Peptides

<p>Cellulose synthase is a crucial enzyme involved in the synthesis of cellulose. Cellulose is an aggregation of unbranched polymer chains made of β-(1-4)-linked glucose residues, and is a component of primary and secondary cell walls - functioning to primarily maintain strength and shape in cells.Cellulose is synthesised by large cellulose synthase complexes (CSCs), which consist of synthase protein isoforms (CesA) that are arranged into a unique hexagonal structure.Specifically the isoform cellulose synthase 7 takes part in secondary cell wall cellulose synthesis.</p>

<p>The coronavirus (CoV) nucleoprotein is the major component of CoV structural proteins. The nucleoprotein has a critical role in virus assembly and RNA transcription. The nucleoprotein is essential in the formation of helical ribonucleoproteins and in regulating viral RNA synthesis. The nucleoprotein can also regulate infected host cellular mechanisms. It is highly expressed during infection and may induce protective immune responses against SARS-CoV and SARS-CoV-2.The nucleoprotein residues HIDAYKTFPPTEPKK (356-370) from SARS-CoV-2 have been identified as a T-cell epitope with a predicted HLA restriction. Immune targeting of confirmed epitopes may potentially offer protection against SARS-CoV-2 and help the development of vaccines for long-lasting immunity.</p>

<p>Liraglutide is sold under the brand name €˜Victoza' and is a medication used to treat diabetes mellitus type 2 and obesity.Liraglutide binds to and activates the GLP-1 (glucagon-like peptide-1) receptor to bring about an increase in insulin secretion and a decrease in glucagon secretion and gastric emptying.</p>

<p>The RGD peptide is an adhesive peptide present in extracellular matrix proteins allowing them to attach to a range of biological materials. It is labelled with Alexa Fluor 647.</p>

<p>Alyerserin-1b is a C-terminally α-amidated 23 residue Cationic anti-microbial peptide (AMP). Anti-microbial peptides (AMPs) are produced by the innate immune system and are expressed when the host is challenged by a pathogen. The Alyerserin family of peptides was first identified in norepinephrine-stimulated skin secretions of the midwife toad-Alytes obstetricans-(Alytidae). Alyteserin-1 peptides have limited structural similarity to the ascaphins from the skins of frogs of the Leiopelmatidae family. Alyteserin-1 peptides are selective at inhibiting growth activity of Gram-negative bacteria-such as Escherichia coli and show weak haemolytic activity against human erythrocytes.Alyteserin contain at least 50% hydrophobic amino acids. Hydrophobic residues contribute to the insertion of the peptide into the hydrophobic membrane core which results in membrane disruption and death of the pathogen. Due to their mechanism of action it is thought to be less likely for resistance to develop towards these peptides compared to conventional antibiotics.</p>

<p>The cyclic AMP (cAMP) response element binding protein (CREB) is a transcription factor that regulates the transcription of several genes that mediate important cellular processes. CREB is phosphorylated by several kinases, including PKA- Akt- and CamK I, II, and IV. Phosphorylated pCREB translocates to the nucleus, where it forms homodimers or heterodimers, and recruits p300/CREB binding protein (CBP) to initiate transcription of its target genes. pCREB is an important regulator of apoptosis and is also involved in modulating several immune processes and neuronal plasticity. CREB signalling has a critical role in the formation of memories and may be dysfunctional in the brains of Alzheimer's disease (AD).Peptide is labelled with an N-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.</p>

<p>Fibrinogen is a vital biopharmaceutical, but purification has remained problematic. GPRPK pentapeptide is a synthetic ligand designed to bind fibrinogen, it can be immobilised on Fractogel and used over 50 times without losing capacity and achieving over 95% protein purity. Fibrin fragments can also be purified from plasma due to the recognition of the GPR residues. This has been clinically applied to help atherosclerosis patients by removing fibrinogen from the plasma, reducing the viscosity, and thus improving microcirculation blood flow. A batchwise process of fibrinogen production has been superseded in efficiency by the generation of GPRPK bound to a novel sucrose-based polymer (SUBPOL) for affinity chromatography.</p>

<p>CIGB-300 is an anti-casein kinase 2 (CK2) peptide. CK2 is a serine-threonine protein kinase with more than 300 substrates which plays a role in several cellular processes including cell growth and proliferation, cell viability, and apoptosis. CK2 is also frequently dysregulated in many human tumours phosphorylation by CK2 is a biochemical event involved in human oncogenesis. CIGB-300 binds to the phospho-acceptor domain of CK2 substrates, impairing the correct phosphorylation by the enzyme, thus reducing tumour cell adhesion, migration and invasion. CIGB-300 therefore has potential as a cancer therapy. P15 is fused to the cell-penetrating peptide derived from the HIV-Tat protein that has been extensively used for delivering peptides cargoes within cells. P15-Tat induces apoptosis in a variety of tumour cell lines.</p>

