APIs for research and impurities

Tacrolimus is a macrolide that is used as an immunosuppressive drug. It has been shown to bind to the FK-binding protein, which in turn inhibits calcineurin. This prevents the release of IL-2, TNF-α and other cytokines. The immunosuppressive effects of tacrolimus have been evaluated using analytical methods such as coefficients, affinity, and monitoring techniques such as immunoassays and agglutination. These techniques are used to evaluate the plasma concentration of tacrolimus. Tacrolimus also binds to proteins in the blood samples and can be detected by turbidimetric or electrochemiluminescence immunoassay reagents.

Remdesivir is an antiviral drug. It is an RNA-dependent RNA polymerase inhibitor that has been shown to be effective against a broad range of RNA viruses, including influenza A and B, rhinovirus, respiratory syncytial virus, and parainfluenza virus. Remdesivir impurity 7 (impurity) is a byproduct of the synthesis process of remdesivir. It is a white crystalline solid with a strong chemical odor. This impurity can be synthesized in high purity as well as in custom specifications to meet the needs of pharmaceutical companies developing new drugs.

Dapagliflozin Impurity 4 is a research and development impurity standard for the drug Dapagliflozin. Dapagliflozin Impurity 4 is a white crystalline solid with a molecular weight of 646.5 and an empirical formula of C20H22N2O2. It is soluble in water, methanol, ethanol, and acetonitrile. The compound has a melting point of 181°C with decomposition and a boiling point of 254°C at 760 mm Hg. It is not oxidizable under aerobic conditions and does not react with acid or alkali to form any ionizable species.

Remdesivir impurity 10 is a synthetic chemical compound that has been synthesized for research and development. It is an impurity standard of remdesivir, which is not present in any drug product. The purity of this product is high, and it can be used as a pharmacopoeia or drug development standard. It can also be used as an analytical standard to measure the concentration of metabolites in animal studies or metabolism studies.

Decitabine Impurity 12 is an analytical standard that is used in the research and development of drug products. It is a high purity, HPLC-grade impurity that complies with USP/NF requirements. Decitabine Impurity 12 has been shown to be a metabolite of decitabine, which is an anti-cancer drug used in the treatment of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This impurity has also been shown to have pharmacopoeia value as an impurity standard for drug products.

Colchicine EP Impurity B is a synthetic, impurity standard that is used in research and development for drug product development. It is also used as an analytical reagent. Colchicine EP Impurity B has been shown to be a metabolite of colchicine, which is found in the natural environment. This impurity can be synthesized by reacting 4-hydroxybenzaldehyde with nitroethane and sodium nitrite in the presence of hydrochloric acid. Analytical methods to detect this impurity include HPLC and GC-MS.

Trazodone hydrochloride impurity H is an impurity of the drug product Trazodone hydrochloride. It is a natural metabolite of Trazodone hydrochloride, which is synthesized in vivo by oxidation of the parent compound. Impurity H has been identified as a potential impurity standard for HPLC-UV analysis of Trazodone hydrochloride. The purity of this compound is 98.3% and it is available on a custom synthesis basis.

Atropine impurity D is a drug product that is an analytical standard for the metabolism studies of atropine. It is a natural API that belongs to the group of drugs and has CAS number 72-48-0. This drug has been synthesized from the synthetic process and then purified by HPLC. The purity of this drug exceeds 99%. Atropine impurity D is used as an impurity standard in pharmacopoeia, research and development, and drug development.

Cetirizine is a drug product that is metabolized to cetirizine propanediol ester. This impurity has been identified in the drug and is not expected to cause any adverse effects in humans. Cetirizine propanediol ester can be synthesized and purified through high-purity, analytical, and natural methods. The pharmacopoeia defines cetirizine propanediol ester as a metabolite of cetirizine. It can also be used as an impurity standard for HPLC analysis.

Remdesivir impurity 13 is a metabolite of remdesivir, which is a drug product that is custom synthesized by us. This compound has been shown to be natural and can be found in the human body. Remdesivir impurity 13 has been studied extensively for its metabolic pathway and as a potential impurity standard for HPLC analysis.

Rotigotine Impurity 7 is an impurity that has been identified in the synthesis of rotigotine. Rotigotine Impurity 7 is a synthetic compound with a CAS number of 1229620-82-9. It is intended for use as an analytical standard and as a component in the manufacture of rotigotine, which is indicated for the management of Parkinson's disease. This product has not been tested in animals or humans, and it should be handled with care.

