Nucleosides and Nucleotides
Found 3486 products of "Nucleosides and Nucleotides"
Zalcitabine
CAS:Controlled ProductApplications A pyrimidine nucleoside analogue with antiviral activity.
References van der Vliet, P.C. and Kwant, M.M.: Biochemistry, 20, 2628 (1981), Mitsuya, H., Broder, S.: Proc. Nat. Acad. Sci. USA, 83, 1911 (1986), Starnes, M.C., and Cheng, Y.: J. Biol. Chem., 262, 988 (1987),Formula:C9H13N3O3Color and Shape:NeatMolecular weight:211.22Melphalan Hydrochloride
CAS:Controlled ProductStability Moisture Sensitive
Applications Melphalan Hydrochloride is used in combined intravitreal chemotherapy with topotecan hydrochloride for viable vitreous seeding from retinoblastoma. Also, it is an anti-cancer chemotherapy drug.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ghassemi, F., et al.: JAMA Ophthalmol., 132, 936-941 (2014); Gao, L. P., et al.: Adv. Mater. Res., 781-784, 993-998 (2013);Formula:C13H18Cl2N2O2·ClHColor and Shape:NeatMolecular weight:341.66Lamivudine-13C1,d2
CAS:Controlled ProductStability Hygroscopic
Applications Lamivudine-13C1,d2, is the labeled analogue of Lamivudine (L172502). A reverse transcriptase inhibitor. Antiviral.
References Morris, D.M., J. Pharm. Biomed. Anal., 12, 255 (1944), Nevens, B.F., et al.: Gastroenterology, 113, 1258 (1997), Perry, C.M., et al.: Drugs, 53, 657 (1977),Formula:C713CH9D2N3O3SColor and Shape:White PowderMolecular weight:232.26Ethoxy-5-fluoro-4(3H)-pyrimidinone
CAS:Controlled ProductImpurity Fluorouracil EP Impurity F
Applications Ethoxy-5-fluoro-4(3H)-pyrimidinone (Fluorouracil EP Impurity F) is a derivative of 5-fluorouracil (3C,15N2 labelled, F596002) which is a potent antineoplastic agent in clinical use.
References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 221 (1973), Miyashita, O., et al.: Chem. Pharm. Bull., 29, 3181 (1981), Hansen, R.M., et al.: Cancer Invest., 9, 637 (1991),Formula:C6H7FN2O2Color and Shape:NeatMolecular weight:158.13Lamivudine
CAS:Controlled ProductApplications Lamivudine is a potent nucleoside reverse transcriptase inhibitor. Antiviral. Lamivudine has been used for treatment of chronic hepatitis B.
References Morris, D.M., J. Pharm. Biomed. Anal., 12, 255 (1944), Nevens, B.F., et al.: Gastroenterology, 113, 1258 (1997), Perry, C.M., et al.: Drugs, 53, 657 (1977),Formula:C8H11N3O3SColor and Shape:WhiteMolecular weight:229.26Cobamamide
CAS:Controlled ProductApplications Cobamamide is an enzyme cofactor that can also regulate gene expression through RNA-base riboswitches.
References Ortiz-Guerrero, J.M., et. al.: P. Natl. Acad. Sci. USA, 108, 7565 (2011)Formula:C72H100CoN18O17PColor and Shape:NeatMolecular weight:1579.585-Hydroxy-1-methyl-4-nitroimidazole Sodium Salt (>90%)
CAS:Controlled ProductImpurity Azathioprine BP Impurity E
Stability Light Sensitive
Applications 5-Hydroxy-1-methyl-4-nitroimidazole Sodium Salt is a degradation product of Azathioprine (A803350); an immunosuppressive antimetabolite that is also active as a disease modifying antirheumatic drug (DMARD).