<p>SMRT peptide (amino acids 1414-1430 corresponding to the SMRT BCL6 binding domain.</p>

<p>The SARS-CoV-2 spike protein is present on the outside of the virus particles and can bind to angiotensin-converting enzyme II (ACE2) present on the host cells. The C-terminal receptor binding domain (RBD) of the spike protein binds to the N-terminal peptidase M2 domain of ACE2. This receptor binding results in the internalisation of the virus-receptor complex and is, therefore the mechanism of entry of SARS-CoV-2 into host cells.The spike protein residues LITGRLQSL (996-1004) from C have been identified as a T-cell epitope with a predicted HLA restriction. Immune targeting of confirmed epitopes may potentially offer protection against SARS-CoV-2 and help the development of vaccines for long-lasting immunity.</p>

<p>Acetyl-(Arg)9, derived from (Arg)9 is a cationic cell-penetrating peptide consisting of 9 arginines. Arginine rich CPPs enter cells in a passive manner through membrane multilamellarity and fusion. Evidently as a CPP, (Arg)9 can function to deliver specific molecules to target cells and can be used for drug delivery purposes.</p>

<p>Fibroblast growth factor 22 (FGF22) is a cytokine that belongs to the FGF family. FGF22 has been shown to play a role in the modulation of glucose homeostasis and the regulation of insulin secretion. FGF22 is produced by pancreatic β cells, liver, kidney, muscle, and fat tissue. It has been shown to be involved in the regulation of cellular proliferation and apoptosis, as well as the control of inflammation and immune response.</p>

<p>This is a Biologically Active Peptides, Short=PN-II, Proteomics, Amyloid Precursor Protein, New England Peptide calibrated to 25nmol. This peptide has been shown to be a major component of amyloid plaques in Alzheimer's Disease. It is one of the most abundant proteins in the brain and is found in association with beta-amyloid protein (A4). The precursor protein for APP is encoded by the gene on chromosome 21. APP and its products are involved in many cellular processes such as signal transduction, cell proliferation, apoptosis and inflammation. APP can be cleaved by Beta-secretase or Gamma secretase to release A4 and N-APP.</p>

<p>Nucleolar Protein 3 (NOP3) is a human protein that belongs to the nucleolar-enriched phosphoproteins. NOP3 is an activator of RNA polymerase II and is involved in the regulation of ribosomal RNA transcription. The ligand for NOP3 has been identified as a peptide corresponding to the C-terminal domain of the protein. NOP3 also interacts with Ion channels and may be involved in the regulation of ion channel activity, including voltage-gated potassium channels.</p>

<p>Anti Amyloid B-Protein (1-40), human serum is a recombinant inhibitor of amyloid beta protein (Aβ) that inhibits the formation of amyloid plaques in Alzheimer's disease. This product is used as a research tool for studying the mechanism of Aβ toxicity. It is also used as a reagent for antibody detection and other research purposes.</p>

<p>RFamide-Related Peptide-1, human is a protein that belongs to the family of G-protein coupled receptors. It is activated by RFamide-related peptides and has been shown to be involved in the regulation of ion channels, such as potassium channels. The activation of these channels leads to the inhibition of neuronal excitation and can affect many other biological functions, such as cell proliferation or differentiation. RFamide-Related Peptide-1, human has been used as a pharmacological research tool for studying its ligand binding properties and protein interactions.</p>

<p>Anti GRF/GH-RH (Rat) Serum is a research tool that is used to detect the presence of GH and GRF receptors. This antibody can be used for the study of GH and GRF receptor interactions and their roles in cell biology. Anti GRF/GH-RH (Rat) Serum can also be used as an inhibitor to block protein interactions.</p>

<p>Insulin is a peptide hormone that regulates the metabolism of carbohydrates, fats, and proteins. Insulin has been shown to bind to insulin receptors in the cell membrane. When insulin binds to the receptor, it triggers a series of biochemical reactions that lead to increased glucose uptake by cells and increased synthesis of glycogen in the liver. Insulin also activates ion channels, which leads to an increase in calcium influx into cells. Insulin is involved in many other functions within the body, such as promoting growth and development, regulating protein synthesis, and controlling lipid storage.<br>Insulin is used as a research tool for studying carbohydrate metabolism or as an antidiabetic drug for people who have diabetes mellitus. The most common form of insulin used today is human recombinant insulin (H-insulin). Human recombinant insulin can be synthesized from genetically engineered bacteria or yeast cultures.</p>

