Nucleosides and Nucleotides
Nucleosides are compounds formed by a nitrogenous base linked to a sugar (ribose or deoxyribose). When a phosphate group is added to the nucleoside, a nucleotide is formed. These compounds are essential in cellular biology, as nucleotides are the fundamental building blocks of DNA and RNA, responsible for storing and transmitting genetic information. Nucleosides have applications in the treatment of viral diseases, acting as inhibitors of viral replication. Nucleotides, besides their structural role in nucleic acids, are involved in energy processes, such as ATP synthesis.
At CymitQuimica, we offer a wide range of nucleosides and nucleotides essential for research in molecular biology, virology, and pharmacology.
Found 3491 products of "Nucleosides and Nucleotides"
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2-Acetamido-9-[[2-(acetyloxy)ethoxy]methyl]-6,9-dihydro-1H-purin-6-one
CAS:2-Acetamido-9-[2-(acetyloxy)ethoxy]methyl-6,9-dihydro-1H-purin-6-one (ademetionine) is a prodrug that is metabolized in the liver to form ademetionine. Ademetionine is a potent inhibitor of guanosine deaminase, which is an enzyme that breaks down guanosine into guanine and ammonia. Ademetionine has shown efficacy in cancer treatment and may also be used to treat tuberculosis. The metabolism of this drug takes place in the liver, where it undergoes oxidation by cytochrome P450 enzymes to form the active metabolite ademetionine. Metabolism of this drug can be inhibited by drugs such as trifluoromethanesulfonic acid (TFMS), which are used for the treatment of malaria. TFMS inhibits the formation of ademetionine but does not affect the formationFormula:C12H15N5O5Purity:Min. 95%Color and Shape:White PowderMolecular weight:309.28 g/molDecitabine impurity 13
CAS:Decitabine is a drug product that is being developed for the treatment of cancer. It has been shown to inhibit the proliferation of human tumor cells in vitro and to induce apoptosis in prostate cancer cells. Decitabine is metabolized to an active form, dideoxycitidine (DDC), which binds to DNA and inhibits the enzyme DNA polymerase alpha, leading to inhibition of DNA synthesis. Impurity 13 is a by-product of the synthesis process and can be used as an analytical standard. It can also be used as a research and development impurity standard or as a pharmacopoeia impurity standard.Formula:C4H6N6O2Purity:Min. 95%Molecular weight:170.13 g/mol4-Amino-7-iodopyrrolo[2,1-f][1,2,4]triazine
CAS:4-Amino-7-iodopyrrolo[2,1-f][1,2,4]triazine is an impurity standard of the drug product. It is a high purity synthetic compound with a niche in pharmacopoeia and drug development. 4-Amino-7-iodopyrrolo[2,1-f][1,2,4]triazine has been shown to be a metabolite of the natural product.Formula:C6H5IN4Purity:Min. 97 Area-%Color and Shape:PowderMolecular weight:260.04 g/mol3,5-Di-O-(4-chlorobenzoyl)-2-deoxy-a-D-ribofuranosyl isocyanate
3,5-Di-O-(4-chlorobenzoyl)-2-deoxy-a-D-ribofuranosyl isocyanate (CAS No. 53477) is a drug product that belongs to the class of drugs called nucleosides. 3,5-Di-O-(4-chlorobenzoyl)-2-deoxy-a-D-ribofuranosyl isocyanate has been shown to be metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. This product has been shown to have antiplasmodial activity and may be useful in the treatment of malaria.Formula:C20H15Cl2NO6Purity:Min. 95%Molecular weight:436.24 g/molRemdesivir impurity 6
CAS:Remdesivir impurity 6 is an impurity standard for a research and development drug product. It is a synthetic compound that has been custom synthesized for use in pharmacopoeia drug products. The purity of this compound is high and it has been shown to have no toxic effects on metabolism studies. Remdesivir impurity 6 is a metabolite of remdesivir, which is used as an antiviral agent for the treatment of HIV infection.Formula:C15H24NO5PPurity:Min. 95%Molecular weight:329.33 g/molRemdesivir Related Compound 4
