Amino Acids (AA)

Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde, also known as ZILEAL, is a potent immunosuppressant that binds to the Toll-like receptor (TLR) and inhibits NF-κB binding activity. It has been shown to reduce the activation of macrophages by inhibiting the production of proinflammatory cytokines such as tumor necrosis factor alpha (TNFα), IL-1β, and IL-6. This drug has been shown to inhibit HIV replication in vitro and was also found to have an antiviral effect against herpes simplex virus type 1 in vivo. ZILEAL also inhibits dsDNA binding activity, which may have potential applications in cancer treatment.

Please enquire for more information about 2-Chloromethyl-4-(3-methoxypropoxy)-3-methylpyridine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about H-Ala-Ala-Ala-Tyr-Ala-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page

Suc-Ala-Gly-Pro-Phe-pNA is an amide that has been synthesized for the stabilization of proteins, peptides and nucleic acids. It has shown to be effective in preventing isomerization of casein and phosphatase (casein kinase II) by stabilizing the alpha helix structure. Suc-Ala-Gly-Pro-Phe-pNA also prevents fk506 binding to endoplasmic reticulum protein tyrosine kinases and isomerizes tyrosine to phenylalanine. The tetrapeptide sequence has been shown to be similar to sequences found in cellular proteins. This compound is a synthetic analog of the natural amino acid proline and can be used as a substitute in peptides or nucleotide sequences, due to its ability to stabilize these molecules against proteolysis or hydrolysis.

Please enquire for more information about (D-Ser4)-LHRH trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page

Kemptamide is a peptide that has been shown to have cytotoxic and anti-proliferative effects on renal cancer cells. It is a synthetic analogue of an endogenous peptide, Lys-Lys-Arg-Pro-Gln-Arg-Ala-Thr-Ser-Asn-Val-Phe, that is found in porcine kidney. Kemptamide’s cytotoxic activity may be due to its ability to inhibit the activity of phosphatases. Kemptamide also has regulatory properties and can modulate the expression of genes that are involved in cell growth and apoptosis. This peptide has been shown to be reactive with kidney cells, which may lead to its therapeutic effect on renal cancer.

Please enquire for more information about Fmoc-D-thiazolidine-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about H-2,5-Diiodo-His-OH·HCl including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Neuromedin S (human) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Z-Leu-Met-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Ac-D-Ala-D-lactic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Osteocalcin (45-49) (human) including the price, delivery time and more detailed product information at the technical inquiry form on this page

Z-Gly-Pro-Ala-OH is a peptidase that hydrolyzes the terminal amino acids from the N-terminal of peptides and proteins. It is used as a drug therapy for neurodegenerative diseases. Z-Gly-Pro-Ala-OH has an acidic active site and can be synthesized in an on-line process. It can be monitored using a number of techniques, including monitoring by bovine serum, kinetic analysis, and analytical methods. The optimum pH for this enzyme is 5.5 to 7.0.

1-O-Octadecyl-rac-glycerol is a fatty acid that has been shown to have antiinflammatory properties. It is also known as 1,1'-dioctadecyl-rac-glycerol, or DOG. 1-O-Octadecyl-rac-glycerol has been shown to inhibit the production of inflammatory mediators such as prostaglandin E2 and monocyte chemotactic protein 1 (MCP1) in vitro and in vivo. It has also been shown to stimulate the production of colony stimulating factor (CSF), which stimulates the growth and differentiation of stem cells into macrophages, neutrophils, dendritic cells, erythrocytes, and lymphocytes. These cells are needed for wound healing and repair.

Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human, bovine, porcine) trifluoroacetate salt is a peptide hormone that regulates blood pressure by causing the kidneys to excrete sodium and water. It is used as a model system for studying the physiological effects of urodilatin and has been shown to inhibit the cyclase enzyme. Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human, bovine, porcine) trifluoroacetate salt may also have an antihypertensive effect through its ability to reduce levels of natriuretic peptides in plasma. This drug is also being investigated as a possible treatment for congestive heart failure. The small molecular weight makes it suitable for use as a natriuretic or antihypertensive drug with minimal side effects.

