Peptides

<p>Custom research peptide; min purity 95%.</p>

<p>Portion of Influenza M</p>

<p>Custom research peptide; min purity 95%.</p>

<p>A biotinylated, synthetic spider toxin, which can be used as a reagent for a localization study of the omega-Agatoxin IVA binding site. This product has disulfide bonds between Cys4-Cys20, Cys12-Cys25, Cys19-Cys36 and Cys27-Cys34 and is available as a trifluoroacetate salt and as a 0.1mg vial.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Portion of EBV LMP2A</p>

<p>Lipoprotein Lipase is a type of enzyme that is involved in the breakdown of fats (lipids) into smaller components like free fatty acids and glycerol. This enzyme is made up of two subunits, an alpha subunit and a beta subunit. The alpha subunit has four domains, while the beta subunit has three domains. Lipoprotein Lipase is found in human plasma and tissue, where it performs its function by attaching to the surface of cells or lipoproteins and releasing free fatty acids. It also binds to cholesterol, which may be due to its ability to form hydrogen bonds with this molecule.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Big ET-2 (human, 22-37) Antiserum is an antibody that reacts with the Big ET-2 (human, 22-37) peptide. It can be used as a research tool to study the function of Ion channels, Life Science, Receptor, Ligand and Protein interactions. The high purity of this antibody makes it a valuable resource for drug development.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Fmoc-Dbz is a hydrophobic chemical that can be used as a linker in peptide synthesis. It is used to connect two amino acids via a carbon-carbon bond, and has been shown to be more reactive than its analogs. Fmoc-Dbz is also an antibacterial agent, which may be due to its ability to inhibit protein synthesis. The chemical structure of Fmoc-Dbz is similar to the cyclic peptides found in plants such as cyclotides, which are composed of 21 amino acids. Cyclic peptides are composed of three disulfide bridges and have potent antiviral and antibiotic activities. These peptides may be useful for treating influenza and other viruses because they bind to the viral membrane and disrupt the virus’s ability to function.</p>

<p>A synthetic snake toxin peptide sourced from the Green Mamba, Dendroaspis angusticeps. It is an agonist for Muscarinic Acetylcholine Receptor-1 (M1) and has disulfide bonds between Cys3-Cys24, Cys17-Cys42, Cys46-Cys58, and Cys59-Cys64. This product is available as a 0.1mg vial.</p>

<p>Lysenin Antiserum is a peptide that was originally isolated from the venom of the Brazilian Wandering Spider, Phoneutria nigriventer. It has been shown to activate ion channels and inhibit protein interactions. It has also been shown to be a potent inhibitor of voltage-gated potassium channels in rat dorsal root ganglion neurons. This peptide is used as a research tool for studying ion channel function at the molecular level and as an antibody for identifying specific proteins in cells.</p>

<p>Anti Chromogranin A (343-360) (Rat) Serum is a high purity antibody that can be used as a research tool in cell biology and pharmacology. It has been shown to inhibit the activation of ion channels, such as sodium channels, which are involved in the transmission of nerve impulses. The antibody also binds to the ligand-binding site of receptors such as acetylcholine and serotonin receptors. Anti-Chromogranin A (343-360) (Rat) Serum is a purified protein that can be used for the detection of specific proteins by Western blotting or immunoprecipitation.</p>

<p>Guangxitoxin-1E is a research tool that belongs to the class of ion channel activators. It can activate ligand-gated ion channels and voltage-gated ion channels, which are important for the transmission of nerve signals. Guangxitoxin-1E can be used as an antibody for immunohistochemistry or Western blotting to detect protein interactions and to study cell biology. It is also useful as a pharmacological tool for studying peptides, proteins, and life science.</p>

<p>Fibronectin is a soluble protein that belongs to the group of linker proteins. It is found in blood plasma and extracellular fluids, where it helps to maintain the integrity of the blood vessel walls. Fibronectin also provides a scaffold for cell migration, which is especially important during wound healing. Fibronectin has been found to interact with thrombotic factors and help organize clot formation. Fibronectin also binds to collagen, which forms an insoluble network within the extracellular matrix. This insoluble network serves as a framework for cells to grow and migrate within tissues.</p>

<p>Amino-dPEG®4-(m-dPEG®24)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®4-(m-dPEG®24)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Amyloid beta-Protein (Human, 1-40) (Scrambled) is a peptide that consists of 40 amino acids. It is a fragment of the amyloid precursor protein. Amyloid beta-protein has been found to have many different effects in the body, including receptor binding, ion channel activation and inhibition, and protein interactions. The peptide is also an activator for the high-affinity nicotinic acetylcholine receptor in the brain. This product can be used as a research tool or as an antibody to study amyloid beta protein in cellular biology.</p>

