Amino Acids (AA)

<p>Applications A Boc-protected bifunctional linking reagent.<br>References Jimenez-Castells, C., et al.: Bioorg. Med. Chem. Lett., 17, 5155 (2007), Carmona, S., et al.: Mol. Pharm., 6, 706 (2009), Nagahori, N., et al.: Biochem., 48, 583 (2009),<br></p>

<p>Applications 5'-O-Methylthymidine (cas# 14504-60-0) is a useful research chemical.<br></p>

<p>Applications 3-Methyl-2-furoic Acid-d is a deuterated version of 3-Methyl-2-furoic Acid (M219553), a useful reactant in the synthesis of therapeutic agents.<br>References Dragovich, Peter S., et al.: Bioorg. &amp; Med. Chem. Let., 24(3), 954-962 (2014);Garcia-Barrantes, Pedro M., et al.: J. of Med. Chem., 58(20), 7959-7971 (2015)<br></p>

<p>Applications An essential amino acid found in naturally produced peptides. Unlike its stereoisomer, L-tryptophan, it is not used in structural or enzyme proteins.<br>References Karunakaran, S.et al.: Bochem. J., 414, 343 (2008); Pallaghy, P.K. et al.: Biochem., 38, 11553 (1999);<br></p>

<p>Stability Hygroscopic<br>Applications A labelled metabolite of Methyl isocyanate.<br>References Slatter, J. G., et al.: Chem. Res. Toxicol., 4, 157 (1991),<br></p>

<p>Applications α-Chloro-p-methyltoluene is a building block that has been used as a reactant for the preparation of 6-aminoquinolone derivatives as submicromolar hepatitis C virus NS5B inhibitors<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Manfroni, G., et. al.: J. Med. Chem., Ahead of Print (2013)<br></p>

<p>Stability Hygroscopic<br>Applications L-Saccharopine is a product of breakdown of essential amino acid Lysine (L468895). Saccharopine is also part of the α-aminoadipate pathway of fungal lysine biosynthesis.<br>References Higashino, K., et al.: Biochem. Biophys. Res. Commun., 20, 285 (1965); Johansson, E., et al.: Structure, 8, 1037 (2000)<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-Acetate 4-Methanesulfonate 1,4-Butanediol is used in the facile cleavage of ethers. A Busulfan Impurity<br>References Mazur, Y., et al.: J. Org. Chem., 36, 532 (1971);<br></p>

<p>Applications Naphthalenecarboxylic acid derivatives known for their antidote activity against urea and other herbicides.<br></p>

<p>Applications (4S)-4-Hydroxy-L-isoleucine is 4S isomer of 4-Hydroxyisoleucine, which is used as a treatment for type II diabetes.<br>References Martinez-Force, E., et al.: Biotechnol. Tech., 5, 209 (1991); Sauvaire, Y., et al.: Diabetes, 47, 206 (1998), Narender, T., et al.: Bioorg. Med. Chem. Lett., 2006, 16, 293 (2006);<br></p>

<p>Applications 4,4'-Methylenebis(2,6-dimethylphenol) is used in thermosetting resin composition for the industrial manufacture of metal-clad laminates and printed circuit boards.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References You, J., et al.: Faming Zhuanli Shenqing. 19 pp. (2019)<br></p>

<p>Applications 2-Hydroxy-3-methylbutyric Acid is a α-hydroxylated butyric acid derivative used as a marker in chemical diagnosis of organic aciduria and other inborn errors. 2-Hydroxy-3-methylbutyric Acid is also used as a metabolomic biomarkers in preeclampsia.<br>References Nakagawa, K. et al.: J. Chrom. B Anal. Technol. Biomed. Life Sci., 878, 942 (2010); Kenny, L.C. et al.: Reprod. Sci., 15, 591 (2008); Garcia, A. et al.: Clin. Chem., 44, 1905 (1999);<br></p>