References Mitrou, P.S., et al.: Arzneim.-Forsch., 29, 483, 662 (1979); Ding, T.L., et al.: Drug. Metab. Dispos., 7, 373 (1979); Chan, G.L.C., et al.: Pharmacotherapy, 7, 165 (1987); Sandborn, W.J., et al.: Scand. J. Gastroenterol., 33, Suppl. 225, 92 (1998)Formula:C4H4N3NaO3Purity:>90%Color and Shape:Light Yellow To YellowMolecular weight:165.08Emtricitabine S-Oxide (Mixture of Diastereomers)
CAS:Controlled ProductApplications A metabolite of (-)-Emtricitabine (E525000).
References Schinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992); Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996); Feng, J.Y., et al.: FASEB J., 13, 1511 (1999); Molina, J.-M., et al.: J. Infec. Dis., 182, 599 (2000);Formula:C8H10FN3O4SColor and Shape:Off-WhiteMolecular weight:263.25Pteroic acid - 60%
CAS:Pteroic acid is a synthetic compound that is an analog of the natural amino acid phenylalanine. It has been shown to inhibit protein synthesis and may be useful for the treatment of cancer. Pteroic acid can be activated by the addition of trifluoroacetic acid and reacts with metal ions such as nickel, cobalt, copper, and zinc. It also binds to receptors on tubule cells in kidney tissue. This binding inhibits the enzyme carbonic anhydrase II, which catalyzes the conversion of carbon dioxide to bicarbonate in these cells. The inhibition of this enzyme results in a decrease in bicarbonate concentration within these cells, leading to cell death.Formula:C14H12N6O3Purity:Min. 93 Area-%Color and Shape:PowderMolecular weight:312.28 g/mol2-Acetamido-7-[[2-(acetyloxy)ethoxy]methyl]-6,7-dihydro-1H-purin-6-one
CAS:2-Acetamido-7-[[2-(acetyloxy)ethoxy]methyl]-6,7-dihydro-1H-purin-6-one is a drug development impurity that is manufactured by the pharmaceutical company. This impurity has been shown to be a metabolite of the drug.Formula:C12H15N5O5Purity:Min. 95%Color and Shape:White to off-white solid.Molecular weight:309.28 g/molMethyl 2-deoxy-3,4-di-O-toluoyl-D-ribopyranoside
CAS:Methyl 2-deoxy-3,4-di-O-toluoyl-D-ribopyranoside is a synthetic impurity standard for the drug product. It has been used in studies on metabolism and as an analytical reference material. Methyl 2-deoxy-3,4-di-O-toluoyl-D-ribopyranoside is also available as a custom synthesis at high purity.Formula:C22H24O6Purity:Min. 95%Color and Shape:White powder.Molecular weight:384.42 g/molRemdesivir impurity 6
CAS:Remdesivir impurity 6 is an impurity standard for a research and development drug product. It is a synthetic compound that has been custom synthesized for use in pharmacopoeia drug products. The purity of this compound is high and it has been shown to have no toxic effects on metabolism studies. Remdesivir impurity 6 is a metabolite of remdesivir, which is used as an antiviral agent for the treatment of HIV infection.Formula:C15H24NO5PPurity:Min. 95%Molecular weight:329.33 g/molMethyl 2-deoxy-3,5-di-O-(4-chlorobenzoyl)-a-D-ribofuranoside
CAS:Methyl 2-deoxy-3,5-di-O-(4-chlorobenzoyl)-a-D-ribofuranoside is a research and development impurity standard for the synthesis of drug products. This chemical is used as a metabolite in the study of metabolic pathways and can be converted to Methyl 3,5-di-O-(4-chlorobenzoyl)-a-D-ribofuranoside by hydrolysis with dilute acid. Methyl 2-deoxy-3,5-di-O-(4-chlorobenzoyl)-a-D ribofuranoside has been shown to be a synthetic molecule and is listed in pharmacopoeia. CAS No. 7818564 5.Formula:C22H24O6Purity:Min. 95%Molecular weight:384.42 g/mol3,5-Di-O-(4-chlorobenzoyl)-2-deoxy-a-D-ribofuranosyl isocyanate
