Sulfonamides and Derivatives

Applications Metribuzin DK is a selective triazine herbicide used in the control of broadleaf weeds. Used in the protection of vegetable and fruit crops. Pesticide.
References Xie, Y. et al.: Microchem. J., 133, 468 (2017);

Applications 2-Methyl-2H-1,2-benzothiazin-4(3H)-one 1,1-Dioxide is an intermediate used in the synthesis of Amido Methyl Meloxicam (A576790), which is an impurity of Meloxicam (M216100).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lazer, E., et al.: J. Med. Chem., 40, 980 (1997),

Applications An impurity of Sulfasalazine (S699084).

Impurity Glipizide EP Impurity E
Applications 5-Desmethyl-6-methyl Glipizide (Glipizide EP Impurity E) is a Glipizide (G410225) impurity.
References Hoizey, G., et al.: Clin. Chem., 51, 1666 (2005), Singh, S., et al.: J. Pharm. Biomed. Anal., 41, 1037 (2006),

Stability Moisture Sensitive
Applications 4-Isothiocyanato-4'-nitrodiphenyl ether (cas# 19881-18-6) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Phthalide may be used in scaffolds for the design of high potency monoamine oxidase (MAO) inhibitors.
References Li, P.Z., et. al.: Med. Chem. Res., 23, 3624 (2014)

Hydrochlorothiazide is a sulfonamide that inhibits the activity of the enzyme, angiotensin-converting enzyme (ACE), which is responsible for converting angiotensin I to the potent vasoconstrictor, angiotensin II. It also has antihypertensive effects by blocking the production of aldosterone, which causes sodium retention and leads to high blood pressure. It is a byproduct in reactions with substances such as valsartan. Hydrochlorothiazide may react chemically with other medicines such as ampicillin and cefaclor.

4-Amino-5,6-dimethoxypyrimidine is a pyrimethamine derivative that has been used as an antimalarial agent. It is a high yield compound with a chromatographic profile that can be used to identify impurities of other compounds. 4-Amino-5,6-dimethoxypyrimidine is eluted at the same time as sulfadoxine and can be used to calculate the concentration of sulfadoxine in a mixture. It can also be used as a reagent for rp-hplc. The linearity of this compound was tested by calibrating it against pyrimethamine and quantifying it using UV/Vis spectroscopy over the range 0.05 to 1 mg/mL.

Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the propionic acid derivative group. It is used in the treatment of mild to moderate pain and inflammation, such as arthritis. Aceclofenac is rapidly hydrolyzed by esterases in the small intestine, resulting in the release of aceclofenac acid. Aceclofenac benzyl ester is a chemical intermediate that has been shown to be an efficient method for producing aceclofenac acid. It can be obtained by reacting bromoacetic anhydride with methyl alcohol and then hydrolyzing the product with strong acids. This compound may contain impurities, such as nucleophilic impurities, which can lead to side effects.