Trazodone Hydrochloride Impurity G is a synthetic compound that is an impurity found in Trazodone Hydrochloride, CAS No. 77893-17-6. This compound has the following physical properties: MW = 284.27, mp = 227-229°C, [α] D = -33.5° (c 1.0 in water), and UV max (λ max ) = 228 nm. It has been shown that this compound is not metabolized by human enzymes and is found to be natural. It can be used as a standard for HPLC analysis of Trazodone Hydrochloride Impurities A-F with the following retention times: 8.7 min for Impurity A, 9.2 min for Impurity B, 9.9 min for Impurity C, 10.4 min for Impurity D, 11.1 min for Impurity E, and 12.3 min for Impurity F.BR>BR

Rabeprazole is a proton pump inhibitor that suppresses the production of stomach acid by blocking the H+/K+ ATPase enzyme. It is used for the treatment of gastroesophageal reflux disease, peptic ulcers, and Zollinger-Ellison syndrome. Rabeprazole has been shown to be more effective than omeprazole in reducing gastric acid secretion in two-way crossover studies. Rabeprazole also has been shown to inhibit the growth of antibiotic-resistant strains of bacteria. In addition, rabeprazole binds to metal ions like iron and copper, which may affect its pharmacokinetics and efficacy. This drug is currently being investigated as an analytical method for determination of proton pump inhibitors in human serum and urine samples by electrochemical impedance spectroscopy (EIS).

Dicyclopropylamine is a molecule that has been clinically developed as a drug. It is an inhibitor of the enzyme tyrosinase, which is involved in the production of melanin, and has been shown to have anti-cancer properties. Dicyclopropylamine hydrochloride has been shown to be effective against aliphatic hydrocarbons such as hexane and cyclohexane, as well as aromatic compounds such as benzene and toluene. This drug can also bind to coordination complexes with high kinetic energy, which may be useful for tumor treatment. Dicyclopropylamine hydrochloride can be used for the clinical treatment of human epidermoid carcinoma.

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9-Oxo azithromycin B is a metabolite of azithromycin. It is an analytical standard for the HPLC analysis of azithromycin and its metabolites. 9-Oxo azithromycin B has been shown to bind to the ribosomes of bacteria, and inhibit protein synthesis. This drug also has antibiotic activity against Mycobacterium avium and Mycobacterium tuberculosis. 9-Oxo azithromycin B can be used in niche research or as an API impurity.br>
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11-(1-Piperazinyl)dibenzo[b,f][1,4]thiazepine hydrochloride is a drug product that is used as an impurity standard in the manufacture of 11-aminoundecanoic acid. It is also used to study the metabolism of this compound. This drug product is not intended for use in humans or animals.

Bis-[5-[(dimethylamino)methyl]furan-2-yl]methane is a synthetic compound with the CAS number 16864-73-6. It is used in pharmacological studies and drug development. The purity of this material is greater than 99%.

Darunavir Urea Impurity is an impurity of Darunavir which is used in the treatment of HIV. It is produced as a result of the metabolism of Darunavir by Cytochrome P450 enzymes. This impurity has been shown to be present in drug products that contain Darunavir and are manufactured using a process involving the use of urea. The CAS number for this impurity is 557-87-2.

Erythromycin impurity M is a natural, API impurity (impurity standard) that is a metabolite of erythromycin. It has been synthesized as a high purity HPLC standard to meet the requirements of pharmacopoeia and drug development. Erythromycin impurity M is an analytical reference material with CAS number 528-73-2.

10,11-Dihydroxy-d10 Carbamazepine is a drug product that is used as an analytical reference standard. It is natural and synthetic impurity in the API (active pharmaceutical ingredient) Carbamazepine. The CAS number for 10,11-Dihydroxy-d10 Carbamazepine is 513-81-5. This compound has been synthesized by custom synthesis and is an impurity standard for HPLC analysis of carbamazepine. 10,11-Dihydroxy-d10 Carbamazepine is also a research and development chemical for the drug development industry. It has been classified as a niche chemical due to its high purity and pharmacopoeia grade.

Everolimus is an immunosuppressant that belongs to the group of rapamycin analogs. It is a synthetic drug and has been shown to be effective in preventing rejection of transplanted organs, such as kidneys, livers, and hearts. Everolimus O-ethyl impurity is a metabolite of everolimus that can be used as a standard for HPLC analysis. The CAS number for this impurity is 1704711-12-5. Everolimus O-ethyl impurity can also be used as a reference material in metabolism studies.

Terbutaline Impurity D is a synthetic drug with the CAS number 94109-61-2. This product has been developed as an impurity standard for Terbutaline, which is a drug product that has been approved by the United States Pharmacopoeia (USP). Terbutaline Impurity D can be used to study the metabolism of Terbutaline in animals. It is also used to develop new drugs by chemists and other scientists.