<p>Applications Pteroyltri-γ-L-glutamic acid is a folate derivative found in various foods such as yeast, spinach, beef liver, beef fillet and peas.<br>References Tamura, T., et al.: Br. J. Haematol., 25, 513 (1973); Ndaw, S., et al.: J. Chromatogr. A, 928, 77 (2001)<br></p>

<p>Applications Ethametsulfuron-methyl is a regulator of the early steps of complement activation on mucosal surfaces. It can be used in combination treatment of ohmic heating with various essential oil components for inactivation of food-​borne pathogens in buffered peptone water and salsa.<br>References Kim, S. S., et al.: Food Control, 80, 29 (2017); Reichhardt, M. P., et al.: Front Immunol, 7, 85 (2016)<br></p>

<p>Applications A metabolite of S-propylcysteine.<br>References Jones, A.R., et al.: Xenobiotica, 10, 827 (1980), 25) Ramu, K., et al.: Chem. Res. Toxicol., 8, 515 (1995), Krause, R., et al.: Drug Metab. Dispos., 25, 1013 (1997), Powley, M., et al.: Chem. Res. Toxicol., 16, 1448 (2003),<br></p>

<p>Applications An intermediate in the preparation of Ethosuximide.<br></p>

<p>Applications N-Methyl-d3-formamide (CAS# 87955-92-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Thiodiglycolic Acid-d4 acts as a reagent for the synthesis of metabolites of S-carboxymethyl-L-cysteine and S-methyl-L-Cysteine and of some isotoically labelled (2H, 13C) analogs.<br>References Meese, C. O., et al.: Archiv der Pharmazie, 323, 957 (1990)<br></p>

<p>Applications N-t-Boc-2-bromoethylamine (Technical grade, ~90%) (cas# 39684-80-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Methyl-d3-catechol (CAS# 83719-41-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Methylenepiperidine Hydrochloride is a building block that can be coupled with aryl halides via Suzuki cross-coupling to give benzyl piperidines and related compounds.<br>References Vice, S., et al.: J. Org. Chem., 66, 2487 (2001);<br></p>

<p>Applications 3-Hydroxy-4-methylaniline<br></p>

<p>Applications 4-Methyldibenzothiophene, is an alkyldibenzothiophene present in crude oil. Research concerning the biodegradation of Dibenzothiophene by different types of bacteria is a currently being carried out, as these bacteria have the ability to breakdown other harmful PAH’s as well. This may be used in removing spilled oil from marine and terrestrial environments.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boberg, F., et al.: Erdoel &amp; Kohle, Erdgas, Petrochemie, 47, 187 (1994); Tanaka, Y., et al.: Applied Microbiology and Biotech., 59 (2), 325 (2002); Prince, R., Spill Sci. Tech. Bulletin, 8 (2), 145 (2003);<br></p>

<p>Applications N-Acetyl-L-phenylalanine is an protected analogue of L-Phenylalanine (P319415), an essential amino acid produced for medical, feed, and nutritional applications such as in the preparation of Aspartame.<br>References Sriram, S., et al.: J. Med. Chem., 56, 2540 (2013); Parker, B.M., et al.: J. Biotech., 155, 396 (2011);<br></p>

<p>Applications D,L-o-Tyrosine is a metabolite of Phenylalanine (P319415). A precursor in the formation of catecholamines. Used as biomarkers of protein oxidative damage in β-thalassemia.<br>References Tsugita, A., et al.: Eur. J. Biochem., 124, 585 (1982), Nielsen, F., et al.: Clin. Chem., 43, 1209 (1997), Mates, J., et al.: Clin. Biochem., 32, 595 (1999),<br></p>

