Amino Acids (AA)

<p>Applications L-Cysteine Hydrochloride<br></p>

<p>Applications 5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine is a reagent in the synthesis and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone which is an antibacterial agent. Benzoxazinyl-oxazolidinone had potent activity against Gram-positive pathogens. 5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine is also an intermediate in the synthesis of Tedizolid (T013750).<br>References Xin, Q., et al.: J. Med. Chem., 54, 7493 (2011)<br></p>

<p>M06199 - BOC-SER(TBU)-OH DCHA</p>

<p>Applications 2-Bromo-3-methylbutenoic Acid Methyl Ester (cas# 51263-40-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Fmoc-Ser(TBDMS)-OH (cas# 146346-81-8) is a useful research chemical.<br></p>

<p>Applications 2-Methyl-2-(1-Methylbutyl)-propanedioic Acid 1,3-Diethyl Ester is an intermediate in the synthesis of 2,3-Dimethyl-hexanoic Acid (D473405) which is used to prepare Mono-2,3-dimethylhexyl Phthalate (M539400), a metabolite of Dibutyl phthalate (DBP) (D429495), which is widely used in consumer products.<br>References Silva, M., et al.: Arch. Toxicol., 77, 561 (2003), Silva, M., et al.: Toxicology, 210, 123 (2005), Silva, M., et al.: J. Anal. Toxicol., 29, 819, (2005)<br></p>

<p>Applications L-threo-Phenylserine is a valuable chiral synthon.<br></p>

<p>Applications N-Boc-piperazine-d8 is a useful synthetic intermediate for the preparation of labelled compounds.<br></p>

<p>Applications 5-amino-2-methyl-benzenesulfonamide (cas# 6973-09-7) is a useful research chemical.<br></p>

<p>Applications L-Lysine-3,3,4,4,5,5,6,6-d8 Dihydrochloride, is the labelled L-Lysine, a naturally occurring amino acid which is used in the labelling of human bone marrow mesenchymal stem cells for analysis.<br>References Rocha, B. et al.: J. Prot. Res., 11, 5350 (2012); Kumar, D. et al.: Polym. J., 45, 160 (2013);<br></p>

<p>Applications 2-Chloro-1-methylquinolinium tetrafluoroborate (cas# 16843-24-6) is a useful research chemical.<br></p>

<p>Applications N-Boc-piperazine (cas# 57260-71-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Methylfuran-2(3H)-one is an aromatic compound responsible for the aroma of caramel, dried and roated nori, wine, and brewed coffee.<br>References Paravisini, L., et. al.: Flavour Frag. J., 27, 424 (2012); Shu, N., Shen, H.: Flavour Frag. J., 27, 157 (2012); Chin, S., et. al.: J. Chrom. A, 1218, 7487 (2011)<br></p>

<p>Applications (±)-Aspartic Acid, is a non-essential amino acid found in food sources. Its conjugate base D-aspartate has potential use as a a therapeutic agent in the treatment of schizophrenia-related symptoms.<br>References Errico, F. et al.: J. Neurosci., 28, 10404 (2008); Denu, J.M. et al.: Biochem., 34, 3396 (1995); Chen, P.E. et al.: Mol. Pharmacol., 67, 1470 (2005);<br></p>

<p>Applications Derivatizing reagent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Webster, S., et al.: Bioorg. Med. Chem. Lett., 20, 3265 (2010), Chezal, J., et al.: Eur. J. Med. Chem., 45, 2044 (2010),<br></p>

<p>Applications This compound contains up to 25% of the two other regioisiomers.<br></p>

<p>Applications 1-(2-Chloroethoxy)-2-methoxy benzene, is an impurity of Carvedilol (C184625), a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is an antihypertensive used in the treatment of congestive heart failure.<br>References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990); Packer, M., et al.: N. Engl. J. Med., 334, 1349 (1996);<br></p>