<p>Ac-Abu-D-Tyr-Leu-Gln-VS is a synthetic peptide that can be used as a research tool, an activator, or an inhibitor. It is a high purity product that has been extensively tested for its use in ion channels and receptor pharmacology.</p>

<p>Big endothelin-1 (ET-1) is a peptide with a molecular weight of 37.7 kDa that belongs to the class of endothelin peptides. ET-1 is an activator of ion channels and has been implicated in many physiological and pathological processes, including vasoconstriction, angiogenesis, cellular proliferation, and inflammation. The antibody reacts with human ET-1 with a high degree of specificity. It has been used as an immunological reagent for Western blotting and immunoprecipitation experiments.</p>

<p>D-Amino Acid Oxidase is an enzyme that catalyzes the conversion of D-amino acid to alpha keto acid and ammonia. It is also known as DAAO or DAO.</p>

<p>Arg-MCA is a synthetic peptide that activates the receptor for bradykinin. It is used as a research tool in cell biology and pharmacology to study the interactions of peptides with various receptors and ion channels. Arg-MCA has been shown to inhibit the activity of ligand-gated ion channels, such as nicotinic acetylcholine receptors and glutamate receptors.</p>

<p>Anti GIP (18-42) (Rat) Serum is a research tool used to activate the Ligand, Receptor, Cell Biology, Antibody, Ion channels, High purity, Protein interactions, Pharmacology, Peptides, Life Science. It can be used in the inhibition of GIP receptor and is an excellent choice for pharmacological studies.</p>

<p>Der P1 Protein is a recombinant protein that inhibits the activity of the protease dermaseptin-1. This protein is mainly found in the skin and is an important regulator of epidermal permeability barrier function. Der P1 Protein binds to the protease and prevents it from degrading other proteins, which are essential for maintaining skin integrity. Der P1 Protein can also be used as a research tool to study protein interactions, activators, ligands, receptors, ion channels, and antibodies.</p>

<p>Flt3 ligand is a peptide that functions as an inhibitor of the receptor tyrosine kinase, Flt3. It is used in cell biology research to study protein interactions and receptor signaling pathways. Flt3 ligand binds to the extracellular domain of Flt3 and can activate the receptor by binding to it. This activation leads to phosphorylation of a number of proteins that regulate cellular processes such as ion channels, transcription factors, and other protein kinases.</p>

<p>Anti GLP-2 (Rat) Serum is a high purity and potent activator of the GLP-2 receptor. It is a peptide that binds to the GLP-2 receptor and activates it. The GLP-2 receptor is a G protein coupled receptor that belongs to the class of receptors for peptides. Activation of this receptor leads to an increase in intracellular calcium ions and increased cell proliferation, differentiation, and survival. This product can be used as a research tool for Cell Biology, Pharmacology, or Biochemistry studies.</p>

<p>Uroguanylin is a peptide that activates the guanylate cyclase receptor. It is composed of 8 amino acids and has a molecular weight of 1036.5 Da. Uroguanylin is an agonist for the GUCY1A2 receptor, which is responsible for mediating the release of urinary and gastrointestinal hormones such as vasopressin, renin, and gastrin. Uroguanylin binds to one or more other receptors in the kidney or intestine. It can be used as a research tool in cell biology and biochemistry to study ion channels and ligands.br&gt;br&gt;<br>br&gt;br&gt;<br>Uroguanylin is also known by its CAS number 71405-27-8.BR&gt;BR&gt;</p>

<p>Acid-dPEG®9-NHS Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Acid-dPEG®9-NHS Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Amino acids 1-37 of the Human Big Endothelian-2 peptide formed as a result of furin cleavage of proendothelin which in turn is produced from EDN2 gene transcription. Due to the actions of the Endothelin-Converting Enzymes: ECE-1 and ECE-2, Big Endothelin-2 is converted into Endothelin-2 (ET-2) peptide. ET-2 has affinity for ETA and ETB G-protein coupled receptors which are found in a variety of tissues, including lungs, heart, kidneys, uterus and vasculature. It is believed that ET-2 is a potent vasoconstrictor and may play a role in cancer, immunology and heart failure. This product has is available as a 0.1mg vial and has disulfide bonds between Cys1-Cys15 and Cys3-Cys11.</p>