CAS:Remdesivir Related Compound 4 is a synthetic compound that is structurally related to remdesivir. It has been shown to have anti-HIV activity in vitro. Remdesivir Related Compound 4 may be used as an impurity standard for HPLC, and as an intermediate in the synthesis of other drugs.Formula:C32H32N4O5Purity:Min. 95%Molecular weight:552.62 g/molDecitabine impurity 11
CAS:Decitabine is a drug product that is used as an anti-cancer drug. It is a synthetic, natural, and research and development (R&D) metabolite with the CAS No. 909402-26-2. Decitabine has shown anticancer activity in vitro and in vivo against leukemia cells. This compound is an impurity of the API decitabine that is manufactured by a chemical synthesis process. The analytical impurities are 11 compounds that have been identified from the HPLC standard of this API. The metabolites of these compounds are also included in this standard. High purity decitabine should be obtained for pharmacopoeia studies and niche applications such as HPLC standards, pharmaceuticals, or research purposes.Formula:C9H13N3O5Purity:Min. 95%Molecular weight:243.22 g/molMethyl 2-deoxy-3,4-di-O-toluoyl-D-ribopyranoside
CAS:Methyl 2-deoxy-3,4-di-O-toluoyl-D-ribopyranoside is a synthetic impurity standard for the drug product. It has been used in studies on metabolism and as an analytical reference material. Methyl 2-deoxy-3,4-di-O-toluoyl-D-ribopyranoside is also available as a custom synthesis at high purity.Formula:C22H24O6Purity:Min. 95%Color and Shape:White powder.Molecular weight:384.42 g/mol1-b-D-Ribofuranosyl-1,2,4-triazole-3-carboxylic acid methyl ester
CAS:Intermediate in the synthesis of ribavirinFormula:C9H13N3O6Purity:Min. 95%Color and Shape:White PowderMolecular weight:259.22 g/molAcyclovir
CAS:Acyclovir is an antiviral drug that inhibits the replication of herpes viruses by selectively inhibiting viral DNA polymerase. The drug is active against a broad range of herpes viruses, including both types of herpes simplex virus (HSV-1 and HSV-2) and varicella zoster virus. Acyclovir has also been shown to be effective against aciclovir-resistant mutants. This drug can be used as a prophylaxis or in combination with other antiviral agents for the treatment of active infections. Acyclovir can cause headaches, nausea, vomiting, and diarrhea when taken orally. It should not be taken with certain medicines such as aminoglycosides or high doses of aspirin because this may increase the risk for kidney problems.
Formula:C8H11N5O3Purity:Min. 95%Color and Shape:White PowderMolecular weight:225.2 g/molDapagliflozin Impurity 30
CAS:Dapagliflozin Impurity 30 is a natural impurity found in the drug Dapagliflozin. It is an analytical standard used for HPLC quantification of dapagliflozin, and it can be used as a pharmacopoeia reference material or research and development material. Dapagliflozin Impurity 30 is synthesized by using a custom synthesis protocol. The CAS number for this compound is 1373321-04-0.Formula:C21H25ClO6Purity:Min. 95%Color and Shape:PowderMolecular weight:408.9 g/molDecitabine impurity 14
CAS:Decitabine impurity 14 is an impurity of decitabine. It is a stable, natural product that has been synthesized for use as an analytical standard and pharmacopoeia reference material. Decitabine impurity 14 is a white crystalline powder with a melting point of about 152°C. It is soluble in water, ethanol and ether. The chemical name for this compound is 2-amino-4,6-dihydroxypyrimidine-5-carbonitrile hydrochloride.Formula:C5H11NO3Purity:Min. 95%Molecular weight:133.15 g/mol2-Acetamido-7-[[2-(acetyloxy)ethoxy]methyl]-6,7-dihydro-1H-purin-6-one