<p>Applications 4-Methoxyresorcinol (cas# 6100-60-3) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications Pantothenic Acid is a member of the B complex vitamins; essential vitamin for the biosynthesis of coenzyme A in mammalian cells. Occurs ubiquitously in all animal and plant tissue. The richest common source is liver, but jelly of the queen bee contains 6 times as much as liver. Rice bran and molasses are other good sources.<br>References Gardner, P., et al.: Food Chem., 68, 471 (2000); Ou, B., et al.: J. Agric. Food Chem., 50, 2772 (2002); Bahorun, T., et al.: J. Sci. Food Agric., 84, 1553 (2004)<br></p>

<p>Applications 1-BOC-2,3-Dihydropyrrole-4-boronic acid, pinacol ester is a useful research chemical for organic synthesis and other chemical processes.<br>References Lewis, R. T., et al.: From PCT Int. Appl. (2017), WO 2017004359 A1 20170105<br></p>

<p>Applications Intermediate in transsulfuration whereby the mammal transfers the sulfur of methionine via homocysteine to cysteine.<br>References Prochazka, Z., et al.: Collection Czechoslov. Chem. Commun., 45, 1982 (1980), Yorek, M.A. &amp; Spector, A.A.: Prog. Clin. Biol. Res., 179, 361 (1985)<br></p>

<p>Stability Hygroscopic<br>Applications 5-Methyl-2-furanmethanol (cas# 3857-25-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Hydroxy-O-methyl-L-tyrosine Hydrochloride is used in the preparation of tyrosine-based components of natural products such as saframycin MX1 and its analogs, which are naturally potent anti-tumor agents currently under clinical development.<br>References Schmidt, E.W.; et al.: Tetrahedron Lett, 45, 3921 (2004); Nelson, J.T.; et al.: AEM, 73, 3575 (2007)<br></p>

<p>Applications 2-Methyldibenzothiophene, is an alkyldibenzothiophene present in crude oil. Research concerning the biodegradation of Dibenzothiophene by different types of bacteria is a currently being carried out, as these bacteria have the ability to breakdown other harmful PAH’s as well. This may be used in removing spilled oil from marine and terrestrial environments.<br>References Boberg, F., et al.: Erdoel &amp; Kohle, Erdgas, Petrochemie, 47, 187 (1994); Tanaka, Y., et al.: Applied Microbiology and Biotech., 59 (2), 325 (2002); Prince, R., Spill Sci. Tech. Bulletin, 8 (2), 145 (2003);<br></p>

<p>Applications 9-(N-Methylaminomethyl)anthracene is a reactant that has been used in the synthesis of anthracene-oxyquinoline dyad as a fluorescent indicator for Hg(II).<br>References Praveen, L., et. al.: Tetrahedron Lett., 53, 3951 (2012)<br></p>

<p>Applications 7-Methoxy-3,4-dihydro-1-naphthalenyl-acetonitrile (cas# 861960-34-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(3-Methoxypropyl)-4-piperidinamine is a useful synthetic intermediate in the synthesis of Prucalopride Succinate (P838950); a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe.<br>References Shah, N., et al.: Am. J. Gastroenterol., 103, 1746 (2008); McKinnell, R., et al.: J. Med. Chem., 52, 5330 (2009); Shah, N., et al.: Am. J. Gastroenterol., 103, 1746 (2008); Yuan, Y., et al.: Zhongguo Yiyao Gongye Zazhi, 43, 5 (2012)<br></p>

<p>Applications 4,4'-Methylenedianiline is used in the production of polyurethane foams and epoxy resins (1). Potential contributor in pulmonary arterial hypertension (PAH) in rats through alteration of the serotenergic transport system (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Dyes and metabolites, Environmental Testing.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Hebert V. et al.: Cardiovas. Toxicol., 2011 Dec;11(4):316-24.2. Carroll-Turpin, M. et al.: Toxicol. Sci. 2015 Sep;147(1):235-45<br></p>

<p>Applications Potassium 2-hydroxy-4-methoxybenzoate (cas# 152312-71-5) is a useful research chemical.<br></p>