<p>Anti PACAP (1-15) is a peptide that belongs to the class of activators. It has been shown to activate ion channels, increase intracellular calcium levels, and inhibit ligand-induced receptor desensitization. Anti PACAP (1-15) has also been shown to bind to a number of receptors with high affinity, including the corticotropin-releasing hormone receptor type 2 (CRHR2). This peptide is used as a research tool in cell biology and pharmacology studies.</p>

<p>This peptide is a specific inhibitor of human preprorenin, which is the precursor of renin. The peptide has been shown to inhibit the activation of renin with high specificity and potency.</p>

<p>Cytochrome B5 Reductase 3, human, recombinant is a high-quality protein used in research and scientific studies. Produced using Escherichia Coli, this protein is essential for various biological processes. Cytochrome B5 Reductase 3 plays a crucial role in electron transfer reactions and is involved in the metabolism of drugs and toxins. It has been extensively studied for its ability to catalyze the reduction of cytochrome b5, an important component of the electron transport chain. This recombinant protein provides researchers with a reliable tool to investigate cellular processes and advance scientific knowledge.</p>

<p>Anti-Rattin-24 is a monoclonal antibody that binds to the major allergen of rat R. rattus, Rattin-24. It has been shown to inhibit the binding of this protein to its receptor, which prevents activation of the receptor and the subsequent release of inflammatory mediators. Anti-Rattin-24 can be used as a research tool for studying protein interactions, receptor signaling pathways, peptide ligands, and ion channels. This antibody can also be used in cell biology and immunology studies as an inhibitor that blocks or inhibits certain biological processes.</p>

<p>it is a non-glycosylated polypeptide chain containing 350 amino acids (31-359 a.a) with a molecular mass of 38.6kDa.  It is fused to a 21 amino acid His-tag at N-terminus.</p>

<p>Elafin is a peptide that is secreted by human neutrophils. It has been shown to inhibit the activity of ion channels and play a role in the regulation of cell proliferation and differentiation. Elafin also interacts with receptors and ligands, which are molecules that bind to other molecules. It is also used as a research tool for studying protein interactions in cell biology. Elafin has been shown to have an anti-inflammatory effect on cells, which may be due to inhibition of the production of prostaglandins.</p>

<p>Anti TGF-Alpha, humanSerum is a recombinant antibody that specifically binds to the ligand of the Transforming Growth Factor-alpha receptor. It is used as a research tool for protein interactions, pharmacology and cell biology.</p>

<p>Carboxyl-dPEG®4-(m-dPEG®8)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Carboxyl-dPEG®4-(m-dPEG®8)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>monoFITC INSL5 is a peptide that can be used as a research tool to investigate the interactions between proteins and ligands. It is an activator of the Insulin-like growth factor 1 receptor (IGF1R). This peptide has been shown to inhibit IGF1R-mediated signaling pathways that lead to cell proliferation.</p>

<p>The HIV-1 p24 Core Recombinant is a recombinant protein made from the HIV-1 p24 core protein. It has been purified by immunoaffinity chromatography and is specific to the HIV-1 antigen, with minimal cross-reactivity to other viruses. The HIV-1 p24 Core Recombinant is found in the form of a chain of polypeptides, which are chains of amino acids that form proteins. This protein can be used as an immunoreactive reagent for detecting antibodies against HIV-1 in human serum or plasma.</p>

<p>MAL-dPEG®4-NHS Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®4-NHS Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>A synthetic cone snail toxin sourced form the marine snail, conus striatus. This product has disulfide bonds between Cys1-Cys16,Cys8-Cys20, and Cys15-Cys26 and is available as a 0.5mg vial.</p>

<p>Autoinducing peptide (AIPs) are produced by Staphylococcus aureus bacterium in order to regulate virulence.</p>

<p>A standard for use in proteomics</p>

<p>Maleimide-activated BSA (BSA-M) is a maleimide-activated form of Bovine Serum Albumin (BSA). It is a peptide that can be used for immunization, as well as in biochemistry experiments. BSA-M has been shown to stimulate antibody production and can be used in the development of new vaccines.</p>

<p>H-Trp-2-ClTrt-Resin is a resin that has been used for the synthesis of peptides. It can be used as a building block for peptides, or as a building block in the synthesis of other compounds. H-Trp-2-ClTrt-Resin is available in two mesh sizes: 200 mesh and 400 mesh. The resin is soluble in ethyl acetate and alcohols, but insoluble in water.</p>

<p>Big Gastrin, is a hormone which exerts its effects through activating the G-protein coupled receptor CCK2R and plays a role in gastric acid secretion. Big Gastrin can be used in research applications such as pharmacology and cell biology. This product is also a potential growth factor in some cancer tumors, including prostate cancer. It is available as an ammonium salt and as a 0.1mg vial.</p>

