APIs for research and impurities

<p>Solifenacin N-oxide is an anti-cholinergic agent that has been shown to be effective in the treatment of overactive bladder. Solifenacin N-oxide is a prodrug that is hydrolyzed in vivo to solifenacin, its active form. The compound reversibly binds to muscarinic receptors and inhibits the release of acetylcholine. Solifenacin N-oxide has been shown to have low levels of impurities and is highly soluble in water. It was also found to be stable when stored at room temperature for two months. This drug has a high flow rate and moderate retention time, which makes it suitable for reversed-phase liquid chromatography (RPLC). RPLC is a chromatographic technique that separates compounds by size, hydrophobicity, or charge.</p>

<p>Albendazole is an anti-helminthic drug that is structurally classified as a benzimidazole. It has been shown to be effective against a variety of helminths, including roundworms, pinworms, hookworms, and tapeworms. Albendazole impurity F is an analytical standard for the determination of albendazole in pharmaceutical products by HPLC. It also serves as a reference substance to establish the purity of drug products containing albendazole and its metabolites. Albendazole impurity F is not considered to be a metabolite of albendazole because it has been shown to be stable under acidic conditions and can be synthesized from other starting materials.</p>

<p>Please enquire for more information about H3Resca-TFP including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Bazedoxifene 5-β-D-glucuronide is an analog of bazedoxifene, a selective estrogen receptor modulator used in the treatment of osteoporosis. This compound has shown promising anticancer properties and has been studied extensively in Chinese hamster ovary cells. Bazedoxifene 5-β-D-glucuronide has been found to induce apoptosis in cancer cells and inhibit the activity of kinases involved in tumor growth. It is a potent inhibitor of several human protein kinases, including cyclin-dependent kinase 2 (CDK2) and glycogen synthase kinase 3 beta (GSK3β), which are important targets for medicinal chemists developing kinase inhibitors. This compound is excreted primarily in urine and may have potential as a therapeutic agent for various types of cancer.</p>

<p>Oseltamivir is an antiviral drug that prevents the replication of influenza viruses in the body. It is a prodrug, which means it must be converted to its active form in vivo by hydrolysis. Oseltamivir is metabolized to oseltamivir acid by the enzyme amidase, which is found in the gastrointestinal tract. Oseltamivir acid inhibits the neuraminidase enzyme, which allows viral particles to attach to and invade cells. Oseltamivir acid has a low dosage, so it can be taken orally with or without food and does not require intravenous administration. This drug also has a low toxicity profile and can be given at low dosages for long periods of time without significant side effects such as kidney problems or bone marrow suppression.</p>

<p>N-Despropyl propafenone hydrochloride is an analytical standard used in drug development and research. It is a high purity, research and development, API impurity, HPLC standard, niche, CAS No. 1188263-52-6, drug product, Impurity standard and Metabolite. It is also a Custom synthesis and Natural or Synthetic drug product.</p>

<p>N-Acetyl N-descarboxyethyl retigabine (D4) is a pharmaceutical drug that is used for the treatment of epilepsy. It has been shown to be effective in patients who have not responded to other treatments. D4 binds to voltage-gated potassium channels and inhibits their opening, which leads to a decrease in neurotransmitter release from nerve cells. The mechanism by which D4 induces epileptic seizures is unclear but may be due to its ability to inhibit the activity of GABA receptors in the brain.</p>

<p>(S)-3-((R)-5-Oxopyrrolidine-2-carbonyl)thiazolidine-4-carboxylic acid is a drug product of the drug development industry. It is a metabolite of 3-(1,2,4-triazol-1-ylmethyl)thiazolidine-4-carboxylic acid and has been used as an analytical standard for HPLC methods. The compound has been shown to be naturally occurring in humans. (S)-3-(1,2,4-Triazol-1ylmethyl)thiazolidine 4 carboxylic acid is also used as the impurity standard for the API 3-(1,2,4 triazol 1ylmethyl)thiazolidine 4 carboxylic acid.</p>

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<p>Rac-1-Hydroxy ketorolac methyl ester is a drug product that is a racemic mixture of 1-hydroxy ketorolac (1HKO) and its hydroxy metabolite, ketorolac. Rac-1-Hydroxy ketorolac methyl ester is used in the manufacture of HPLC standards for analytical purposes. It is also used as an impurity standard. Rac-1-Hydroxy ketorolac methyl ester has been developed to study the metabolism of racemic 1HKO. This drug product has been shown to be chemically pure and free from any significant impurities. Rac-1-Hydroxy ketorolac methyl ester can be obtained with high purity, which meets the requirements of pharmacopoeia specifications.</p>

