Salts and Derivatives of Active Pharmaceutical Ingredients (API)
The salts of Active Pharmaceutical Ingredients (APIs) are compounds formed by the reaction of an acid with a base, resulting in an ionic equilibrium. These salts often improve the solubility and stability of APIs, facilitating their absorption in the body. API derivatives are chemical variants of an active ingredient that may have enhanced or modified properties to optimise therapeutic efficacy. API salts are used in the formulation of oral, injectable, and topical medications. Additionally, API derivatives can improve the pharmacokinetics of drugs, such as enabling controlled release of active substances.
At CymitQuimica, we provide API salts and derivatives with the necessary purity and quality for research and pharmaceutical formulation development.
Found 79283 products of "Salts and Derivatives of Active Pharmaceutical Ingredients (API)"
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Allopurinol-13C,15N2
CAS:Controlled Product<p>Applications Allopurinol-13C,15N2, is the labeled analogue of Allopurinol (A547300), acting as an Xanthine oxidase inhibitor, and used in treatment of hyperuricemia and chronic gout.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978), Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005), Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005),<br></p>Formula:C413CH4N215N2OColor and Shape:NeatMolecular weight:139.09Febuxostat-d7
CAS:Controlled Product<p>Applications Febuxostat-d7, is the labeled analogue of Febuxostat-d7 (F229000), a Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>Formula:C16H9D7N2O3SColor and Shape:NeatMolecular weight:323.42Diclofenac Diethylamine Salt
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Diclofenac Diethylamine is a nonsteroidal anti-inflammatory compound; a decycloxygenase (COX) inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kenny, J. R., et al.: J. Med. Chem., 47, 2816 (2004); Sasaki, A., et al.: J. Pharmacol. Sci., 108, 266 (2008); Dalvie, D., et al.: Chem. Res. Toxicol., 22, 357 (2009)<br></p>Formula:C14H11Cl2NO2·C4H11NColor and Shape:NeatMolecular weight:369.293’-Amino-2’-Hydroxy-[1,1’]biphenyl-3-carboxylic Acid
CAS:Controlled Product<p>Applications 3’-Amino-2’-Hydroxy-[1,1’]Biphenyl-3-carboxylic Acid is used in the synthesis of monoethanolamine salts. A hydrazine cleavage product from Eltrombopag (E508000), an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia<br>References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),<br></p>Formula:C13H11NO3Color and Shape:NeatMolecular weight:229.231N-(R)-Glycidyl Phthalimide
CAS:Controlled Product<p>Applications Reagent used for the simultaneous preparation of amino alcohol solvating agents as well as preparation of orally available anticoagulants.<br>References Roehrig, S. et al: J. Med. Chem., 48, 5900 (2005); Bozkurt, S. et al: Tetra: Asymm., 22, 541 (2011);<br></p>Formula:C11H9NO3Color and Shape:NeatMolecular weight:203.19R-(+)-Warfarin
CAS:Controlled Product<p>Applications The R-(+)-form of Warfarin (W498500). Coumarin anticoagulant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hagan, E.C., et al.: J. Am. Pharm. Assoc. Sci. Ed., 42, 379 (1953), Bell, R.G., et al.: Biochemistry, 11, 1959 (1972), Valente, J.E., et al.: J. Med. Chem., 20, 1489 (1977), Back, N., et al.: Pharmacol. Res. Commun., 10, 445, (1978), Babhair, S.A., et al.: Anal. Profiles Drug Subs., 14, 423 (1985), Takahashi, H., et al.: Echizen, Clin. Pharmacokinet., 40, 587 (2001),<br></p>Formula:C19H16O4Color and Shape:NeatMolecular weight:308.33Mivacurium Chloride (mixture of isomers)
CAS:Controlled ProductFormula:C58H80N2O14·2ClColor and Shape:NeatMolecular weight:1100.17Febuxostat 2-Butyl Isomer
CAS:Controlled Product<p>Applications Febuxostat 2-butyl Isomer is an impurity of Febuxostat (F229000) which is a xanthine oxidase/xanthine dehydrogenase inhibitor.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>Formula:C16H16N2O3SColor and Shape:NeatMolecular weight:316.37Ramipril Diketopiperazine
CAS:Controlled Product<p>Impurity Ramipril EP Impurity D<br>Stability Hygroscopic<br>Applications Ramipril Diketopiperazine (Ramipril EP Impurity D) is a metabolite of Ramipril (R111000).<br>References Tabata, S., et al.: J. Biopharm. Sci., 1, 235 (1990),<br></p>Formula:C23H30N2O4Color and Shape:WhiteMolecular weight:398.50Trimethylamine Monohydrochloride
CAS:Controlled ProductFormula:C3H9N·ClHColor and Shape:NeatMolecular weight:95.5712Diclofenac Acyl-β-D-glucuronide