<p>Applications N-Acetyl-L-cystine is an antioxidant, used in the treatment of influenza A virus pandemic (1). N-Acetyl-L-cystine promotes fertilization by reducing disulfide bonds in zona pellucida of mouse (2).Releases N-Acetyl-L-cysteine, which is an antidote for paracetamol poisoning.<br>References (1) Zhang, R., et al.: (2014) Int. Immunopharmacol. 22: 1-8 (2) Takeo, T., et al.: Biol Reprod. (2015) 92: 1-7<br></p>

<p>Applications 2-Methyl-Pentanoic acid is a useful building block for organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Air Sensitive<br>Applications A metabolite of Methyl Isocyanate.<br>References Slatter, J. G., et al.: Chem. Res. Toxicol., 4, 157 (1991),<br></p>

<p>Stability Hygroscopic<br>Applications Galactosylceramides play an important roles in promoting the regulation of nerve cells, regulating protein kinase C activities and modulating the function of the hormone receptor. It has shown to have significant immunostimulatory and anti-umor activity in mice with liver metastasis of the Colon26 adenocarcinoma.<br>References Morita, M., et al.: J. Med. Chem., 38, 2176 (1995), Sakai, T., et al.: J. Med. Chem., 42, 1836 (1999),<br></p>

<p>Applications Ethylenediaminetetraacetic Acid-d16 (CAS# 203805-96-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl 4-Methoxybenzoate is also used in the synthesis of oxadiazole-based, GSK-3 inhibitors. Methyl 4-Methoxybenzoate is used in the synthesis of substituted hydrazides for their antitubercular properties.<br>References Lo Monte, F. et al.: Eur.J. Med. Chem., 61, 26 (2013); Gupta, R. et al.: Asian J. Pharm. Clin. Res., 5, 251 (2012);<br></p>

<p>Applications 4-(Boc-amino)-1-methylpyrrole-2-carboxylic Acid is an unnatural amino acid for preparing heteroaromatic oligoamides for regulating gen expression in biotechnology.<br>References Baird, E., et al.: J. Am. Chem. Soc., 118, 6141 (1996); White, S., et al.: Nature, 391, 468 (1998)<br></p>

<p>Applications D-Homocysteine is the stereoisomer of L-Homocystine, increased levels lead to hyperhomocysteinemia; a cardiovascular risk factor in prediction of coronary heart disease as well as being associated with congenital birth defects, pregnancy complications and cancer.<br>References Geisel, J. et al.: Clin. Chem. Lab. Med., 41, 1513 (2003); Geisel, J. et al.: Clin. Chem. Lab. Med., 41, 1513 (2003);<br></p>

<p>Applications 2-(3-Methoxyphenoxy)propanoic acid<br></p>

<p>Applications N-Boc-propargylamine is used in the preparation of triazolobenzylidene-thiazolopyrimidines which act as CDC25 phosphatase inhibitors. Also used in the synthesis of β-glucan polysaccharide analogs.<br>References Duval, R. et al.: J. Comb. Chem., 11, 947 (2009); Tanaka, H. et al.: Tetrahedron Lett., 53, 4104 (2012);<br></p>

<p>Applications L-Leucic Acid is a reagent in the synthesis of cryptophycins based macrocyclic depsipeptides which are used as tubulin inhibitors.<br>References Kumar, A., et al.: Eur. J. Med. Chem., 93, 55 (2015)<br></p>

<p>Applications 2-Methyl-4-oxo-4-phenylbutyric Acid is a chemical reagent used in the synthesis of various pharmaceutically active compounds. Used in the synthesis of Minozac, a suppressor of brain proinflammatory cytokine up-regulation.<br>References Hu, W. et al.: Bioog. Med. Chem. Lett., 17, 414 (2007); Qabaja, G. ET AL.: J. ORG. CHEM., 80, 133 (2015);<br></p>

<p>Applications 2-Hydroxy-2-methylpropanamide (cas# 13027-88-8) is a useful research chemical.<br></p>

