Amino Acids (AA)

<p>Amyloid beta-protein (Aβ) is a protein that is involved in the metabolic processes that are thought to be associated with Alzheimer's disease. Aβ is a peptide of 39-43 residues and is found in amyloid plaques, which are aggregates of Aβ. The amino acid sequence of human Aβ has been determined by sequencing the cDNA and gene for this protein. The structure of the protein has been studied using molecular modeling, kinetic data, and predictive biomarker studies. Cleavage products have been identified from the protein, including beta-amyloid peptide (1-40), which can be used as a diagnostic marker for Alzheimer's disease. Structural analysis has also shown lysine residues that may serve as pharmaceutical targets for therapeutic intervention.</p>

<p>FA-Asp-Ala-OH is a catalytic, acidic, and hydrophilic molecule. It has been shown to be an activating residue for carboxypeptidases. This molecule can hydrolyze other amino acids in the presence of water. Mutations to the FA-Asp-Ala-OH have been shown to have a profound effect on the kinetic properties of carboxypeptidases. The FA-Asp-Ala-OH residue is also important because it can increase the activity of carboxypeptidases by as much as 3 times as compared to wild type enzymes.</p>

<p>Please enquire for more information about Fmoc-Ser(tBu)-Wang resin (100-200 mesh) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Boc-Leu-Lys-Arg-AMC is a synthetic substrate that has been used in a number of clinical studies to identify the serine proteases that are involved in autoimmune diseases. It is a synthetic peptide composed of the amino acid sequence found in soybean trypsin. The peptide was shown to have high salt tolerance and was able to be hydrolyzed by polyclonal antibodies with specificity for amyloid protein, suggesting it may be useful as a biochemical marker for Alzheimer's disease. Boc-Leu-Lys-Arg-AMC has also been shown to be an efficient substrate for collagenase, which is an enzyme that breaks down collagen and causes tissue damage. This property makes this compound useful as a proteolytic agent for the removal of unwanted scar tissue or other lesions from diseased organs. Boc-Leu-Lys-Arg-AMC also has an optimum pH level of 7.5 and is active against influenza</p>

<p>Please enquire for more information about Z-His-Leu-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Z-Val-Leu-Arg-4MbNA·HCl including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>H-Glu(Glu(Glu-OH)-OH)-OH trifluoroacetate salt is a casein that is used as a model system for pancreatic β-cells. It has been shown to induce cell apoptosis in malignant cells and sequences that are associated with the development of pancreatic cancer. H-Glu(Glu(Glu-OH)-OH)-OH trifluoroacetate salt also induces endothelial cell proliferation and decreases cell function, which may be due to its ability to promote uptake of this compound.</p>

<p>H-Gln-Glu-OH is a pharmacological inhibitor that blocks the epidermal growth factor receptor (EGFR) and inhibits cell proliferation. It has been shown to inhibit endothelial cell proliferation in vitro. H-Gln-Glu-OH also inhibits the tyrosine kinase activity of EGFR, which is necessary for the activation of phospholipase C. This inhibition prevents atherogenic cell functions and has been shown to inhibit the growth of human epidermoid carcinoma in tissue culture.</p>

<p>Please enquire for more information about tert-Butyl6-[(1e)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-di oxane-4-acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 1-Boc-4-Iodomethyl-Piperidine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Neuropeptide W-23 (rat) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(Des-Gly10, tBu-D-Gly6,Pro-NHEt 9)-LHRH acetate salt Pyr-His-Trp-Ser-Tyr-tBu-D-Gly-Leu-Arg-Pro-NHEt acetate salt is a synthetic hormone that belongs to the group of gonadotropin releasing hormones (GnRH). It is used in veterinary medicine to stimulate ovulation and follicular growth in animals. (Des-Gly10, tBu-D-Gly6, Pro -NHEt9)-LHRH acetate salt Pyr -His -Trp -Ser -Tyr -tBu -D -Gly -Leu -Arg -Pro NHEt acetate salt is a prodrug that is hydrolyzed in vivo to buserelin, its active form. This drug has been shown to be effective against estradiol benzoate and sodium salts</p>

<p>Please enquire for more information about Z-Leu-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Suc-Ala-Pro-pNA is a glycoprotein that has been shown to have a number of different functions. It is an inhibitor of tissue culture, and it has been shown to inhibit the growth of cervical cancer cells by binding to epidermal growth factor (EGF). It also inhibits peptide hormones such as prolactin and insulin, which can lead to breast cancer. Suc-Ala-Pro-pNA may be clinically relevant for treatment of carcinoma cell lines due to its ability to bind platinum-based chemotherapy drugs. This protein has been shown to be expressed on the surface of mammary carcinoma cells, where it acts as a receptor for the monoclonal antibody mcf7. The protein's function as a surface glycoprotein means that it can act as a marker for cancerous tumors in the body.</p>

<p>Please enquire for more information about H-Arg(Pbf)-2-chlorotrityl resin (200-400 mesh) (Low Substitution) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

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<p>Acetyl-(Ala11·15)-Endothelin-1 (6-21) Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile<br>TrpOH is a recombinant peptide that is a potent endothelin receptor antagonist. It binds to the endothelin receptor, blocking the binding of endothelin and preventing activation of the receptor. Acetyl-(Ala11·15)-Endothelin (6–21) Ac has been shown to inhibit atrial natriuretic peptide levels and reduce blood pressure in experimental models. This drug also prevents balloon injury by blocking the binding of endothelin to its receptors and inhibits growth factor β1, which is an important mediator in pulmonary hypertension. The mechanism of action for this drug is not fully understood, but it may work through inhibiting</p>

