Sulfonamides and Derivatives

Impurity Furosemide EP Impurity A
Applications Iso Furosemide (Furosemide EP Impurity A) is a Furosemide (F865000) derivative which enhanced urinary excretion of active kallikrein.
References Kirk, K., et al.: J. Biol. Chem., 267, 23475 (1992), Kirk, K., et al.: Biochem. J., 311, 761 (1995), Egee, S., et al.: J. Physiol., 542, 795 ( 2002),

Applications An antibacterial used in the treatment of dermatitis herpetiformis.
References Francis, J., et al.: Br. J. Pharmacol., 5, 565 (1950), Uetrecht, J., et al.: Clin. Dermatol., 7, 111 (1989); Reszka, K., et al.: Chem. Res. Toxicol., 22, 1137 (2009), Santos, J., et al.: Bioorg. Med. Chem., 17, 3795 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),

Impurity Sulfasalazine EP Impurity F
Stability Hygroscopic
Applications A positional isomeric impurity of Sulfasalazine (S699084). Sulfasalazine EP Impurity F
References Zalipsky, J.J. et al.: J. Pharmac. Sci., 67, 387 (1978);

Impurity Aceclofenac EP Impurity D
Applications Aceclofenac Methyl Ester (Aceclofenac EP Impurity D) is a 2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetyl derivative as anti-inflammmatory and analgesic agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Sulfamethizole is a sulfonamide based antibiotic that exhibit bactericidal activities towards gram-negative bacteria. Sulfamehizole was shown to be effective in treating gram-negative Bacillus AmpC enzyme in elderly patients with lower respiratory tract infection and as well as against microbs responsible for tuberculosis.
References Mondelli, M., et al.: J. Molec. Struct., 1036, 180 (2013); Leelakrishnana, S., et al.: Adv. App. Sci. Res., 3, 3502 (2012); Ghoreishi, S.M., et al.: Anal. Lett., 46, 323 (2012);

Impurity Piroxicam EP Impurity E
Applications Piroxicam impurity E.
References Lombardino, J., et al.: J. Med. Chem., 14, 1171 (1971), Turck, D., et al.: Clin. Drug Invest., 9, 270 (1995),

Applications A labelled nonsteroidal anti-inflammatory drug (NSAID); activity resides primarily in the (S)-isomer.
References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986), Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993), Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998),

Stability Hygroscopic, Unstable in DMSO
Applications Post-emergence sulfonylurea herbicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gubbiga, N.G., et al.: Weed Technol., 9, 574 (1995), Ukrainczyk, L., et al.: J. Agric. Food Chem., 43, 855 (1995)

Impurity Etodolac EP Impurity E
Applications 8-Propyl Etodolac (Etodolac EP Impurity E) is an impurity in the synthesis of Etodolac (E933100), may have use in the treatment of myeloma. COX-1/COX-2/β-catenin inhibitors.
References Humber, L.G., et al.: Med. Res. Rev., 7, 1 (1987); Balfour, J.A, et al.: Drugs, 42, 274 (1991); Kato, et al.: J. Pharm. Pharmacol., 53 1679 (2001);

Applications Anti-inflammatory. Selective cyclooxygenase-2 (COX-2) inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Glasson, et al.: Biochem, Pharmacol., 18, 633 (1969), Boissier, et al.: Therapie, 26, 211 (1971), Sorenson, J.R.J., et al.: J. Med. Chem., 19, 135 (1976), Barnett, J., et al.: Biochim. Biophys. Acta, 1209, 130 (1994), Johnson, J.L., et al.: Arch. Biochem. Biophys., 324, 26 (1995),

Stability Hygroscopic
Applications 4-Amino-4'-hydroxydiphenylsulfone is a diaryl sulfone with antileprotic activity. 4-Amino-4'-hydroxydiphenylsulfone is an antibacterial agent.
References Colwell, W.T. et al.: J. Med. Chem., 17, 142 (1974); Agrawal, V.K. et al.: Acta Microb iol. Immunol. Hung., 50, 385 (2003);

Impurity Glipizide EP Impurity H
Applications 1-Cyclohexyl-3-(p-sulfamoylphenethyl)urea (Glipizide EP Impurity H) is an impurity of Glipizide (G410225).
References Jurca, B. et al.: J. Therm. Anal. Calor., 62, 859 (2000);

Applications Ibuprofen (I140000) impurity, an anti-inflammatory compound.
References Rubin, A., et al.: J. Pharm. Sci., 74, 82 (1985), Tracy, T., et al.: Drug Metab. Dispos., 20, 322 (1992),

Applications Penoxsulam is an acetolactate synthase inhibitor herbicide developed for controlling grasses, sedges, and broadleaf weeds in rice culture.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Jabusch, T., and Tjeerdema, R.: J. Agric. Food Chem. 53, 18, 7179-183 (2005); Bamcjero, M., et al.: Sci. Total Environ. 807, 1, 160793 (2021)

Applications A major metabolite of Sulfadiazine.
References Woolley, J., et al.: Drug Metab. Dispos., 7, 94 (1979), Nielsen, P., et al.: Biochem. Pharmacol., 35, 2509 (1986), Anari, M., et al.: Anal. Chem., 76, 823 (2004), Edlund, P., et al.: J. Pharm. Biomed. Anal., 34, 1079 (2004),