Amino Acids (AA)

<p>Applications 4-(3-Methoxypropoxy)-2,3-dimethylpyridin-1-ium-1-olate is used in preparation of Picolylsulfides and related drugs by using Esterification and Thioetherification as the key steps.<br>References Wang, D., et al.: Faming Zhuanli Shenqing, (2019);<br></p>

<p>Applications Labelled Tiopronin. It is used as antidote against heavy metal poisoning; hepatoprotectant; mucolytic.<br>References Capasso, F., et al.: Agents Actions, 11, 741 (1981), Amor, B., et al.: Arthritis Rheum., 25, 698 (1982), Ichida, F., et al.: J. Int. Med. Res., 10, 325 (1982),<br></p>

<p>Applications A protected glutamic acid for use in peptide synthesis.<br>References Takahashi, M., et al.: J. Exp. Biol., 200, 401 (1997), Michaelis, E., et al.: Prog. Neurobiol., 54, 369 (1998), Koch, H., et al.: Mol. Pharmacol., 55, 1044 (1999), O'Kane, R., et al.: J. Biol. Chem., 274, 31891 (1999),<br></p>

<p>Applications This compound contains up to 25% of the two other regioisiomers.<br></p>

<p>Applications H-PRO-GLU-OH (cas# 67644-00-2) is a useful research chemical.<br></p>

<p>Applications D-Homotyrosine hydrobromide<br></p>

<p>Applications N-[(R)-1-Carbethoxybutyl]-(S)-alanine is an intermediate in the synthesis of Perindoprilat (P287530), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.<br>References Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)<br></p>

<p>Applications Methyl 5-(Ethylsulfonyl)-2-methoxybenzoate (cas# 62140-67-4) is a useful research chemical.<br></p>

<p>Applications N-Succinimidyl 3-Methoxy-4-nitrobenzoate (cas# 2006277-78-5) is a useful research chemical.<br></p>

<p>Applications 4-METHYL-2-PHENYL-2-PENTENAL (cas# 26643-91-4) is a useful research chemical.<br></p>

<p>Applications 2-Amino-6-methylpyrimidin-4(3H)-one (cas# 3977-29-5) is a useful research chemical.<br></p>

<p>Applications 4-Methylenepiperidine Hydrochloride is a building block that can be coupled with aryl halides via Suzuki cross-coupling to give benzyl piperidines and related compounds.<br>References Vice, S., et al.: J. Org. Chem., 66, 2487 (2001);<br></p>

<p>Applications A substrate for pyroglutamate aminopeptidase. Used for colorimetric determination of pyrrolidonyl peptidase activity in bacteria.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Szewczuk, A., et al.: Eur. J. Biochem., 8, 63 (1969), Szewczuk, A., et al.: Anal. Biochem., 39, 268 (1971)<br></p>

<p>Applications It is used as labelled biomarker for metabolic age.<br>References Selmer, T., et al.: Eur. J. Biochem., 268, 1363 (2001), Connelly, J., et al.: Drug Metab. Dispos., 30, 1357 (2002), Lindon, J., et al.: Pharm. Res., 23, 1075 (2006), Monteagudo, E., et al.: Xenobiotica, 37, 1000 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications endo-9-Methyl-9-azabicyclo[3.3.1]nonan-3-amine Acetate is an impurity of Granisetron HCl (G780000), a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy<br>References Kilpatrick, G.J., et al.: Nature, 330, 746 (1987), Durig, T., et al.: J. Pharm. Sci., 86, 1092 (1997), Yuasa, H., et al.: Chem. Pharm. Bull., 44, 1361 (1996),<br></p>

<p>Impurity Levodopa EP Impurity A; Levodopa USP Related Compound A<br>Stability Hygroscopic<br>Applications 6-Hydroxy-L-DOPA (Levodopa EP Impurity A; Levodopa USP Related Compound A) is the 6-hydroxy derivative of the amino acid L-DOPA (D533751) with neurotoxic properties. Studies show that exogenously administered 6-Hydroxy-L-DOPA is biotransformed by amino acid decarboxylase to the highly potent and catecholamine-selective neurotoxin, 6-Hydroxydopamine. The treatment of 6-Hydroxy-L-DOPA in rats resulted in the stimulation of acetylcholinesterase.<br>References Jaim-Etcheverry, G. et al.: Brain Res., 100, 699 (1975); Kostrzewa, R.M. et al.: Amino Acids, 14, 175 (1998); Berthet, A. et al.: J. Neurosci., 29, 4829 (2009);<br></p>

<p>Applications L-Tryptophan-d3 is a deuterium labelled amino acid, which is a protein building block. The unlabelled L-Tryptophan (T947210) is also available.<br>References Goze, C., et al.: Eur. J. Pharmacol., 643, 153 (2010), Bhandare, P., et al.: J. Chem. Pharm. Res., 2, 372 (2010),<br></p>

<p>Applications Labeled Sucrose (S697000). Yuanzhen sugar is a polysaccharide polymer, containing a certain amount of fructooligosaccharides.<br>References Watanabe, T., et al.: Biosci. Biotech. Biochem., 72, 3167 (2008), You, Y., et al.: J. Agric. Food Chem., 57, 709 (2009),<br></p>