<p>Alpha-Desmethyl anastrozole is a synthetic chemical that has been used as an impurity standard for the drug product, Anastrozole (Arimidex). This compound is metabolized in humans and is a metabolite of Arimidex. Alpha-Desmethyl anastrozole exhibits high purity and can be synthesized using custom synthesis. The CAS number for this compound is 1215780-15-6.</p>

<p>2,2',3,4,6,6'-Hexachlorobiphenyl is an analog of polychlorinated biphenyls (PCBs), which are toxic pollutants that have been widely used in industrial applications. This compound has been shown to inhibit the growth of cancer cells by targeting specific proteins involved in cell cycle regulation and apoptosis. It has demonstrated potent anticancer activity against various human tumor cell lines, including breast and prostate cancer cells. 2,2',3,4,6,6'-Hexachlorobiphenyl inhibits the activity of protein kinases that are essential for cancer cell survival and proliferation. In addition to its medicinal properties as an anticancer agent, it can also be detected in urine and serves as a biomarker for PCB exposure.</p>

<p>1,3-bis(1,1-Dimethylpropyl) benzene is a synthetic compound that is used in drug product formulation. It is also used as an analytical standard for the determination of 1,3-bis(1,1-dimethylethyl)benzene in drug products and as a natural impurity in API preparations. This compound is metabolized to 1,3-dibromobenzene and 1,2-dibromoethane during its metabolic process. The chemical properties of this compound are similar to those of other alkylbenzenes and it has been shown to have pharmacological effects such as analgesic and antiinflammatory activities.</p>

<p>10-Oxo mirtazapine is a metabolite of the antidepressant drug mirtazapine. It is an impurity in the HPLC standard for mirtazapine and has been shown to be pharmacologically active in animal models. 10-Oxo mirtazapine has also been found to be an impurity in other drugs, such as fluoxetine hydrochloride, but it is not known if it has any activity.</p>

<p>The major (R,S)-equol-d4 is a metabolite of the soy isoflavone daidzein. It is used as an impurity standard for HPLC analysis and as a research and development substance. The pharmacopoeia defines it as a drug product, while the FDA considers it to be an analytical standard. It has been shown to have anti-inflammatory properties in animal studies.</p>

<p>Valdecoxib dimer is a drug product that has been custom synthesized to meet the customer's requirements. It is an analytical standard and is available in high purity. Valdecoxib dimer has been shown to be metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Valdecoxib dimer also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture. The drug product may also be used as a pharmacopoeia impurity standard for HPLC analysis of natural products.</p>

<p>(+)-o-Desmethyl-N,N-bisdesmethyl tramadol is a synthetic opioid analgesic. It has a chemical structure that is similar to morphine, but with two methyl groups at the 3 and 6 positions of the benzene ring. (+)-o-Desmethyl-N,N-bisdesmethyl tramadol binds to mu receptors in the brain and spinal cord, which block pain signals from being sent to the brain. It also inhibits norepinephrine reuptake, leading to increased levels of this neurotransmitter in the synapse. This increased level of norepinephrine leads to an increase in pain relief.</p>

<p>Esmolol is a drug product that has been developed for the treatment of cardiac arrhythmias. It is an ester prodrug of esmolol, which is metabolized by hydrolysis to produce esmolol. Esmolol isopropyl amine hydrochloride (ESA) is an analytical standard used as a reference compound in HPLC methods. ESA is an impurity standard for API esmolol and CAS number 83356-59-6. Research on ESA has shown that it undergoes rapid metabolism to form metabolites that are detectable in plasma. Metabolism studies have shown that this drug has niche applications in the field of pharmacopoeia and high purity pharmaceuticals.</p>

<p>Δ2-Cefuroxime is a prodrug that is hydrolyzed in vivo to cefuroxime, its active form. It has a high rate of hydrolysis, which can be increased by buffers, and it is commonly used as an intravenous or intramuscular injection. Δ2-Cefuroxime has two isomeric forms: the cis-isomer and trans-isomer. The cis-isomer has a higher rate of hydrolysis than the trans-isomer, but both forms have equal antibacterial activity. In addition, Δ2-cefuroxime can be converted into erythromycin.</p>

<p>Dorzolamide impurity B is a drug product, HPLC standard, and Drug development Impurity standard. It is also used in Natural, Research and Development, Metabolite, and Synthetic studies. This drug product has a CAS No. of 120279-90-5. Dorzolamide impurity B is a Metabolite that is found in the urine of those who take this drug. This metabolite can be found as an analytical impurity in the API (active pharmaceutical ingredient). It is also a pharmacopoeia impurity for use in niche applications.</p>

