Sulfonamides and Derivatives
Sulphonamides are compounds that contain a sulphonamide functional group (-SO₂NH₂), where a sulphur atom is bonded to an amino group. They were among the first synthetic antibiotics used in medicine, inhibiting folic acid synthesis in bacteria, which gives them antimicrobial properties. They are mainly used to treat bacterial infections, although their use has declined due to antimicrobial resistance. In addition to their use as antibiotics, sulphonamides also have applications in the treatment of diseases such as malaria and inflammatory bowel diseases.
At CymitQuimica, we offer high-purity sulphonamides and their derivatives for research in microbiology and pharmaceutical development.
Found 2592 products of "Sulfonamides and Derivatives"
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N,N-Dimethylnicotinamide-2-sulfonamide
CAS:Controlled Product<p>Applications N,N-Dimethylnicotinamide-2-sulfonamide (cas# 112006-75-4) is a compound useful in organic synthesis.<br></p>Formula:C8H11N3O3SColor and Shape:NeatMolecular weight:229.26Bumetanide
CAS:Controlled ProductFormula:C17H20N2O5SColor and Shape:Light YellowMolecular weight:364.422-Amino-5-chlorobenzenesulfonamide
CAS:Controlled Product<p>Applications 2-Amino-5-chlorobenzenesulfonamide is a metabolite of IDRA-21 (I232500), which inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 is more able to cross the blood-brain barrier than Cyclothiazide (C988960).<br>References Cannazza, G., et. al.: Bioorg. Med. Chem. Lett., 19, 1254 (2009); Zivkovic, et al.: J. Pharmacol. Exp. Ther., 272, 300 (1995); Dingledine, R., et al.: Pharmacol. Rev., 51, 7 (1999); Sun, Y., et al.: Nature, 417, 245 (2002); Thomsen, R., et al.: J. Med. Chem., 49, 3315 (2006)<br></p>Formula:C6H7ClN2O2SColor and Shape:NeatMolecular weight:206.65Indomethacin Diamide
CAS:Controlled Product<p>Applications Indomethacin Diamide is an impurity of Indomethacin (I641000), an non-steroidal anti-inflammatory drug commonly used in the treatment of fever, pain and swelling.<br>References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)<br></p>Formula:C33H27Cl2N3O5Color and Shape:NeatMolecular weight:616.49Hydrochlorothiazide-13C,15N2,d2
CAS:Controlled Product<p>Applications Labelled Hydrochlorothiazide (H714560). Hydrochlorothiazide is a carbonic anhydrase inhibitor as a diuretic.<br>References Piala, J.J., et al.: J. Pharmacol. Exp. Ther., 134, 273 (1961), Deppeler, H.P., et al.: Anal. Profiles Drug Subs., 10, 405 (1981),<br></p>Formula:C613CH6D2ClN15N2O4S2Color and Shape:NeatMolecular weight:302.73Nafamostat Mesylate
CAS:<p>Applications A non-peptide proteaseinhibitor.<br>References Ayoyama, T., et al.: Chem. Pharm. Bull., 33, 1458 (1985)<br></p>Formula:C19H17N5O2·2CH4O3SColor and Shape:NeatMolecular weight:539.58Sulfadiazine-13C6
CAS:<p>Applications The isotopically labelled drug Sulfadiazine. Antibacterial.<br>References Bohni, et al.: Chemotherapy, 14, 195 (1969), Carr, et al.: Antimicrob. Agents Chemother., 4, 585 (1973), Stober, H., et al.: Anal. Profiles Drug Subs., 11, 523 (1982),<br></p>Formula:C6C4H10N4O2SColor and Shape:Off-WhiteMolecular weight:256.23rac Bendroflumethiazide-d5
CAS:Controlled ProductFormula:C15H9D5F3N3O4S2Color and Shape:NeatMolecular weight:426.453-Ethyl-2,5-dihydro-4-methyl-2-oxo-N-(2-phenylethyl)-1H-pyrrole-1-carboxamide
CAS:Controlled Product<p>Applications Intermediate for the preparation of Glimepiride.<br></p>Formula:C16H20N2O2Color and Shape:NeatMolecular weight:272.344-Acetamidophenyl β-D-Glucuronide Sodium Salt