<p>Applications 3-Methyl-1-butyl-d11 Alcohol (CAS# 170678-50-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications The urinary 1- and 3-methylhistidine (1- and 3-MH) metabolites as potential biomarkers of skeletal muscle toxicity. These metabolites were highly correlated to sex-, dose-, and time-dependent development of cerivastatin-induced myotoxicity. Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.<br>References Berna, M., et al.: Anal. Chem., 79, 4199 (2007), Pritt, M., et al.: Toxicol. Sci., 103, 382 (2008), Tonomura, Y., et al.: Toxicology, 266, 48 (2009),<br></p>

<p>Applications H-D-Ala-D-Leu-OH (cas# 67392-69-2) is a useful research chemical.<br></p>

<p>Impurity Azathioprine EP Impurity C<br>Applications 5-Chloro-1-methyl-4-nitroimidazole (cas# 4897-25-0) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications L-Formiminoglutamic acid is a useful research chemical. It is used medically in the diagnosis of Cobalt deficiencies in Cattle and sheep.<br>References Marsh, K. B., et al.: New Zeal. J. Agric. Res., 31, 273 (1988); Quirk, M. F., et al.: J. Agric. Sci., 110, 465 (1988); Quirk, M. F., et al.: Aust. J. Agric. Res., 38, 1071 (1987)<br></p>

<p>Applications 4-Methyl-2(5H)-furanone (cas# 6124-79-4) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Catecholamines.<br>References Kopin, I.J., et al.: J. Biol. Chem., 236, 2109 (1961), Short, F.W., et al.: J. Med. Pharm. Chem., 5, 642 (1962)<br></p>

<p>Applications 5-Amino-6-methylbenzimidazolone<br></p>

<p>Impurity Flumazenil EP Impurity E<br>Applications Ethyl 5-Methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate (Flumazenil EP Impurity E) is used in the biological studies and preparation of imidazobenzodiazepines as probes for diazepaminsensitive receptor pharmacophore.<br>References Zhang, P., et al.: J. Med. Chem., 38, 1679 (1995)<br></p>

<p>Applications 1-(4-Hydroxy-3-methoxyphenyl)-1-propanone is a derivative of Guaiacol, a precursor to various flavorants, such as eugenol and vanillin.<br>References Allen, C., et al.: Org. Synth., 3, 418 (1955); Esposito, L., et al.: Kirk-Othmer Encyclopedia of Chemical Technology, 4th edition, 24, 812 (1997)<br></p>

<p>Applications Protected 1,2-Phenyldiamine, an intermediate in the synthesis of histone deacetylase agents and antitumor agents.<br>References Andrews, D., et al.: Bioorg. Med. Chem. Lett., 18, 2580 (2008), Mahboobi, S., et al.: J. Med. Chem., 52, 2265 (2009),<br></p>

<p>Applications L-Ornithine-2,3,3,4,4,5,5-d7 hydrochloride is the labelled analogue of L-Ornithine Hydrochloride (O695550), a non-essential amino acid for human development but is required intermediate in arginine biosynthesis. L-Ornithine is found in virtually all vertebrate tissues as well as incorporated into proteins, such as tyrocidine. Isolation from chicken excreta.<br>References Fattori, D., et al.: J. Med. Chem., 50, 550 (2007), Gomez-Alonso, S., et al.: J. Agric. Food Chem., 55, 608 (2007), Subramaniam, R., et al.: Bioorg. Med. Chem. Lett., 18, 3333 (2008),<br></p>

<p>Applications A proteinogenic amino acids involved in the biosynthesis of purines and pyrimidines. Inhibitor of serine palmitoyltransferase. A neuromodulator.<br>References Junjaud, G. et al.: J. Neurochem., 98, 1159 (2006); Hanada, K. et al.: FEBS Lett., 474, 63 (2000); Pollegionni, L. et al.: Cell. Mol. Life Sci., 67, 2387 (2010);<br></p>