<p>Applications 5-Methoxy-1-methylindole-2-boronic acid pinacol ester (cas# 1256360-41-4) is a useful research chemical.<br></p>

<p>Applications N-(2-Hydroxyethyl)glycine (~90%) (cas# 5835-28-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Acetyl-d3 L-Carnitine Hydrochloride is labelled Acetyl L-Carnitine Hydrochloride (A171990) which is used for transmembrane action potential studies. Acetylcarnitine has antinociceptive activity that may be mediated by enhanced activity of muscarinic cholinergic receptors or mGlu2 glutamate receptors.<br>References Matsui, K., et al.: Japanese J. Pharmcol., 39, 263 (1985); Chlechio, S., et al.: J. Endocrinol. Invest., 27, 171 (2004): Walker, R., et al.: Comparative General Pharmacol., 4, 65 (1973)<br></p>

<p>Applications 4-(4-Methoxyphenyl)-2-butanone is also used in the synthesis of novel axially chiral Rh-NHC complexes. Used to synthesize carbonyl complexes as novel traceless linkers.<br>References Duan, W. et al.: Chem. Comm., 23, 2916 (2003); Gibson, S. et al.: Tetrahedron. Lett., 40, 1417 (1999);<br></p>

<p>Applications 2-(4-Hydroxyphenyl)-3-methyl-1H-indol-5-ol is used as a reagent in the synthesis of tethered indoles as functionalizable ligands for estrogen receptor.<br>References Trogden, B.G., et al.: Bioorg. Med. Chem. Lett., 19, 485 (2009)<br></p>

<p>Applications 1-methoxypropan-2-amine hydrochloride (cas# 677743-83-8) is a useful research chemical.<br></p>

<p>Applications Increased levels lead to hyperhomocysteinemia; a cardiovascular risk factor in prediction of coronary heart disease as well as being associated with congenital birth defects, pregnancy complications and cancer.<br>References Geisel, J. et al.: Clin. Chem. Lab. Med., 41, 1513 (2003); Geisel, J. et al.: Clin. Chem. Lab. Med., 41, 1513 (2003);<br></p>

<p>Applications Hydroxyprolines are valuable chiral building blocks for organic synthesis of pharmaceuticals. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.<br>References Lawrence, C., et al.: Biochem. J., 313, 185 (1996), Mori, H., et al.: J. Bacteriol., 179, 5677 (1997), Clifton, I., et al.: Eur. J. Biochem., 268, 6625 (2001),<br></p>

<p>Applications 3-Methyl-2-hexanamine HCl Salt is more stable and easier to purify compared to the free base.<br></p>

<p>Impurity Rifaximin EP Impurity A<br>Applications 2-Amino-4-methylpyridine (Rifaximin EP Impurity A) is an impurity of Rifaximin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications N-Methyl-3,3-diphenylpropylamine is an intermediate for the synthesis of SNRI-NMDA antagonist and neuroprotectants.<br>References Olney, J. et al.: Sci., 244, 1360 (1989); Williams, W., et al.: Mol. Pharmacol. 44, 851 (1993);<br></p>

<p>Applications 1-Bromo-3-methylbutane, is used as an extraction solvent to determine various polycyclic aromatic hydrocarbons in water samples though dispersive liquid-liquid microextraction along with GC-MS (gas chromatography- mass spectrometry).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rezaee, M., et al.: J. Chromat. A., 1116, 1 (2006)<br></p>

<p>Applications D,L-β-Chloroalanine Methyl Ester Hydrochloride (cas# 33646-31-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 8-Chloro-4-hydroxy-2-methylquinoline (cas# 5236-87-3) is a useful research chemical.<br></p>

<p>Applications L-Methionine-3,3,4,4-d4 (CAS# 67866-75-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications A derivative of imidazole used in the synthesis of heteroxanthine.<br>References Sarasin, J., et al.: Helv. Chim. Acta, 7, 713 (1924),<br></p>

