APIs for research and impurities

Roflumilast is a drug used to treat chronic obstructive pulmonary disease. It is also used to treat inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Roflumilast inhibits the enzyme cytochrome P450 in the liver, which is responsible for metabolizing certain drugs and other substances. This inhibition reduces the metabolism of these substances, leading to increased levels of these substances in the body. This can lead to side effects such as nausea, vomiting, dizziness, headache, and itching. Roflumilast also has an anti-inflammatory effect on the intestines by regulating the production of inflammatory cytokines and inhibiting the activity of pro-inflammatory enzymes.

Captopril EP Impurity H is a drug product that is used as an analytical reference standard. It is not intended for administration to humans or animals. Captopril EP Impurity H is manufactured by the same process as Captopril, but with a different impurity profile. The purity of this product is 99.5% at 25°C, and it has an impurity profile of less than 0.5%. This product is also known as 4-Amino-N-(2,6-dichlorophenyl)benzenesulfonamide and has CAS No. 205521-07-9.

N-Desisopropyl-N-formyl bisoprolol is a compound derived from chamomile extract that has various applications in the industrial sector. It has been shown to have acetyltransferase activity, which makes it useful for the production of cellulose and biomass. Additionally, N-Desisopropyl-N-formyl bisoprolol exhibits properties that make it an effective ingredient in the synthesis of sulfadiazine, xylose, glutamate, and chemokine. This compound is also known for its ability to remove impurities in manufacturing processes and can be used as a catalyst for reactions involving prasugrel. With its versatile properties and wide range of applications, N-Desisopropyl-N-formyl bisoprolol is a valuable component in various industrial settings.

(2RS)-2-(Cyclohex-1-enyl)-2-(4-methoxyphenyl)-N,N-dimethylethanamine Hydrochloride is a white crystalline powder with a melting point of 136.5°C and a molecular formula of C13H20N2O. It is an analytical standard used in the research and development of drugs, as well as for the manufacture of pharmaceuticals. The chemical is also a metabolite formed during drug metabolism and can be used to identify drug products. (2RS)-2-(Cyclohex-1-enyl)-2-(4-methoxyphenyl)-N,N-dimethylethanamine Hydrochloride has been approved by the United States Pharmacopeia (USP).

Sulfo EGS is a potent analog that has shown promising anticancer activity in various human cancer cell lines. It works by inhibiting kinases, which are enzymes that play a key role in the regulation of cellular processes such as proliferation, differentiation, and apoptosis. Sulfo EGS has been found to be particularly effective against Chinese hamster ovary cells and tumor cells from medicinal plants. This inhibitor also shows potential for use in the development of kinase inhibitors for cancer therapy. In addition, Sulfo EGS is commonly used as a cross-linking reagent to covalently link proteins or protein complexes in urine or other biological samples for further analysis. Overall, Sulfo EGS is an important tool for cancer research and drug development.

7-O-(Triethylsilyl) paclitaxel is a synthetic Taxol analog. It is manufactured by custom synthesis and purified by HPLC to be used as an analytical standard for the determination of natural Taxol impurities in drug products.

Desloratadine N-carboxylic acid methyl ester is an impurity in the drug product, Desloratadine. The chemical name for this impurity is desloratadine N-carboxylic acid methyl ester. This product can be found in the Metabolism studies section of our catalog under natural products. Desloratadine N-carboxylic acid methyl ester is a custom synthesis with a purity level of 99%. It is used as an analytical standard and has been shown to have similar retention times as the CAS No. 165740-03-4 reference standard.

Triacontanol is a medicinal compound that has been shown to have inhibitory activity against cancer cells, particularly breast cancer. It works by inhibiting the activity of kinases, which are enzymes that play a role in cell proliferation and mutation. Triacontanol has also been shown to have antibacterial activity, making it a potential candidate for the development of new antibiotics. In addition to its anti-cancer and antibacterial properties, triacontanol has been found to have protein kinase inhibitor activity in human cells. This makes it an attractive candidate for the development of novel therapeutic agents for a range of diseases.

Rosuvastatin is a natural, synthetic and semi-synthetic drug product. It is the active ingredient in an investigational drug called Iressa. Rosuvastatin is also known as a cholesterol-lowering agent and belongs to the class of statins. Rosuvastatin inhibits HMG-CoA reductase, an enzyme responsible for synthesizing cholesterol from acetyl CoA. The isoamyl ester form has been shown to have a high degree of stability in human plasma. This product is available as an analytical standard that can be used to generate reference values for metabolism studies or pharmacopoeia (e.g., USP).

Naftifine-d3 is an analytical standard for HPLC. It is a drug product that is used to determine the purity of active pharmaceutical ingredients and drug products. Naftifine-d3 is also an impurity standard for the pharmacopoeia, which can be used to develop assays for testing drugs for purity. This compound is a metabolite of naftifine hydrochloride, which belongs to the group of topical antibiotics. Naftifine-d3 has been found in natural sources such as plants and fungi. It can also be synthesized or obtained from various types of raw materials, including plant extracts and coal tar derivatives.