<p>Impurity Verapamil EP Impurity K<br>Applications (Verapamil EP Impurity K)<br></p>

<p>Applications 2-ethyl-6-methylpyrazine (cas# 13925-03-6) is a useful research chemical.<br></p>

<p>Applications 3-Mercapto-3-methylbutyl formate is one of the major odor-active thiol in pan-roasted white sesame seeds.<br>References Czerny, M., et al.: J .Agric. Food Chem., 47, 695 (1999), Steinhaus, M., et al.: Eur. Food Res. Technol., 226, 45 (2007), Tamura, H., et al.: Agric. Food Chem., 2010, 58, 7368 (2010),<br></p>

<p>Applications N-Methyl-L-alanine is a reactant used in the preparation of site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity.<br>References Pillow, T.H., et. al.: J. Med. Chem., 57, 7890 (2014)<br></p>

<p>Stability Hygroscopic<br>Applications Used as a substrate for methionine adenosyltransferase from rat liver.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lombardini, J.B., et al.: Biochem. Pharmacol., 32(3), 489 (1983), Kajander, E., et al.: Cancer Res., 46 (6), 2866 (1986), Kajander, E., et al.: Biochem. J., 267 (3), 767 (1990)<br></p>

<p>Applications L-Tyrosine-13C9 ,15N is labelled analogue of L-Tyrosine (T899975), one of the 22 proteinogenic amino acids that are used by cells to synthesize proteins. L-Tyrosine is biologically converted from L-phenylalanine and is in turn is converted to L-DOPA and further converted into the neurotransmitters: dopamine, norepinephrine, and epinephrine.<br>References Rasmussen D.D. et al.: J. Clin. Endocrinol. Metab., 57, 760 (1983); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977)<br></p>

<p>Applications L-Homocysteine Thiolactone Hydrochloride is used to prepare substituted homocysteine analogs as inhibitors of peptidylglycine α-amidating monooxygenase. It is also used to synthesize (mercaptoacyl)alanylprolines as metalloprotease inhibitors.<br>References Erion, M., et al.: J. Med. Chem., 37, 4430 (1994); Slusarchyk, W., et al.: Bioorg. Med. Chem. Lett., 5, 753 (1995)<br></p>

<p>Applications N-(2-Methyl-1-phenylpropan-2-yl)acetamide is a byproduct from the preparation of benzolactams by palladium-catalyzed carbonylation of arylethylamines and α-amino benzenepropanoates.<br>References Lopez, B., et al.: Chem. Commun., 47, 1054 (2011); Albert, J., et al.: Organometallics, 32, 649 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Isotope labelled 1,6-Anhydro-β-D-glucopyranose (A648100), an compound that have been proven to be a valuable synthon for the preparation of various biologically important and structurally diverse products (e.g. rifamycin S, indanomycin, thromboxane B2, (+)-biotin, tetrodotoxin, quinone, and macrolide antibiotics) as well as for modified sugars.<br>References Fraser-Reid, B., et al. J. Am. Chem. Soc. 106, 731 (1984); Edwards, M.P., et al. J. Org. Chem. 49, 3503 (1984); Kelly, A.G., and Roberts, J.S. J. Chem. Soc., Chem. Commun. 228, (1980); Ogawa, T., et al. Carbohydr. Res. 57, C31 (1977); Isobe, M., et al. Tetrahedron Lett. 28, 6485 (1987);<br></p>

<p>Applications (E)-Ethyl 4-Bromo-3-methyl-2-butenoate (cas# 51318-62-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Methyluracil (cas# 615-77-0) is a compound useful in organic synthesis.<br></p>

<p>Applications (E)-3-Methoxy-5-styrylphenol (cas# 35302-70-6) is a useful research chemical.<br></p>

<p>Applications 5-((2-Hydroxyethyl)amino)-2-methylphenol (cas# 55302-96-0) is a useful research chemical.<br></p>