<p>HG1 toxin is a peptide that is found in the venom of the scorpion Heterometrus fulvipes. It is a member of the short-chain scorpion toxins, which are composed of a single chain of amino acids. This protein has been shown to bind to potassium channels and inhibit their function, leading to paralysis of the prey's nervous system. HG1 toxin has been shown to be able to activate or inhibit ion channels and other receptors. It can also bind to ligands such as peptides or antibodies and affect cellular activity. HG1 toxin is produced by recombinant DNA technology and purified by HPLC for use in biochemical research and pharmacological studies.</p>

<p>Gly-Phe is a kinetic glycolytic inhibitor that has antiviral properties. It has been shown to be effective against a number of viruses, including the herpes simplex virus type 1 (HSV-1), influenza virus A/PR/8/34 (PR8), and human immunodeficiency virus type 1 (HIV-1). Gly-Phe inhibits viral growth by blocking the synthesis of nucleic acids in cells infected with these viruses. The antiviral activity of Gly-Phe was demonstrated in animal models and humans, where it acted as an effective treatment for HSV-1 infection. Gly-Phe also has anti-inflammatory properties, which may be due to its ability to inhibit bacterial enzymes in the intestinal tract.</p>

<p>MAL-dPEG®12-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®12-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Obestatin (Human)-EIA Kit is a specialty product for the detection of obestatin in human serum or plasma. Obestatin is an endogenous peptide hormone which is structurally related to ghrelin, which is produced by the stomach and regulates appetite. The kit contains one antibody labeled with a radioactive isotope and one control antibody. The kit can be used as a screening test for levels of obestatin in blood serum or plasma samples.</p>

<p>D-Arginyl-[Hyp3,Thi5,8,D-Phe7]-Bradykinin is a biochemicals that acts as an antagonist of bradykinin. Bradykinins are peptides that are active in the human body and have a variety of physiological effects. D-Arginyl-[Hyp3,Thi5,8,D-Phe7]-Bradykinin has been shown to inhibit the release of neurotransmitters from nerve cells and has anti-inflammatory properties. It also has been shown to inhibit the activity of protein kinase C.</p>

<p>Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp is a peptide that is an elastase substrate derived from PAI-1</p>

<p>DOTA-tris(Acid)-Amido-dPEG®11-Maleimide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DOTA-tris(Acid)-Amido-dPEG®11-Maleimide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Dns-Glu(Cys-Gly) is a peptide that is reactive and can be used as a biochemical. It has been shown to have both reactive metabolites and biologically active peptides.</p>

<p>The ELISA (enzyme-linked immunosorbent assay) is a powerful and sensitive technique to detect and quantify antigens of interest in biological samples. The Insulin ELISA kit from Specialty Products and Technologies contains the reagents necessary for in vitro measurement of human insulin in serum, plasma, or urine. This kit utilizes a monoclonal antibody specific for human insulin as the detection antibody. The Insulin ELISA Kit is designed to measure human insulin concentrations in range 0.5-25 ng/mL with an accuracy of ±15%.</p>

<p>Matrix Metalloproteinase-1 is a recombinant human protein that is used as a research tool to study the function of matrix metalloproteinases. It has been shown to bind to peptides and activate them, which may lead to new insights into their function. Matrix Metalloproteinase-1 also binds to ion channels and ligands, which may be useful for understanding the role of these molecules in diseases such as cancer.</p>

<p>The leptin (RAT)-HS ELISA Kit is a sandwich enzyme-linked immunosorbent assay kit for the quantitative measurement of rat leptin in serum or plasma. Rat leptin is a protein hormone that regulates body weight, food intake, and energy expenditure. Leptin is synthesized and secreted by adipose tissue in proportion to fat mass. The human form of this hormone is called human leptin.</p>

<p>CTGF Human is a research tool that is used to investigate how CTGF interacts with its receptor and other proteins. The CTGF protein can bind to the Cell Biology, Antibodies, Ion Channels, Pharmacology, Peptides, and Life Science fields. It is an inhibitor for Lipases.</p>

<p>Anti PACAP38, humanSerum is a research tool that can be used to study the role of PACAP in various biological processes. The antibody is generated against human PACAP38 and has been shown to inhibit the activity of this peptide. The antibody also binds to the receptor for this peptide, which is a G protein-coupled receptor. This antibody can be used as an inhibitor of PACAP and its receptor in various cell types.</p>