<p>Applications 4-Methoxy-6-(trifluoromethyl)-1,3,5-triazin-2-amine can be used as reactant/reagent in preparation of N-phenylsulfony-N'-pyrimidinylureas as herbicides.<br>References Hamprecht, G., et al.: Ger. Offen., DE 4322726 A1 19950112 (1995)<br></p>

<p>Stability Moisture Sensitive<br>Applications 2,3-dihydroxy-3-methylbutanoic acid (cas# 1756-18-9) is a useful research chemical.<br></p>

<p>M02961 - H-Phe-OH</p>

<p>Applications 5-Methoxyindole-3-acetic Acid is a chemical reagent used in the analysis of the physiological properties of auxins.<br>References Ferro, N. et al.: J. Clin.Info. Model., 46, 1751 (2006);<br></p>

<p>Applications 1-Bromo-3-methylbutane, is used as an extraction solvent to determine various polycyclic aromatic hydrocarbons in water samples though dispersive liquid-liquid microextraction along with GC-MS (gas chromatography- mass spectrometry).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rezaee, M., et al.: J. Chromat. A., 1116, 1 (2006)<br></p>

<p>Applications N-Methyl-2,4-dinitroaniline-d3 (cas# 91808-45-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications A naturally occurring nitrostable secondary amine found in tabacco smoke condensate.<br>References Singer, G.M. et al.: J. Agric. Food Chem. 24, 553(1976); Bush, L. P. et al.: Can. J. Plant Sci. 50, 289(1970).<br></p>

<p>Applications 4-Chloro-benzoic Acid 1-(4-Methoxyphenyl)hydrazide Hydrochloride is a derivative of (4-Methoxyphenyl)hydrazine Hydrochloride (M265880). It is a useful synthetic intermediate for the preparation of Indomethacin (I641000); a potent, time-dependent, nonselective inhibitor of the cyclooxygenase enzymes COX-1 and COX-2.<br>References Blobaum, Anna L., et al.: ACS Med. Chem. Lett., 4(5), 486-490 (2013); Prusakiewicz, Jeffery J., et al.: Biochemistry, 43(49), 15439-15445 (2004)<br></p>

<p>Applications 8-Chloro-4-hydroxy-2-methylquinoline (cas# 5236-87-3) is a useful research chemical.<br></p>

<p>Applications Ethametsulfuron-methyl is a regulator of the early steps of complement activation on mucosal surfaces. It can be used in combination treatment of ohmic heating with various essential oil components for inactivation of food-​borne pathogens in buffered peptone water and salsa.<br>References Kim, S. S., et al.: Food Control, 80, 29 (2017); Reichhardt, M. P., et al.: Front Immunol, 7, 85 (2016)<br></p>

<p>Applications N-Boc-4-hydroxypiperidine is a 4-hydroxypyridine with a boc protecting group used in the preparation of neurologically active agents and other pharmaceutical compounds.<br>References Kwon, Y.E. et al.: Bioorg. Med. Chem., 15, 6596 (2007); Knutsen, L.J.S. et al.: J. Med. Chem., 42, 3463 (1999);<br></p>

<p>Applications A proteinogenic amino acids involved in the biosynthesis of purines and pyrimidines. Inhibitor of serine palmitoyltransferase. A neuromodulator.<br>References Junjaud, G. et al.: J. Neurochem., 98, 1159 (2006); Hanada, K. et al.: FEBS Lett., 474, 63 (2000); Pollegionni, L. et al.: Cell. Mol. Life Sci., 67, 2387 (2010);<br></p>

<p>Applications L-Ornithine-2,3,3,4,4,5,5-d7 hydrochloride is the labelled analogue of L-Ornithine Hydrochloride (O695550), a non-essential amino acid for human development but is required intermediate in arginine biosynthesis. L-Ornithine is found in virtually all vertebrate tissues as well as incorporated into proteins, such as tyrocidine. Isolation from chicken excreta.<br>References Fattori, D., et al.: J. Med. Chem., 50, 550 (2007), Gomez-Alonso, S., et al.: J. Agric. Food Chem., 55, 608 (2007), Subramaniam, R., et al.: Bioorg. Med. Chem. Lett., 18, 3333 (2008),<br></p>

<p>Applications 2-Methylpentane is used as a raw material/intermediate in organic synthesis, rubber solvent, and vegetable oil extraction solvent.<br>References Choi, D., et al.: Adv. Funct. Mater. 25, 920 (2015)<br></p>

<p>Applications 3-Amino-4-methylbenzamide is useful for preparing heteroaryl compounds ERK1/ERK2 inhibitors.<br>References Qiao, L.: PCT Int. Appl. (2016), WO 2016100452 A2<br></p>

<p>Impurity Duloxetine EP Impurity B<br>Applications A Duloxetine intermediate. Duloxetine EP Impurity B.<br></p>

<p>Impurity Rabeprazole EP Impurity G<br>Applications Used in the preparation of 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazoles derivatives as anti helicobacter pylori agents.<br>References Kuehler, T. et al.: J. Med. Chem., 41, 1777 (1998)<br></p>

<p>Applications N-(2-Hydroxyethyl)glycine (~90%) (cas# 5835-28-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 4,4-methylenebis(N,N-diethylaniline) (cas# 135-91-1) is a useful research chemical.<br></p>