Amino Acids (AA)

<p>Stability Toxic<br>Applications 2-Chloro-4-methylpyrimidine (cas# 13036-57-2) is a compound useful in organic synthesis.<br></p>

<p>Applications L-Valine is an essential amino acid and one of 20 proteinogenic amino acids. L-Valine cannot be manufactured by the body and must be acquired through diet or supplementation. L-valine is found in grains, dairy products, mushrooms, meats, peanuts and soy proteins. L-Valine has been used in studies to attenuate arrhythmias and induce hypotensive effects.<br>References Choi, C.W. et al.: Anim. Feed Sci. Technol., 102, 15 (2002); Kolarski, D. et al.: Krmiva, 30, 155 (1988); Oba, M. et al.: J. Dairy Sci., 93, 2044 (2010); Mitrega, K. et al.: Pharmacol. Res., 64, 218 (2011);<br></p>

<p>Stability Hygroscopic, Temperature Sensitive<br>Applications A carnitine ester of unsaturated fatty acid. Used in the studies of fibroblasts in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency and fatty acid oxidation disorders.<br>References Gross R.W., et al.: J. Biol. Chem., 258, 5221 (1983),<br></p>

<p>Applications Labelled L-Ornithine. A non-essential amino acid for human development but is required intermediate in arginine biosynthesis. L-Ornithine is found in virtually all vertebrate tissues as well as incorporated into proteins, such as tyrocidine. Isolation from chicken excreta.<br>References Fattori, D. et al.: J. Med. Chem., 50, 550 (2007); Gomez-Alonso, S. et al.: J. Agric. Food Chem., 55, 608 (2007); Subramaniam, R. et al.: Bioorg. Med. Chem. Lett., 18, 3333 (2008);<br></p>

<p>Applications Pipecolic acid is involved in synaptic transmission in the central nervous system.<br>References Nomura Y., et al.: Neurochem. Res., 6, 391 (1981),<br></p>

<p>Applications N-(4-Cyanophenyl)-glycine (cas# 42288-26-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Methyldibenzothiophene, is an alkyldibenzothiophene present in crude oil. Research concerning the biodegradation of Dibenzothiophene by different types of bacteria is a currently being carried out, as these bacteria have the ability to breakdown other harmful PAH’s as well. This may be used in removing spilled oil from marine and terrestrial environments.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boberg, F., et al.: Erdoel &amp; Kohle, Erdgas, Petrochemie, 47, 187 (1994); Tanaka, Y., et al.: Applied Microbiology and Biotech., 59 (2), 325 (2002); Prince, R., Spill Sci. Tech. Bulletin, 8 (2), 145 (2003);<br></p>

<p>Applications (+)-α-Methyl-β-alanine is a reactant for the chemoenzymatic assembly of cryptophycins as potent anticancer therapeutics.<br>References Magarvey, N.A., et al.: ACS Chem. Biol., 1, 766-779 (2006)<br></p>

<p>Applications 5-Bromo-3-methyl-2(5H)-furanone is used as a reactant in the synthesis of strigolactone analogs.<br>References Artuso, Emma, et al.: J. of Nat. Products, 78(11), 2624-2633 (2015);Jia, Kun-Peng, et al.: Mol. Plant, 9(9), 1341-1344 (2016)<br></p>

<p>Applications 3’,5’-Diiodo-L-thyronine is a thyroid hormone that has been shown to increase malic enzyme activity, and the activity of glucose-6-phosphate dehydrogenase in teleost Anabas testudineus. Thus, showing short term effect on lipid metabolism.<br>References Davey, K.G.: Insect Biochem. Mol. Bio., 30, 877 (2000); Shameena, B., et. al.: Endocr. Res., 26, 431 (2000)<br></p>

<p>Applications Caerulein is a ten amino acid oligopeptide that stimulates smooth muscle and increases digestive secretions. It is similar in action and composition to cholecystokinin. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction. It is used to induce pancreatitis in experimental animal models.<br>References Anastasi,E., et al.: Ep., 23, 699 (1997); De Caro, G., et al.: Br. J. Pharmac Chemother., 33, 48 (1968)<br></p>

<p>Applications 4-Methyl-valerophenone is an intermediate used in the synthesis of a-Pyrrolidinoisohexanophenone (Hydrochloride) (P841230), which is a phenone derivative used for research purposes.<br>References Guo, Z.K., et al.: Marine Drugs, 16, 45/1 (2018)<br></p>

<p>Applications 2,4-Dinitrophenylhydrazone (DNPH) derivative.<br>References Lindsay, R.C., et al.: J. Food Sci., 29, 266 (1964),<br></p>

<p>Applications 3-Methyl Salicylic Acid is a toxic compound, it’s toxicity is similar to salicylic acid. Reagent used in manufacturing and preparation of dyes.<br>References Egorova, T. V., et al.: Tekstil'naya Promyshlennost , 3, 48 (1987); Keshavarz, M. H., et al.: J. Hazard. Mater., 237, 79 (2012)<br></p>

<p>Applications Fmoc-n-me-lys(boc)-oh<br></p>

<p>Applications Pteroyltri-γ-L-glutamic acid is a folate derivative found in various foods such as yeast, spinach, beef liver, beef fillet and peas.<br>References Tamura, T., et al.: Br. J. Haematol., 25, 513 (1973); Ndaw, S., et al.: J. Chromatogr. A, 928, 77 (2001)<br></p>

