Terpenoids and Derivatives

Applications Artemisic Acid is a derivative of Artemisinin (A777500), an antimalarial constituent of the tradional Chinese medicinal herb Artemisia annua L., Compositae, which has been known for almost 2000 years as Qinghao. Antimalarial.
References Klayman, D.L., et al.: Science, 228, 1049 (1985), Price, R.N., et al.: Expert Opin. Invest. Drugs, 9, 1815 (2000), Meshnick, S.R., et al.: Int. J., Parasitol., 32, 1655 (2002),

Applications Triptolide O-Methyl Phosphate Dibenzyl Ester is a derivative of Triptolide (T815600), a prodrug used for treatment of cancer.

Stability Hygroscopic
Applications Olivetolic Acid is a precursor in the synthesis of primin and tetrahydrocannabinol.
References Schilmiller, A. L., et al.: Plant J., 54, 702 (2008)

Applications (3R,4R,4aS,7R,8S,8aR)-Hexahydro-3-hydroxy-4,7-dimethyl-8-(3-oxobutyl)-1,2-benzodioxin-8a(3H)-carboxaldehyde is an impurity of Artesunate (A777800).
References Baker, J.K., et al.: Pharmaceut. Res., 10, 662 (1993),

Applications (2’S, 3’R)-Cabazitaxel is a stereoisomer of Cabazitaxel (C046500), a novel tubulin binding taxane, that acts as a second-line treatment for those with castration-resistant prostate cancer.
References Paller, C. & Antonarakis, E.: Drug Des. Devel. Ther., 5, 117 (2011); Pal, S., et al.: Clin. Interv. Aging, 5, 395 (2010)

Applications DL-Camphene, is a minor constituent of many essential oils such as turpentine, cypress oil, camphor oil, citronella oil (C525020), neroli, ginger oil, and valerian. It can also be used in fragrances and as a food additive for flavoring.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Perino-Issartier, S., et al.: J. Chromatography A, 1305 (2013); Zhang, L., et al.; Shizhen Guoyi Guoyao, 23, 3061 (2012);

Stability Light and Temperature Sensitive
Applications An isomer of all-trans-Retinal (R240000).
References Nakayama, T.A., et al.: J. Biol. Chem., 265, 15762 (1990), Rando, R.R., et al.: Chem. Biol., 3, 255 (1996)

Applications Maytansinol is used in the preparation of site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity.
References Pillow, T.H., et. al.: J. Med. Chem., 57, 7890 (2014)

Stability Hygroscopic
Applications 3-Hydroxy Midostaurin-13C6 is the labelled analogue of 3-Hydroxy Midostaurin (H939985), a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.
References Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Pedeboscq, S., et al.: PLoS. One., 7, 36811 (2012);

Applications 2,2-Dichloroethanol is a reagent in the preparation of tunable molecular catalysts via functionalizing methylene bridge of bis(N-heterocyclic carbene) ligands.
References Zhong, R., et al.: ChemPlusChem, 79, 1294-1303 (2014)

Impurity Paclitaxel - In House Impurity
Stability Hygroscopic
Applications A metabolite of Paclitaxel (P132500). Paclitaxel - In House Impurity.
References Gut, I., et al.: Xenobiotica, 36, 772 ( 2006), Zhang, J., et al.: Drug Metab. Dispos., 36, 418 (2008), Li, S., et al.: J. Pharm. Biomed. Anal., 49, 81, (2009),

Stability Light Sensitive, Temperature Sensitive
Applications An oxo analogue of 9-cis,13-cis-Retinoic Acid (R245015): a major plasma metabolite of 9-cis Retinoic Acid (R245000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Stability Light Sensitive, Temperature Sensitive
Applications Echinenone is a protective carotenoid. Echinenone is an analogue of β-Carotene (C184250), the most important of the provitamins A. Widely distributed in the plant and animal kingdom. In plants it occurs almost always together with chlorophyll. Vitamin A precursor. Ultraviolet screen.
References Karrer, et al.: Helv. Chim. Acta, 12, 1142 (1929); Fischli, M., et al.: Helv. Chim. Acta, 58, 1584 (1975); Desmet, J., et al.: Biochem. Biophys. Acta, 912, 211 (1987); Tan, C., et al.: Food Chem., 92, 661 (2005); Chu, B., et al.: J. Agric. Food Chem., 55, 6754 (2007)

Applications 13-Acetyl-9-dihydrobaccatin-III is an apoptosis inducer.

7-O-(Triethylsilyl) paclitaxel is a synthetic Taxol analog. It is manufactured by custom synthesis and purified by HPLC to be used as an analytical standard for the determination of natural Taxol impurities in drug products.

N-Debenzoyl-N-hexanoylpaclitaxel (DHBPTx) is an analog of paclitaxel. It inhibits cell proliferation by binding to the diketone group at the C-10 position of baccatin III, which inhibits the synthesis of taxol and other natural products with a diketone group at this position. DHBPTx is effective against colorectal carcinoma cells in culture, but has not been tested in vivo. This drug has also been shown to be effective against breast cancer cells that express high levels of 10-deacetylase activity. It is metabolized into 10-deacetylbaccatin III, which binds to cellular protein kinase C and causes inhibition of mitosis and apoptosis. In addition, DHBPTx can be conjugated with other drugs such as doxorubicin or vincristine to increase their effectiveness.

Midostaurin Impurity 2 is a drug product that has been custom synthesized by our scientists. It is of high purity, and is used in analytical studies to understand its metabolism. This impurity also plays a role in drug development and pharmacopoeia. It can be found under CAS No. 155848-20-7, and has the molecular formula C10H16N4O2S. This compound has an analytical standard at HPLC, which can be used to make sure that it's purity meets FDA standards for research and development purposes.

Campesterol is a plant sterol that lowers cholesterol, has anti-cancer and anti-inflammatory properties, and can help with specific prostate conditions.

Fenchone (AI3-00736) is a monoterpene found in plants with anti-inflammatory, antioxidant, antifungal and anti-injury activities.

Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria. α-Terpineol (Terpineol) shows anticonvulsant, and anti-inflammatory activities, it inhibits the gene expression of the IL-6 receptor.