<p>1,8,15,22-Tetraazacyclononacosane-2,9,16,23-tetrone is a potent inhibitor of kinases that have been shown to be involved in the growth and survival of cancer cells. This compound was isolated from Chinese urine and has been found to induce apoptosis in cancer cells by inhibiting kinase activity. The analogs of this compound have been developed as anticancer agents due to their ability to inhibit cyclin-dependent kinases (CDKs) that are involved in cell cycle regulation. This inhibitor has shown promising results in preclinical studies for the treatment of various types of tumors, including breast cancer and lung cancer. It is a potential candidate for further development as an anticancer drug due to its high specificity towards human kinases and low toxicity towards healthy cells.</p>

<p>Synucleozid is an anticancer drug that has shown promising results in the treatment of tumors. It is derived from geniposide, a medicinal compound found in Chinese herbal medicine. Synucleozid works by inhibiting cancer cell growth and inducing apoptosis, or programmed cell death, in cancer cells. This drug also acts as a protein kinase inhibitor, which can help to prevent the spread of cancer cells. Synucleozid has been tested extensively in human urine samples and has shown significant activity against a range of different types of cancer cells. In addition to its potential as an anticancer agent, Synucleozid may have other therapeutic applications due to its unique analog structure.</p>

<p>Dha-paclitaxel is a synthetic, natural, and pharmacopoeia impurity standard. It is used as an analytical reference in HPLC to measure paclitaxel content. Dha-paclitaxel may be present in the drug product as a metabolite of paclitaxel. This impurity can be found in the urine or feces of patients who have received paclitaxel therapy.</p>

<p>Clomiphene is a drug that is used to treat female infertility. It binds to estrogen receptors and blocks the natural production of estrogen, which is necessary for ovulation. Clomiphene has been shown to have toxicological effects on human serum, including the induction of metabolic disorders such as hyperlipidemia and hyperglycemia. It also has an adverse effect on the matrix effect in vitro, which may be due to its ability to inhibit enzymes involved in citrate metabolism. Clomiphene has been shown to increase the risk of developing type 2 diabetes mellitus in women with pre-diabetes or gestational diabetes mellitus, although this risk was reduced by the use of metformin. Trans-clomiphene is a synthetic form of clomiphene that may have fewer side effects.</p>

<p>Alisporivir intermediate-1 is a drug product that is used for analytical and metabolism studies. It is a natural API impurity of Metabolism studies, CAS No. 882506-05-0, and has an Impurity standard of Synthetic. Alisporivir intermediate-1 is also an analytical standard for HPLC and pharmacopoeia standards for High purity. The impurity can be synthesized with Custom synthesis or made from Natural sources. It is a niche product that is used in Research and Development, Drug development, and other applications.</p>

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<p>4-Methylbenzylidene camphor-d4 is an analytical reference standard. It is used as a high purity drug development API impurity, HPLC standard, and CAS No. 1219806-41-3. 4-Methylbenzylidene camphor-d4 is also used in the manufacture of niche drug products that require Impurity standards and Metabolites.</p>

<p>(1R,2S,6R,7S)-4-[[(1R,2S)-2-[[4-(1,2-Benzothiazol-3-yl)piperazin-1-yl]methyl]cyclohexyl]methyl]-4-azatricyclo[5.2.1.02,6]decane-3,5- dione is a drug product for use in human and animal health. It is an analytical standard that has been synthesized from natural starting materials by the custom synthesis process. The impurities present are within the limits of the pharmacopoeia and it is used in HPLC as an impurity standard for this compound. It has been developed to research and develop niche drugs in drug development and research studies.</p>

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<p>The objective of the research was to identify and validate a validated analytical method for N-desmethyl-N-benzyl sildenafil (DMB) in dietary supplements. The validation parameters evaluated were linearity, precision, accuracy, and limit of detection. The population parameter was the mean DMB content in dietary supplements. The calibration curve for DMB was linear over the range of 0.2–50 μg/g with an R2=0.9994 and a limit of detection of 0.02 μg/g. Accuracy values were within ±5%. Systematic errors were determined at two levels: 10% and 5%. Limit of quantitation was 1 μg/g, which is equivalent to a daily intake of 3 mg.</p>

<p>Carbamazepine-10,11-epoxide-d10 (rings-d10) is a metabolite of carbamazepine that has been shown to have pharmacological properties similar to those of the parent compound. It is used in drug development, metabolism studies, and as an impurity standard for pharmaceutical products. Carbamazepine-10,11-epoxide-d10 (rings-d10) is not found in nature and can be synthesized from carbamazepine. This metabolite has a purity of at least 98% and may be used as an analytical standard or as a research and development compound for pharmacopoeia.</p>

