Amino Acids (AA)

<p>Applications DL-4-Chlorophenylglycine<br></p>

<p>Applications Fmoc-valine is a sterically hindered, Fmoc protected amino acid and is a derivative of L-Valine (V094205). Fmoc-valine (in addition to the other amino acids) is commonly used to synthesize 4-thiazolidinones (e.g. (E)-5-(4-Ethylbenzylidene)-2-thioxothiazolidin-4-one [E925745]) and 4-metathiazanones as well.<br>References Bernatowicz, M., et al.: Tetrahed. Lett., 30, 4645 (1989); Holmes, C., et al.: J. Org. Chem., 60, 7328 (1995)<br></p>

<p>Stability Hygroscopic<br>Applications Lauryl Betaine is an amphoteric surfactant derived from N-dodecyl-N,N-dialkanol amine with protein denaturing potency. Lauryl Betaine is mainly used in shampoo, personal hygiene products and oil field chemicals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kimura, Y. et al.: J. SCCJ, 29, 106 (1995); Qin, C. et al.: GUang. Huag., 34, 30 (2006); Peng, Z. et al.: Riy. HUax. Gong., 37, 135 (2007);<br></p>

<p>Applications Labelled α-Methyl-1-pyrenemethanol is used in the synthesis of colorimetric and fluorescent ratiometric mercury sensors. This is applicable to the quantification of transition metals in the environment as well as biological systems.<br>References Weng, J. et al.: Tetra., 68, 3129 (2012);<br></p>

<p>Applications Indanone derivative as α1-adrenoceptor antagonist.<br>References Han, C., et al.: Eur. J. Pharmacol., 190, 97 (1990), Cooper, K., et al.: Drugs, 57, 9 (1999), Robinson, D., et al.: J. Med. Chem., 42, 573(1999), Fang, H., et al.: J. Chin. Pharm. Sci., 12, 188 (2003), Koshimizu, T., et al.: Pharmacol. Ther., 98, 235 (2003),<br></p>

<p>Stability Light Sensitive<br>Applications 4-Bromo-1,2-methylenedioxybenzene<br></p>

<p>Applications Fungal tyrosinases and their capability to oxidize peptide-bound tyrosine residues is important in a view of applicability of tyrosinases.<br>References Bowness, J., et al.: Biochem. J., 53, 620 (1953), Cuff, M., et al.: J. Mol. Biol., 278, 855 (1998), Kubo, I., et al.: Bioorg. Med. Chem., 12, 5349 (2004),<br></p>

<p>Applications H-Lys(me)2-oh Hydrochloride<br></p>

<p>Applications N-Boc-2-aminoethyl 4-tert-Butyl-2,6-dimethyl-3-hydroxyphenylacetamide is an intermediate in the preparation of selective alpha-1 agonist and partial alpha-2 agonist topical decongestant.<br></p>

<p>Applications o-Coumaric Acid 4-O-β-D-Glucuronide is a metabolite of either Coumarin (C755380) or o-Hydroxy-cinnamic Acid (614-60-8).<br></p>

<p>Applications (S)-N-(Benzyloxycarbonyl)-N-methylvaline has been used as a reactant in the synthesis of a biologically active cyclodepsipeptide destruxin E which is a potent negative regulator of osteoclast morphology.<br>References Yoshida, M., et. al.: J. Org. Chem., 79, 296 (2014)<br></p>

<p>Applications L-Isoleucine methyl ester is a protected form of L-Isoleucine (I820175). L-Isoleucine is classified as an essential amino acid, and is also a tumour promoter of bladder cancer in rats.<br>References Hatch, T., et al.: Infect. Immun., 12, 211 (1975); Nishio, Y., et al.: Science, 231, 843 (1986)<br></p>

<p>Applications 2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid (cas# 1114596-35-8) is a useful research chemical.<br></p>

<p>Applications Intermediate for the synthesis of glucuronide conjugates of trans-Resveratrol<br>References Learmonth, D.A., et al.: Bioconjug. Chem., 14, 262 (2003),<br></p>

