Amino Acids (AA)

<p>Applications DL-Histidine-alpha,beta,beta-d3 (CAS# 344299-50-9) is a useful isotopically labeled research compound.<br></p>

<p>Stability Very Hygroscopic<br>Applications A component of elastin. It can be measured in all body fluids as biomarkers for in vivo degradation of matrix tissue elastin in man and animals.<br>References Sato, F., et al.: Clin. Biochem., 39, 746 (2006), Koenders, M., et al.: J. Pathol., 218, 446 (2009), Ma, S. et al.: J. Chrom. Anal. Tech. Biomed. Life Sci., 879, 1893 (2011),<br></p>

<p>Impurity Cefalexin EP Impurity D<br>Applications 3-Hydroxy-4-methyl-2(5H)-thiophenone (Cefalexin EP Impurity D) is an acid degradation product of Cephalexin (C256800) and Cefaclor (C235250), antibiotics.<br>References Dinner, A.: J. Med. Chem. 20, 963 (1977); Baetschi, S.W., et. al.: J. Pharmaceut., Sci., 86, 526 (1997)<br></p>

<p>Applications 8-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione is an intermediate used to prepare selective inhibitors of dipeptidyl peptidase 4 (DPP4) for potential use in the treatment of type 2 diabetes.<br>References Sutton, J., et al.: Bioorg. Med. Chem. Lett., 22, 1464 (2012); Lai, Z., et al.: Eur. J. Med. Chem., 83, 547 (2014)<br></p>

<p>Applications 4-methyl-2-(piperidin-4-yl)pyridine (cas# 1260886-47-2) is a useful research chemical.<br></p>

<p>Applications N-Cinnamylglycine is a derivative of ferulic acid (F308900), a widely distributed compound in plants that is used as an antioxidant and food preservative.<br>References Jellum,E., et al.: J. Pharma. Biomed. Anal., 9, 663 (1991); Kayahara, H., et al.: Anticancer. Res., 19, 3763 (1999); Bollina, V., et al.: Plant. Molec. Biol., 77, 355 (2011);<br></p>

<p>Applications An intermediate in the preparation of Ethosuximide.<br></p>

<p>Applications N1-(2-AMINOETHYL)-N1-METHYLETHANE-1,2-DIAMINE (cas# 4097-88-5) is a useful research chemical.<br></p>

<p>Applications 2-Methoxy-4-nitroaniline is a derivative of 4-Nitroaniline (N491770), which is used in the synthesis of photorefractive polymers, as novel chromophores in analytical study. As well, due to the absorption spectrum associated with 4-Nitroaniline, it is used to determine catechol derivatives in syntheses.<br>References Nagaraja, P. et al.: J. Pharm. Biomed. Anal., 25, 417 (2001);<br></p>

<p>Applications Guaiacol-beta-D-glucopyranoside, is a Guaiacol Conjugate, that has shown to present in fermentation of grapes that had been exposed to bushfire smoke and can potentially yield unpalatable, smoke-affected wine.<br>References Hayasaka, Y.m et al.: J. Arg. Food Chem., Vol. 58, Issue 4, P: 2076; 2081 (2010);<br></p>

<p>Applications 3-Hydroxy-4-methoxycinnamic acid, trans-Isoferulic acid<br></p>

<p>Applications 4-Methoxy-6-(trifluoromethyl)-1,3,5-triazin-2-amine can be used as reactant/reagent in preparation of N-phenylsulfony-N'-pyrimidinylureas as herbicides.<br>References Hamprecht, G., et al.: Ger. Offen., DE 4322726 A1 19950112 (1995)<br></p>

<p>Applications 2-Methylpentane is used as a raw material/intermediate in organic synthesis, rubber solvent, and vegetable oil extraction solvent.<br>References Choi, D., et al.: Adv. Funct. Mater. 25, 920 (2015)<br></p>

<p>Applications L-Glutamine (Alpha-15n, 98%) (cas# 80143-57-3) is a useful research chemical.<br></p>

<p>Applications An acylglycine present in urniary excretion that can be analyzed and be used as diagnostic tool for metabolic disorders, complementary to organic acids and acylcarnitine profiles.<br>References Bonafe, L. et al.: Mol. Genetics Metab., 69, 302 (2000);<br></p>

<p>Applications 2-Methylindoline is an intermediate in the production of various indole derivatives<br>References Severino, B., et al.: Bioorg. Med. Chem., 16, 6009 (2008); Zlotos, D., et al.: J. Med. Chem., 52, 826 (2009);<br></p>

<p>Applications 7-Methoxy-4-(trifluoromethyl)coumarin is a biochemical for proteomics research.<br></p>