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 4-Acetamidophenyl β-D-Glucuronide is a major urinary metabolite of Acetaminophen (A161220) (Paracetamol) in human (1). Acetaminophen is an analgesic and antipyretic agent and used as a pain reliever to treat headache, muscle aches, and arthritis (2,3).<br>References (1) Johnston, D., et al.: J. Chem. Res., Synop., 12, 406 (1988)(2) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(3) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974)<br></p>Formula:C14H16NO8·NaColor and Shape:White To Light RedMolecular weight:349.272-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-4(1H)-pyrimidinone
CAS:Controlled Product<p>Applications Degradation product/impurity of trimethoprim (T795615).<br>References Roth, B., et al.: J., Med. Pharm. Chem., 5, 1103 (1962), Bergh, J., et al.: J. Pharm. Sci., 78, 348 (1989),<br></p>Formula:C14H17N3O4Color and Shape:NeatMolecular weight:291.30rac 2-(4-Formylphenyl)propionic Acid (Ibuprofen Impurity K)
CAS:<p>Impurity Ibuprofen EP Impurity K<br>Applications rac 2-(4-Formylphenyl)propionic Acid (Ibuprofen EP Impurity K) is a degradation product of Ibuprofen arising from oxidative and thermal treatments. Ibuprofen impurity K.<br>References Heikkinen, L., et al.: Acta Pharm. Fenn., 92, 275 (1983), Vargas, F., et al.: Pharmazie, 11, 767 (1991), Lee, J., et al.: Pharm. Res., 9, S170 (1995),<br></p>Formula:C10H10O3Color and Shape:White To Light YellowMolecular weight:178.181-Propyl Etodolac
CAS:Controlled Product<p>Impurity Etodolac EP Impurity G<br>Applications 1-Propyl Etodolac (Etodolac EP Impurity G) is an impurity in the synthesis of Etodolac (E933100), may have use in the treatment of myeloma. COX-1/COX-2/β-catenin inhibitors, or anti-inflammatory agent.<br>References Robinson, W. et al.: J. Pharm. Exp. Ther., 203, 729 (1977); Humber, L.G., et al.: Med. Res. Rev., 7, 1 (1987); Balfour, J.A, et al.: Drugs, 42, 274 (1991); Kato, et al.: J. Pharm. Pharmacol., 53 1679 (2001);<br></p>Formula:C18H23NO3Color and Shape:NeatMolecular weight:301.38(R)-(-)-Etodolac
CAS:Controlled Product<p>Applications The R-enantiomer of Etodolac (E933090). Anti-inflammatory; analgesic.<br>References Boxenbaum, H., et al.: J. Pharmacokin. Biopharm., 10, 201 (1982), Iwatsubo, T., et al.: Biopharm. Drug Dispos., 17, 273 (1996), Obach, R., et al.: J. Pharmacol. Exp. Ther., 283, 46 (1997),<br></p>Formula:C17H21NO3Color and Shape:NeatMolecular weight:287.3544-Chloro-3-sulfamoylbenzoic Acid
CAS:Controlled ProductFormula:C7H6ClNO4SColor and Shape:NeatMolecular weight:235.64Phenacetin-d3
CAS:Controlled Product<p>Applications Phenacetin-d3 is the labeled analogue of Phenacetin (P294580), an analgesic, antipyretic; component of APC tablets, analgesic mixture also containing aspirin and caffeine. Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing Phenacetin are listed as known human carcinogens.<br>References Boyd, et al.: Toxicol. Appl. Pharmacol., 1, 240 (1959); Dubach, C.U., et al.: N. Engl. J. Med., 308, 357 (1983)<br></p>Formula:C10H10D3NO2Color and Shape:NeatMolecular weight:182.234-Demethyltrimethoprim
CAS:<p>Applications 4-Demethyltrimethoprim is an impurity of Trimethoprim (T795615), an antibacterial agent.<br>References Mengelers, M.J.B., et al.: J. Vetern. Pharmacol. Therap., 20, 24 (1997); Manius, G.J., et al.: Anal. Profiles Drug Subs., 7, 445 (1978), Roth, B., et al.: J. Med. Chem., 23, 379 (1980), Brogden, R.N., et al.: Drugs, 23, 405 (1982),<br></p>Formula:C13H16N4O3Color and Shape:NeatMolecular weight:276.29Saccharin Sodium Salt Dihydrate
CAS:Formula:C7H4NO3S·Na·2H2OColor and Shape:White Crystalline PowderMolecular weight:241.20Mesosulfuron-methyl