CAS:2-Acetamido-7-[[2-(acetyloxy)ethoxy]methyl]-6,7-dihydro-1H-purin-6-one is a drug development impurity that is manufactured by the pharmaceutical company. This impurity has been shown to be a metabolite of the drug.Formula:C12H15N5O5Purity:Min. 95%Color and Shape:White to off-white solid.Molecular weight:309.28 g/mol2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone
CAS:2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone is a synthetic building block which can undergo reaction with nucleophilic carbon species to afford C-ribosides (via the corresponding hemiacetal). Treatment of 2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone with stronger reducing agents, such as sodium borohydride, affords ring opened products with a stereo-defined poly-oxygenated carbon chain backbone.Formula:C26H26O5Purity:Min. 98 Area-%Color and Shape:White Off-White PowderMolecular weight:418.48 g/molIsoribavirin
CAS:Isoribavirin is a ribonucleoside monophosphate analog that inhibits viral RNA polymerase. Isoribavirin has been shown to be active against influenza virus, herpes simplex virus, and vesicular stomatitis virus in cell culture. Isoribavirin is stable in an acetonitrile solution in the presence of phosphoric acid at pH 3-4 or in the presence of sulfate ions at pH 9-10. It can be purified by chromatography on a silica gel column using an acetonitrile/water mobile phase gradient. The impurities of isoribavirin are not detectable by liquid chromatography and have no significant effect on its sensitivity. Isoribavirin elutes from the silica gel column with the impurities.
Formula:C8H12N4O5Purity:Min. 95%Color and Shape:White PowderMolecular weight:244.21 g/mol2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate
CAS:2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate (CDFMP) is a potent antitumor agent that has been shown to have a strong anti-angiogenic effect. It inhibits the cancer cell's production of microvessels and interferes with the formation of new blood vessels from pre-existing ones, which can be used to deliver chemotherapy drugs to the tumor. CDFMP is synthesized by reacting 2'-deoxy-2',2'-difluorocytidine with phosphoric acid and then converting it into the monophosphate form using phosphorus oxychloride. This drug is also resistant to platinum-based chemotherapy agents, making it a promising drug for patients who are resistant to other treatments.Formula:C9H12F2N3O7PPurity:Min. 97 Area-%Color and Shape:PowderMolecular weight:343.18 g/molβ-lactamase Protein, E. coli, Recombinant (His & SUMO)
This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.Color and Shape:Lyophilized PowderMolecular weight:52.5 kDa (predicted)Ref: TM-TMPH-00588
5µg130.00€10µg211.00€20µg351.00€50µg520.00€100µg714.00€200µg1,027.00€500µg1,607.00€1mg2,350.00€β-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO)
Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E.Color and Shape:Lyophilized PowderMolecular weight:56.7 kDa (predicted)Ref: TM-TMPH-03165
5µg130.00€10µg211.00€20µg351.00€50µg520.00€100µg714.00€200µg1,027.00€500µg1,607.00€1mg2,350.00€3’-O-(5’-Deoxy-β-D-ribofuranosyl) Capecitabine
CAS:Controlled ProductImpurity Capecitabine 3-O-BDR Impurity (USP)
Applications Capecitabine (C175650) impurity. Capecitabine 3-O-BDR Impurity (USP).Formula:C20H30FN3O9Color and Shape:NeatMolecular weight:475.472,3,5-Tri-O-acetyl-6-chloropurine-9-β-D-ribofuranoside (~90%)
CAS:Controlled ProductApplications 2,3,5-Tri-O-acetyl-6-chloropurine-9-β-D-ribofuranoside is a nucleoside compound with inhibitory activity on a rho-GTPase cell protein.
References Mounetou., et al.: J. Med. Chem., 40, 2902 (1997), Panero, J., et al.: Biotech. Lett., 28, 1077 (2006),Formula:C16H17ClN4O7Purity:>90%Color and Shape:NeatMolecular weight:412.78
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