Amino Acids (AA)

<p>Applications 3-Methoxy-2,2-dimethylpropylamine Hydrochloride (cas# 171268-71-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Methylthiazol-4-amine (cas# 103392-01-4) is a useful research chemical.<br></p>

<p>Applications 3-Methoxyphenylacetone is a substituted phenylacetone used in the preparation of optically active cyanohydrins. 3-Methoxyphenylacetone is also used in the preparation of CNS active compounds.<br>References Roberge, C. et al.: Tetrahed. Asymm., 18, 208 (2007); Hutchison, G.I. et al.: Aus. J. Chem., 33, 2699 (1980);<br></p>

<p>Applications 2-Methylpyrazine-d6 (CAS# 1219804-84-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Fmoc-(13C9,15N)-L-Tyrosine O-Tertbutyl Ether is the isotope labelled protected form of L-Tyrosine (T899975), an essential amino acid that exhibits in vitro antioxidant and antiradical activities. L-Tyrosine is used as a precursor to synthesize catecholamines (e.g. Norepinephrine HCl [N674500]) in human keratinocytes, and also for the synthesis of proteins and thyroid hormones.<br>References Gülçin, ?.: Amino Acids, 32, 431 (2007); Langen, K., et al.: Nuc. Med. Biol., 29, 625 (2002); Schallreuter, K., et al.: J. Invest. Derm., 104, 953 (1995); Zhang, W., et al.: Neuropharmacology, 47, 438 (2004)<br></p>

<p>Applications Fmoc-l-propargylglycine has been used to study the bioorthogonal chemical tagging of protein cholesterylation in living cells.<br>References William P. H., et al., ChemComm., 47, 4081-4083 (2011)<br></p>

<p>Applications 4-Methoxybenzoyl Chloride is used in the synthesis of stilbene and dihydrostilbene derivatives as potential anti-cancer agents. It is also used in the synthesis of coumarin dimers with potential HIV-1 activity.<br>References Cushman, M., et al.: J. Med. Chem., 34, 2579 (1991); Mao, P., et al.: Chem. Pharm. Bull. 50, 1634 (2002);<br></p>

<p>Applications Epsilon-n-methyl-l-lysine Hydrochloride<br></p>

<p>Applications 2-(4-Methylthiazol-5-yl)ethanamine is used in the synthesis and biological testing of several new H2 (Histamine) agonists.<br>References Timmerman, H., et al.: J. Quant. Struct-Act. Rel., 11, 219 (1992)<br></p>

<p>Applications 3-Bromo-4-methylphenol is a component of the marine alga polysophornia Sphaerocarpa. It is also a useful raw material for organic synthesis and pharmaceuticals.<br>References Flodin, C., et al.: Phytochemistry, 53, 77 (2000); Munday, S. D., et al.: ChemCatChem, 9, 2512 (2017)<br></p>

<p>Applications 2-Iodo-4-(1-methylethyl)-6-(trifluoromethyl)pyrimidine is a pyrimidine compound, generally used in the synthesis of pharmaceutical compounds, it may be used in the synthesis of cycloindoles for the treatment of hepatitis C.<br></p>

<p>Applications L-Aspartic Acid (13c4, 99%; 15n, 99%) (cas# 202468-27-7) is a useful research chemical.<br></p>

<p>Applications N-Cbz-D-glutamic acid is an N-Cbz-protected form of D-Glutamic acid (G596965). D-Glutamic acid is an unnatural isomer of L-Glutamic acid (G596960), and is found in bacterial cell wall peptidoglycan of gram-positive and gram-negative bacteria. D-Glutamic acid also occurs as poly-gamma-Glutamic acid, which is a weak immunogen but is capable of acting as a hapten (a small molecule that induces the production of antibodies, as well as binding to them).<br>References Dougherty, T., et al.: J. Bacteriol., 175, 111 (1993); Goodman, J. &amp; Nitecki, D.: Immunology, 13, 577 (1967); Robinson, T.: Life Sci., 19, 1097 (1976)<br></p>

<p>Applications Fmoc-3,4-dimethoxy-l-phenylalanine<br></p>

<p>Stability Hygroscopic<br>Applications 1-(2-Amino-7H-purin-6-yl)-1-methylpyrrolidinium Chloride (cas# 680622-68-8) is a compound useful in organic synthesis.<br>References Pauly, G., et al.: J. Med. Chem., 51, 7144 (2008),<br></p>

<p>Applications N-Methyl-d3-acetamide (CAS# 3669-71-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications N2-[(Phenylmethoxy)carbonyl]-L-lysine id used in the synthesis of hydroxamic acids and mycobacterium inhibitors.<br>References Hu, J. et al.: J. Am. Chem. Soc., 119, 3462 (1997); Xue, C. J. Med. Chem., 44, 2636 (2001);<br></p>

<p>Applications 1-(2-Hydroxy-5-methylphenyl)ethanone (cas# 1450-72-2) is a useful research chemical.<br></p>