<p>Impurity Paliperidone USP Related Compound A<br>Applications 3-Ethyl-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (Paliperidone USP Related Compound A) is used in the synthesis of Paliperidone (P141000). Intermediate.<br>References Rein, A., et al.: Curr. Opin. Drug Discovery Dev., 3, 734 (2000),<br></p>

<p>Applications 4-Methoxyresorcinol (cas# 6100-60-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Felypressin(Octapressin) is a vasopressin 1 agonist and a peptide containing eight amino acids including cystine. Felypressin is used as a vasoconstrictor.<br>References Boissonnas, G., et al.: Helv. Chim. Acta, 43, 190 (1960), Farkas, D., et al.: Curr. Drug Metab., 6, 111 (2005), Elferink, M., et al.: Toxicol. Appl. Pharmacol., 229, 300 (2008),<br></p>

<p>Stability Air Sensitive<br>Applications L-Homocysteine is the hydrolysis product of adenosine (A280400), a purine nucleoside. Metabolic fate of L-Homocysteine is converted back to L-Methionine( M260440) via tetrahydrofolate.<br>References Liu, X.D., et al.: Org. BIomolec. Chem., 11, 4258 (2013); Chen, C.S., et al.: Nueroendocrinol., 97, 232 (2013);<br></p>

<p>Applications 4-methyl-2-(piperidin-4-yl)pyridine (cas# 1260886-47-2) is a useful research chemical.<br></p>

<p>Applications Pipecolic acid is involved in synaptic transmission in the central nervous system.<br>References Nomura Y., et al.: Neurochem. Res., 6, 391 (1981),<br></p>

<p>Applications 4-Aminobutyl-d8 Guanidine is the labelled analog of the decarboxylation product of the amino acid arginine (A769500) and also an intermediate in polyamine biosynthesis.<br>References Golding, B.T., et al.: Biochem. Soc. Trans., 22, 391S (1994);<br></p>

<p>Applications This not naturally occurring amino acid was first observed after alkali treatment of different proteins. Synthetic Lysinoalanine was found to have a strong chelating ability for metals.<br>References Schwass, D., et al.: J. Agric. Food Chem., 32, 1377 (1984), Ahmed, M., et al.: J. Biol. Chem., 261, 8816 (1986), Wells-Knecht, K., et al.: Biochem., 34, 3702 (1995),<br></p>

<p>Applications 4-(3-Methoxypropoxy)-2,3-dimethylpyridin-1-ium-1-olate is used in preparation of Picolylsulfides and related drugs by using Esterification and Thioetherification as the key steps.<br>References Wang, D., et al.: Faming Zhuanli Shenqing, (2019);<br></p>

<p>Stability Light Sensitive<br>Applications α-Methacrylic acid is used in chemistry as a stabilizing agent, forming a thin capping layer on the surface of nanoparticles. α-Methacrylic acid is also used as a surfactant, so that control is maintained during nanocrystal growth. α-Methacrylic acid is also used as a chelating agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Peng, W., et al.: J. Cryst. Growth, 279, 454 (2005); Qu, S., et al.: Appl. Phys. Lett., 80, 3605 (2002); Zhao, G., et al.: Phys. C: Supercond., 468, 2317 (2008)<br></p>

<p>Applications Threonine derivative used in the synthesis of peptide.<br>References Dekker, C.A., et al.: J. Biol. Chem., 180, 155 (1949),<br></p>

<p>Applications 3,5-Diiodo-DL-tyrosine is used for diagnosis of hypothyroidism caused by DEHAL1 gene defects.<br>References Encinas, S., et al.: Chem. Res. Toxicol., 11, 946 (1998), Daneshvar, A., et al.: Chemosphere, 80, 301 (2010), Eriksson, J., et al.: Photochem. Photobiol., 86, 528 (2010),<br></p>