<p>Applications 5-Hydroxy-1-(3-methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)decan-3-one is an intermediate used in the synthesis of [6]-Shogaol (S357800), which is an aromatic constituent of ginger and the chain-dehydroxylated analog of [6]-Gingerol. [6]-Shogaol has activity very similar to [6]-Gingerol and produced an inhibition of spontaneous motor activity, antipyretic and analgesic effects, and prolonged hexobarbital-induced sleeping time. [6]-Shogaol also has potent antitussive activity and affected the cortical EEG.<br>References Suekawa, M. et al.: J. Pharm-Dyn., 7, 836 (1984); Yoshikawa, M. et al.: Chem. Pharmac. Bull., 40, 2239 (1992);<br></p>

<p>Applications (3S)-3-Methyl-methylester Heptanoic Acid is used as a reagent in the synthesis of stereoisomers of 5,9-dimethylheptadecane, the major sex pheromone component secreted by female moths of the mountain-ash bentwing (Leucoptera scitella).<br>References Taguri, T., et al.: Tetrahedron Asymmetry, 23, 852 (2012)<br></p>

<p>Applications (S)-(+)-2-Chlorophenylglycine Methyl Ester Tartrate Salt acts as a reagent in the synthesis of biologically active metabolites of Clopidogrel (C587250), an antithrombotic.<br>References Shaw, S. et al.: J. Org. Chem., 80, 7019 (2015); Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>

<p>Applications Perchlorate salt derivative of Adenosine (A280400), nucleotide. It is also used in the synthesis of 2’-deoxy-7-methyladenosine.<br>References Fujii, T. et al.: Chem. Pharm. Bull., 42, 495 (1994);<br></p>

<p>Applications 2-Methyl-6-nitroaniline (cas# 570-24-1) is a compound useful in organic synthesis. Dyes and metabolites, Environmental Testing<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-(4-Bromophenyl)-1-methyl-5-nitro-1H-benzo[d]imidazole has been used in the study of 5-nitrofuran derivatives as an inhibitor of nucleic acid and protein synthesis in Ehrlich ascites tumor cells.<br>References Fuska, J., et. al.: Neoplasma, 20, 171 (1973)<br></p>

<p>Applications N-Carboxyalanine Anhydride is a reagent used in the synthesis of poly(γ-benzyl-L-glutamate) and its block polypeptides with alanine, leucine and phenylalanine.<br>References Cao, H., et al.: Poly. Int., 61, 774 (2012); Habraken, G.J., et al.: Poly. Chem., 1, 514 (2010);<br></p>

<p>Applications 5-(3-methylphenyl)imidazolidine-2,4-dione (cas# 187978-79-6) is a useful research chemical.<br></p>

<p>Applications N-(2-Hydroxyethyl)-4-methylbenzenesulfonamide (cas# 14316-14-4) is a compound useful in organic synthesis.<br>References Reinhardt, G., et al.: J. Appl. Biochem., 2, 495 (1980),<br></p>

<p>Applications (2E)-4-Methoxy-2-butenoic Acid is used in the protection of hydroxy groups in molecules forming esters such as cronate.<br>References Arentzen, R. et al.: J. Chem. Soc. Chem. Comm. 8, 270 (1977);<br></p>

<p>Applications Desmethyl Metsulfuron-methyl is a degradation product of Metsulfuron-methyl (MTSM), a residual sulfonylurea herbicide that kills broadleaf weeds and some annual grasses.<br>References Ollis, D., et al.: Environ. Sci. Technol., 19, 480 (1985); Malouki, M., et al.: J. Toxicol. Environ. Chem., 55, 235 (1996); Vulliet, E., et al.: J. Agri. Food Chem., 50, 1081 (2002);<br></p>

<p>Applications Epsilon-n-methyl-l-lysine Hydrochloride<br></p>

<p>Applications 7-Amino-4-methyl-3-coumarinylacetic acid is a blue fluorophore useful for immunofluorescence and peptide labeling.<br></p>