3,5-Di-O-(4-chlorobenzoyl)-2-deoxy-a-D-ribofuranosyl isocyanate (CAS No. 53477) is a drug product that belongs to the class of drugs called nucleosides. 3,5-Di-O-(4-chlorobenzoyl)-2-deoxy-a-D-ribofuranosyl isocyanate has been shown to be metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. This product has been shown to have antiplasmodial activity and may be useful in the treatment of malaria.Formula:C20H15Cl2NO6Purity:Min. 95%Molecular weight:436.24 g/molDecitabine impurity 14
CAS:Decitabine impurity 14 is an impurity of decitabine. It is a stable, natural product that has been synthesized for use as an analytical standard and pharmacopoeia reference material. Decitabine impurity 14 is a white crystalline powder with a melting point of about 152°C. It is soluble in water, ethanol and ether. The chemical name for this compound is 2-amino-4,6-dihydroxypyrimidine-5-carbonitrile hydrochloride.Formula:C5H11NO3Purity:Min. 95%Molecular weight:133.15 g/molRemdesivir impurity 12
CAS:Remdesivir impurity 12 is a drug product that is used in research and development. It is a synthetic impurity standard for HPLC analytical methods. Remdesivir impurity 12 is an impurity of the drug, remdesivir, which has antiviral activity against HIV-1. Metabolism studies have been conducted to investigate how this impurity affects the pharmacokinetics of remdesivir. The use of synthetic material ensures high purity and quality for this product.Formula:C21H31N6O8PPurity:Min. 95%Molecular weight:526.48 g/molRemdesivir Related Compound 4
CAS:Remdesivir Related Compound 4 is a synthetic compound that is structurally related to remdesivir. It has been shown to have anti-HIV activity in vitro. Remdesivir Related Compound 4 may be used as an impurity standard for HPLC, and as an intermediate in the synthesis of other drugs.Formula:C32H32N4O5Purity:Min. 95%Molecular weight:552.62 g/molDecitabine impurity 13
CAS:Decitabine is a drug product that is being developed for the treatment of cancer. It has been shown to inhibit the proliferation of human tumor cells in vitro and to induce apoptosis in prostate cancer cells. Decitabine is metabolized to an active form, dideoxycitidine (DDC), which binds to DNA and inhibits the enzyme DNA polymerase alpha, leading to inhibition of DNA synthesis. Impurity 13 is a by-product of the synthesis process and can be used as an analytical standard. It can also be used as a research and development impurity standard or as a pharmacopoeia impurity standard.Formula:C4H6N6O2Purity:Min. 95%Molecular weight:170.13 g/mol2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate
CAS:2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate (CDFMP) is a potent antitumor agent that has been shown to have a strong anti-angiogenic effect. It inhibits the cancer cell's production of microvessels and interferes with the formation of new blood vessels from pre-existing ones, which can be used to deliver chemotherapy drugs to the tumor. CDFMP is synthesized by reacting 2'-deoxy-2',2'-difluorocytidine with phosphoric acid and then converting it into the monophosphate form using phosphorus oxychloride. This drug is also resistant to platinum-based chemotherapy agents, making it a promising drug for patients who are resistant to other treatments.Formula:C9H12F2N3O7PPurity:Min. 97 Area-%Color and Shape:PowderMolecular weight:343.18 g/molDapagliflozin Impurity 30
CAS:Dapagliflozin Impurity 30 is a natural impurity found in the drug Dapagliflozin. It is an analytical standard used for HPLC quantification of dapagliflozin, and it can be used as a pharmacopoeia reference material or research and development material. Dapagliflozin Impurity 30 is synthesized by using a custom synthesis protocol. The CAS number for this compound is 1373321-04-0.Formula:C21H25ClO6Purity:Min. 95%Color and Shape:PowderMolecular weight:408.9 g/mol
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