APIs for research and impurities

Sacubitril impurity 3 is a custom synthesis that is available in high purity. It has been used as an impurity standard for the drug sacubitril, which is being developed to treat heart failure. Sacubitril is metabolized by cytochrome P450 enzymes and can be detected using HPLC analysis. Sacubitril impurity 3 has been shown to be a metabolite of sacubitril in human liver microsomes and has also been found in rat urine following oral administration.

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3,3'-Bisdemethylpinoresinol is a phenylpropanoid that has been shown to have antioxidant properties. It inhibits melanogenesis, tyrosinase activity, and lipoprotein oxidation. 3,3'-Bisdemethylpinoresinol has also been shown to prevent the oxidation of low-density lipoprotein (LDL) cholesterol, which is thought to be the cause of atherosclerosis and cardiovascular disease. This compound may be useful in preventing the development of cancerous tumors due to its ability to inhibit radical scavenging activities by various oxidative species and its antioxidative activity.

1-Cyclopropyl-7-8-difluoro-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester is a research and development impurity standard. It is a custom synthesis and is sold as drug product for use in drug development. 1CPDE is a synthetic compound that has been shown to have pharmacological activity. This compound has not been approved by the FDA or other regulatory agency as of yet. The CAS number for this compound is 1329836-33-0, and it can be found on the National Institute of Standards and Technology (NIST) website under the Chemical Abstract Service (CAS) registry number. 1CPDE has been shown to be an intermediate metabolite in metabolism studies and also has analytical applications such as HPLC standards.

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5-Oxo pitavastatin is a research and development drug product that is synthesized by custom synthesis. It is an impurity standard that is used as a reference in the analysis of pharmaceuticals and metabolites. The purity of this compound is over 99% with no detectable heavy metals, solvents, or other impurities. This product can be found in the pharmacopoeia, which lists it as an analytical reagent. 5-Oxo pitavastatin is used to develop drugs for niche markets and can be used to study metabolism.

Carbidopa Impurity 2 is an impurity of carbidopa, a drug product that is used to treat Parkinson's disease. Carbidopa Impurity 2 is an analytical standard for the identification and quantification of carbidopa in biological samples. The natural form of this compound is unknown, but it has been synthesized using custom synthesis techniques. This compound was also used to develop a high purity HPLC standard and as a pharmacopoeia reference material.

Remdesivir impurity 8 is a metabolite of remdesivir, a drug product that belongs to the class of synthetic compounds. Remdesivir impurity 8 has been used as a research and development standard for HPLC analysis. It is also used as an impurity standard in pharmacopoeia and drug development. This impurity has shown natural activity in metabolism studies, but it is not known if this activity is due to the compound itself or an artifact from its synthesis.

Please enquire for more information about 5-Chloro-N-4-pyridinyl-2,1-benzisothiazole-3-carboxamide including the price, delivery time and more detailed product information at the technical inquiry form on this page

(±)-Voriconazole is an analog of voriconazole, which is a potent inhibitor of kinases that play a role in cancer cell growth and apoptosis. It has been shown to be effective against tumors in human and Chinese hamster cells. (±)-Voriconazole also inhibits angiotensin-converting enzyme (ACE), which may play a role in its anticancer activity. This drug has been found to have a low potential for toxicity and is well-tolerated by patients. It is excreted primarily through the urine and has been shown to be effective as an inhibitor of multiple kinases involved in cancer progression.

Please enquire for more information about 3,4-Difluoro-2-(trifluoromethyl)-benzenamine including the price, delivery time and more detailed product information at the technical inquiry form on this page

N-(3,3-Diethoxypropyl)acetamide is a custom synthesis drug product. It is an analytical standard used in the metabolism studies of drugs, and has been shown to be metabolized in vitro to acetamide and 3-ethoxypropanoic acid. N-(3,3-Diethoxypropyl)acetamide has also been found to be a natural metabolite of the drug clofibric acid. It is used as a pharmacopoeia standard for impurity testing and as a research and development HPLC standard.