<p>Applications Ethametsulfuron-methyl Sodium Salt, a regulator of the early steps of complement activation on mucosal surfaces. It can be used in combination treatment of ohmic heating with various essential oil components for inactivation of food-​borne pathogens in buffered peptone water and salsa.<br>References Kim, S. S., et al.: Food Control, 80, 29 (2017); Reichhardt, M. P., et al.: Front Immunol, 7, 85 (2016)<br></p>

<p>Applications 4-Methoxy-d3-benzoic Acid (CAS# 27914-54-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Methoxy-1,2-propanediol is used to prepare phosphorothioate analogs of sn-2 radyl lysophosphatidic acid as metabolically stabilized LPA receptor agonists. It is also used to synthesize diacylglycerol analogs as potential second-messenger antagonists.<br>References Jiang, G., et al.: Bioorg. Med. Chem. Lett., 23, 1865 (2013); Briggs, J., et al.: Bioorg. Med. Chem. Lett., 2, 127 (1992)<br></p>

<p>Applications (E)-Ethyl 4-Bromo-3-methyl-2-butenoate (cas# 51318-62-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide is used in the novel synthesis of benzoin catalyzed by thiazolium salts.<br></p>

<p>Applications 1-Ethyl-1-methylcyclopentane, is one of the chemical components of Gas-Phase organic carbon emissions from motor vehicles. It is also a volatile component of frying oils.<br>References Gentner, D. R., et al.: Environ. Sci. Tech., 47, 11937 (2013); Prevot, A. Frying Food, 155 (1988);<br></p>

<p>Applications (3-Methyl-2-butenyl)triphenyl-phosphonium Bromide (cas# 1530-34-3 ) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Fluoro-3-methoxyphenylboronic acid<br></p>

<p>Applications D-Homophenylalanine<br></p>

<p>Applications 3-Hydroxy-2'-methoxy-2-naphthanilide (cas# 135-62-6) is a useful research chemical.<br></p>

<p>Applications N-Methylformamide is used in amidation or transamidation chemical reactions where formamide is insufficient.<br>References Rao, S. et al.: Org. Lett., 15, 1496 (2013); Xu, K. et al.: Chem. A. Eur. J., 18, 9793 (2012);<br></p>

<p>Stability Moisture Sensitive<br>Applications N-Methyl-1H-imidazole-1-carboxamide is a useful Methyl Isocyanate (MIC) substitute.<br></p>

<p>Applications D-Serine Methyl Ester Hydrochloride (cas# 5874-57-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 4'-Methylacetanilide (cas# 103-89-9) is a compound useful in organic synthesis.<br></p>

<p>Applications N-[(R)-1-Carbethoxybutyl]-(S)-alanine is an intermediate in the synthesis of Perindoprilat (P287530), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.<br>References Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)<br></p>

<p>Applications N-Acetyl-L-glutamic Acid is the N-Acetyl analogue of the non-essential amino acid, L-glutamic acid (G596960). N-Acetyl-L-glutamic Acid activates carbamoyl phosphate synthetase in the urea cycle.<br>References Saheki, T. et al.: J. Biochem., 77, 659 (1975); Rivas, J. et al.: Acta Biol. Med. Ger., 36, 1673 (1977); Zollner, H.: Biochim. Biophys. Acta, 676, 170 (1981);<br></p>

<p>Applications 5-Bromo-3-methyl-2(5H)-furanone is used as a reactant in the synthesis of strigolactone analogs.<br>References Artuso, Emma, et al.: J. of Nat. Products, 78(11), 2624-2633 (2015);Jia, Kun-Peng, et al.: Mol. Plant, 9(9), 1341-1344 (2016)<br></p>

<p>Stability Light Sensitive<br>Applications trans-β-Methylstyrene is an isomer of β-Methylstyrene (M301155), a styrene derivative that is used as a chemical intermediate in the manufacture of plasticizers, resins and polymers. trans-β-Methylstyrene is also produced from the combustion of methamphetamine (M258795).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lin, H., et al.: Tetrahedron, Asym., 22, 134 (2011); Hirata, T., et al.: Tetrahedron., 54, 15993 (1998);<br></p>