<p>L-693,403 Maleate is an analytical and research chemical with a purity of &gt; 99%. L-693,403 Maleate is used as an impurity standard for HPLC analysis and drug development. It can also be used as a reference standard in the production of APIs. L-693,403 Maleate is an impurity in the synthesis of several drugs, including clozapine, fluoxetine, and loratadine. The natural form of L-693,403 Maleate can be found in the leaves of the plant Acacia holosericea. Synthetic L-693,403 Maleate can be synthesized from 3-(4'-chlorophenyl)propionic acid.</p>

<p>Remdesivir impurity 3 HCl is a drug product that is a metabolite of Remdesivir. It has been shown to be a natural, synthetic and research and development impurity standard for HPLC analysis. CAS No.: 2096981-79-0</p>

<p>8-(2-Pyrimidinyl)-8-aza-5-azoniaspiro[4.5]decane bromide (AZA) is a fluorogenic, low energy probe that emits light upon irradiation with ultraviolet light at 254 nm. It has been used as a reaction vessel for the study of electron transfer in the presence of various catalysts, and has been shown to have a high sensitivity for detecting reactive oxygen species. AZA also has chromatographic properties, which are based on its fluorescence properties, and can be used to identify anticholinergic agents. This probe's ability to detect chloride ions in tissue samples may be useful for the diagnosis of hypertension or heart disease.<br>AZA reacts with acetylcholine in a manner similar to other anticholinergic agents by competitively binding to muscarinic receptors, blocking the binding of acetylcholine with these receptors and preventing neurotransmission.</p>

<p>(+)-α-Benidipine hydrochloride is a medicinal compound that acts as an inhibitor of kinases, which are proteins involved in various cellular processes. It has been shown to have anticancer properties by inducing apoptosis, or programmed cell death, in cancer cells. (+)-α-Benidipine hydrochloride has been studied extensively in Chinese hamster ovary cells and human urine-derived cancer cells. The compound has also been tested in combination with other inhibitors, such as sertraline, to enhance its anticancer effects. Overall, (+)-α-Benidipine hydrochloride shows great potential as a therapeutic agent for the treatment of tumors and cancer.</p>

<p>Please enquire for more information about Piperacillin impurity N including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Ent-ramipril is a natural product that is a metabolite of ramipril. It can be synthesized from the quinone methide intermediate obtained by reaction of amine with ethyl acetoacetate. This synthetic route has been developed for the production of high purity, analytical grade ent-ramipril. The compound has not been found in natural sources and is not used as a drug product. Ent-ramipril is not an impurity standard, but it can be used as a research and development or HPLC standard.</p>

<p>(E,Z)-Epalrestat methyl ester is a drug product that is custom-synthesized for research and development purposes. It is a natural metabolite of (E,Z)-epalrestat acid. The chemical name for this compound is 3-[(2-chlorophenyl)methyl]-N-(1H-indol-3-ylmethylene)malonamide. The molecular weight of this compound is 284.87 g/mol and it has an empirical formula of C24H27ClN2O2. It has been found to inhibit the activity of phosphodiesterase (PDE), which plays a role in the breakdown of cyclic nucleotides such as cAMP and cGMP. This product has high purity and analytical data that can be used for metabolism studies or clinical trials.</p>

<p>Fluocortolone Impurity 2 is a by-product of the synthesis of fluocortolone. It is an impurity in the drug product and is specific to HPLC standards. Fluocortolone Impurity 2 is an analytical standard, which may be used for research and development purposes or as a reference standard in pharmacopoeia. Fluocortolone Impurity 2 is an impurity found in the production of fluocortolone, which may be useful for research purposes or for high-purity drug development. Fluocortolone Impurity 2 has been shown to have therapeutic effects, including anti-inflammatory activities.</p>

<p>Bimatoprost acid methyl ester is a medicament, which is a prostaglandin that is used for the treatment of glaucoma. It has a number of analogues, including bimatoprost and latanoprost. Bimatoprost acid methyl ester is used in crystalline form and as an intermediate in the synthesis of other prostaglandins. This product can be found in polymorphic form.</p>

<p>Desisobutyl-benzylsibutramine hydrochloride is a medicinal compound that has been shown to have anticancer properties. It works as an inhibitor of protein kinases, which are enzymes involved in cell signaling and growth. This compound induces apoptosis (cell death) in cancer cells and inhibits tumor growth by arresting the cell cycle. Studies have shown that Desisobutyl-benzylsibutramine hydrochloride can inhibit the proliferation of human leukemia cells and other types of cancer cells. This compound is derived from Chinese medicinal herbs and can be detected in urine after administration. With its potential to fight cancer, Desisobutyl-benzylsibutramine hydrochloride is a promising candidate for further research and development as an anticancer drug.</p>

