APIs for research and impurities

10-{3-[4-(2-Chloro-ethyl)-piperazin-1-yl]-propyl}-2-trifluoromethyl-10H-phenothiazine is a nonselective, competitive antagonist of glutamate and quinpirole. It has been shown to block the glutamate receptors in the brain and reduce dopamine release. 10-[3-[4-(2-Chloro-ethyl)-piperazin-1-yl]-propyl]-2-trifluoromethylphenothiazine has a high affinity for the ryanodine receptor, which is found in the sarcoplasmic reticulum of striatal neurons. This drug also binds to calmodulin with high affinity, which may account for its ability to inhibit covalent adducts of dopamine to proteins. 10-[3-[4-(2-Chloro-ethyl)-piperazin-1-yl

Please enquire for more information about 3,4-o-Isopropylidenelincomycin including the price, delivery time and more detailed product information at the technical inquiry form on this page

Butanilicaine hydrochloride is a molecular weight heparin that is structurally related to the natural pentasaccharide sequence of heparin. Its anticoagulant activity is due to its ability to form a coordination complex with calcium in the presence of magnesium and other cations. Butanilicaine hydrochloride has been shown to have anti-inflammatory and angiogenic properties, which may be due to its inhibition of pro-inflammatory factors such as TNF-α and IL-1β. It also inhibits production of angiogenic factors, such as VEGF and HGF.

2,3,3',4,4',5,5'-Heptachlorobiphenyl is an analog of polychlorinated biphenyls (PCBs) that has been shown to have tumor-inhibiting properties. It acts as a kinase inhibitor and disrupts the cell cycle in cancer cells. Studies have also shown that it inhibits elastase activity and reduces the level of certain proteins in urine, indicating its potential use as an anticancer agent. Additionally, 2,3,3',4,4',5,5'-Heptachlorobiphenyl induces apoptosis in Chinese hamster ovary cells and human leukemia cells. Its unique characteristics make it a promising candidate for further research into cancer treatment options.

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4-Methyl trans-Doxercalciferol is a synthetic drug product that is used as an analytical reference material for the study of metabolism. It is a natural, API impurity, and synthetic metabolite that has been prepared as an impurity standard for HPLC analysis. 4-Methyl trans-Doxercalciferol has not been evaluated in living systems, but it may be useful in research and development of drugs, such as those used to treat cardiovascular disease. 4-Methyl trans-Doxercalciferol has shown no adverse effects in pharmacological studies.

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<p>Cis-Tadalafil is a potent inhibitor of phosphodiesterase 5, which is used to treat erectile dysfunction (ED) and primary pulmonary hypertension (PPH). It works by increasing blood flow to the penis, allowing men with ED to achieve and maintain an erection. Cis-Tadalafil is also used to treat symptoms of prostatic hyperplasia (enlarged prostate) in men. This drug has been shown to be effective in treating PPH by reducing pulmonary arterial pressure and improving exercise capacity. Cis-Tadalafil belongs to the carboline class of drugs and is a phosphodiesterase 5 inhibitor that selectively inhibits cGMP-specific phosphodiesterase type 5 (PDE5). This drug has been shown to be highly effective in treating both ED and PPH with minimal side effects.</p>

<p>(S)-4-(2-Methylpropyl)-2-pyrrolidinone is a lactam that has been synthesized in the laboratory. It is an organic solvent that is used in the synthesis of other compounds. The compound has a potential for producing impurities, such as isopropyl and phosphite, during synthesis. (S)-4-(2-Methylpropyl)-2-pyrrolidinone can be synthesized by reacting 2-methylpropionic acid with one equivalent of methylamine. This reaction takes place in an organic solvent and requires kinetic control to avoid side reactions.</p>

nicotinic acetylcholine receptor antagonist

<p>Applications epi-Glycochenodeoxycholic Acid Sodium Salt-d7 is a labelled epimer analogue of Glycochenodeoxycholic Acid Sodium Salt (G641255), which is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.<br>References Ollila, F., et al.: Langmuir, 17, 7107 (2001); Uekama, K., et al.: Chem. Pharm. Bull., 52, 900 (2004); Tongiani, S., et al.: J. Pharm. Sci., 94, 2380 (2005);<br></p>

<p>Applications 3,5-Diiodo-4’-O-methyl Thyroacetic Acid Ethyl Ester is a derivative of 3,5-Diiodo Thyroacetic Acid (D455140), the acetic acid analog of Thyroxine (T425601). It is a reactant in the preparation of bifunctional thyrointegrin inhibitors, thyroxine (T425601) and triiodothyronine (T795380).<br>References Bridoux, A. et al.: J. Enz. Inh. Med. Chem., 26, 871 (2011); Wilkinson, J.: Biochem. J., 63, 601 (1956); Wilkinson, J.: Chem. Ind., 1352 (1955)<br></p>

<p>2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine is a cytosine analog that is used as an industrial chemical. It is prepared by the reaction of 5'-deoxycytidine with acetic anhydride in the presence of sodium bicarbonate, followed by a purification procedure. 2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine reacts with toluene and trifluoromethanesulfonic acid to form 2',3'-di-O-acetyl 5'-deoxyfluorocytidine. This compound can be converted to 5'-deoxyfluorocytosine by heating in the presence of sodium tetrachloride. The yield for this process is high.</p>

Glycopyrrolate related B is a drug product that belongs to the class of drugs for research and development. It is a natural metabolite of glycopyrrolate and is used as an analytical standard. The metabolite can also be used as a synthetic intermediate or impurity standard in pharmaceutical production. It has been shown that glycopyrrolate related B has niche applications in drug development and metabolism studies. Glycopyrrolate related B is not found in the pharmacopeia, but it can be synthesized by reacting the corresponding amine with pyrrole-2-carboxaldehyde.

<p>5,6-Dehydro-tigecycline is a synthetic antibiotic that is used for the treatment of multi-drug resistant bacterial infections. 5,6-Dehydro-tigecycline binds to the 30S ribosomal subunit and blocks protein synthesis by inhibiting peptidyl transferase activity. This drug has been shown to be effective in treating methicillin resistant Staphylococcus aureus (MRSA) infections. 5,6-Dehydro-tigecycline also inhibits the growth of Mycobacterium tuberculosis and Mycobacterium avium complex, although it is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex. Metabolism studies have shown that 5,6-Dehydro-tigecycline undergoes oxidative metabolism via CYP450 enzymes to form reactive metabolites like N2-[(</p>

<p>Please enquire for more information about Vildagliptin carboxylic acid methyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Rosuvastatin (3R,5R) isomer calcium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

N-Succinyl-L-tyrosine is a synthetic compound that is used as an impurity standard for the determination of the purity and quality of drug products. It is also used in research and development to study metabolism. N-Succinyl-L-tyrosine is a metabolite of tyrosine, which has been shown to be an important intermediate in the biosynthesis of some neurotransmitters and hormones. This product can be used in HPLC assays to provide a standard curve for quantification.

<p>Descarboxyl febuxostat is a synthetic drug that is metabolized to its active form, febuxostat. This drug product has been custom synthesized and is of high purity. Descarboxyl febuxostat has been used in the development of drugs for hypertension, hypercholesterolemia, and gout. It has also been used as a research tool for studying the metabolism of drugs in humans.</p>