<p>Applications 2-Methoxypropanol is a susbtance used in the relative parameter sensitivity in prenatal toxicity studies with substances classified as developmental toxicants. Also applied in the studies for the analysis of volatile organic compounds in cigarette packaging materials by SPME-GC/MS.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rorije, E., et al.: Reprod. Toxicol., 34, 284 (2012); Hong, W, et al.: Fujian Fenxi Ceshi, 19, 24 (2010)<br></p>

<p>Applications 4-Chloro-2-methoxyphenol is used as a reagent in the synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists which may be used in development of treatment against autoimmue diseases and viral infections. Also used in the synthesis of novel inhibtors of P. falciparum enoyl-ACP-reductase which may be used in treatment of malaria.<br>References Guerrero, M., et al.: Bioorg. Med. Chem. Lett., 22, 537 (2012); Belluti, F., et al.: J. Med. Chem., 56, 7516 (2013);<br></p>

<p>Applications 2-amino-5-methylhexanoic acid (cas# 3558-32-5) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Isotope labelled N-Acetyl-S-(2-cyanoethyl)-L-cysteine Ammonium Salt is a metabolite of Acrylonitrile (AN) and acrylamide (AM). Are commonly used in the synthesis of plastics and polymers.<br>References van Bladeren, P., et al.: Drug Metab. Dispos., 9, 246 (1981), Guengerich, F., et al.: Chem. Res. Toxicol., 4, 168 (1991),<br></p>

<p>Applications 2-(3-Methoxyphenoxy)propanoic acid<br></p>

<p>Impurity Carvedilol EP Impurity E; Carvedilol Impurity E; Carvedilol USP E<br>Applications 2-(2-Methoxyphenoxy)ethylamine Hydrochloride (Carvedilol EP Impurity E; Carvedilol Impurity E; Carvedilol USP E) is an impurity of Carvedilol synthesis.<br>References Smith, L., et al.: J. Med. Chem., 20, 1653 (1977),<br></p>

<p>Applications 1-methoxypropan-2-amine hydrochloride (cas# 677743-83-8) is a useful research chemical.<br></p>

<p>Applications N-Boc-piperazine-d8 is a useful synthetic intermediate for the preparation of labelled compounds.<br></p>

<p>Applications 4-methoxy-3-methylaniline (cas# 136-90-3) is a useful research chemical.<br></p>

<p>Applications H-PRO-GLU-OH (cas# 67644-00-2) is a useful research chemical.<br></p>

<p>Applications DMTMM, a conjugating agent that efficiently conjugat PnPS to Luminex microspheres without affecting the antigenicity of a broad set of PnPS.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wrzesien, J. &amp; Graham, D.: Tetrahedron, 68, 1230 (2012); Schlottmann, S. et al.: J. Im. Meth., 309, 75 (2006)<br></p>

<p>Applications 3-Methyl-1,3-butanediol is a useful compound in carbon oxygen coupling reactions.<br></p>

<p>Stability Hygroscopic<br>Applications 1,2-Cyclohexanedicarboxylic Acid Mono 4-Methyl-7-carboxy-heptyl Ester is a possible metabolite of the di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) monoester (MINCH).<br>References Koch, H., et al.: Arch. Toxicol., 87, 799 (2013)<br></p>

<p>Applications 4-Methoxy-d3-benzoic Acid (CAS# 27914-54-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled analogue of L-Phenylalanine, an essential amino acid. L-Phenylalanine is biologically converted into L-tyrosine, another one of the DNA-encoded amino acids, which in turn is converted to L-DOPA and further converted into dopamine, norepinephrine, and epinephrine. L-Phenylalanine is produced for medical, feed, and nutritional applications such as in the preparation of Aspartame.<br>References Hollunger, G. et al.: Acta Pharmacol. Toxicol., 34, 391 (1974); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977);<br></p>

<p>Applications Ademethionine-d3 1,4-Butanedisulfonate, is a labeled analogue of Ademethionine 1,4-Butanedisulfonate (A280355), used in the synthesis of sulfonio-adenosyl-L-methionine (SAMe) salts.<br></p>

<p>Applications Perfluoro(4-methyl-3,6-dioxaoct-7-ene)sulfonyl Fluoride is used as a reagent in the synthesis of novel perfluorinated vinyl ether containing sulfonimide functionality which can be copolymered with tetrafluoroethylene to yield a novel perfluorinated copolymer.<br>References Zhu, S., et al.: Chinese J. Chem., 21, 921 (2003);<br></p>