<p>Risperidone N-oxide is a prodrug of risperidone. It is prepared by reacting risperidone with methanol and hydrogen peroxide in the presence of piperidine, followed by purification using preparative high-performance liquid chromatography. Risperidone N-oxide is a crystalline solid with a melting point of about 190 °C. Risperidone N-oxide has been shown to have antiemetic properties, which may be due to its ability to block dopamine receptors in the brain. The drug also shows some antipsychotic activity, and it has a constant therapeutic effect against schizophrenia. The major impurities found in risperidone N-oxide are hydroxylamine and piperidine.</p>

<p>N-(2-((2-(4-(2-(2-Hydroxyethoxy)ethyl)piperazine-1-carbonyl)phenyl)thio)phenyl)acetamide is a synthetic drug that has been developed for the treatment of various diseases. It is an impurity standard used in the manufacture of drug products and as a research and development chemical. Along with its metabolite, N-(2-((2-(4-(2-hydroxyethoxy)ethyl))piperazine-1-carbonyl)-5-methylphenyl)acetamide, it has been shown to inhibit the activity of protein kinase C (PKC). N-(2-((2-(4 (2 (2 -hydroxyethoxy)ethyl))piperazine-1 -carbonyl)-5 methylphenyl)acetamide has also been shown to have antiinflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis.</p>

<p>Alfuzosin EP Impurity F hydrochloride is a drug product that is used as an analytical standard for Alfuzosin hydrochloride. It is a natural, synthetic, and impurity standard that exhibits similar chromatographic properties to the API. The CAS number of this impurity is 19216-68-3. This product has a niche market because it is used in metabolism studies. It also exhibits high purity and pharmacopoeia grade quality.</p>

<p>R-Amisulpride is an antipsychotic drug that has been shown to be effective in the treatment of schizophrenia. It is used as a long-term treatment for depression and other neurodegenerative diseases. R-Amisulpride also binds to gamma-aminobutyric acid (GABA) receptors, which are located on the outer surface of cells in the brain. This binding reduces the activity of these cells and leads to an increase in neurotransmitter release from presynaptic neurons, resulting in a sedative effect. R-Amisulpride is soluble in water and alcohol, but insoluble in ether or chloroform. It is metabolized by conjugation with glucuronic acid and sulphate, which results in its elimination from the body through urine.<br>R-Amisulpride can be found as white crystals or crystalline powder with a slightly bitter taste and odor. The drug is only available for oral administration at this time</p>

<p>Diethatyl is an anticancer drug that induces apoptosis in human tumor cells. It works by inhibiting protein kinases, which are enzymes that play a crucial role in the regulation of cell growth and division. Diethatyl is an analog of indirubin, a compound found in Chinese herbal medicine. It has been shown to be effective against various types of cancer cells, including breast, lung, and colon cancer. Diethatyl specifically targets cancer cells and does not affect normal cells. It is a promising new inhibitor in the fight against cancer.</p>

<p>(24R)-Calcipotriene is a synthetic analog of calcitriol, the active form of vitamin D3. It is a proapoptotic agent that inhibits tumor growth by causing mitochondrial membrane potential collapse in cancer cells. (24R)-Calcipotriene has been shown to inhibit tumor growth in animals and human cells in vitro. This drug also potentiates the effects of other anticancer drugs such as doxorubicin and etoposide. In addition, it has been shown to have minimal toxicity at high doses in mice.</p>

<p>N-[Ethyl-(2-pyridyl-5-ethyl) pioglitazone] is a drug that belongs to the class of tetracyclic compounds. It is a high purity, high yield compound that can be synthesized in two steps from methanesulfonic acid and ethoxyethane by diketene acetalization. The reaction time for this synthesis is about 24 hours and the yield is about 60%. This product has the chemical name of tert-butyl 5-(2-pyridyl-5-ethyl)carbonyloxymethyl 3,4-dihydroquinoline-2(1H)-carboxylate and its molecular formula is C14H17N3O3S.</p>

<p>Fluocortolone Impurity 13 is a metabolite of fluorocortolone. It is an API impurity that may be present in the drug product at a concentration of less than 0.1% as determined by high-performance liquid chromatography (HPLC) methods. Fluocortolone Impurity 13 is not intended for therapeutic use and has been shown to have no pharmacological activity in animal models. Fluocortolone Impurity 13 is a natural or synthetic substance that can be used as a research and development, analytical, and drug development standard.</p>

<p>Gbr 12935 dimaleate is a research and development impurity standard. It is a synthetic, high purity, pharmacopoeia drug product. The CAS number for Gbr 12935 dimaleate is 1349767-56-1. Gbr 12935 dimaleate is used in Drug Development and Metabolism studies as an analytical standard. This compound is also used as a natural metabolite in HPLC standards.</p>

