Amino Acids (AA)

<p>Applications A product from thermal and hydrolytic degradation of Orlistat. Orlistat impurity.<br>References Stalder, H., et al.: Helv. Chimica Acta, 75, 1593 (1992),<br></p>

<p>Applications 2-Methoxypropyl Acetate causes moderate irritation, significant reduction in body weight development and thymic atrophy in rats as well as pronounced prenatal toxicity in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ma-Hock, L., et al.: Hum. Exp. Toxicol., 24, 95-99 (2005)<br></p>

<p>Applications A synthetic intermediate.<br>References Blakemore, R., et al.: Eur. J. Med. Chem., 22, 91 (1987),<br></p>

<p>Applications Valeric Acid Sodium Salt (cas# 6106-41-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Deoxy-2-chloro-D-glucose is a D-Glucose (G595000) derivative used in the synthesis of sugar nucleotides and oligosaccharides.<br>References Herr, D., et al.: Euro. J. App. Microbiol., 1, 41 (1975);<br></p>

<p>Applications A reagent used to synthesize 5-HT2A and 5-HT3 receptor ligands for use in treating CNS-related disorders.<br>References Bermudez, J., et al.: J. Med. Chem., 33, 1924 (1990),<br></p>

<p>Impurity Piroctone USP Related Compound B<br>Applications 4-Methyl-6-(2,4,4-trimethylpentyl)-2H-pyran-2-one is used in the synthesis of antibacterials and antimycotics. Related to Piroctone (P509400), an anti-dandruff agent used in shampoo formulations. Piroctone USP Related Compound B<br>References Georgalas, A. et al.: J. Cosm. Sci., 55, S207 (2004); Mayser, P. et al.: J. Cosm. Sci., 54, 263 (2008);<br></p>

<p>Applications 4,5-Dihydro-5-methyl-3,4-diphenyl-5-isoxazolol is an intermediate for the preparation of Valdecoxib.<br></p>

<p>Applications L-Aspartyl-L-phenylalanine is an impurity of Thiamine (T344185). Thiamine Impurity B.<br>References Aluwihare, L., et al.: Science, 308, 1007 (2005), Koch, B., et al.: Anal. Chem., 79, 1758 (2007), Reemtsma, T., et al.: Environ. Sci. Technol., 42, 1430 (2008),<br></p>

<p>Stability Very Hygroscopic<br>Applications A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells.<br>References Vallence, P., et al.: Lancet, 339, 572 (1992),<br></p>

<p>Applications alpha-Methylene-gamma-valerolactone (cas# 62873-16-9) is a useful research chemical.<br></p>

<p>Applications A labelled derivative of Dibarbituric acid.<br>References Hitchings, G.H., et al.: J. Biol. Chem., 177, 357 (1949),<br></p>

<p>Applications Isotope labelled L-Serine is used in the synthesis of purines and pyrimidines as antibacterial/antifungal agents, as well as acting as a proteinogenic compound.<br>References Olivella, M. et al.: Bioorg. Med. Chem., 20, 6109 (2012);<br></p>

<p>Applications 3-Methyl-1-butyl-d11 Alcohol (CAS# 170678-50-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Ethyl-2-methyl-2-(3-methylbutyl)-oxazolidine is a oxazolidine-based moisture scavenger for use in urethane coatings, sealants and elastomers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Naphthalenecarboxylic acid derivatives known for their antidote activity against urea and other herbicides.<br></p>

<p>Applications Dl-leucine<br></p>

<p>Applications A red azoic dye. Dyes and metabolites, Environmental Testing<br>References Hoover, K., et al.: Chem. Res. Toxicol., 18, 1497 (2005), Altenburger, R., et al.: Environ. Toxicol. Chem., 24, 324 (2005), Gonzalez, M., et al.: Bioorg. Med. Chem., 13, 1775 (2005),<br></p>

<p>Applications 2-Methoxytetrahydrofuran is a reactant in the preparation of ruthenium(III) chloro benzimidazolylmethylamine derivative complexes as oxidation catalysts.<br>References Murali, M., et. al.: Eur. J. Inorg. Chem., 22, 3238 (2009)<br></p>