<p>Applications (S)-N-(Benzyloxycarbonyl)-N-methylvaline has been used as a reactant in the synthesis of a biologically active cyclodepsipeptide destruxin E which is a potent negative regulator of osteoclast morphology.<br>References Yoshida, M., et. al.: J. Org. Chem., 79, 296 (2014)<br></p>

<p>Applications 2'-Methoxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic Acid is a reagent which can be used for preparation of pyrazolone derivatives useful in thrombocytopenia treatment<br>References Duffy, K., et al.: U.S. Pat. Appl. Publ. (2011), US 20110212054 A1 20110901;Deng, B., et al.: Faming Zhuanli Shenqing (2010), CN 101928281 A 20101229;<br></p>

<p>Applications N2-Cbz-D-glutamine is an N-Cbz-protected form of D-Glutamine (G597295). D-Glutamine is an unnatural isomer of L-Glutamine (G597000) that is present in human plasma an is a source of liberated ammonia. D-Glutamine can be synthesized by enzymatic means or can be found in cheeses, wine and vinegars as well. It is often used to determine the activity of Glutamine synthetase, an enzyme that is commonly found in the mammalian liver and brain that controls the use of nitrogen in cells.<br>References Almassy, R., et al.: Nature, 323, 304 (1986); Frank, H., et al.: J. Chromatog. B: Biomed. Sci. Appl., 224, 177 (1981); Jayme, D.: Cytotechnology, 5, 15 (1991); Kagan, H. &amp; Meister, A.: Biochemistry, 5, 725 (1966); Levintow, L. &amp; Meister, A.: J. Am. Chem. Soc., 75, 3039 (1953); Raj, D., et al.: Am. J. Phys. Endo. Metab., 280, E214 (2001); Varadi, M., et al.: Biosens. Bioelect., 14, 335 (1999)<br></p>

<p>Applications 2,5-dimethoxy-N-methylaniline (cas# 10224-66-5) is a useful research chemical.<br></p>

<p>Applications DL-Leucine-d7 (iso-propyl-d7) (CAS# 259225-40-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Fmoc-Arg(Pbf)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.<br></p>

<p>Applications Boc-L-cysteic acid (cas# 277316-57-1) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-Methyl-7-nitroisatoic Anhydride is a reagent for RNA SHAPE-MaP experiments. Enables analysis of RNA secondary structures at single nucleotide resolution in &lt;70 seconds.<br></p>

<p>Applications methyl 2-amino-4-fluoro-3-methylbenzoate (cas# 928839-58-1) is a useful research chemical.<br></p>

<p>Applications N-Guanyl-S-Methyl-Isothiourea Hydroiodide is a reactant used in the synthesis of novel compounds that may be used as HIV entry inhibitors.<br>References Wilkinson, R. et al.: Antimicrob. Agents Chemother., 55, 255 (2011);<br></p>

<p>Applications 4-Methoxy-1-cyclohexenyl Trifluoromethanesulfonate is an intermediate used in the synthesis of 4-Methoxycyclohexene-1-boronic Acid Pinacol Ester (M262385), which is used in the synthetic preparation of pyrazine compounds as phosphodiesterase 10 inhibitors. These inhibitors are useful in the treatment of various disorders and diseases such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder and obsessive-compulsive disorder.<br>References Allen, J.R., et al.: PCT Int. Appl., 2010:626289 (2010)<br></p>

<p>Applications L-Alanine-N,N,O-d3 (CAS# 19470-97-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-(Benzyloxy)-4-bromo-2-methoxybenzene<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications N-methyl-2H-1,3-benzodioxol-5-amine (cas# 34060-22-5) is a useful research chemical.<br></p>

<p>Applications 2-Methoxyphenol-3,4,5,6-d4,OD (CAS# 20189-11-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-(2,6-Difluoro-4-methoxyphenyl)-2-oxoacetic Acid is a derivative of 3,5-Difluoroanisole (D445395), which is used in the preparation of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 antagonists. Also used in the preparation of imidazo[1,5-a]pyrido[3,2-e]pyrazines and imidazo[1,5-a]quinoxalines as orally active phosphodiesterase 10A inhibitors.<br>References Procopiou, P.A., et al.: J. Med. Chem., 56, 1946 (2013); Malamas, M.S., et al.: J. Med. Chem., 54, 7621 (2011)<br></p>

<p>Applications 5-Methyl-2-hexanone is used in the preparation od S1P1 receptor agonists. Also used in the preparation of indoles in an efficient synthesis involving the use of TCT (2,4,6-trichloro-1,3,5-triazine).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bolli, M. et al.: J. Med. Chem., 57, 78 (2014); Siddalingamurthy, E. et al.: Tetrahedron Lett., 54, 5591 (2013);<br></p>

<p>Applications (3-(furan-2-yl)-1-methyl-1H-pyrazol-5-yl)methanamine (cas# 1365938-03-9) is a useful research chemical.<br></p>

<p>Applications 3-Methoxytoluene-alpha,alpha,alpha-d3 (CAS# 20369-34-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications (R)-4-Benzyl-3-((R)-2-methylbut-3-enoyl)oxazolidin-2-one is an intermediate in the synthesis of Domoic Acid (D531300), an excitatory amino acid isolated from the red alga Chondria armata Okamura.<br>References Lawrence, J.F., et al.: J. Chromatogr., 462, 349 (1989),<br></p>