CAS:<p>Stability Unstable in Solution<br>Applications Mesosulfuron-methyl can be used in biological study of targeted screening and safety evaluation of 276 agrochemical residues in raisins using buffered ethyl acetate extraction and liquid chromatography-tandem mass spectrometry analysis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shabeer, T. P. A., et al.: Chemosphere, 184, 1036 (2017)<br></p>Formula:C17H21N5O9S2Color and Shape:NeatMolecular weight:503.51N-Methyl Metribuzin
CAS:Controlled ProductFormula:C9H16N4OSColor and Shape:NeatMolecular weight:228.312-Amino-4-chloro-5-sulfamoyl-o-benzotoluidide
CAS:Controlled Product<p>Applications 2-Amino-4-chloro-5-sulfamoyl-o-benzotoluidide is an intermediate in the synthesis of Metolazone (M338750); a diuretic and antihypertensive agent.<br>References Curry, C.L., et al.: Clin. Ther., 9, 47 (1986); Kiyingi, A., et al.: Lancet, 335, 29 (1990); Chen, G., et al.: Shenyang Yaoke Daxue Xuebao, 21, 109 (2004)<br></p>Formula:C14H14ClN3O3SColor and Shape:NeatMolecular weight:339.82-Acetamido-5-mercapto-1,3,4-thiadiazole
CAS:Controlled Product<p>Impurity Acetazolamide EP Impurity C<br>Applications Acetazolamide intermediate. Acetazolamide EP Impurity C<br>References Almajan, G., et al.: Bioorg. Med. Chem. Lett., 15, 2347 (2005), Talath, S., et al.: Eur. J. Med. Chem., 41, 918 (2006), Srinivasu, P., et al.: J. Pharm. Biomed. Anal., 52, 142 (2010),<br></p>Formula:C4H5N3OS2Color and Shape:NeatMolecular weight:175.23Dapsone Hydroxylamine-d4
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications A labelled metabolite of Dapsone.<br>References Preuss, C.V., et al.: Biochem. Pharmacol., 51, 1661 (1996),<br></p>Formula:C12H8D4N2O3SColor and Shape:NeatMolecular weight:268.324,4’-Dichlorodiphenyl Sulfone
CAS:Controlled Product<p>Applications 4,4’-Dichlorodiphenyl Sulfone is an impurity of Dapson (D193250), an antibacterial used in the treatment of dermatitis herpetiformis.<br>References Carlsson, L., et al.: J. Chem. Info. Model., 49, 2551 (2009); Chan, T.S., et al.: Toxicol. App. Pharmacol., 232, 456 (2008);<br></p>Formula:C12H8Cl2O2SColor and Shape:Off-WhiteMolecular weight:287.161,2-Benzisoxazole-3-methanesulfonate Sodium Salt
CAS:Controlled ProductFormula:C8H6NO4S·NaColor and Shape:NeatMolecular weight:235.19Mesotrione
CAS:<p>Applications Mesotrione is a herbicide that works by inhibiting 4-hydroxyphenylpyruvate dioxygenase (HPPD), a crucial enzyme for the biosynthesis of carotenoid in plants. Mesotrione is also a synthetic analog of lepospermone.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Deng, L., et al.: Indus. Crops. Prod., 39, 154 (2012); Pileggi, M., et al.: Chemosphere., 86, 1127 (2012); McElroy, J., S., Hort. Technol.,22, 627 (2012);<br></p>Formula:C14H13NO7SColor and Shape:Light YellowMolecular weight:339.32N2-Methyl Trimethoprim (Impurity)
CAS:Controlled Product<p>Applications N2-Methyl Trimethoprim is an impurity of Trimethoprim (T795615), an antibacterial agent that is commonly prescribed in conjunction with Sulfametoxazole (S699086) to treat patients afflicted with urinary tract infections.<br>References Dauber-Osguthorpe, P., et al.: Proteins, 4, 31, (1988); Darrell, J., et al.: J. Clin. Pathol., 21, 202 (1968); Zhanel, G., et al.: Antimicrob. Agents Ch., 44, 1089 (2000)<br></p>Formula:C15H20N4O3Color and Shape:NeatMolecular weight:304.34Zonisamide-d4
CAS:Controlled Product<p>Applications Labelled sulfonamide antiseizure agent; blocks repetitive firing of voltagesensitive sodium channels and reduces voltage-sensitive T-type calcium currents. Heterocyclic methanesulfonide with anticonvulsant properties. The compound is under investigation for potential therapeutic use as an antiepileptic drug. Anticonvulsant.<br>References Masuda, Y., et al.: Arzneim.-Forsch., 30, 477 (1980), Hammond, E.J., et al.: Gen. Pharmacol., 18, 303 (1987), Schmidt, D., et al.: Epilepsy Res., 15, 67 (1993), Sorkin, E.M., et al.: Drugs, 45, 760 (1993),<br></p>Formula:C82H4H4N2O3SColor and Shape:Light Brown SolidMolecular weight:216.25Nimesulide
