Amino Acids (AA)

<p>Applications (E)-(3,4-Dihydro-7-methoxy-1(2H)-naphthalenylidene)acetonitrile is an intermediate used in the synthesis of (E)-N-[2-(3,4-Dihydro-7-methoxy-1(2H)-naphthalenylidene)ethyl]acetamide(Agomelatine Impurity) (D450485), which is an impurity of Agomelatine (A430000) which is a melatoninergic agonist and selective antagonist of 5-HT2C receptors and used in the treatment of major depressive disorder. Agomelatine Impurity 2<br>References Yous, S., et al.: J. Med. Chem., 35, 1484 (1992), Zhdanova, I., et al.: J. Clin. Endocrinol. Metab., 86, 4727 (2001), Cajochen, C., et al.: J. Pineal Res., 35, 149 (2003),<br></p>

<p>Applications 3-Methoxyphenylacetic Acid (cas# 1798-09-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Methyl-3-propyl-1H-pyrazole-5-carboxylic Acid-d3 is an isotope labelled intermediate in the synthesis of Sildenafil (S435000) and respective analogs.<br>References Terrett, N., et al.: Bioorg. Med. Chem. Lett., 6, 1819 (1996),<br></p>

<p>Applications D-Glutamic Acid 1,5-Dimethyl Ester Hydrochloride, is a diester analogue of D-Glutamic Acid (G596965), a non-essential amino acid. It can also be used for the synthesis of more complex pharmaceutical compounds.<br>References McEntee, W. et al.: Psychopharmacology, 111, 391 (1993); Manev, H. et al.: Mol. Pharmacol., 36, 106 (1989);<br></p>

<p>Applications N-(4-Hydroxy-2-methyl-6-quinolinyl)acetamide is an intermediate in the synthesis of NSC 23766 (N900280), which is a highly soluble and membrane permeable Rac GTPase inhibitor. NSC 23766 inhibits Rac GTPase by targeting Rac activation by guanine nucleotide exchange factor (GEF). NSC 23766 has been shown to inhibit the anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells.<br>References Gao, Y., et. al.: Proc. Natl. Acad. Sci. U.S.A., 101, 7618, (2004); Akbar, H., et. al.: Methods Enzymol, 406, 554 (2006)<br></p>

<p>Applications 5-Amino-3-methylisothiazole Hydrochloride (cas# 52547-00-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Boc-α-Methylalanine is used as a catalyst in the preparation of 2-benzopyranone derivatives (isocoumarin) as well as arylbenzeneacetic acids.<br>References Lu, Y. et al.: Chem. Sci., 2, 967 (2011); Engle, K. et al.: JK. Am. Chem. Soc., 133, 18183 (2011);<br></p>

<p>Applications 2-methylquinoline-4,6-diamine Dihydrochloride Salt is an intermediate in the synthesis of NSC 23766 (N900280), which is a highly soluble and membrane permeable Rac GTPase inhibitor. NSC 23766 inhibits Rac GTPase by targeting Rac activation by guanine nucleotide exchange factor (GEF). NSC 23766 has been shown to inhibit the anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells.<br>References Gao, Y., et. al.: Proc. Natl. Acad. Sci. U.S.A., 101, 7618, (2004); Akbar, H., et. al.: Methods Enzymol, 406, 554 (2006)<br></p>

<p>Applications Reagent used to synthesize many pyrrole derivatives<br></p>

<p>Applications N-tert-Boc-2-(4-hydroxy-2-methoxyphenoxy)ethylamine-d3 (cas# 1189659-07-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Used in the preparation of piperazine-1-carboxamide derivatives as fatty acid amide hydrolase (FAAH) inhibitors.<br>References Glorius, F., et al.: Org. Biomol. Chem., 3, 4171 (2005),<br></p>

<p>Applications 4-Bromo-5-methylbenzene-1,3-diol is used in the synthesis of phenanthrenes which displays antioxidant and anti-inflammatory activities.<br>References Kanekar, Y., et al.: Eur. J. Med. Chem., 67, 454-463 (2013)<br></p>

<p>Applications An intermediate in the preparation of DOPA-decarboxylase inhibitors<br></p>

<p>Applications 4-Methyl-benzenesulfonic Acid 2-[3-(Dimethylphenylsilyl)cyclobutylidene]hydrazide is an intermediate used in synthesizing 2-Cyclobutenyl-3-trifluoromethyl-5-chloro-1H-indole-1-carboxylic Acid Ethyl Ester, which is synthesized from 5-chloro-2-oxindole (C375030), that is used in the preparation of novel GSK-3β inhibitors as anticancer agents.<br>References Choi, M.J., et al.: Bull. Korean. Chem. Soc., 32, 2015 (2011); Otani, M., et al.: Bioorg. Med. Chem. Lett.. 20, 4259 (2010); Jhan, Y.H., et al.: Tetrahedron. Lett., 54, 1155 (2013); Hsieh, J.C., et al.: Org. Biomolec. Chem., 10, 6404 (2012);<br></p>

<p>Applications (R)-3,5-Dihydroxy-3-methylpentanenitrile is an intermediate in enantioselective synthesis of mevalonolactone.<br>References Eliel, E. L., et al.: Tetrahedron. Lett., 22, 2859 (1981);<br></p>

<p>Applications 1-(Cyano-(4-methoxyphenyl)ethyl)cyclohexanol-d11 is an intermediate in the synthesis of N,O-Didesmethylvenlafaxine, a metabolite of Venlafaxine.<br>References Klamerus, K. J., et al.: J. Clin. PHarmacol., 32, 716 (1992), Gelenberg, A.J., et al.: J. Am. Med. Assoc., 283, 3082 (2000)<br></p>

<p>Applications 7-(2-Butyn-1-yl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione is a reagent used in the preparation of pharmaceuticals for the treatment of fatty liver diseases.<br>References Muramoto, K. PCT Int. Appl. (2005), WO 2005053695 A1 20050616.<br></p>

<p>Applications 4-[[4-(Acetyloxy)-3,5-diiodophenyl]methylene]-2-methyl-5(4H)-oxazolone _x000D_(E/Z Mixture) (cas# 93087-37-7) is a compound useful in organic synthesis.<br></p>

<p>Applications O-TBS 2'-Deoxy-N-methyl-cytidine-d3 is an intermediate used in the synthesis of 2'-Deoxy-N-methyl-cytidine-d3 (D242412), which is the labelled form of 2'-Deoxy-N-methyl-cytidine (D242410). 2'-Deoxy-N-methyl-cytidine is a nucleotide derivative used as an analytical reagent.<br>References Dupret, D.: Biomed. Health. Res., 23(Human Genome Analysis), 244-255 (1998)<br></p>

<p>Applications 4-(2,4-Dichloro-5-methoxyphenoxy)aniline is an intermediate formed in the synthesis of 2-[4-(2,4-Dichloro-5-hydroxyphenoxy)phenoxy]propanoic Acid Methyl Ester (D434675), the metabolite of Diclofop-methyl, used as a herbicide.<br>References Tanaka, F. S., et al.: J. Agri. Food Chem., 38, 553 (1990)<br></p>