<p>TentaGel Macrobead PHB Resin is a polymer resin which is used for the synthesis of peptides. The resin can be used as a building block in peptide synthesis, as well as being mixed with other resins for use in other applications. TentaGel Macrobead PHB Resin is supplied in particles that are made up of polystyrene beads and hydroxypropyl-b-cyclodextrin (PHB) groups. The PHB groups are designed to bind to peptides during the synthesis process, while the polystyrene bead provide a support matrix. This product is primarily used by researchers who are interested in using it for the study of protein structure and function.</p>

<p>m-dPEG®12-Propionaldehyde is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®12-Propionaldehyde is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Anti Galanin (9-30), humanSerum is a peptide that inhibits the activity of galanin, which is a neuropeptide. It has been shown to have an effect on ion channels and receptors in the central nervous system. Anti Galanin (9-30), humanSerum binds to the receptor for galanin and blocks the binding of galanin molecules to these receptors, preventing activation of these cells. Anti Galanin (9-30), humanSerum is used as a research tool for studying protein interactions and as a pharmacological inhibitor for studying ion channels and receptors in the central nervous system.</p>

<p>SPDP-dPEG®4-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. SPDP-dPEG®4-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Bz-Arg-OEt • HCl (BAEE) is a peptide substrate of trypsin. It is an enzyme that cleaves proteins by hydrolyzing the peptide bonds at the carboxyl termini of polypeptides. The Bz-Arg-OEt • HCl (BAEE) reacts with trypsin to form a complex that has a unique spectrum of absorption and emission maxima, which can be used to identify BAEE in solution.</p>

<p>CINC-1/gro (Rat) Antiserum is a research tool that can be used in the study of protein interactions and cell biology. This antibody is an activator of Ligands and Receptors. CINC-1/gro (Rat) Antiserum binds to ion channels and has been found to inhibit the activity of these channels in pharmacology studies. This antibody also inhibits the activity of peptides, which are small proteins that function as hormones or neurotransmitters. CINC-1/gro (Rat) Antiserum is high purity and will not react with other antigens.</p>

<p>Angiotensin II is a peptide hormone that regulates blood pressure and water balance. It is an important component of the renin-angiotensin system, which causes vasoconstriction and release of aldosterone from the adrenal gland. Angiotensin II binds to angiotensin receptors on cells, initiating a second messenger cascade that results in increased blood pressure and electrolyte retention. Val5-Angiotensin II is a synthetic form of this hormone that has been shown to increase glomerular filtration rate by inhibiting angiotensin converting enzyme (ACE). Angiotensin II also stimulates epidermal growth factor, which may be responsible for its anti-inflammatory effects. The optimum pH for Val5-Angiotensin II is between 7.0 and 8.0.</p>

<p>MAL-dPEG®4-(m-dPEG®11)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®4-(m-dPEG®11)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Standard for use in proteomics studies</p>

<p>Heat Shock Protein 70kDa is a protein that belongs to the heat shock protein family. It is an important regulator of the intracellular proteolytic and metabolic pathways. Heat Shock Protein 70kDa has been shown to be involved in the regulation of ion channels, receptor-ligand interactions, and protein synthesis. It also plays a role in cell cycle regulation, apoptosis, and other cellular processes. The recombinant human HSP70KD protein is produced in E. coli and has been purified by a series of chromatographic steps. This product is provided as lyophilized powder in 100% pure water with no additives or preservatives.</p>

<p>M CSF Mouse is a research tool that is an activator, ligand, and receptor in cell biology. It is a cell-surface protein that binds to the receptor for macrophage colony-stimulating factor (M-CSF). M-CSF Mouse stimulates the proliferation of hematopoietic progenitor cells and enhances their differentiation into macrophages. This product has been extensively used as an antibody with high purity. M CSF Mouse has also been shown to be a natural inhibitor of ion channels, which may be due to its ability to bind to voltage-gated potassium channels.</p>

<p>Streptavidin-NC is a recombinant protein that is used in immunoassays. It binds to biotin and can be used as an alternative to the antigen-antibody reaction. Streptavidin-NC binds to the biotinylated antigen at the same time as it binds to the specific antibody, forming a sandwich complex. Streptavidin-NC has been shown to be more sensitive than antibodies in cardiac muscle and skeletal muscle immunoassays, with better specificity for cardiac troponin I and T than monoclonal antibodies. The molecular mass of this protein is about 50000 Da, which corresponds to a chain with about 500 amino acids.</p>

<p>A TIMP1 Heavy Tryptic Peptide Standard for protein identification and quantitation studies. TIMP1, also known as TIMP metallopeptidase inhibitor 1 is an inhibitor of matrix metalloproteinases, which are enzymes that break down the extracellular matrix. It has also been associated with cell proliferation promotion and may have a role in apoptosis.</p>

