TCM Compound Library

<p>Applications N-Nitrosodibenzylamine (NDBzA) is mutagenic to Salmonella typhimurium and induces DNA strand breaks in isolated rat hepatocytes.<br>References Dunn, W., et al.: Bioorg. Chem., 10, 29 (1981), Rose, S., et al.: J. Med. Chem., 25, 769 (1982), Basak, S., et al.: J. Pharm. Sci., 73, 429 (1984), Zielenska, M., et al.: Mutation Res., 180, 11 (1987),<br></p>

<p>Applications N-Nitrosodiisobutylamine is a nitrosoamine compound that shows carcinogenic effect.<br>References Scanlan, R., et al.: Cancer Res., 43, 2435 (1983), Spiegelhalder, B., et al.: Carcinogenesis, 4, 1147 (1983), Lijinsky, W., et al.: Mutat. Res., 443, 129 (1999), Robichova, S., et al.: Chem. Biol. Interact., 148, 163 (2004),<br></p>

<p>Stability Light Sensitive<br>Applications N-Methyl-N’-nitrosopiperazine was used as a reagent in the organic synthesis of several compounds including that of (4-methoxyphenoxy)acetic and (3,4,5-trimethoxyphenoxy)acetic acid amides and hydrazides which display antimicrobial and anthelmintic properties and may act as potential neurotropic and cardiovascular agents. N-Methyl-N’-nitrosopiperazine also diplayed strong nasal carcinogenity and genotoxicity toward nasal cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Valenta, V., et al.: Collect. Czech. Chem. C., 52, 3013 (1987); Klein, R., et al.: Carcinogenesis, 20, 1629 (1999);<br></p>

<p>Applications N-Methyl-N’-nitrosopiperazine-d4 is the isotope labelled analog of N-Methyl-N’-nitrosopiperazine (M325800), which is used as a reagent in the organic synthesis of several compounds including that of (4-methoxyphenoxy)acetic and (3,4,5-trimethoxyphenoxy)acetic acid amides and hydrazides which display antimicrobial and anthelmintic properties and may act as potential neurotropic and cardiovascular agents. N-Methyl-N’-nitrosopiperazine also diplayed strong nasal carcinogenity and genotoxicity toward nasal cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Valenta, V., et al.: Collect. Czech. Chem. C., 52, 3013 (1987); Klein, R., et al.: Carcinogenesis, 20, 1629 (1999);<br></p>

<p>Stability Light Sensitive<br>Applications N-Nitroso-di-n-butylamine (cas# 924-16-3) is a compound useful in organic synthesis.<br></p>

<p>Applications One of the N-nitrosamines found in the water sources and water treatment process. Carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Raska, I., et al.: Bioorg. Med. Chem., 13, 6830 (2005), Puzyn, T., et al.: Environ. Sci. Technol., 42, 5189 (2008),<br></p>

<p>Applications Labelled NEMA (N525950). One of the N-nitrosamines found in the water sources and water treatment process. Carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Raska, I., et al.: Bioorg. Med. Chem., 13, 6830 (2005), Puzyn, T., et al.: Environ. Sci. Technol., 42, 5189 (2008),<br></p>

<p>Applications N-Nitrosodimethylamine-d6 (1.0 mg/mL in Methanol) is a highly toxic semi-volatile organic compound and a suspected human carcinogen. It induces liver tumors in rats after chronic exposure to low doses (1,2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br>References Chem. and Eng. News, p.5, Feb. 25, 2019<br></p>

<p>Stability Light Sensitive<br>Applications A carcinogenic nitrosocompound.<br>References Wong, H., et al.: Carcinogenesis, 24, 291<br></p>

<p>Applications Labelled N-Nitrosodiisobutylamine (N525610). N-Nitrosodiisobutylamine is a nitrosoamine compound that shows carcinogenic effect.<br>References Scanlan, R., et al.: Cancer Res., 43, 2435 (1983), Spiegelhalder, B., et al.: Carcinogenesis, 4, 1147 (1983), Lijinsky, W., et al.: Mutat. Res., 443, 129 (1999), Robichova, S., et al.: Chem. Biol. Interact., 148, 163 (2004),<br></p>

<p>Applications A nitrosoamino acid with oncogenic activity. The LD50 of a single ip dose given to Swiss-Webster mice is 203 +/- 22 mg / kg.<br>References Nagasawa, H.T., et al.: J. Med. Chem., 16 (5), 583-585 (1973)<br></p>

<p>Applications A carcinogenic compound.<br>References Lu, S., et al.: Cancer Res., 46, 1485 (1986), Tricker, A., et al.: Eur. J. Cancer Prev., 6, 226 (1997),<br></p>

<p>Applications N-tert-Butyl-N-ethylnitrosamine is a tyrosinase inhibitor and a possible carcinogen.<br>References Yuan, Jintao, et al.: Chem. Res. in Toxic., 24(12), 2269-2279 (2011);Ponce, Yovani M., et al.: QSAR &amp; Combi. Sci., 26(4), 469-487 (2007)<br></p>

<p>Applications N-Nitrosodiphenylamine is the N-nitroso analogue of diphenylamine that was once used as a rubber additive but is no longer due to undesirable carcinogenic effects (1). N-Nitrosodiphenylamine may have potential carcinogenic activity and is currently classified as a probable carcinogen by EPA with genetic toxicity (2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Boyland, D. et al.: Eur. J. Cancer. 1968. May;4(2):233-2342. Iversen, O. et al.: Eur. J. Cancer. 1980 May;16(5):695-8.3. McGregor, D. et al.: Mutat. Res. Rev. Gen. Toxicol. 1994 Jun:317(3):195-211<br></p>

<p>Applications A novel anti-androgenic compound. A carcinogenic agent.<br>References Singer, G., et al.: Chem-Biol. Interact.,19, 133 (1977), Chou, J., et al.: J. Med. Chem., 22, 792 (1979), Dunn, W., et al.: Bioorg. Chem., 10, 29 (1981), Basak, S., et al.: J. Pharm. Sci., 73, 429 (1984),<br></p>