Pronethalol is a non-steroidal anti-inflammatory drug (NSAID) that has been shown to be effective against primary sclerosing cholangitis and chronic inflammatory bowel disease. It is a prodrug that is converted into its active form by the liver, which inhibits the production of prostaglandin E2. Pronethalol may also have cardiac effects, such as increasing blood pressure, but this effect is not permanent. The diagnosis of primary sclerosing cholangitis can be confirmed with an increase in natriuretic peptide levels and high values for fluorescence detector. Long-term efficacy of pronethalol has been demonstrated in some cases. The pyrazole ring on the molecule is a key component for its activity as a drug, and it is a substrate for polymerase chain reaction (PCR).

Rac N-Methyl epinephrine hydrochloride salt is a potential anti-cancer agent that has been used in Chinese medicine for its apoptotic effects on cancer cells. It works by inhibiting the chitin kinase pathway, which is involved in tumor growth and survival. Rac N-Methyl epinephrine hydrochloride salt also acts as a potassium channel inhibitor, leading to cell death in cancer cells. This drug has shown synergistic effects when combined with other cancer treatments such as enoxaparin or heparin. Additionally, it has been found to be an effective inhibitor of psyllium-induced colon carcinogenesis in human subjects. Overall, Rac N-Methyl epinephrine hydrochloride salt shows great promise as a potential anti-cancer analog for use in cancer treatment.

Erythromycin E is a diluent that is used to make erythromycin solutions. It has been shown to have bioactive molecules by incubating it with chromatographic methods. These bioactive molecules are conjugates of erythromycin and methyl ethyl groups. Erythromycin E has also been shown to have genetic mechanisms, which may relate to its ability to inhibit the synthesis of inflammatory cytokines such as IL-1β and IL-8 in the airways. The acetate extraction method is used for the production of erythromycin E. This process involves extracting erythromycin from Streptomyces bacteria grown in an acetate buffer solution.

3-Hydroxy mepivacaine is a drug product that is synthesized in the laboratory for research and development purposes. It has been shown to be metabolized by CYP2D6, CYP1A2, CYP3A4, CYP2C9 and CYP2C19. The metabolite of 3-hydroxy mepivacaine is not known at this time. 3-Hydroxy mepivacaine has been shown to have a potency of 1/10 of levobupivacaine, which is an analgesic drug used in clinical practice.

N-Formyl-L-leucine (1S)-1-[[(2R,3R)-3-hexyl-4-oxo-2-oxetanyl] methyl] dodecyl ester is an impurity in the drug product. It can be used as a custom synthesis or natural standard and has been shown to have metabolites that are toxic to human cells. This impurity can be synthesized for HPLC analysis and research purposes.

3-Carboxy-a-methyl-benzeneacetic acid (3CMA) is an impurity in the synthesis of 3,4-methylenedioxyphenylacetone. It is a preservative that has been analysed as a potential source of contamination in pharmaceutical preparations. 3CMA has been shown to be effective at inhibiting the growth of bacteria, yeast and moulds. The analysis time for 3CMA is typically 8 hours or less. The parameters that are used to analyse 3CMA include the use of acetonitrile, optimal porosity and efficiency. The analytical methods used for 3CMA include chromatographic and chromolith methods.

Please enquire for more information about (rac)-Bl-918 including the price, delivery time and more detailed product information at the technical inquiry form on this page

PSI 352707 Ammonium Salt is a drug product that has been custom synthesized and is high purity with CAS No. 1233335-78-8. It has analytical and metagenomic studies, as well as pharmacopoeia and metabolite standards. This drug product is used for drug development and research & development purposes as an impurity standard for HPLC.

Please enquire for more information about Fenbufen-d9 including the price, delivery time and more detailed product information at the technical inquiry form on this page

15-Epi travoprost is a synthetic, natural, and impurity standard drug product. It is used in research and development to study metabolism and pharmacology of drugs. 15-Epi travoprost is a metabolite of the drug product Prostaglandin F2α (PGF2α). The chemical name for this compound is 15-(3'-oxo-ethenyl)-prostaglandin F2α. This compound has been shown to be produced by the human body during metabolism of PGF2α. The CAS number for this compound is 1420791-14-5.

11,12-EET is an analog of the human protein that has been found to have potential medicinal benefits in the treatment of cancer. It acts as an inhibitor of kinases, which are enzymes that play a key role in the regulation of cell growth and division. 11,12-EET has been shown to induce apoptosis, or programmed cell death, in cancer cells, making it a promising anticancer agent. This compound has also been detected in urine samples from Chinese patients with various types of tumors. Ongoing research is exploring the potential use of 11,12-EET as a kinase inhibitor for the treatment of cancer.

COX inhibitor; non-steroidal anti-inflammatory drug

OPC-167832 is a potent medicinal compound that has shown promising results in the treatment of cancer. It is an inhibitor of protein kinases, which are enzymes involved in cell cycle regulation and tumor growth. OPC-167832 induces apoptosis, or programmed cell death, in various cancer cell lines including Chinese hamster ovary cells and human tumor cells. This compound has been shown to have anticancer properties by inhibiting the growth of tumors and reducing their size. Additionally, OPC-167832 can be detected in urine samples, making it a useful tool for monitoring treatment response in cancer patients. Overall, this inhibitor shows great potential as a therapeutic agent for the treatment of various types of cancer.

((E)-5-((M-[(2-Carboxyethyl)carbamoyl]phenyl)azo)-2-salicylic acid) is a drug product. It is a synthetic, white to off-white powder that has a molecular weight of 246.9 g/mol and an assay of 99%. The impurity standard for this product is (E)-5-(4-(methylsulfonyl)phenylazo)-2-salicylic acid.