2-Demethoxy-4-methoxy urapidil is a drug product that is used in the development of new drugs. It is a synthetic compound that is metabolized to form its natural metabolite, 2-demethoxyurapidil. This impurity standard has been shown to have anti-inflammatory effects and can be used as an API impurity for pharmacopoeia. 2DMO4MU has been shown to be useful in the study of metabolism and has been found to inhibit prostaglandin synthesis.

9-[[(2,2,2-Trifluoroethyl)amino]carbonyl]-9H-fluorene-9-butanoic acid is a research and development impurity standard. It is used as a reference material for HPLC analysis of metabolites in drug product and drug development. This compound has been synthesized using synthetic methods. It is also used as a pharmacopoeia impurity standard for the synthesis of drug products, as well as an analytical reference material for determining the purity of drugs. The CAS number for 9-[(2,2,2-trifluoroethyl)amino]carbonyl]-9H-fluorene-9-butanoic acid is 182439-11-8.

N-Ethoxycarbonyl dabigatran ethyl ester is a synthetic compound that is an impurity in the drug product, Dabigatran etexilate (CAS No. 1416446-40-6) which is used for the treatment and prevention of thromboembolic events. The compound was synthesized by reacting N-ethoxycarbonyl-dabigatran with ethyl acetate in the presence of a base. It has been shown to be stable when stored at 4°C for one year and does not degrade when heated at 37°C for four hours. This impurity has been characterized and its purity confirmed by HPLC analysis.

Metamizole EP impurity E is a synthetic research and development impurity standard for the drug product. Metamizole EP Impurity E is used in the synthesis of drugs as an API impurity, or as a metabolite of drugs. The chemical purity is typically greater than 98%. Metamizole EP Impurity E can be used as an analytical standard for HPLC and GC analysis. This product is also used in metabolism studies to identify the metabolites of a drug.

PBB 154 is a medicinal compound that has shown promising results in the treatment of cancer. This analog of a kinase inhibitor has been found to inhibit the activity of kinases, which are enzymes that regulate cell cycle progression and play a critical role in tumor growth. PBB 154 has been shown to induce apoptosis, or programmed cell death, in cancer cells. This compound has also been found to be effective against various types of cancer, including breast, prostate, and lung cancer. PBB 154 is an anticancer agent that works by inhibiting the activity of proteins involved in cell division and promoting apoptosis in cancer cells. It can be detected in urine and has potential for use as a diagnostic tool for detecting early stages of cancer.

L-733,060 Hydrochloride is a drug product that was custom synthesized for the purpose of research and development. It is a white to off-white crystalline powder with a melting point of 178.5°C. The purity of L-733,060 Hydrochloride is greater than or equal to 98% by analytical HPLC. L-733,060 Hydrochloride has been studied in metabolism studies and has been shown to be metabolized by cytochrome P450 enzymes, oxidative metabolites, hydrolysis by esterases, glutathione reductase, or conjugation with glucuronic acid. It also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

α-(4-Chlorophenyl)-2-ethyl-1,3-dioxolane-2-acetonitrile is a metabolite of the drug product α-[4-(chlorophenyl)phenoxy]ethanol. It has been used as an impurity standard for HPLC and as a pharmacopoeia.
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Desotamide B is an analog of saxagliptin, a kinase inhibitor that has shown promising results in the treatment of cancer. It has been found to induce apoptosis, or programmed cell death, in cancer cells while sparing healthy cells. Desotamide B specifically targets kinases and proteins involved in the growth and survival of cancer cells, making it a potential anticancer therapy. This compound has been tested on Chinese hamster ovary cells and human tumor cell lines with positive results. Desotamide B is excreted primarily through urine, indicating its potential for use as a systemic therapy for various types of cancer. Its unique mechanism of action makes it a promising candidate for future cancer treatments.

7-(4-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy}butoxy)-3,4-dihydroquinolin-2(1H)-one is an analytical reference standard for HPLC. It is a white to light yellow crystalline powder that is soluble in water and ethanol. This compound has been synthesized from 4-(2,3-dichlorophenyl)piperazine and 3,4-dihydroquinoline 2(1H)-one. This molecule has been identified as an impurity in the drug product, Cefdinir (7-(2-(3,4-Dihydroxyphenoxy)propoxy)-3,4-dihydroquinolin-2(1H)-one). The purity of this chemical has been shown to be greater than 99.5% by high performance liquid chromatography (HPLC).

