APIs for research and impurities

2-Amino-N-(2-benzoyl-4-chlorophenyl)-N-methylacetamide is an impurity in the drug product, which is a metabolite of the active drug. It has been classified as a research and development compound and is used as an analytical standard for HPLC. This chemical has been shown to be metabolized in the liver by cytochrome P450 enzymes, generating metabolites that are excreted in urine. 2-Amino-N-(2-benzoyl-4-chlorophenyl)-N-methylacetamide exhibits pharmacological activity similar to other benzodiazepine drugs.

PSB-1584 is a medicinal analog that acts as an inhibitor of Chinese hamster ovary (CHO) cell tumor kinase (CHK). It has been shown to be effective in inhibiting the activity of various kinases, making it a promising anticancer drug. PSB-1584 has demonstrated potent anticancer activity in multiple cancer cell lines, including breast, colon, and lung cancer cells. This drug induces apoptosis in cancer cells and inhibits the growth of tumors. PSB-1584 can be detected in human urine after administration, indicating its potential for clinical use as an orally available protein kinase inhibitor.

5-(4-Methoxyphenyl)-3-methyl-1-oxa-3-azaspiro[5.5]undecane is an analytical standard used in HPLC and GC. It can also be used as a research and development standard or impurity to aid in the identification of compounds with similar structures. 5-(4-Methoxyphenyl)-3-methyl-1-oxa-3-azaspiro[5.5]undecane has a purity of 99% and a melting point of 80°C. The CAS number for this compound is 93413-70-8, and it is available for custom synthesis, natural, or synthetic production.

Varioxepine A is a research and development drug that has been proven to be a high purity, pharmacopoeia grade, custom synthesis, and synthetic. It is being developed as an impurity standard for analytical purposes. Varioxepine A has been shown to be metabolized through two pathways: N-demethylation and hydroxylation. The metabolites of this compound have not been fully characterized.

Sacubitril impurity 3 is a custom synthesis that is available in high purity. It has been used as an impurity standard for the drug sacubitril, which is being developed to treat heart failure. Sacubitril is metabolized by cytochrome P450 enzymes and can be detected using HPLC analysis. Sacubitril impurity 3 has been shown to be a metabolite of sacubitril in human liver microsomes and has also been found in rat urine following oral administration.

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(S)-4-(2-Methylpropyl)-2-pyrrolidinone is a lactam that has been synthesized in the laboratory. It is an organic solvent that is used in the synthesis of other compounds. The compound has a potential for producing impurities, such as isopropyl and phosphite, during synthesis. (S)-4-(2-Methylpropyl)-2-pyrrolidinone can be synthesized by reacting 2-methylpropionic acid with one equivalent of methylamine. This reaction takes place in an organic solvent and requires kinetic control to avoid side reactions.

Cis-Tadalafil is a potent inhibitor of phosphodiesterase 5, which is used to treat erectile dysfunction (ED) and primary pulmonary hypertension (PPH). It works by increasing blood flow to the penis, allowing men with ED to achieve and maintain an erection. Cis-Tadalafil is also used to treat symptoms of prostatic hyperplasia (enlarged prostate) in men. This drug has been shown to be effective in treating PPH by reducing pulmonary arterial pressure and improving exercise capacity. Cis-Tadalafil belongs to the carboline class of drugs and is a phosphodiesterase 5 inhibitor that selectively inhibits cGMP-specific phosphodiesterase type 5 (PDE5). This drug has been shown to be highly effective in treating both ED and PPH with minimal side effects.

Applications 3,5-Diiodo-4’-O-methyl Thyroacetic Acid Ethyl Ester is a derivative of 3,5-Diiodo Thyroacetic Acid (D455140), the acetic acid analog of Thyroxine (T425601). It is a reactant in the preparation of bifunctional thyrointegrin inhibitors, thyroxine (T425601) and triiodothyronine (T795380).
References Bridoux, A. et al.: J. Enz. Inh. Med. Chem., 26, 871 (2011); Wilkinson, J.: Biochem. J., 63, 601 (1956); Wilkinson, J.: Chem. Ind., 1352 (1955)

Applications epi-Glycochenodeoxycholic Acid Sodium Salt-d7 is a labelled epimer analogue of Glycochenodeoxycholic Acid Sodium Salt (G641255), which is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.
References Ollila, F., et al.: Langmuir, 17, 7107 (2001); Uekama, K., et al.: Chem. Pharm. Bull., 52, 900 (2004); Tongiani, S., et al.: J. Pharm. Sci., 94, 2380 (2005);

2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine is a cytosine analog that is used as an industrial chemical. It is prepared by the reaction of 5'-deoxycytidine with acetic anhydride in the presence of sodium bicarbonate, followed by a purification procedure. 2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine reacts with toluene and trifluoromethanesulfonic acid to form 2',3'-di-O-acetyl 5'-deoxyfluorocytidine. This compound can be converted to 5'-deoxyfluorocytosine by heating in the presence of sodium tetrachloride. The yield for this process is high.