CAS:Controlled Product<p>Applications A metabolite of Diclofenac, a nonsteroidal inflammatory compound and cyclooxygenase (COX) inhibitor.<br>References Kenny, J. R., et al.: J. Med. Chem., 47, 2816 (2004)<br></p>Formula:C20H19Cl2NO8Color and Shape:NeatMolecular weight:472.27Argatroban
CAS:<p>Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.</p>Formula:C23H36N6O5SPurity:99.77% - >99.99%Color and Shape:White To Off-White Crystalline SolidMolecular weight:508.632-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic Acid Ethyl Ester
CAS:<p>Applications 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic Acid Ethyl Ester, can be used for the synthesis of Febuxostat (F229000), an antipodagrics.<br>References Zheng, F., et al.: Zhongguo Yiyao Gongye Zazhi, 40, 726 (2009);<br></p>Formula:C14H12N2O3SColor and Shape:NeatMolecular weight:288.32Desbutyl Dronedarone Hydrochloride
CAS:<p>Impurity Dronedarone USP Related Compound A<br>Applications A metabolite of Dronedarone (D679445). Dronedarone impurity D. Dronedarone USP Related Compound A.<br>References Bolderman, R.W. et al.: J Chrom. B:Anal. Tech. Biomed. Life Sci., 887, 1727 (2009); Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008); Hoy, S., et al.: Drugs, 69, 1647 (2009);<br></p>Formula:C27H36N2O5S·ClHColor and Shape:NeatMolecular weight:537.11E,E-Farnesylacetone
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications E,E-Farnesylacetone, is a natural organic compound which is present in many essential oils. It has been shown that, Farnesylacetone inhibits electron transport in isolated rat liver mitochondria.<br>References Dupont, J. et al.: Biology of the Cell, 67(2), 141-146 (1989); Gaviria, M. et al.: Chem. & Biodiversity 8, 532 (2011)<br></p>Formula:C18H30OColor and Shape:NeatMolecular weight:262.4315-Keto Travoprost
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications An impurity of the selective FP prostaglandin receptor agonist Travoprost (T715600) used as an ocularly applied intraocular pressure reducing agent.<br></p>Formula:C26H33F3O6Color and Shape:NeatMolecular weight:498.533-(4H-1,2,4-Triazol-4-yl)-1H-pyrazole-4-carboxamide
CAS:Controlled Product<p>Impurity Allopurinol EP Impurity C / Allopurinol USP Related Compound C<br>Applications 3-(4H-1,2,4-Triazol-4-yl)-1H-pyrazole-4-carboxamide (Allopurinol EP Impurity C) is an impurity of Allopurinol (A547300).<br></p>Formula:C6H6N6OColor and Shape:Off-WhiteMolecular weight:178.15Δ23-FK-506(>90%)
CAS:Controlled Product<p>Impurity Tacrolimus Diene Impurity (USP)<br>Applications Δ23-FK 506 is an impurity of FK-506 (Tacrolimus) (F370000), an immunosuppressant macrolactam.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Namiki, Y., et al.: J. Antibiot 1993, 46, 1149,,Akashi, T; J Pharm Biomed Anal 1996, 14, 339,,,,Wiedeman, P; J Med Chem 1999, 42, 4456,,,<br></p>Formula:C44H67NO11Purity:>90%Color and Shape:NeatMolecular weight:786.00Perindoprilat Lactam B
CAS:<p>Impurity Perindopril EP Impurity D<br>Applications Perindoprilat Lactam B (Perindopril EP Impurity D) is the active metabolite of Perindopril (P287500) in plasma and urine.<br>References Hillaert, S., et al.: J. Pharm. Biomed. Anal., 25, 775 (2001), Ozoemena, K., et al.: Talanta, 62, 681 (2004),<br></p>Formula:C17H26N2O4Color and Shape:White To Off-WhiteMolecular weight:322.40N-Despropyl-macitentan
CAS:Controlled Product<p>Applications N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH)<br>References Atsmon, J., et al.: Clin. Pharmacokinet., 525, 685 (2013); Sidharta, P.N., et al.: Clin. Drug Invest. (2014)<br></p>Formula:C16H14Br2N6O4SColor and Shape:NeatMolecular weight:546.19Cyclosporin H
CAS:<p>Applications Cyclosporin is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Formula:C62H111N11O12Color and Shape:NeatMolecular weight:1202.61N-Nitroso Moexipril
CAS:Controlled ProductFormula:C27H33N3O8Color and Shape:Off-WhiteMolecular weight:527.57N-(2,6-Dichlorophenyl)aniline
CAS:Controlled Product<p>Applications N-(2,6-Dichlorophenyl)aniline is an analog of Diclofenac (D436450), a nonsteroidal anti-inflammatory compound an decycloxygenase (COX) inhibitor.<br>References Moser, P. et al.: J. Med. Chem., 33, 2358 (1990); Encinas, S. et al.: Photochem. Photobiol., 68,640 (1998); Kenny, J. R., et al.: J. Med. Chem., 47, 2816 (2004), Sasaki, A., et al.: J. Pharmacol. Sci., 108, 266 (2008), Dalvie, D., et al.: Chem. Res. Toxicol., 22, 357 (2009),<br></p>Formula:C12H9Cl2NColor and Shape:WhiteMolecular weight:238.112-(4-(Methylsulfonamido)phenoxy)acetic Acid