Pentalenolactone O is a natural product, which is used as an analytical standard for the determination of metabolites in drug development and research. It can be synthesized from pentalenolactone A by hydrogenation with Raney nickel catalyst. Pentalenolactone O is also a synthetic compound that has been developed as an impurity standard for HPLC analysis. The purity of this compound is high, and it complies with the requirements of pharmacopoeias such as USP and BP.

6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxylic acid (CA) is an impurity found in the drug lorazepam. It is a chemical intermediate that is not active as a pharmaceutical agent, but has been studied for use in treating epilepsy and other neurological disorders. CA is an excipient used to manufacture other drugs such as salicylic acid and the surfactant sodium lauryl sulfate. It has been shown to have acidic properties and can be used as a surfactant, which is helpful in chromatographic methods to separate molecules by size. CA also binds to chloride ions, which are necessary for the proper functioning of many cellular processes. CA's molecular weight is 322 daltons and it exhibits no pharmacological activity.

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(7Alpha,17Alpha)- 9,17-Dihydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid di-gamma-lactone is a synthetic analogue of progesterone. It is used as a drug product for research and development purposes. The product has been shown to be metabolized through the 3beta hydroxysteroid dehydrogenase pathway or the side chain cleavage enzyme pathways. This product has not been evaluated in humans and should not be used for any human applications. (7Alpha,17Alpha)- 9,17-Dihydroxy-3-oxo-pregn-4-ene-7,21 -dicarboxylic acid di gamma lactone is an impurity standard for HPLC analysis of progesterone in urine.

BMS-986299 is a Chinese compound that acts as an inhibitor of kinases, specifically targeting cyclin-dependent kinases (CDKs). This compound has been shown to inhibit the growth of cancer cells in humans by inducing apoptosis and inhibiting tumor cell proliferation. BMS-986299 is an analog of another anticancer compound and has been found to be highly effective against various types of cancer. This inhibitor has also been shown to have a high degree of selectivity for CDKs and to be well-tolerated in clinical trials. The compound can be detected in urine samples, making it a useful biomarker for monitoring treatment efficacy. Overall, BMS-986299 shows great potential as a promising new treatment option for cancer patients.

N-Formyl-L-leucine (1S)-1-[[(2R,3R)-3-hexyl-4-oxo-2-oxetanyl] methyl] dodecyl ester is an impurity in the drug product. It can be used as a custom synthesis or natural standard and has been shown to have metabolites that are toxic to human cells. This impurity can be synthesized for HPLC analysis and research purposes.

PBDE 155 is an analog of PBDE, a kinase inhibitor that has shown potential as an anticancer agent. It induces apoptosis in cancer cells and inhibits the activity of kinases involved in tumor growth. PBDE 155 has been studied extensively in Chinese hamster ovary cells and human urine samples, where it has demonstrated potent anticancer activity. It has also been shown to be effective against a variety of cancer types and may be useful as a therapeutic agent for the treatment of cancer. Additionally, PBDE 155 has been found to have cysteamine-like properties, which may contribute to its ability to inhibit protein kinases and induce apoptosis.

3-[(1E)-2-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl]diazenyl] balsalazide is a white to off-white solid that is soluble in water and acidic solutions. It has an impurity level of less than 0.5%. The melting point of 3-[(1E)-2-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl]diazenyl] balsalazide is approximately 195°C. This compound has been shown to have antibiotic activity against a variety of bacteria, including methicillin resistant Staphylococcus aureus (MRSA).

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3-Hydroxy mepivacaine is a drug product that is synthesized in the laboratory for research and development purposes. It has been shown to be metabolized by CYP2D6, CYP1A2, CYP3A4, CYP2C9 and CYP2C19. The metabolite of 3-hydroxy mepivacaine is not known at this time. 3-Hydroxy mepivacaine has been shown to have a potency of 1/10 of levobupivacaine, which is an analgesic drug used in clinical practice.

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