<p>Applications (4-Methylphenyl)-2-pyridinylmethanone is a useful reactant in organic synthesis.<br>References Hu, Zhiyuan, et al.: Org. &amp; Biomol. Chem., 16(31), 5653-5660 (2018);Liao, Yang, et al.: J. of Organometallic Chem., 881, 1-12 (2019)<br></p>

<p>Applications 5-methoxypentanoic acid (cas# 70160-05-3) is a useful research chemical.<br></p>

<p>Applications The selenocyanation and thiocyanation of electron rich arene, 1-Methylindole, achieved using N-iodosuccinimide (NIS) as a catalyst and aqueous tert-Bu hydroperoxide (TBHP) as an oxidant at room temperature.<br>References Muniraj, N., et al.: ChemistrySelect, 1, 1033-1038 (2016)<br></p>

<p>Applications 2-Methyl-4-oxo-4-phenylbutyric Acid is a chemical reagent used in the synthesis of various pharmaceutically active compounds. Used in the synthesis of Minozac, a suppressor of brain proinflammatory cytokine up-regulation.<br>References Hu, W. et al.: Bioog. Med. Chem. Lett., 17, 414 (2007); Qabaja, G. ET AL.: J. ORG. CHEM., 80, 133 (2015);<br></p>

<p>Applications 2-Bromo-4'-methylpropiophenone (cas# 1451-82-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Methoxybenzene-1,2-Diamine (cas# 37466-89-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Methylnaphth[1,2-d]oxazole (cas# 85-15-4) is a useful research chemical.<br></p>

<p>Applications 3-[4-(2-methoxyphenyl)piperazin-1-yl]propan-1-amine (cas# 20529-23-1) is a useful research chemical.<br></p>

<p>Applications N-(2-Hydroxyethyl)glycine (~90%) (cas# 5835-28-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Methyldibenzothiophene, is an alkyldibenzothiophene present in crude oil. Research concerning the biodegradation of Dibenzothiophene by different types of bacteria is a currently being carried out, as these bacteria have the ability to breakdown other harmful PAH’s as well. This may be used in removing spilled oil from marine and terrestrial environments.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boberg, F., et al.: Erdoel &amp; Kohle, Erdgas, Petrochemie, 47, 187 (1994); Tanaka, Y., et al.: Applied Microbiology and Biotech., 59 (2), 325 (2002); Prince, R., Spill Sci. Tech. Bulletin, 8 (2), 145 (2003);<br></p>

<p>Impurity Lisinopril EP Impurity B/ Anastrozole EP Impurity F<br>Applications 4-Methylbenzenesulfonic Acid Monohydrate (Lisinopril EP Impurity B) is used in the synthesis of resveratrol. Also used in the synthesis of oxane derivatives as antimalarial agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Davis, M. et al.: Org. Prep. Proc. Int., 45, 304 (2013); Wang, X. et al.: J. Med. Chem., 56, 2547 (2013);<br></p>

<p>Applications 3-Ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide is used in the novel synthesis of benzoin catalyzed by thiazolium salts.<br></p>

<p>Applications 4-Bromo-6-methyl-3H-1,3-benzodiazole<br></p>

<p>Applications 4,4'-Methylenedianiline is used in the production of polyurethane foams and epoxy resins (1). Potential contributor in pulmonary arterial hypertension (PAH) in rats through alteration of the serotenergic transport system (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Dyes and metabolites, Environmental Testing.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Hebert V. et al.: Cardiovas. Toxicol., 2011 Dec;11(4):316-24.2. Carroll-Turpin, M. et al.: Toxicol. Sci. 2015 Sep;147(1):235-45<br></p>

<p>Applications 5-Methoxy-1-methylindole-2-boronic acid pinacol ester (cas# 1256360-41-4) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications 4-Methoxyphenylhydrazine hydrochloride was used in the preparation of 5-cyano-3-(5-methoxy-2-methylindol-3-yl)-1,2,4-thiadiazole. It was also used to synthesize diarylpyrazoles as possible cyclooxygenase 2 ((COX-2)) inhibitors.<br>References Iwakawa, T., et al.: Chem. Pharm. Bull., 48, 160 (2000); Penning, T., et al.: J. Med. Chem., 40, 1347 (1997)<br></p>

<p>Impurity Temozolomide USP Related Compound B<br>Applications N'-Methyl-N,N-diphenylurea is used in the stabilization of thermal propellants. Temozolomide USP Related Compound B.<br>References Bohn, M. et al.: Prop. Exp. Pyro.,et al.: 19, 266 (1994); Muthurajan, H. et al.: J. Hazard. Mat., 133, 30 (2006);<br></p>

<p>Applications A derivative of imidazole used in the synthesis of heteroxanthine.<br>References Sarasin, J., et al.: Helv. Chim. Acta, 7, 713 (1924),<br></p>

