Pharmaceutical and Veterinary Compounds and Metabolites

<p>NE58018 is a compound which has bioactive.</p>

<p>Cyclanilide is a plant growth regulator. It is used in cotton at different stages of growth.</p>

<p>Deacetyldiltiazem is a metabolite product of Diltiazem which is a coronary vasodilator, and is present in the plasma of individuals taking Diltiazem.</p>

<p>Olopatadine is an antihistamine and anti-allergy medication for itchy eyes, also possibly treats red skin syndrome.</p>

<p>Larsucosterol, a cholesterol metabolite in human liver, modulates lipid synthesis, inflammation, and apoptosis gene transcription.</p>

<p>Normetanephrine, an endogenous metabolite found in cerebrospinal fluid, has applications in hypertension research [1] [2].</p>

<p>β-Muricholic acid (β-MCA) is a murine-specific primary bile acid.[1],[2] Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.[3] Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.[4]</p>

<p>11β-Prostaglandin F2α is a bioactive metabolite catalyzed by AKR1C3 that stimulates prostaglandin F receptors and induces slug expression in breast cancer.</p>

<p>(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME , a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin.</p>

<p>Nicotinamide-d4 is a deuterium-labelled compound of nicotinamide for isotope tracing. Nicotinamide, a vitamin B3 derivative, inhibits SIRT1 and SIRT2.</p>

<p>15-keto Prostaglandin F2α is a metabolite of Prostaglandin F2α that lowers intraocular pressure in rabbits.</p>

<p>12-Doxyl stearic acid, a derivative of stearic acid featuring a 4,4-dimethyl-3-oxazolinyloxy (DOXYL) group, functions as a hydrophobic spin label. This compound is prevalently utilized in research to investigate the molecular characteristics of membranes and hydrophobic proteins.</p>

<p>α-Laurodimyristin, a triacylglycerol, comprises myristic acid and lauric acid [1].</p>

Indole-2,4,5,6,7-d5-3-acetic-2,2-d2 Acid is a deuterated compound of Indole-3-acetic Acid. Indole-3-acetic Acid has a CAS number of 87-51-4. 3-Indoleacetic acid (IAA) is the most common plant hormone of the auxin class and it regulates various aspects of plant growth and development.

<p>Indole-3-methanamine has been detected, but not quantified in, barley, cereals, and cereal products.</p>

1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine is an endogenous metabolite.

<p>PNU-200579 is a bio-active chemical.</p>

<p>H-Arg-Lys-OH is a dipeptide formed from L-lysine residues and L-arginyl.</p>

IA-14069 is a TNF-a inhibitor with anti-inflammatory activity and pro-inflammatory cytokine production, and is used in the study of colon cancer.

<p>Ranelic acid chelates metals; its strontium salt treats osteoporosis, boosting bone density.</p>

<p>1,2-Dipalmitoyl-sn-glycerol 3-phosphate, a phosphatidic acid, is a human endogenous metabolite.</p>

<p>Nicodan Percutan (Propylnicotinat) is the propyl ester form of niacin, which is found in various animal and plant tissues to form the coenzymes NAD and NADP.</p>

<p>GS-566500 is a compound of Sofosbuvir metabolite.</p>

<p>PAT-494 is an inhibitor of type II Autotaxin.</p>

<p>Lauramide propyl amine oxide is an amphoteric surfactant</p>

Tetrachlorvinphos, an organophosphate cholinesterase inhibitor, is used as an insecticide. It has low toxicity to mammals.

<p>5'-GTP disodium salt boosts myogenic differentiation and fuels cellular processes.</p>

<p>Thevetin A is a useful organic compound for research related to life sciences. The catalog number is T124930 and the CAS number is 37933-66-7.</p>

Meclofenamic acid: non-selective gap-junction blocker, FTO inhibitor, anti-inflammatory.

<p>PTC-510 TFA salt inhibits hypoxia-induced VEGF expression.</p>

<p>Applications Metomidate is a the methyl ester analogue of Etomidate (E933300), with sedative and hypnotic properties. Metomidate is mainly used as an anesthetic for veterinary use on its own or in combination with Azaperone (A802200) and other sedatives.<br>References Mgasa, M.N. et al.: J. Vet. Med. Ser. A, 36, 225 (1989); Roztocil, V. et al.: Acta Vet. Brno, 41, 339 (1972); Mattson, N.S. et al.: Aquaculture, 83, 89 (1989);<br></p>

<p>3-Phenylbutyric acid, from compost soil, metabolizes via benzene and side-chain oxidation.</p>

<p>Deoxycorticosterone, an adrenal steroid, is an aldosterone precursor with mineralocorticoid effects.</p>

<p>1-Decanesulfonic acid (Decane-1-sulfonic acid) is a potential amyloid beta peptide (Aβ40) inhibitor, useful for studying cardiovascular diseases.</p>

MIPS1455 is a photoactivatable allosteric M1 muscarinic acetylcholine receptor ligand.

<p>JBP485 is an inhibitor of renal transporters OAT1 and OAT3. JBP485 is an antihepatitis agent as a substrate for intestinal PEPT1.</p>

<p>KB 5666, a quinazoline derivative, is a lipid peroxidation inhibitor. It protects the brain from both cellular and functional consequences of ischemia.</p>

<p>MitoPBN: mitochondria-targeted antioxidant, inhibits UCP1-3 at 250 nM, traps hydroxyl &amp; carbon radicals, prevents lipid peroxidation.</p>

<p>N-Acetylhistamine (N-Omega-acetylhistamine) is a metabolite of histamine.</p>

<p>Cholesteryl palmitoleate, a cholesterol ester, exhibits elevated plasma levels in ApoE-/- mice following exposure to cigarette smoke and in pediatric patients diagnosed with biliary atresia. It serves as a standard for identifying cholesterol esters in human meibomian gland secretions.</p>

<p>Levophencynonate HCl is a muscarinic receptor antagonist.</p>

<p>Glutamamide is an anticancer drug.</p>

<p>CAY10762, a MAGL inhibitor (IC50=34.1 nM), curbs H2O2-induced LDH in Neuro2a cells and boosts 2-AG in mouse brains at 10 mg/kg.</p>

<p>Benanserin HCl is a serotonin antagonist. It causes psychotropic effects in humans.</p>

<p>Eprozinol dihydrochloride has anti-bronchoconstrictive activity.</p>

STF-038533 is an inhibitor of CREB target gene transcription.

<p>MDK-4683, also known as CA IX/XII Inhibitor, is a hCA IX and hCA XII inhibitor.</p>

<p>ADP disodium salt blocks serotonin binding to 5-HT2 receptors in the heart.</p>