CAS:<p>Applications Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-alpha production.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pairet, M., et al.: Inflamm. Res., 47, S93 (1998), Fukutake, M., et al.: Carcinogenesis, 19, 1939 (1998), Okajima., E., et al.: Cancer Res., 58, 3028 (1998), Azab, A., et al.: Life Sci., 63, 323 (1998)<br></p>Formula:C13H12N2O5SColor and Shape:Light YellowMolecular weight:308.31rac Bendroflumethiazide
CAS:Controlled ProductFormula:C15H14F3N3O4S2Color and Shape:WhiteMolecular weight:421.41Dapsone-d4
CAS:Controlled Product<p>Applications A labelled antibacterial used in the treatment of dermatitis herpetiformis.<br>References Francis, J., et al.: Br. J. Pharmacol., 5, 565 (1950), Uetrecht, J., et al.: Clin. Dermatol., 7, 111 (1989); Reszka, K., et al.: Chem. Res. Toxicol., 22, 1137 (2009), Santos, J., et al.: Bioorg. Med. Chem., 17, 3795 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),<br></p>Formula:C12H8D4N2O2SColor and Shape:NeatMolecular weight:252.332-Methylindole
CAS:Controlled Product<p>Applications 2-Methylindole is an intermediate in the synthesis of indole derivative with potential antifungal activities.<br>References Rodriguez, S., et al.: Natural. Prod. Res., 22, 253 (2008); Zhang, B.G., et al.: Bioresource., 100, 5687 (2009);<br></p>Formula:C9H9NColor and Shape:NeatMolecular weight:131.1745Hydrochlorothiazide
CAS:Formula:C7H8ClN3O4S2Color and Shape:White Crystalline PowderMolecular weight:297.74N-(Methylsulfonyl)-4-(desnitro) Nimesulide
CAS:<p>Impurity Nimesulide EP Impurity E<br>Applications N-(Methylsulfonyl)-4-(desnitro) Nimesulide is an impurity of Nimesulide (N477500).<br>References Kulkarni, S., et al.: Curr. Sci., 83, 1442 (2002), Nguyen, D., et al.: J. Sep. Sci., 29, 1836 (2006), Zacharis, C., et al.: J. Pharm. Biomed. Anal., 49, 726 (2009),<br></p>Formula:C14H15NO5S2Color and Shape:NeatMolecular weight:341.40N-(p-Chlorobenzoyl)-p-anisidine
CAS:Controlled Product<p>Applications N-(p-Chlorobenzoyl)-p-anisidine is a COX-1 inhibitor analgesics that do not cause gastric damage.<br>References Kakuta, H., et al.: J. Med. Chem., 51, 2400 (2008);<br></p>Formula:C14H12ClNO2Color and Shape:White To Off-WhiteMolecular weight:261.7Ibuprofen Lysinate
CAS:Controlled Product<p>Applications Ibuprofen Lysinate is used in the treatment of hemodynamically significant patent ductus arteriosus in neonates greater than 27 week gestational age.<br>References Pai, V.B., et. al.: Pharmacotherapy, 28, 1162 (2008)<br></p>Formula:C13H18O2·C6H14N2O2Color and Shape:YellowMolecular weight:352.468N-(2-Pyridyl)oxamic Acid
CAS:Controlled Product<p>Applications A metabolite of Tenoxicam (T019500). A degradation product and pathway of Lornoxicam.<br>References Tsuchiya, S., et al.: Cancer Res., 42, 1530 (1982), Talanian, R., et al.: J. Med. Chem., 43, 3351 (2000), Fuentes-Prior, P., et al.: Biochem. J., 384, 201 (2004), Han, Y., et al.: Bioorg. Med. Chem. Lett., 15, 1173 (2005),<br></p>Formula:C7H6N2O3Color and Shape:WhiteMolecular weight:166.132’-[4-(2-Pyridylsulfamoyl)phenyl] Sulfasalazine Hydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 2’-[4-(2-Pyridylsulfamoyl)phenyl] Sulfasalazine Hydrochloride is an impurity of Sulfasalzine (S699084).<br></p>Formula:C29H22N6O7S2•xHClPurity:>85%Color and Shape:NeatMolecular weight:630.65 + x(36.46)rac 2-Hydroxy Ibuprofen