<p>Applications Intermediate in transsulfuration whereby the mammal transfers the sulfur of methionine via homocysteine to cysteine.<br>References Prochazka, Z., et al.: Collection Czechoslov. Chem. Commun., 45, 1982 (1980), Yorek, M.A. &amp; Spector, A.A.: Prog. Clin. Biol. Res., 179, 361 (1985)<br></p>

<p>Applications N-Methyltaurine Sodium Salt is used in the analysis of the changing properties of anionic surfactants and the development of new skin cleansers or soaps. It is the salt of N-Methyltaurine, a compound used in sperm cryopreservation studies. N-Methyltaurine is also used in the studies relating to effects on oxidative damage to erythrocytes via phenylhydrazine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pokhrel, P.K. et al.: Adv. Exp. Med. Biol., 483, 503 (2000); Miyahara, R. et al.: Fragr. J., 28, 11 (2000); Garde, J.J. et al.: Bio. Repro., 69, 602 (2003);<br></p>

<p>Impurity Ondansetron EP Impurity C<br>Applications 1,2,3,9-Tetrahydro-9-(methyl-d3)-4H-carbazol-4-one (Ondansetron EP Impurity C) is used in the preparation of 5-HT3 modulators useful in the treatment and prevention of 5-HT3 receptor-mediated diseases. 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one is an impurity of Ondansetron (O655000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Huang, W. et al.: Zhong. Yao. Dax. Xueb., 30, 1 (1999); Kim, M. et al.: Heterocycles, 45, 2041 (1997); Feng, R. et al.: Zhong. Yaox. Zaz., 46, 1436 (2011);<br></p>

<p>Stability Hygroscopic, Moisture Sensitive<br>Applications Hexahydro-4-methylphthalic Anhydride, can be used in the mixture of other isomers nanofiber supported 3D interconnected BN nanosheets for epoxy nanocomposites with ultrahigh thermal management capability<br>References Chen, J., et al.: Adv. Funct. Material., 27, 5 (2017)<br></p>

<p>Applications Labelled 4-Methylimidazole (M312990). 4-Methylimidazole is a monomethylated imidazole that can be used as a building block in the preparation of a wide range of biologically active compounds. 4-Methylimidazole is a product which results from the interaction of reducing sugars with ammonia. 4-Methylimidazole showed convulsant activity in animals and is listed as a possible carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nishie, K. et al.: Toxicol. Appl. Pharmacol., 14, 301 (1969): Cunha, S.C. et al.: J. Food Comp. Anal., 24, 609 (2011); Chan, P.C. et al.: Arch. Toxicol., 82, 55 (2008);<br></p>

<p>Applications N-Jasmonyl-L-Isoleucine (Mixture of Diastereomers) is a plant horomone.<br>References Chen, Y., Chen, Z.: J. Separation Sci., 36, 892 (2013)<br></p>

<p>Applications 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxylic acid (cas# 144059-86-9) is a useful research chemical.<br></p>

<p>Applications 2-(Diphenylmethoxy)-N-methylethylamine is used in the pereparation of H1 and H2 receptor antagonists containing Diphenhydramine (D486900) derivatives. Diphenhydramine is a H1-histamine receptor antagonist. Diphenhydramine (D486900) is categorized as an antihistaminic; sedative, hypnotic.<br>References Wolf, C. et al.: Archiv. de Pharm., 329, 87 (1996); Gruhzit, O.M., et al.: J. Pharmacol. Exp. Ther., 89, 227 (1947), Holcomb, I.J., et al.: Anal. Profiles Drug Subs., 3, 173 (1974), Scavone, J.M., et al.: J. Clin. Pharmacol., 38, 603 (1998),<br></p>

<p>Applications 3-Methylindole metabolite.<br>References Skordos, K., et al.: Chem. Res. Toxicol., 11, 741 (1998), Lanza, D., et al.: Drug Metab. Disposition, 29, 950 (2001), Hoenicke, K., et al.: J. Agric. Food Chem., 50, 4303 (2002),<br></p>

<p>Applications The main metabolite of o-xylene.<br>References Gregus, Z., et al.: Drug Metab. Dispos., 26, 1082 (1998), Gregus, Z., et al.: Xenobiotica, 29, 547 (1999), Gonzalez-Reche, L., et al.: Arch. Toxicol., 77, 80 (2003),<br></p>