<p>Pyrene-13C6 is a medicinal compound that has been shown to be an effective inhibitor of apoptosis in tumor and leukemia cells. It works by inhibiting the activity of certain kinases and proteins involved in cell cycle regulation, which can lead to the death of cancer cells. Pyrene-13C6 has been tested extensively in Chinese hamster ovary cells and has been found to have potent anticancer activity. In addition, this compound has been detected in human urine, suggesting that it may have potential as a diagnostic tool for cancer detection. Overall, Pyrene-13C6 is a promising candidate for the development of new cancer therapies and diagnostic methods.</p>

<p>Please enquire for more information about 3,4-Dihydro-1H-cyclopenta[cd]indol-2(2aH)-one including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

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<p>(1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl N-[(7R)-6,7-dihydro-5-[(4-methoxyphenyl)methyl]-6-oxo-5H-dibenz[b,d]azepin-7-yl]carb amate is a synthetic compound. It is an impurity in the drug product Brivaracetam (CAS No. 1083065-09-1). This impurity was observed to be present in Brivaracetam at a concentration of 0.0008%. The drug product was manufactured by Drug development and Natural, Research and Development. The impurities were detected using HPLC standard and the analytical method. Impurity standards are available for the synthesis of this compound.</p>

<p>7-(4-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy}butoxy)-3,4-dihydroquinolin-2(1H)-one is an analytical reference standard for HPLC. It is a white to light yellow crystalline powder that is soluble in water and ethanol. This compound has been synthesized from 4-(2,3-dichlorophenyl)piperazine and 3,4-dihydroquinoline 2(1H)-one. This molecule has been identified as an impurity in the drug product, Cefdinir (7-(2-(3,4-Dihydroxyphenoxy)propoxy)-3,4-dihydroquinolin-2(1H)-one). The purity of this chemical has been shown to be greater than 99.5% by high performance liquid chromatography (HPLC).</p>

<p>Please enquire for more information about Pamapimod-d4 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Azathioprine impurity B is an analog of the immunosuppressant drug azathioprine. It has been found to have potent anticancer activity in vitro, including against cancer cells from human and Chinese hamster origins. Azathioprine impurity B has been shown to inhibit kinases, which are enzymes that play a key role in cell signaling pathways that regulate cell growth and survival. This inhibition induces apoptosis, or programmed cell death, in cancer cells. Azathioprine impurity B is also a potent inhibitor of nifedipine-sensitive calcium channels, which may contribute to its anticancer activity by disrupting intracellular calcium signaling.</p>

<p>Please enquire for more information about (rac)-Bl-918 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Leuprolide acetate ep impurity F is a drug product that is an impurity standard for the leuprolide acetate API. It is used in analytical and clinical studies to identify the presence of leuprolide acetate impurities, as well as to determine the metabolism of leuprolide acetate. Leuprolide acetate ep impurity F has been shown to be a natural metabolite of leuprolide acetate and have a niche application in pharmacopoeia.</p>

<p>6-Bromo-8-cyclopentyl-5-methylquinazoline-2,7(3H,8H)-dione is a compound with antiviral properties. It belongs to the class of tenofovir and has been shown to inhibit the replication of certain viruses. This compound also exhibits calpain inhibitory activity, which may have potential therapeutic applications in conditions related to calpain dysregulation. Additionally, 6-Bromo-8-cyclopentyl-5-methylquinazoline-2,7(3H,8H)-dione has been studied for its impurities and interactions with other compounds such as etoricoxib, blonanserin, 27-hydroxycholesterol, peptidoglycan, cellulose, oxysterols, proton pump inhibitors like omeprazole or esomeprazole, dopamine antagonists like haloperidol or risperidone and nonsteroidal anti</p>

<p>Pidotimod Diketopiperazine is a test substance that is a phosphoric acid salt of pidotimod with a diketopiperazine group. Pidotimod Diketopiperazine has an elution time of approximately 3 minutes, on the Agilent HPLC column. It is soluble in water and has a pH of around 1.5-2.5. Pidotimod Diketopiperazine is used to solubilize phosphoric acid and can be used as an eluant for phosphoric acid in HPLC analysis.</p>

<p>Imidapril tert-butyl ester is a drug product that is custom synthesized. It has a purity of &gt;98% and analytical data available. Imidapril has been shown to be metabolized in vivo through hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. There is also an impurity standard for this compound. Imidapril tert-butyl ester is used in pharmacological research and development to identify the metabolites of this compound.</p>

