Sulfonamides and Derivatives

Impurity Etodolac EP Impurity E
Applications 8-Propyl Etodolac (Etodolac EP Impurity E) is an impurity in the synthesis of Etodolac (E933100), may have use in the treatment of myeloma. COX-1/COX-2/β-catenin inhibitors.
References Humber, L.G., et al.: Med. Res. Rev., 7, 1 (1987); Balfour, J.A, et al.: Drugs, 42, 274 (1991); Kato, et al.: J. Pharm. Pharmacol., 53 1679 (2001);

Applications 3-[(4-Aminophenyl)sulfonyl]benzenamine is an impurity of Dapsone (D193250), an antibacterial used in the treatment of dermatitis herpetiformis.
References Francis, J., et al.: Br. J. Pharmacol., 5, 565 (1950); Uetrecht, J., et al.: Clin. Dermatol., 7, 111 (1989); Reszka, K., et al.: Chem. Res. Toxicol., 22, 1137 (2009); Santos, J., et al.: Bioorg. Med. Chem., 17, 3795 (2009);Varma, M., et al.: J. Med. Chem., 52, 4844 (2009)

Stability Hygroscopic
Applications 5-Amino-3-(4-sulfonylphenyl)salicyclic Acid Sodium Salt is an impurity of mesalamine (M258100), which is the active metabolite of Sulfasalazine (S699084). Anti-inflammatory (gastrointestinal).
References Friedman, G., et al.: Am. J. Gastroenterol., 81, 141 (1986); Tursi A., Expert Opin. Pharmacother., 6, 69 (2005);

Stability Hygroscopic
Applications A labelled metabolite of Tolbutamide. Formed by the cytochrome CYP2CIIC8 and IIC9 subfamily of P450 enzymes.
References Relling, etl al.: J. Pharmacol. Exp. Ther., 252, 442 (1990), Parent, et al.: J. Pharmacol. Exp. Ther., 261, 780 (1992), Ho, et al.: Life Sci., 52, 21 (1993),

Applications rac-trans Dorzolamide is an impurity of Dorzolamide (D535100).
References Casini, A., et al.: Bioorg. Med. Chem. Lett., 13, 841 (2003), Clare, B., et al.: Bioorg. Med. Chem., 13, 2197 (2005),

Applications 4-Amino-4'-chlorodiphenyl sulfone is a substituted 4-aminodiphenylsulfone as Escherichia coli dihydropteroate synthase inhibitor.
References Lopez de Compadre, R.L., et al.: J. Med. Chem., 31, 2315 (1988),