Please enquire for more information about AQEE-30 (mouse, rat) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Z-Lys-Pro-4MbNA formiate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Seminal Plasma Inhibin (67-94) (human) including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Fluorescein-6-carbonyl-Ala-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone including the price, delivery time and more detailed product information at the technical inquiry form on this page

Boc-Ala-Ala-Asp-pNA is a peptide that has been shown to have cytotoxic activity against the leukemia cell line, basophilic leukemia (BL). It also inhibits hemolytic activity and cytolysin production by staphylococcus. This peptide is expressed in the sequence of Boc-Ala-Ala-Asp and is composed of 20 amino acids. The Boc-Ala sequence has been shown to be involved in apoptosis, while Asp and pNA are responsible for inhibiting hemolytic activity. Functional assays have demonstrated that this peptide has a strong inhibitory effect on the growth of bacteria, including strains of subtilis and hybridization.

Endogenous heptapetide which causes vasodilation and has anti-hypertensive properties.

8-Phenyltheophylline (8PT) is an adenosine receptor agonist that is used as a bronchodilator for the treatment of asthma. It has been shown to increase the intracellular calcium concentration in hl-60 cells and in rat papillary muscles. 8PT also has locomotor activating effects, which are thought to be due to its ability to block potassium channels in the hippocampal formation. These effects may be related to ATP-sensitive potassium channels, which have been shown to be sensitive to ATP in untreated mice. 8PT also has anti-arrhythmic properties, which may be due to its ability to inhibit sodium channels and its effect on heart rate and contractility.

Bosentan is a potent inhibitor of the uptake of organic anions. It is used in the treatment of pulmonary arterial hypertension and has been shown to be effective against pravastatin-resistant HIV protease inhibitors, such as saquinavir, quinidine, and rosuvastatin. Bosentan inhibits uptake by binding to the transporter protein at a site that does not overlap with the binding site for organic anion substrates. This leads to a change in kinetic parameters for substrates, such as pravastatin and saquinavir. The binding site on bosentan may also be elucidated through monolayer experiments with efflux transporters.

Please enquire for more information about H-Asp-Phe-NH2 trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about N2-(S)-1-Carboxy-3-phenylpropyl-L-lysine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Disodium (1-methyl-4-oxoimidazolidin-2-ylidene)phosphoramidate including the price, delivery time and more detailed product information at the technical inquiry form on this page

(Des-Gly10, tBu-D-Gly6,Pro-NHEt 9)-LHRH acetate salt Pyr-His-Trp-Ser-Tyr-tBu-D-Gly-Leu-Arg-Pro-NHEt acetate salt is a synthetic hormone that belongs to the group of gonadotropin releasing hormones (GnRH). It is used in veterinary medicine to stimulate ovulation and follicular growth in animals. (Des-Gly10, tBu-D-Gly6, Pro -NHEt9)-LHRH acetate salt Pyr -His -Trp -Ser -Tyr -tBu -D -Gly -Leu -Arg -Pro NHEt acetate salt is a prodrug that is hydrolyzed in vivo to buserelin, its active form. This drug has been shown to be effective against estradiol benzoate and sodium salts

Please enquire for more information about Fmoc-2,6-dichloro-L-phenylalanine including the price, delivery time and more detailed product information at the technical inquiry form on this page

5-[(1-Methylindole-3-yl)carbonyl]-4,5,6,7-tetrahydro-1H-bezimidazole is a reactive heterocyclic compound. It is a carboxylic acid and an amide with a peptic and cephalalgic effect. The symptoms of 5-[(1-methylindole-3-yl)carbonyl]-4,5,6,7-tetrahydro-1H-bezimidazole are hemicrania and amnesia. It has been expressed in the calf thymus DNA.