<p>Applications di(Dodecanedioic-d20 Acid 1-Methyl Ester) Barium is a labeled salt analogue of Dodecanedioic Acid 1-Methyl Ester (D494535), which is used in cosmetic compostions.<br>References Lodyato, V., et al.: Bioorg. Med. Chem. Lett., 13, 1179 (2003); Lodyato, V., et al.: Bioorg. Med. Chem. Lett., 14, 4253 (2004)<br></p>

<p>Applications α-[[[2-(4-Methoxy-3-methylphenyl)-1-methylethyl](phenylmethyl)amino]methyl]-3-nitro-4-(phenylmethoxy)benzenemethanol is an intermediate in the synthesis of (3R,5S)-Fluvastatin.<br>References Faming Zhuanli Shenqing (2014), CN 103896795 A 20140702.<br></p>

<p>Applications 2-(3-Methoxyphenoxy)ethanamine (cas# 6487-86-1) is a compound useful in organic synthesis.<br></p>

<p>Stability Air Sensitive, Moisture Sensitive<br>Applications 2-ethoxy-4-formylphenyl 2-methylpropanoate (cas# 188417-26-7) is a useful research chemical.<br></p>

<p>Applications N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(2-fluorophenyl)thio]-2-hydroxy-2-methylpropanamide is an intermediate in the synthesis of Bicalutamide (B382000) related compound.<br>References Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),<br></p>

<p>Applications Nα-Fmoc-L-arginine is an N-Fmoc-protected form of L-Arginine (A769505). L-Arginine is an conditionally essential amino acid for humans and adult mammals as it’s requirements exceed production during certain developmental stages in life (such as pregnancy). L-Arginine also prevents blood toxicity from intravenous amino acid administration in humans.<br>References Bronte, V. &amp; Zanovello, P.: Nat. Rev. Immun., 5, 641 (2005); Fahey, J.: J .Clin. Invest., 36, 1647 (1957)<br></p>

<p>Applications 4-Methyloxazole-2-carboxylic Acid is an oxazole compound thus carrying the potential to display biological activity in vitro.<br>References Dondoni, A. et al.: J. Org. Chem., 52, 3413 (1987);<br></p>

<p>Stability Light and Moisture Sensitive<br>Applications A cross-linking reagent.<br>References Biltresse, S., et al.: Bioorg. Med. Chem., 12, 5379 (2004), Shimokawa, K., et al.: Bioorg. Med. Chem. Lett., 19, 92 (2009),<br></p>

<p>Applications Ethyl N-Methyl-beta-alaninate is an intermediate in the synthesis of Tolafentrine (T531000), which is a dual-selective phosphodiesterase 3/4 inhibitor used in chronic experimental pulmonary hypertension.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Huxtable, R., et al.: Pharmacol. Ther., 47, 371 (1990), Tanaka, K., et al.: Cancer Res., 55, 2927 (1995), Wagner, R., et al.: J. Pharmacol. Exp. Ther., 282, 1650 (1997), Cowan, K., et al.: Nat. Med., 6, 698 (2000), Shankavaram, U., et al.: J. Biol. Chem., 276, 19027 (2001),<br></p>

<p>Applications 3-CHLOROMETHYL-1-METHYLPIPERIDINE HYDROCHLORIDE (cas# 66496-82-0) is a useful research chemical.<br></p>

<p>Applications 4-Hydroxy-1-methylpiperidine<br></p>

<p>Applications Fmoc-(4-carboxymethyl)piperazine<br></p>

<p>Applications 2-Methylpropyl-d9-amine HCl (CAS# 1219799-03-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications DL-Phenyl-d5-alanine (CAS# 284664-89-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Chloro-1-methylpiperidine is a reactant in the synthesis of indole and benzimidazole piperazines as histamine H4 receptor antagonist.<br>References Terzioglu, N., et. al.: Bioorg. Med. Chem. Lett., 14, 5251 (2004)<br></p>

<p>Stability Light sensitive<br>Applications Methyl 3-Methyl-2-butenoate is an impurity in the synthesis of Ciclopirox-d11 Sodium Salt.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications N-[(S)-(4-Nitrophenoxy)phenoxylphosphinyl]-1-ethylpropylester-L-Alanine-D4 is a labelled compound form N-[(S)-(4-Nitrophenoxy)phenoxylphosphinyl]-1-ethylpropylester-L-Alanine cas(1884206-50-1)<br></p>

<p>Applications Methyl 2-diethoxyphosphoryl-2-methoxyacetate is a reagent in a Wittig reaction.<br>References Ribereau, P., et al.: Can. J. Chem., 61, 334 (1983);<br></p>

<p>Stability Hygroscopic<br>Applications H-VAL-SER-OH (cas# 13588-94-8) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-Methyl-1H-imidazole-4-sulfonyl chloride (cas# 137049-00-4) is a useful research chemical.<br></p>