<p>Bromoacetamido-dPEG®23-Azide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Bromoacetamido-dPEG®23-Azide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Gly-Gly-Tyr-Arg acetate dihydrate is a tetrapeptide and a ligand for the enzyme papain. It binds to the active site of papain and inhibits its proteolytic activity. Gly-Gly-Tyr-Arg acetate dihydrate has been shown to be an inhibitor of trypsin and chymotrypsin, but not other proteases. It has also been shown to inhibit the polymerase chain reaction and RNA synthesis in vitro.</p>

<p>Carboxyfluorescein-dPEG®24-Amido-dPEG®24-DSPE is a PEG compound containing a fluorescein dye used for tagging biomolecules, and serving as fluorescent probe for bioimaging applications.</p>

<p>Anti Na Channel ll (467-485) (Rat) Serum is an anti-Na channel antibody that can be used for research purposes. It is a monoclonal antibody that has been generated according to the sequence and features of the rat N-type voltage-gated sodium channels. The affinity of this antibody for its target is high, with a Kd of 0.5 nM. This antibody can be used in immunoassays, Western blots and immunoprecipitations to determine the level of Na channel expression in various tissues.</p>

<p>Pancreastatin is a peptide that is an inhibitor of potassium channels. Pancreastatin binds to and blocks the opening of K+ channels, thereby inhibiting the propagation of action potentials. Pancreastatin is a potent inhibitor of voltage-gated K+ channels in pancreatic β-cells and inhibits insulin secretion. Pancreastatin has been shown to inhibit the activity of sodium channels in the central nervous system, which may have therapeutic benefits for patients with epilepsy or other seizure disorders. Pancreastatin also has inhibitory effects on norepinephrine release from sympathetic nerves and acetylcholine release from parasympathetic nerves, which may be beneficial for patients with Parkinson's disease or Alzheimer's disease.</p>

<p>H-Gln-2-ClTrt-Resin is a resin that consists of polystyrene crosslinked with divinylbenzene. It is used in peptide synthesis to provide amino acids and building blocks for the synthesis of peptides and proteins. This resin can be used as a component in the production of amines, alcohols, thiols, and other organic compounds. The crosslinking agent in this resin is divinylbenzene (DVB).</p>

<p>CD2, human, recombinant is a research peptide that is commonly used in scientific studies. It is a protein that is produced using Escherichia Coli bacteria. CD2 plays an important role in immune responses and cell signaling. This recombinant form of CD2 allows researchers to study its function and interactions with other molecules in a controlled laboratory setting. It can be used in various experiments and assays to investigate the mechanisms of immune system regulation and develop potential therapeutic interventions. With its high purity and quality, CD2, human, recombinant is a valuable tool for researchers in the field of immunology and molecular biology.</p>

<p>MAL-dPEG®2-NHS Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®2-NHS Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>TentaGel; is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix.</p>

<p>The amyloid β-protein (Aβ) is a peptide of 40 amino acids that is a major constituent of the amyloid deposits in the brain. The Aβ peptide is derived from the proteolytic cleavage of the beta-amyloid precursor protein (APP). This product can be used as a research tool and as an activator or ligand for receptor, cell biology, antibody, ion channels, and pharmacology. It can also be used to study protein interactions and peptides in life science.</p>

<p>Anti Preprogalanin (89-124) (Rat) Serum is a research tool that can be used to study the interactions of proteins with other proteins, peptides, and receptors. Anti Preprogalanin (89-124) (Rat) Serum has been shown to activate ion channels and ligand-gated ion channels. It also has an antibody against it, which can be used in immunoassays. This serum is purified from rat plasma and contains no preservatives.</p>

<p>BD 3 MOUSE is a peptide that is used as a research tool for the study of ion channels. BD 3 MOUSE is an activator of the nicotinic acetylcholine receptor. It can be used to inhibit protein interactions, such as those between ligands and receptors. BD 3 MOUSE is also an inhibitor of potassium channels, which are important for neuronal excitability and muscle contraction. This peptide has been shown to bind to voltage-gated sodium channels, leading to a decrease in sodium current. This inhibition leads to an increase in action potential duration and amplitude.</p>

<p>Eledoisin-related peptide is a research tool that can be used to study the activation of G protein-coupled receptors. It is a ligand and an activator of the human beta-adrenergic receptor. Eledoisin-related peptide binds to the beta2-adrenergic receptor with high affinity, but does not activate the receptor. Instead, it inhibits the binding of other ligands such as epinephrine and norepinephrine to their respective receptors. Eledoisin-related peptide has been shown to inhibit ion channels in cell biology studies. This peptide has also been shown to bind to antibodies and interact with proteins in pharmacological studies.</p>