<p>Applications: (3,5-Di-tert-butyl-4-methoxyphenyl)boronic acid (cas# 233584-42-4) is a useful research chemical.<br></p>

<p>Stability Toxic<br>Applications 2-Chloro-4-methylpyrimidine (cas# 13036-57-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Methyl-d3-catechol (CAS# 83719-41-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Methyl-valerophenone is an intermediate used in the synthesis of a-Pyrrolidinoisohexanophenone (Hydrochloride) (P841230), which is a phenone derivative used for research purposes.<br>References Guo, Z.K., et al.: Marine Drugs, 16, 45/1 (2018)<br></p>

<p>Stability Moisture Sensitive<br>Applications 3-Glycidoxypropyltrimethoxysilane (cas# 2530-83-8) is a useful research chemical.<br></p>

<p>Applications [2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-1-yl]acetic acid (cas# 1171565-50-6) is a useful research chemical.<br></p>

<p>5-Chloro-L-tryptophan (5CTP) is a chemical compound that belongs to the class of cyclic peptides. It is biosynthesized by plants and other organisms from 4-chloro-L-tryptophan. 5CTP is synthesized from 4CTP by a two step process, involving an oxidative decarboxylation followed by a deamination reaction. The oxidative decarboxylation converts the amino acid into an intermediate, which is then deaminated and converted into 5CTP. This compound has been shown to have potential as a drug against cancer cells, with its mechanism of action being related to its ability to form metal chelates with heavy metals such as copper and mercury. 5CTP has also been used in molecular modeling studies, genetic analyses, and biochemical investigations of substrate binding and enzyme catalysis.</p>

<p>H-gamma-carboxy-Glu-OH is a synthetic peptide with the amino acid sequence H-gamma-Carboxy-Glu. It is a glp-1 analogue and its function is to regulate glucose homeostasis. The protein has been shown to have antiapoptotic effects in human osteosarcoma cells. H-gamma-carboxy-Glu-OH has also been shown to regulate mitochondrial membrane potential, which is required for cell signaling pathways and calcium binding. H-gamma-carboxy-Glu-OH's receptor molecule is known as the GPCR, which plays an important role in the regulation of cell signaling pathways and calcium binding. H gamma carboxy Glu OH is a cyclic peptide that contains disulfide bonds. This compound has the basic structure of an alpha helix, which consists of many turns of amino acids bonded together by hydrogen bonds between individual amino acids</p>

<p>DL-Arginine is an amino acid that is important in the formation of proteins. It also can be converted to nitric oxide, which causes vasodilation and increased blood flow. DL-Arginine is a precursor for the synthesis of polyamines, which are involved in protein synthesis and cell growth. DL-Arginine has been shown to be effective in treating atrial fibrillation by increasing the amount of nitric oxide available for vasodilation; it may also increase the production of cGMP, which inhibits platelet aggregation and prolongs clotting time. DL-Arginine has also shown potential as a therapeutic agent for diabetes mellitus type II through inhibition of glucose release from pancreatic beta cells and activation of insulin receptors.</p>

<p>Please enquire for more information about N-(4-methylthio(3H-2,3,5-triazolyl))-3-phenylprop-2-enamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Hippuryl-arginine is a peptide hormone that is released by the hypothalamus and stimulates the pituitary gland to release other hormones. It has been shown to increase chemotactic activity in human serum, although it has no effect on carboxypeptidase or soybean trypsin activity. Hippuryl-arginine binds with basic proteins, such as albumin and immunoglobulins, and increases their enzymatic activities. This hormone also inhibits enzymes such as carboxy terminal phosphatases and aminopeptidases that are responsible for degrading amino acids. Activation of hippuryl-arginine may be due to its carboxy terminal group, which is susceptible to cleavage by proteolytic enzymes.</p>

<p>Fmoc-Tyr(tBu)-OH is an amide that binds to the natriuretic receptor. It has a disulfide bond with a hydroxyapatite, which makes it more stable and inhibits its degradation. Fmoc-Tyr(tBu)-OH is hemolytic in vitro and minimally toxic in vivo at high concentrations. It also has a hydroxyl group, which can be used to synthesize other molecules. Fmoc-Tyr(tBu)-OH also has antimicrobial properties, as it inhibits the growth of bacteria and fungi by binding to cell membranes and disrupting their integrity.br&gt;br&gt; Fmoc-Tyr(tBu)-OH is taken up by cells through sodium/hydrogen antiporter system. This uptake process is mediated by the protein Na+, K+ -ATPase, which provides energy for transport across the membrane.</p>