<p>Applications Dl-lysine monohydrate<br></p>

<p>Applications 3-Mercapto-3-methylbutanoic Acid Ethyl Ester is an intermediate in the synthesis of 3-Mercapto-3-methylbutyl Formate (M253540), which is one of the major odor-active thiol in pan-roasted white sesame seeds.<br>References Czerny, M., et al.: J .Agric. Food Chem., 47, 695 (1999), Steinhaus, M., et al.: Eur. Food Res. Technol., 226, 45 (2007), Tamura, H., et al.: Agric. Food Chem., 2010, 58, 7368 (2010),<br></p>

<p>Stability Very Hygroscopic<br>Applications A component of elastin. It can be measured in all body fluids as biomarkers for in vivo degradation of matrix tissue elastin in man and animals.<br>References Sato, F., et al.: Clin. Biochem., 39, 746 (2006), Koenders, M., et al.: J. Pathol., 218, 446 (2009), Ma, S. et al.: J. Chrom. Anal. Tech. Biomed. Life Sci., 879, 1893 (2011),<br></p>

<p>Applications N-Acetyl-L-(-)-leucine is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. Also used in the preparation of amphiphilic copolymers involving hydrophobic amino acid and oligopeptide side chains for optical tumor imaging in vivo.<br>References Zheng, C. et al.: Bioorg. Med. Chem. Lett., 22, 39 (2012); Miki, K. et al.: Bull. Chem. Soc. Jap., 85, 1277 (2012);<br></p>

<p>Applications N-Methylacetamide can be used for the synthesis of N-​sulfonyl amidines and acyl sulfonyl ureas.Environmental contaminants; food contaminants.<br>References Chow, S. Y., et al.: J. Org. Chem. 82, 2515 (2017)<br></p>

<p>Applications 4-Methyl-5-thiazoleethanol-13C3 is used in the synthesis of novel HldE kinase inhibitors used against gram negative bacteria. Also used in the synthesis of potential antimalarial agents from bis-thiazolium analogues. Refer to M330235.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Desroy, N. et al.: J. Med. CHem., 56, 1418 (2013); Caldarelli, S. et al.: J. Med. CHem., 496, (2013);<br></p>

<p>Applications 2-Methylnaphth[1,2-d]oxazole (cas# 85-15-4) is a useful research chemical.<br></p>

<p>Applications 2-Methyl-d3-propyl-3,3,3-d3 Alcohol (CAS# 72182-69-5) is a useful isotopically labeled research compound.<br></p>

<p>Stability Volatile<br>Applications 1-Chloro-2-methylpropene is a reagent in the synthesis of pyrrolyl and indolyl diketo acids and esters as nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Costi, R., et al.: J. Med. Chem., 56, 7431 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications A labelled metabolite of Methyl isocyanate.<br>References Slatter, J. G., et al.: Chem. Res. Toxicol., 4, 157 (1991),<br></p>

<p>Applications 3-Methylbutyric-2,2-d2 Acid (CAS# 95927-02-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl Lauroyl Arginate Hydrochloride is used as a food antimicrobial in the sanitation of preserved foods. It is also used in cosmetics as a preservative.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brandt, A. et al.: . Food. Sci., 75, M557 (2010); Taormina, P. et al.: J. Food. Prot., 72, 1216 (2009); Chem. and Eng. News Page 14, Nov. 5 (2018)<br></p>

<p>Applications L-Threonine-2,3-d2 (CAS# 1202936-45-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Methyl-4,6-bis(octylsulfanylmethyl)phenol (cas# 110553-27-0) is a useful research chemical.<br></p>

<p>Applications 3-Methoxypropanoic acid<br></p>

<p>Applications 4-Methylimidazole is a monomethylated imidazole that can be used as a building block in the preparation of a wide range of biologically active compounds. 4-Methylimidazole is a product which results from the interaction of reducing sugars with ammonia. 4-Methylimidazole showed convulsant activity in animals and is listed as a possible carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nishie, K. et al.: Toxicol. Appl. Pharmacol., 14, 301 (1969): Cunha, S.C. et al.: J. Food Comp. Anal., 24, 609 (2011); Chan, P.C. et al.: Arch. Toxicol., 82, 55 (2008);<br></p>