CAS:Controlled Product<p>Applications A human metabolite of Ibuprofen.<br>References Bales, J., et al.: Clin. Chem., 31, 757 (1985), Maurer, H., et al.: J. Anal. Toxicol., 25, 237 (2001), Zwiener, C., et al.: Anal. Bioanal. Chem., 372, 569 ( 2002), de Bernardi, B., et al.: J. Clin. Oncol., 21, 1592 (2003),<br></p>Formula:C13H18O3Color and Shape:Off-WhiteMolecular weight:222.284,4'-Bis(4-aminobenzenesulfonyl)hydrazobenzene
<p>Stability Light Sensitive<br>Applications 4,4'-Bis(4-aminobenzenesulfonyl)hydrazobenzene is a dimer impurity of Dapsone (D193250); an antibacterial used in the treatment of dermatitis herpetiformis.<br>References Francis, J., et al.: Br. J. Pharmacol., 5, 565 (1950); Uetrecht, J., et al.: Clin. Dermatol., 7, 111 (1989); Reszka, K., et al.: Chem. Res. Toxicol., 22, 1137 (2009); Santos, J., et al.: Bioorg. Med. Chem., 17, 3795 (2009); Varma, M., et al.: J. Med. Chem., 52, 4844 (2009)<br></p>Formula:C24H22N4O4S2Color and Shape:Off WhiteMolecular weight:494.59Brinzolamide Hydrochloride
CAS:Controlled Product<p>Applications Carbonic anhydrase inhibitor. Antiglaucoma agent.<br>References Silver, L.H., et al.: Am. J. Ophthalmol., 126, 400 (1998), Davies, N., et al.: Clin. Exp. Pharmacol. Physiol., 27, 558 (2000), Stave, J., et al.: Ophthalmologe, 99, 276 (2002),<br></p>Formula:C12H21N3O5S3·ClHColor and Shape:NeatMolecular weight:419.97Isosulfamethoxazole
CAS:<p>Applications Isosulfamethoxazole is an impurity of the antibacterial drug Sulfamethoxazole (S699086). It is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase.<br>References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 467 (1973), Wormser, G.P., et al.: Drugs, 24, 459 (1982), Wharton, M., et al.: Ann. Intern. Med., 105, 37 (1986),<br></p>Formula:C10H11N3O3SColor and Shape:NeatMolecular weight:253.28Methazolamide
CAS:Controlled Product<p>Applications Methazolamide is a carbonic anhydrase inhibitor. Methazolamide is used in the treatment of glaucoma.<br>References Iyer, G.R. et al.: J. Pharmac. Biomed. Anal., 16, 1021 (1998); Maren, T. H. et al.: Invest. Ophthamol. Vis. Sci., 16, 730 (1977);<br></p>Formula:C5H8N4O3S2Color and Shape:NeatMolecular weight:236.277-Ethyltryptophol
CAS:<p>Impurity Etodolac EP Impurity H<br>Applications 7-Ethyltryptophol (Etodolac EP Impurity H) is a key intermediate in the preparation of the non-steroidal anti-inflammatory drug Etodolac.<br>References El Kousy, N., et al.: J. Pharm. Biomed. Anal., 20, 185 (1999),<br></p>Formula:C12H15NOColor and Shape:WhiteMolecular weight:189.25Tolnaftate
CAS:Controlled Product<p>Applications Antifungal.<br>References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010),<br></p>Formula:C19H17NOSColor and Shape:NeatMolecular weight:307.41Sulfachloropyridazine
CAS:<p>Applications Sulfachloropyridazine is an antibacterial compound.This compound is a contaminant of emerging concern (CECs).<br>References Wammer, K.: Environ. Toxicol. Chem. 25, 1480 (2006);<br></p>Formula:C10H9ClN4O2SColor and Shape:WhiteMolecular weight:284.72Cantrodifene
CAS:Controlled Product<p>Stability Moisture Sensitive<br>Applications 4-Isothiocyanato-4'-nitrodiphenyl ether (cas# 19881-18-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C13H8N2O3SColor and Shape:NeatMolecular weight:272.27N-Acetyl Sulfadiazine-d4 (Major)
CAS:Controlled Product<p>Applications A major labelled metabolite of Sulfadiazine.<br>References Woolley, J., et al.: Drug Metab. Dispos., 7, 94 (1979), Nielsen, P., et al.: Biochem. Pharmacol., 35, 2509 (1986), Anari, M., et al.: Anal. Chem., 76, 823 (2004), Edlund, P., et al.: J. Pharm. Biomed. Anal., 34, 1079 (2004),<br></p>Formula:C12H8D4N4O3SColor and Shape:NeatMolecular weight:296.34
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