch., 34, 2933 (1947); Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962); Fraiser, L.H., et al.: Drugs, 42, 781 (1991); Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999);

Applications m-Salicylic Acid is widely used in organic synthesis. It is also an important active metabolite of aspirin (A187780).
References Haynes, M., et al.: CRC H.b Chem. Phys., 92, 306 (2011)

Stability Hygroscopic
Applications A biodegradation product of Malathion (M111000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kim, Y. et al.: Chemosphere, 60, 1349 (2005); Yoshii, K. et al.: J. Health Sci., 54, 535 (2008); Hayasaka, M. et al.: Jap. J. Forensic Toxicol., 12, 15 (1994);

Applications Isotope labelled Parathion (P192220) is an organophosphate insecticide used on cotton, rice and fruit trees.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Seifert, J., et al.: Environ. Toxicol. Pharmacol., 35, 200 (2013); Ciffroy, P., et al.: Environ. Toxicol. Chem., 32, 602 (2013);

Applications Metaraminol Bitartrate is a vasopressor comparable to ephedrine used in the maintenance of arterial pressure during spinal anesthesia. Also used in the treatment of hypotension while under the effect of anaesthesia.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ngan, K. et al.: Anesthes., 95, 307 (2001); Critchley, L. et al.: Br. J. Anaesth., 76, 734 (1996);

Applications Minodronic acid is developed for osteoporosis treatment.
References Tanishima, S., et al.: Clin. Interv. Aging, 8, 185 (2013)