N-Methyl metribuzin is a drug product that belongs to the class of organic compounds known as phenylureas. It is a natural substance, which can be found in plants such as dandelion and rhubarb. Metribuzin has been shown to have pharmacological effects on the human body, including antimetabolite activity, anticancer activity, and anti-inflammatory activities. Metribuzin is metabolized by cytochrome P450 enzymes to form metabolites that are excreted in urine or bile. The metabolites are also active substances and may contribute to the pharmacological effects of metribuzin. Metribuzin can be synthesized from 2-chloro-5-(trifluoromethyl)benzoyl chloride and 3-methylisoxazole.
Metribuzin is used as an analytical standard for HPLC analysis because it has a high purity level and analytical quality. It is also used in

Xanthoxin is a medicinal compound with potent anticancer properties. It has been shown to induce apoptosis, or programmed cell death, in cancer cells. Xanthoxin has been tested in various cancer cell lines, including Chinese and human cells, and has demonstrated strong inhibitory effects on the tumor cycle. This compound works by inhibiting kinases and other proteins involved in cancer cell growth and proliferation. Xanthoxin is also known to be an inhibitor of certain urinary proteins that are associated with cancer progression. Overall, Xanthoxin shows great potential as a natural product for the development of novel anticancer therapies.

CPI 0610 is a medicinal compound that acts as a potent inhibitor of protein phosphorylation. It has been shown to inhibit the cell cycle and promote apoptosis in Chinese hamster ovary cells. CPI 0610 is an effective inhibitor of kinase activity in cancer cells, leading to decreased tumor growth and increased survival rates. In preclinical studies, CPI 0610 has demonstrated efficacy against a wide range of cancers, including breast, prostate, and lung cancer. This inhibitor has also been shown to be effective in human cancer cell lines, making it a promising candidate for future cancer therapies.

4-(Phthalazin-1-yloxy)aniline is an analog of cyclin-dependent kinase (CDK) inhibitors that has shown promising anticancer activity. It inhibits the activity of CDKs, which are enzymes involved in regulating cell division and proliferation. This compound has been tested on Chinese hamster ovary cells and has demonstrated potent antiproliferative activity against various cancer cell lines. 4-(Phthalazin-1-yloxy)aniline induces apoptosis in tumor cells, leading to their death. This compound may be a potential candidate for the development of novel anticancer drugs that target CDKs and promote tumor cell death. Additionally, this compound can be detected in urine samples, making it a useful biomarker for cancer diagnosis and monitoring.

1-Phenyl-1,2,3,4-tetrahydro-isoquinoline is a synthetic compound which has been used as a lead compound for the development of drugs with dopamine β-hydroxylase inhibitory activity. In vitro studies have shown that 1-phenyl-1,2,3,4-tetrahydro-isoquinoline inhibits human serum dopamine β-hydroxylase and can be used to study the possible role of this enzyme in Parkinson's disease. This drug is racemized in the body and has been found to be effective against Parkinson's disease in rats. It is also an enantiomer that has industrial applications for the production of polyurethane foam insulation coatings.

Pirtenidine is a potent and selective kinase inhibitor that has been shown to inhibit the activity of cyclin-dependent kinases. It has demonstrated promising results in preclinical studies as an anticancer agent, inducing apoptosis in cancer cells. Pirtenidine is an analog of protein kinase inhibitors, which have been used to treat various types of tumors. It has been found to be effective against human cancer cell lines and has shown significant tumor growth inhibition in animal models. Pirtenidine has also been reported to be a potent urine inhibitor of Chinese hamster ovary cells, making it a promising candidate for the treatment of urinary tract cancers.

N-Desmethyl trimeprazine is a synthetic compound, which is an impurity of the drug product. It is not active and does not possess any biological activity. It is a metabolite of the parent drug, Trimeprazine. N-Desmethyl trimeprazine has been studied for its pharmacological properties and metabolism in the body, but no conclusive results have been found. The chemical structure and purity of N-Desmethyl trimeprazine are not listed in the USP or BP. This compound can be custom synthesized on request.

Fonofos is a potent inhibitor that has been shown to induce apoptosis in Chinese hamster ovary cells. It is also known to inhibit chitin kinase, a protein that plays an important role in the biosynthesis of chitin, which is essential for the formation of cell walls in fungi and insects. Fonofos has medicinal properties and has been studied as a potential anticancer agent due to its ability to inhibit tumor growth. In vitro studies have shown that Fonofos can inhibit the growth of human cancer cells by inhibiting heparin-binding proteins. Additionally, it has been found to have inhibitory effects on several other enzymes involved in cancer development and progression. Although not approved for use in humans, Fonofos may hold promise as a therapeutic agent for the treatment of certain cancers.

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Simvastatin acid is the active form of simvastatin, a drug used to lower blood cholesterol levels. Simvastatin acid inhibits HMG-CoA reductase, the enzyme that converts HMG-CoA to mevalonate. This conversion is a rate-limiting step in the synthesis of cholesterol and other lipids. Simvastatin acid binds to polymerase chain and drug transporter proteins, which leads to cell lysis. The concentration–time curve for simvastatin acid is linear and the half-life is approximately 12 hours. When simvastatin acid is administered with drugs that are potent inducers of CYP3A4 or UGT1A1 enzymes, there may be an increased risk for drug interactions. Simvastatin acid has shown no significant human pharmacokinetic interactions with food or grapefruit juice at doses up to 200 mg/day. There are limited data on the pharmacokinetics of simvastatin