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<p>Please enquire for more information about H-D-Ala-bNA·HCl including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about O-Hippuryl-L-b-phenyllactic acid sodium salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Cell-permeable Caspase-3 Inhibitor I trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about GRP (1-16) (porcine) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (Glu8·9)-Helodermin including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-AMC trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about N-Me-Val-Leu-anilide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about H-D-Val-2-chlorotrityl resin (200-400 mesh) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>L-Lysine L-malate is a chemical compound that is used in wastewater treatment. It inhibits the activity of enzymes such as carbon disulphide oxidase, copper complexes, and cationic surfactants. L-Lysine L-malate can be synthesized from sodium citrate and malonic acid by reacting with hydrogen peroxide to form a bicyclic heterocycle. This compound has been shown to have biological effects on metabolic disorders in animal studies, which may be due to its ability to inhibit the synthesis of fatty acids and proteins. The adsorption mechanism for this product is unknown.</p>

<p>Please enquire for more information about (Pyr 110)-Prepro-Urotensin II (110-123) (rat) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about H-Gly-Gly-Arg-anilide acetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Z-Leu-Leu-Glu-bNA is a polypeptide that has been shown to activate the cytosolic fatty acid oxidation pathway in Xenopus oocytes. The polypeptide was found to inhibit the activity of enzymes involved in fatty acid synthesis and activation, such as acyl CoA synthetase, lipoyl CoA transferase, and acyl CoA oxidase. Z-Leu-Leu-Glu-bNA also inhibited protein synthesis in Caco2 cells by inhibiting the activity of protein kinase A (PKA) and phosphorylation of protein kinase B (PKB). These effects are mediated by lysine residues and proteolytic cleavage of Z-Leu-Leu-Glu-bNA.</p>

<p>Please enquire for more information about Entero-Kassinin including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Z-Tyr-Leu-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about H-Arg-Gly-NH2·sulfate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Fibronectin CS-1 Fragment (1978-1985) trifluoroacetate salt H-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr-OH trifluoroacetate salt is a peptidomimetic with peroxidase activity. It has the ability to bind to red blood cells and monoclonal antibodies, which are used in spatially specific immunoassays. Fibronectin CS-1 Fragment (1978-1985) trifluoroacetate salt H-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr-OH trifluoroacetate salt also has an effect on hyperresponsiveness and can be used as a costimulatory antigen for cancer immunotherapy.</p>

<p>Please enquire for more information about Caloxin 2A1 trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Amyloid beta/A4 Protein Precursor770 (740-770) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>PAR-2 agonist is a synthetic peptide that activates PAR-2. It binds to PAR-2 receptors, which are present in the mesenteric vasculature and in various other tissues. Activation of PAR-2 leads to an increase in intracellular calcium concentration, activation of protein kinase C, cytosolic calcium ion release, phosphorylation of myosin light chain, muscle cell proliferation, transcription and translation initiation, and increased production of vasoactive intestinal peptide. This drug also has anti-inflammatory effects and stimulates epidermal growth factor (EGF) and thrombin receptor expression as well as growth factor production.</p>

<p>H-D-Pra-OH is a chemical substance that inhibits the synthesis of proteins. It binds to the active site of enzymes, thereby blocking the formation of an enzyme-substrate complex and inhibiting enzyme activity. H-D-Pra-OH is an enzyme inhibitor that can be used to study protein synthesis in vitro. It is most effective on renal proximal tubules cells, where it inhibits potassium uptake by competitive inhibition with d-alanine. H-D-Pra-OH also inhibits the uptake of aziridine, which is a reactive substance that can cause cellular damage. The carbonyl group in this substance may react with other substances such as potassium dichromate, forming a chromium compound that can be seen under the microscope.</p>

<p>Z-Gly-Pro-Gly-Gly-Pro-Ala-OH is a synthetic substrate. It is used in tissue culture to measure collagenase activity, as well as in skin cells to measure the activity of v. anguillarum. The optimum pH for this substrate is 5.5 and it has been shown to be stable in high salt environments. This substrate also reacts with human liver granulosa cells and has been shown to have neutral pH properties. Z-Gly-Pro-Gly-Gly-Pro-Ala-OH is an enzyme substrate that is involved in many different enzyme activities including protein synthesis and hydrogen bonding.</p>

<p>Please enquire for more information about (Phenylac 1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Z-Asp(ONp)-OBzl is a synthetic compound with minimal side-chain that can be used as a condensation and deprotection reagent in the synthesis of peptides. It functions to selectively cleave the N-terminal amino group from an unprotected peptide. This side chain is not present on natural amino acids and therefore provides selectivity for the N-terminal amino acid. Z-Asp(ONp)-OBzl has been found to be a more controllable and selective alternative to other deprotection reagents such as DBU, DCC, or TFA. The use of this reagent in peptide synthesis has been shown to provide high yields of unblocked chains with minimal side reactions.</p>

<p>Used in treatment of nonspecific ulcerative colitis</p>

<p>Please enquire for more information about Z-Gly-Pro-Arg-4MbNA acetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Cyclo(-Arg-Ala-Asp-D-Phe-Cys) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ghrelin-Cys(BMCC-biotinyl) (human) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ac-Gly-Lys-bNA including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about PAR-3 (1-6) amide (human) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Boc-Met-PAM resin (200-400 mesh) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Fmoc-Glu(OtBu)-Wang resin (200-400 mesh) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (Des-Gly10,D-Ser4,D-Ser(tBu)6,Pro-NHEt 9)-LHRH acetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>