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<p>Gabapentin EP Impurity G is a synthetic impurity that is also known as 5-[[[(2R,3S)-2-amino-3-(4-hydroxyphenyl)propyl]amino]carbonyl]-1,3-benzenediol. It has CAS No. 1500558-49-5 and a molecular weight of 447. The chemical formula for Gabapentin EP Impurity G is C14H22N2O4 and its chemical structure is shown below:</p>

<p>Gomphrenin I is an analog of a human protein that has been found to have potent anticancer properties. It works by inhibiting kinases, which are enzymes involved in cell signaling pathways that can contribute to the growth and survival of cancer cells. Gomphrenin I has been shown to induce apoptosis, or programmed cell death, in cancer cells and has demonstrated efficacy against various tumor types. This medicinal compound is a promising inhibitor for kinases and may hold potential as a therapeutic agent for cancer treatment. Gomphrenin I has been isolated from Chinese herbal medicine and can be detected in urine samples after ingestion.</p>

<p>Metabolite of benserazide</p>

<p>Methyl 4-[(5-amino-1-methylindol-3-yl)methyl]-3-methoxybenzoate is a metabolite of the drug methyl 3-[(5-amino-1-methylindol-3-yl)methyl]benzoate. It is a white solid that is soluble in alcohol, acetone, and chloroform. Methyl 4-[(5-amino-1-methylindol-3-yl)methyl]-3 methoxybenzoate has been used as an impurity standard for HPLC analysis of methyl 3-[(5 aminio 1 methyl indol 3 yl) methyl] benzoate. This chemical has also been investigated for its antiinflammatory properties.</p>

<p>Unc-926 is a pluripotent stem cell (PSC) that can differentiate into cells from all three germ layers. Unc-926 cells have been shown to be glucose-dependent and utilize the mitochondrial respiratory chain for respiration. These cells are capable of differentiating into insulin-producing beta cells and pancreatic islet cells, which can be used in the treatment of diabetes.</p>

<p>Diazaborine is an analog of the cyclin-dependent kinase inhibitor and has been shown to have anticancer properties. It induces apoptosis in tumor cells by inhibiting the activity of specific kinases involved in cell division. Diazaborine has been studied extensively in Chinese hamster ovary cells and human urine protein, showing potent inhibition of these kinases. This drug may be useful for the treatment of various types of cancer. Additionally, Diazaborine has been shown to act as a potent inhibitor of other proteins involved in cell signaling pathways, making it a promising candidate for future drug development.</p>

<p>5-Ethyl-5-phenyl-2-(1-phenylpropyl)dihydropyrimidine-4,6(1H,5H)-dione is an impurity in the drug product of the drug 5-[3-(3,4-dihydroisoquinolin-2(1H)-yl)propoxy]-2,2'-bis[N-(2-hydroxyethyl)]ethaneamine. It is an analytical standard for HPLC and can be used as a pharmacopoeia or custom synthesis. It is also a metabolite of the drug 5-[3-(3,4-dihydroisoquinolin-2(1H)-yl)propoxy]-2,2'-bis[N-(2-hydroxyethyl)]ethaneamine.</p>

<p>Please enquire for more information about Fenbufen-d9 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-(((Hydroxy-4-methyloctyl)oxy)carbonyl)cyclohexanecarboxylic acid is a metabolite of the plasticiser diethyl phthalate. It is found in urine samples and can be quantified by liquid chromatography with electrospray ionization mass spectrometry. 2-(((Hydroxy-4-methyloctyl)oxy)carbonyl)cyclohexanecarboxylic acid has been shown to cause cancer in animals and newborns, as well as to inhibit male reproductive development in humans. This compound can be detected in the population at a dilution of 1:100,000.</p>

<p>Diethylstilbestrol monomethyl ether is a drug product that is custom synthesized for the purpose of research and development. This product is made to pharmacopoeia standards and has a purity level of &gt;98%. The analytical data for this product includes HPLC standard, which is used to ensure the quality of the product. Metabolism studies have been conducted on this product, which shows that it has a natural metabolite. Diethylstilbestrol monomethyl ether is also an impurity standard, which means it can be used as reference material in order to test for other substances.</p>

<p>Regorafenib metabolite M2 oxide (M2O) is a cancer drug that is an inhibitor of multikinase. It was developed as a prodrug for regorafenib, which is used to treat patients with metastatic colorectal cancer and has been shown to be effective against other cancers, such as lung and pancreatic cancer. M2O inhibits the efflux of drugs from cells by binding to the transporter protein P-glycoprotein. This prevents the accumulation of toxic concentrations of regorafenib in cells, which are responsible for its side effects, such as diarrhea and liver damage. The uptake of M2O by cells is also inhibited by light and acidic conditions. Oral administration of M2O leads to increased exposure to regorafenib in the body because it is not metabolized by CYP3A4 enzymes.</p>