CAS:Controlled Product<p>Applications 2-(4-(Methylsulfonamido)phenoxy)acetic Acid is a metabolite of antiarrhythmic drug Dofetilide (D525700), which is a is a potassium channel blocker.<br>References Smith, D., et al.: Xenobiotica, 22, 709 (1992); Carmeliet, D., et al.: J. Pharmacol. Exp. Ther., 262, 809 (1992); Walker, D., et al.: Drug Metab. Dispos., 24, 447 (1996); Norgaard, B.L., et al.: Am. Heart J., 137, 1062 (1999); Torp-Pedersen, C., et al.: N. Engl. J. Med. 341, 857 (1999);<br></p>Formula:C9H11NO5SColor and Shape:NeatMolecular weight:245.25Diclofenac Alcohol (Diclofenac Impurity)
CAS:<p>Impurity Diclofenac EP Impurity C<br>Applications Diclofenac Alcohol (Diclofenac EP Impurity C) is a Diclofenac impurity. Anti-inflammatory.<br>References Brogden, R., et al.: Drugs, 20, 24 (1980), Orienti, I., et al.: Eur. J. Pharm. Biopharm., 37, 110 (1991), Sagara, K., et al.: Chem. Pharm. Bull., 40, 3303 (1992), Connors, K., et al.: J. Pharm. Sci., 84, 843 (1995),<br></p>Formula:C13H11Cl2NOColor and Shape:WhiteMolecular weight:268.14N1-[2-(1-Piperazinyl)ethyl]-1,2-ethanediamine Hydrochloride
CAS:Controlled ProductFormula:C8H20N4•x(HCl)Color and Shape:NeatMolecular weight:172.273646N-Carbamoyl Oxcarbazepine
Controlled Product<p>Applications N-Carbamoyl Oxcarbazepine is an impurity of Oxcarbazepine (O869250), a metabolite of Eslicarbazepine acetate, (BIA 2-093), a novel central nervous system drug. A keto derivative of Carbamazepine. Used as an anticonvulsant.<br>References Dam., M., et al.: Epilepsy Res., 3, 70 (1989), Beydoun, A., et al.: Expert Opin. Pharmacother., 3, 59 (2001),<br></p>Formula:C16H13N3O3Color and Shape:NeatMolecular weight:295.291-Chloroethyl Cyclohexyl Carbonate
CAS:<p>Applications 1-Chloroethyl Cyclohexyl Carbonate is a genotoxic impurity used in the synthesis of Candesartan Cilexetil. an angiotensin II receptor antagonist.<br>References Kakasaheb, N. et al.: Int. J. Pharm. Sci., 6, 370 (2014); Mao, Y. et al.: Heterocycles, 81, 1503 (2010);<br></p>Formula:C9H15ClO3Color and Shape:NeatMolecular weight:206.67N-[[(5S)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-acetamide
CAS:Controlled Product<p>Applications N-[[(5S)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-acetamide is an impurity of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formula:C16H19N3O5Color and Shape:NeatMolecular weight:333.34O-Desisobutyl-O-n-propyl Febuxostat
CAS:Formula:C15H14N2O3SColor and Shape:NeatMolecular weight:302.352-Amino-5-(trifluoromethoxy)phenyl Thiocyanate
CAS:<p>Applications An impurity of Riluzole (R510000).<br></p>Formula:C8H5F3N2OSColor and Shape:NeatMolecular weight:234.20(5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone
CAS:Controlled Product<p>Applications (5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone is an intermediate used in the synthesis of dronedarone hydrochloride (I), a class III antiarrhythmia drug for the prevention of cardiac arrhythmias such as atrial fibrillation.<br>References Mali, A. C., et al.: Org. Proc. Res. Dev., 17, 863 (2013)<br></p>Formula:C30H42N2O3Color and Shape:NeatMolecular weight:478.67Dextrosimendan
CAS:Controlled Product<p>Applications Dextrosimendan is an isomer and impurity of Levosimendan (L378000), a bioactive enantiomer of Simendan (S466000). Levosimendan is a positive inotropic agent with vasodilating activity.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995); Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996)<br></p>Formula:C14H12N6OColor and Shape:Yellow To Dark YellowMolecular weight:280.28Disalicylimide
CAS:<p>Applications Disalicylimide is an impurity of Deferasirox (D228650), an orally active tridentate iron chelator.<br>References Hershko, C., et al.: Blood, 97, 1115 (2001), Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003), Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003),<br></p>Formula:C14H11NO4Color and Shape:NeatMolecular weight:257.25Deferasirox Ethyl Ester
CAS:Controlled Product<p>Applications Deferasirox Ethyl Ester is a derivative of Deferasirox (D228650); an orally active tridentate iron chelator.<br>References Hershko, C., et al.: Blood, 97, 1115 (2001); Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003); Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003)<br></p>Formula:C23H19N3O4Color and Shape:White To Light YellowMolecular weight:401.41
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