<p>Applications Labelled DL-Serine is used in the synthesis of novel tryptoline derivatives as IDO (indoleamine 2,3-Deoxygenase) inhibitors, for potential use in Alzheimer’s treatment.<br>References Tanaka, M. et al.: Bioorg. Med. Chem., 21, 1159 (2013);<br></p>

<p>Applications 3-Ethyl-2-methyl-2-(3-methylbutyl)-oxazolidine is a oxazolidine-based moisture scavenger for use in urethane coatings, sealants and elastomers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-Mercapto-3-methylbutanoic Acid Ethyl Ester is an intermediate in the synthesis of 3-Mercapto-3-methylbutyl Formate (M253540), which is one of the major odor-active thiol in pan-roasted white sesame seeds.<br>References Czerny, M., et al.: J .Agric. Food Chem., 47, 695 (1999), Steinhaus, M., et al.: Eur. Food Res. Technol., 226, 45 (2007), Tamura, H., et al.: Agric. Food Chem., 2010, 58, 7368 (2010),<br></p>

<p>Applications D-Tyrosine, the stereoisomer to L-Tyrosine (T899975), is an amino acid used in various organic syntheses for antibiotics. It is used in the synthesis of (-)-anisomycin, as well as BATSI (boronic acid transition state inhibitors) which act on β-lactamases. It has also been studied as an inhibitor of microbial growth on surfaces, reducing microbial attachment to hydrophillic glass and hydrophobic polypropylene surfaces.<br>References Li, Ji. et al.: Chin. Chem. Lett., 23, 647 (2012); Xu, H. et al.: Water Res., 45, 5796 (2011); Ke, W. et al.: Antimicrob. Agents Chemother., 55, 174 (2011);<br></p>

<p>Stability Very Hygroscopic<br>Applications A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells.<br>References Vallence, P., et al.: Lancet, 339, 572 (1992),<br></p>

<p>Stability Hygroscopic<br>Applications 3-Methylglutaconic acid is a glutarate which builds up in the urine in 3-methylglutaconic aciduria. 3-methylglutaconic aciduria is a term used to describe five different disorders that impair the functioning of energy-producing centers within cells (mitochondria)<br>References Walsh, R., et al.: J. Inherit. Metab. Dis., 22, 251 (1999); Gonzalez, I., et al.: Am J Med Genet A., 134, 409 (2005); MacKenzie, J., et al.: Biochim Biophys Acta., 1772, 509 (2007)<br></p>

<p>Applications 5-Hydroxy-N-methyl-2-pyrrolidinone is a metabolite of N-methylpyrrolidone (NMP).<br>References Payan, J., et al.: Drug Metab. Dispos., 30, 1418 (2002), Carnerup, M., et al.: Food Chem. Toxicol., 43, 1441 (2005), Angerer, J., et al.: Toxicol. Sci., 93, 3 (2006),<br></p>

<p>Applications L-Glutamic acid dibenzyl ester 4-toluenesulfonate<br></p>

<p>Applications 1-BOC-2,3-Dihydropyrrole-4-boronic acid, pinacol ester is a useful research chemical for organic synthesis and other chemical processes.<br>References Lewis, R. T., et al.: From PCT Int. Appl. (2017), WO 2017004359 A1 20170105<br></p>

<p>Applications Acetyl-L-carnitine is a mitochondrial metabolite that helps to transport fatty acids into the mitochondria for energy (1). Acetyl-L-carnitine also upregulate metabotropic glutamate receptor 2 (mGlu2) via NF-κB p65 acetylation (2,3). It exhibits antidepressant and neuroprotective properties.<br>References (1) Stephens, F. B., et al.: J Physiol. 581, 431 (2007) (2) Wang, S. M., et al.: J Psychiatr Res. 53, 30 (2014) (3) Cuccurazzu, B., et al.: Neuropsychopharmacology 38, 2220 (2013)<br></p>

<p>Applications L-Alanine-d3 is the labeled analogue of L-Alanine (A481500), which is used to make in-vivo measurement of glucose and alanine metabolism in studies of patients with diabetes. L-Alanine is a non-essential amino acid for human development. L-Alanine is one of the 20 amino acids encoded by the genetic code.<br>References Bier, D.M. et al.: Diabetes, 26, 1005 (1977); Capaldo, B. et al.: J. Clin. Endocrinol. Metab., 71, 1220 (1990); Giacca, A. et al.: Diabetes, 47, 1763 (1998)<br></p>

<p>Applications 5-Methoxy-1-methylindole-2-boronic acid pinacol ester (cas# 1256360-41-4) is a useful research chemical.<br></p>

<p>Applications Ethionine-induced inhibition of protein synthesis and lowering of ATP level in the liver.<br>References Rotig, A., et al.: Lancet, 356, 391 (2000), Forsgren, M., et al.: Biochem. J., 382, 519 (2004), Johnson, A., et al.: J. Biol. Chem., 280, 31397 (2005), Horvath, R., et al.: Neurology, 66, 253 (2006), Mollet, M., et al.: J. Clin. Invest., 117, 765 (2007),<br></p>