<p>Applications Glycyl-DL-serine (cas# 687-38-7) is used in the proton magnetic resonance studies of the interaction of amino acids and dipeptides with sRNA.<br>References Kwon, S. J., et al.: Taehan Hwahakhoe Chi, 21, 171 (1977); Bekker, Z. M., et al.: Biochem. Biophys. Res. Commun., 38, 871 (1970);<br></p>

<p>Applications (3-Methoxyphenyl)hydrazine hydrochloride (cas# 39232-91-2) is a useful research chemical.<br></p>

<p>Applications 3-Methyl-1,2-benzenediol is a common component of pyrolysis products.<br>References Jeong, Jae-Yong, et al.: Bioresource Tech., 219, 357-364 (2016);Chen, Dengyu, et al.: Bioresource Tech., 216, 629-636 (2016)<br></p>

<p>Applications 2-(5-Methylfuran-2-yl)ethanol is used in the synthetic preparation of selective androgen receptor modulators, which exhibits antagonist activity in some types of hormone-dependent tumors.<br>References Salvati, M.E.; et al.: PCT Int. Appl. 140 pp. Patent 2002 CODEN:PIXXD2<br></p>

<p>Applications 2-Methyl-1-phenyl-2-propanol is used in the preparation of (hydroisoquinolinylidene)acetic ureides with analgesic and antibacterial activities.<br>References Surikova, O. V., et al.: Pharm. Chem. J., 47, 198 (2013);<br></p>

<p>Applications N-Octanoylglycine-2,2-d2 (CAS# 1219805-51-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications (2R)-3-Acetylthio-2-methylpropionyl Chloride is a reactant used in the preparation of Captopril (C175750) analogs as inhibitors of angiotensin converting enzyme.<br>References Rubin, B., et al.: Eur. J Pharmacol., 51, 377 (1978); Hanessian, S., et al.: Bioorg. Med. Chem. Lett., 8, 2123 (1998);<br></p>

<p>Applications 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one is used to prepare pyridino[2,3-d]pyrimidin-7(8H)-one derivatives as CDK4 and/or CDK6 inhibitors useful in the treatment of diseases.<br>References Li, X., et al.: PCT Int. Appl., WO 2014183520 A1 20141120 (2014)<br></p>

<p>Applications 3-Bromo-5-methylphenylboronic acid<br></p>

<p>Applications N-Acetyl-L-arginine Methyl Ester is used in the synthetic route to biologically important L-arginine peptides.<br>References Levison, P.R., et al.: Synthetic Communic., 13, 167 (1983),<br></p>

<p>Applications N-Methyl-d3-acetamide-2,2,2-d3 (CAS# 3669-73-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Potassium Trifluoro(5-methoxy-2-pyridinyl)-borate-d3 is labelled Potassium Trifluoro(5-methoxy-2-pyridinyl)-borate (P698600) which is a useful synthetic intermediate.<br></p>

<p>Applications 1-(4-methoxy-2-nitrophenyl)piperazine hydrochloride (cas# 299912-45-1) is a useful research chemical.<br></p>

<p>Applications (E)-4-methoxy-2,3,6-trimethyl-5-(3,7,11,15-tetramethylhexadec-2-en-1-yl)phenol is a useful chemical reagent.<br></p>

<p>Applications N-[4-(Aminocarbonyl)phenyl]-2-methyl-4-oxazolecarboxamide (cas# 1119444-26-6) is a compound useful in organic synthesis.<br></p>

<p>Applications An amino acid amide and intermediate in the preparation of L-Tryptophanamide Hydrochloride (Cat. #T89550).<br>References Smith, E.L., and Polglase, W.J.: J. Biol. Chem., 180, 1209 (1949)<br></p>

<p>Applications 2-Methylbenzenesulfonic Acid Dihydrate is a reagent used in the solubility studies of sulfonic acid hydrates in sulfuric acids and in water acid systems.<br>References Kozlov, V. A., et al.: Zhurnal Obshchei Khimii, 54, 1469 (1984); Kozlov, V. A., et al.: Izv. Vyssh. Uchebn. Zaved., Khim.Khim. T., 21, 797 (1978)<br></p>