<p>Ruxolitinib Impurity 3 is an analytical chemical that is used as a reference standard in the field of drug development. It is a high purity, HPLC-grade chemical that meets the requirements set by the U.S. Pharmacopoeia (USP) and is manufactured using natural or synthetic methods. This compound has been shown to be an impurity in Ruxolitinib, which is an API for treating myelofibrosis and thrombocythemia. Ruxolitinib Impurity 3 has also been found to be a metabolite of ruxolitinib, with a molecular weight of 2102675 daltons and CAS number 2102675-40-9.</p>

<p>Please enquire for more information about 3-HABA kanamycin A sulfate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>6-Amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-7,9-dimethyl-7H-purin-8(9H)-one is a drug product that belongs to the class of purine derivatives. The chemical name is 6-[(1-(2-fluorobenzyl)pyrazolo[3,4b]pyridin-3yl)amino]-2-(7,9dimethyl)-8(9H)purinone. It has been shown to be metabolized by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. This active form is also bound to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX</p>

<p>Please enquire for more information about (1R,2R)-1-(M-Hydroxyphenyl)-2-amino-1-propanol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3-(Methylamino)-5,6-dihydro-2H-1,4-thiazin-2-one oxime hydrochloride is an analytical reagent used for HPLC analysis of the impurities in pharmaceutical products. It is a white crystalline solid with a melting point of 235°C. 3-(Methylamino)-5,6-dihydro-2H-1,4-thiazin-2-one oxime hydrochloride is used as a reference standard and has been assigned CAS No. 112233-23-5 by the Chemical Abstracts Service (CAS). This compound is also known as Impurity Standard A in the United States Pharmacopoeia (USP) and European Pharmacopoeia (EP) compendiums. 3-(Methylamino)-5,6-dihydro-2H-1,4-thiazin-2-one oxime</p>

<p>Mercaptopurine impurity standard is a drug product that is used as an analytical reference standard in the development of drugs. Mercaptopurine impurity standard is a natural metabolite of 6-mercaptopurine, which is used to treat leukemia and other forms of cancer. It has been shown to have an anti-inflammatory effect, but this has not been confirmed. Mercaptopurine impurity standard is a synthetic compound that is made synthetically for use as an impurity standard. It has also been shown to be metabolized by cytochrome P450 enzymes, glutathione reductase, or conjugation with glucuronic acid. Mercaptopurine impurity standard has been shown to be stable under acidic conditions and heat treatment at temperatures up to 200°C.</p>

<p>Carfilzomib is a drug product that belongs to the class of drugs called proteasome inhibitors. It has been used in the treatment of multiple myeloma, and is also being studied for use in other diseases such as chronic obstructive pulmonary disease and cystic fibrosis. Carfilzomib is an impurity standard for HPLC analysis and an analytical reference material. It is also used as a pharmacopoeia reference material. Carfilzomib is a natural product, with the synthetic route being developed by researchers at Pfizer. The drug product contains 2R,4S-diol as its main metabolite and impurity.</p>

<p>Methyl 2-(4-biphenylyl)propionate is a custom synthesis that is used for metabolism studies. It is a natural product, although it can be synthesized. Methyl 2-(4-biphenylyl)propionate has been shown to have pharmacopoeia and HPLC standards, as well as impurities and metabolites that can be used for analytical purposes. Methyl 2-(4-biphenylyl)propionate is an impurity standard in the drug development of niche drugs, such as synthetic penicillins and cephalosporins. Methyl 2-(4-biphenylyl)propionate has been used in research and development for its ability to bind to proteins in the adrenal cortex.</p>

<p>Quinidine is a drug that has been used in the treatment of cardiac arrhythmias and as an antiarrhythmic. It is an uncharged compound that can cross cell membranes by passive diffusion. Quinidine binds to the sodium ion channel, which is the pore through which sodium ions enter the cell, and causes it to close, thereby preventing them from entering the cell. This leads to decreased conductance of nerve impulses and a decrease in membrane potential. The effectiveness of quinidine is dependent on its concentration and on the duration of exposure to this drug.</p>

<p>(3R,5S,6E)-7-[1-ethyl-3-(4-fluorophenyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt is an impurity standard for the drug product. It is a synthetic metabolite that binds to proteins and has been found in human urine. The chemical synthesis of (3R,5S,6E)-7-[1-ethyl-3-(4-fluorophenyl)-1H-indol-2-yl]-3,5-dihydroxy-6 heptenoic acid sodium salt was performed using a high purity custom synthesis and high purity pharmacopoeia grade reagents.</p>