<p>Bromoacetamido-dPEG®4 -TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Bromoacetamido-dPEG®4 -TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Soybean BBI is a protein that belongs to the family of ion channels. It is an activator of receptor-operated calcium channels, which are found in many types of cells and are involved in a variety of physiological processes. Soybean BBI has been shown to inhibit the activity of potassium channels, which help regulate the electrical activity in neurons. Soybean BBI can be used as a research tool for studying protein interactions and peptides. It has also been used as an antibody for Western blot analysis and immunocytochemistry techniques. This protein has a CAS number and is available at high purity.</p>

<p>IGHG1 MS Calibrator-5 is a calibrator for the IGHG1 tryptic peptide. It is used for the quantitative determination of Ig gamma-1 chain C region in proteomics and biologically active peptides.</p>

<p>Anti PHI, humanSerum is a research tool that is used to study protein interactions. It can be used in the study of ion channels, cell biology, and pharmacology. Anti PHI, humanSerum is also an inhibitor that binds to cells and prevents them from functioning normally. This product has been shown to inhibit the activity of erythropoietin receptor (EPOR) and has been used in the inhibition of tumor growth.</p>

<p>GLP-2 (Mouse)-EIA Kit is a kit for the quantitative measurement of GLP-2 in mouse serum. It consists of a standard, antibody and reagents to measure GLP-2 in mouse serum. The assay has been validated for use with sera from mice. For research use only. Not for diagnostic or therapeutic purposes.</p>

<p>Proangiotensin-12 (Rat) Antibody binds to proangiotensin 12 and blocks the activity of the angiotensin II receptor. This antibody is used in research as a ligand, activator, or inhibitor of protein interactions. It can be used in Cell Biology, Antibodies, Ion channels, High purity, Protein interactions, Pharmacology and Peptides.</p>

<p>ANP (human, 5-28) is a peptide that is used as a research tool for studying the function of ion channels. It is also an antibody that can be used to measure protein interactions. ANP (human, 5-28) has been shown to inhibit protein interactions with the receptor and ligand. This peptide has been shown to act as an activator at high concentrations and an inhibitor at low concentrations.</p>

<p>Atosiban is a drug that is used to prevent preterm labor in pregnant women. It works by inhibiting the release of oxytocin from the hypothalamus, which decreases contractions and relaxes the uterus. Atosiban has been shown to be effective in decreasing the incidence of preterm birth in women with bacterial vaginosis who are at high risk for preterm delivery (e.g., those with a history of preterm labor). Clinical trials have shown that it may also be useful as an adjunct therapy in treating women with unexplained infertility and recurrent pregnancy loss. The drug binds to receptors on cells, which inhibits the release of intracellular calcium, thus preventing contraction of uterine muscle cells. This effect can be reversed by administration of estradiol benzoate or other drugs that affect receptor activity. It is not known whether atosiban affects fetal development during pregnancy or if it causes any effects on the mother's heart rate or body mass index after childbirth.</p>

<p>Bis-dPEG®4-Acid is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®4-Acid is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Bromoacetamido-dPEG®4-Amido-DBCO is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Bromoacetamido-dPEG®4-Amido-DBCO is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>IL-1 beta is a cytokine, which belongs to the IL-1 family of cytokines. It is a proinflammatory cytokine that induces fever and pain, and stimulates the immune system. IL-1 beta binds to the IL-1 receptor, which is a member of the class 1 cytokine receptor family. The binding activates phospholipase A2 and protein kinase C, which leads to an increase in prostaglandin production by cyclooxygenase 2. IL-1 beta also has been shown to inhibit ion channel activity and calcium uptake in cells.</p>

<p>Antithrombin III heavy tryptic peptide standard for protein identification and quantitation studies. Antithrombin III is a glycoprotein found in blood plasma and is involved in the regulation of the coagulation process.</p>

<p>t-boc-N-Amido-dPEG®23-Amine is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. t-boc-N-Amido-dPEG®23-Amine is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Beta-ANP is a peptide that belongs to the class of activators. It is an inhibitor of ion channels and has been shown to be a ligand for the beta-1 adrenergic receptor. Beta-ANP has been used as a research tool in cell biology, pharmacology, and biochemistry.</p>

<p>NRG1 B1 Human is a cytokine that is produced by human cells. It belongs to the group of interleukins and functions as an inflammatory mediator. NRG1 B1 Human is involved in a wide range of biological processes, such as the regulation of cellular proliferation, differentiation, and immune response. It may also be used as a treatment for cancer.</p>