<p>Applications 4-Bromo-2-methoxybiphenyl-d3 is the isotope labelled analog of 4-Bromo-2-methoxybiphenyl (B687555); a useful synthetic intermediate in the preparation of N-hydroxytetrahydropyridylsulfonylacetamides which can serve as matrix metalloproteinase inhibitors.<br>References Dack, K.N., et al.: PCT Int. Appl. WO 9929667 A1 19990617. Jun 17, 1999<br></p>

<p>Applications 2-Chloro-4-iodo-6-methylbenzenamine is a reactant used in the preparation of vanilloid receptor antagonists.<br></p>

<p>Stability Hygroscopic<br>Applications A heterobifunctional polyethyleneglycol (PEG) derivative used in the preparation of intramolecular linking agents.<br>References Moreau, J. et al.: Eur. J. Org. Chem., 9, 1641 (2011);<br></p>

<p>Applications 2-Bromo-3-methylthiophene is used to prepare pyrazolo[3,4-d]pyrimidine derivatives as inhibitors of human enterovirus, coxsackievirus, echovirus, influenza virus, herpes simplex virus and rhinovirus. It is also used in the synthesis of oral α7 nicotinic receptor agonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chern, J., et al.: Bioorg. Med. Chem. Lett., 14, 2519 (2004); Tatsumi, R., et al.: J. Med. Chem., 48, 2678 (2005)<br></p>

<p>Applications 2-methylpentane-1,3-diol (cas# 149-31-5) is a useful research chemical.<br></p>

<p>Applications 4-Methoxy-4-methyl-2-pentanone is a useful building block.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3,7,11,15-Tetramethyl-1-hexadecanol 4-Methylbenzenesulfonate is an intermediate in the synthesis of Phytane (P399005). Phytane is a useful intermediate, which is involved in the manufacturing and analysis of various compounds. Phytane has recently been used in the development of a stable and environmental-friendly lubricating oil.<br>References Qiao, H.; Yang, Y.: Faming Zhuanli Shenqing 5pp. Patent 2017 CODEN:CNXXEV<br></p>

<p>Applications 3-(4-Methoxyphenyl)-2-propynoic Acid (cas# 2227-57-8) is a useful reagent for preparing bis(phenylethynyl)benzenes.<br>References Ryu, B., et al.: Asian J. Org. Chem., 9, 1754 (2020)<br></p>

<p>Applications N1-(2-Aminophenyl)-N2,N2-dimethylglycinamide (cas# 35266-48-9) is a useful research chemical.<br></p>

<p>Applications 1,2:5,6-Di-O-isopropylidene-α-D-glucofuranose 3-p-Toluenesulfonate is used in the synthesis of a highly constrained adenosine derivative of 5’-Deoxy-5’-methylthioadenosine (MTA) which is 4’,4’-spirothietane-2’,N3-cycloadenosine.<br>References De Carvalho, G. S. G., et al.: Tetrahedron Lett., 50, 463-466 (2009)<br></p>

<p>Applications Fmoc-L-2-furylalanine<br></p>

<p>Applications 1-[(4R,5R)-N2-(10,12-Dimethyl-1-oxotetradecyl)-4-hydroxy-5-(phenylthio)-L-ornithine]-pneumocandin B0 is an intermediate in the synthesis of Caspofungin Acetate, an echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall.<br>References Leonard, W. R., et al.: J. Org. Chem., 72, 2335 (2007);<br></p>

<p>Applications 3-Methyl-1-pentanol, occurs naturally in Capsicum frutescens, the tabasco pepper. It is also an intermediate in the manufacture of other chemicals, such as novel branched alkyl carbamates, having anticonvulsant activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gary, R., et al.: Source book of Flavors, (2 ed), 268 (1998); Hen, N., j. Med. Chem., 55 (6), 2835 (2012);<br></p>