<p>Stability Hygroscopic<br>Applications Oleoyl-L-carnitine is a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Oleoyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.<br>References Adams, S., et al.: J. Nutrition, 139, 1073 (2009); Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Applications 2-Hydroxy-2-methylpropanamide (cas# 13027-88-8) is a useful research chemical.<br></p>

<p>Applications 3’,5’-Diiodo-L-thyronine is a thyroid hormone that has been shown to increase malic enzyme activity, and the activity of glucose-6-phosphate dehydrogenase in teleost Anabas testudineus. Thus, showing short term effect on lipid metabolism.<br>References Davey, K.G.: Insect Biochem. Mol. Bio., 30, 877 (2000); Shameena, B., et. al.: Endocr. Res., 26, 431 (2000)<br></p>

<p>Applications 2,6-Di-(tert-butyl-d9)-4-methylphenol-3,5-d2,OD (CAS# 64502-99-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 6-Methyl-2-heptanol is an intermediate used to prepare tri- and tetrasubstituted imidazoles as highly potent and specific ATP-​mimetic inhibitors of p38 MAP kinase.<br>References Laufer, S., et al.: J. Med. Chem., 51, 4122 (2008)<br></p>

<p>Applications H-L-METHR-OH (cas# 2812-28-4) is a useful research chemical.<br></p>

<p>Applications N-Acetylglycine-d5 is an isotopic analog of N-Acetyl-glycine (A178260), a derivative of Glycine (G615990). It is an intermediate used to synthesize rac 3-O-Methyl DOPA (M303805) which is an impurity of Levodopa.<br>References Tabar, et al.: Pharmacol. Biochem. Behav., 33, 139 (1989), De Souza Silva, et al.: J. Neurochem., 68, 233 (1997), Feigin, A., et al.: Neurology, 57, 2083 (2001), Perera, A., et al.: J. Labelled Comp. Radiopharm., 46, 389 (2003),<br></p>

<p>Applications 1-Methoxy-2-propanol is used as a reagent in the synthesis of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors. Also used as a reagent in the synthesis of Metolachlor (M338700); a selective pre-emergence herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Titchenell, P.M., et al.: Bioorg. Med. Chem. Lett., 23, 3034 (2013); Zhang, H.: Nongyao Kexue Yu Guanli, 32, 26 (2011)<br></p>

<p>Applications N-Acetyl-L-alanine is used as a biomarker for prostate cancer.<br>References Jansen, R., et al.: Clin. Biochem., 38, 362 (2005),<br></p>

<p>Applications Labelled 2-Methylbutyrylglycine (M294340). 2-Methylbutyrylglycine is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several inborn errors of metabolism (IEM).<br>References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000), Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009), Scalbert, A., et al.: Metabolomics, 5, 435 (2009),<br></p>

<p>Applications DL-Homocysteine-d4 is used in the detection of the biosynthetic pathway for the formation of volatile aroma compound 2-methyltetrahydrothiophen-3-one by the bacterium Chitinophaga.<br>References Nawrath, T., et al.: ChemBioChem., 11, 1914-1919 (2010)<br></p>

<p>Applications cis-Propenylphosphonic Acid (R)-(+)-α-Methylbenzylamine Salt is used as a reagent in the microbial production of Fosfomycin (F727505); a compound used as an antibiotic in the treatment of urinary tract infections.<br>References Watanabe, M., et al.: Appl. Environ. Microb., 65, 1036 (1999); Itoh, N., et al.: Appl. Microbiol. Biot., 43, 394 (1995); White, R.F., et al.: Appl. Microbiol., 22, 55 (1971); Keating, G. et al.: Drugs, 73, 1951 (2013); Demir, T. et al.: Int. J. Infect. Dis., 17, e966 (2013)<br></p>

<p>Stability Hygroscopic<br>Applications 2S,2’S,5S)-5-Hydroxy Lysinonorleucine is one of the stereoisomers of 5-Hydroxylysinonorleucine, reduced collagen cross links.<br>References Astbury, C., et al.: Br. J. Rheumatol., 33, 11 (1994), Watts, N., et al.: Clin. Chem., 45, 1359 (1999), Banse, X., et al.: Bone, 31, 70 (2002),<br></p>

<p>Applications N-Methyltaurine can be used as a counter ion in the formation of soaps.<br>References Miyahara, Reiji, et al.: J. of Oleo Sci., 50(10), 823-830 (2001)<br></p>