<p>Anti PTH (1-34) NH₂ is a peptide that inhibits the activity of parathyroid hormone. It is used to study the effects of parathyroid hormone on calcium homeostasis, and as an inhibitor in receptor binding assays. Anti PTH (1-34) NH₂ is purified from rat serum by affinity chromatography with a column containing immobilized antibodies raised against the peptide, followed by ion-exchange chromatography. The peptide has a molecular weight of 2,633.5 Da and the purity is greater than 98%.</p>

<p>This product is a Substance P antagonist and is available in the Hydrochloride salt form. Substance P is a member of the tachykinin neuropeptide family which is produced in the central nervous system (CNS) and acts through its specific receptor neurokinin 1 receptor (NK-1R). NK-1R is present in neurons and on glial cell types. Substance P is involved in: pain perceptions as a neurotransmitter; gut motility; increased inflammation in the lungs, gastrointestinal tract and the skin and neuroinflammation. Interestingly the levels of Substance P are raised in inflammatory bowel diseases and through its involvement in cytokine release, it contributes to asthma pathology. These diverse selection of functions makes substance P a target for therapeutic research.</p>

<p>Apo B-1 is a major component of the lipoprotein particle. The APOB MS Calibrator provides a high quality, stable preparation of Apo B-1 for use as an internal standard for mass spectrometry analysis. The calibrator also contains a tryptic peptide that can be used for identification and quantification of this protein in proteomics experiments.</p>

<p>Anti GLP-2 (14-33) (Rat) Serum is an antibody that binds to the GLP-2 receptor and blocks its activity. This peptide can be used in research to study the function of the GLP-2 receptor, and is available as a research tool for cell biology, pharmacology, and other life science applications.</p>

<p>MOCA-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH₂ is a peptide that binds to the M1 muscarinic receptor. It is a research tool used in pharmacology and cell biology. This peptide has been shown to activate the M1 receptor, which may be due to its ability to inhibit protein kinase C. This peptide can also be used as an inhibitor of the M1 receptor.</p>

<p>m-dPEG®48-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, m-dPEG®48-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Lipoprotein-associated phospholipase A2 (LP-PLA2) light tryptic peptide standard for protein identification and quantitation studies. LP-PLA2 is a phospholipase A2 enzyme known as platelet-activating factor acetylhydrolase and it is largely associated with low density lipoprotein in the blood.</p>

<p>FRETS-25Met (1 umol) (1umol) is a peptide that binds to the beta2-adrenergic receptor. It is a high purity, research tool and can be used for binding studies as well as for inhibition of the receptor. FRETS-25Met (1 umol) (1umol) has been shown to bind to the beta2-adrenergic receptor with an affinity of 5 nM and an IC50 of 1.6 uM. This peptide has also been shown to act as a potent agonist in stimulating cAMP production in CHO cells expressing the beta2-adrenergic receptor.</p>

<p>FRETS-25Ser is a peptide with a molecular weight of 25.1 Da. It is an activator of the Kv4.3 potassium channel, which has been shown to be involved in memory and learning processes. FRETS-25Ser binds to the extracellular loop 1 of the Kv4.3 channel and modulates its activity by increasing the open probability of the channel and inhibiting fast inactivation. The affinity for this peptide is high, as it binds tightly to its target protein (Kv4.3). FRETS-25Ser also has a low level of inhibition against other channels with similar sequences, as it can only bind to one site on the protein receptor.</p>

<p>Pro BMP 2 Human is a recombinant protein that belongs to the group of proteins that regulate cell growth and differentiation. It has been shown to be an activator of bone morphogenetic protein receptor type IIA. Pro BMP 2 Human has also been shown to inhibit the activity of certain ion channels, such as calcium channels, potassium channels, and sodium channels. This product is supplied at high purity, with a CAS number (CAS No.).</p>

<p>VIC (Mouse) is a peptide that is used as an inhibitor, activator, or ligand in research. It has the CAS number 120928-04-3 and the molecular weight of 4.5 kDa. VIC (Mouse) is a high purity product and can be used in life science research for characterization of receptor and ion channels. VIC (Mouse) can also be used as an antibody to study protein interactions as well as for cell biology research.</p>

<p>TNF-α is a cytokine that is synthesized and secreted by cells such as activated macrophages, T cells, endothelial cells, fibroblasts, and keratinocytes. It has been shown to be a potent mediator of inflammation and plays an important role in the pathogenesis of many diseases. TNF-α is produced in response to immunological stimulation (e.g., LPS) or microbial invasion (e.g., bacteria). It binds to two receptors: TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2), which are expressed on many cell types including monocytes, macrophages, neutrophils, dendritic cells, B lymphocytes, eosinophils, mast cells and keratinocytes. The binding of TNF-α to TNFR1 leads to activation of NF-κB and JNK pathways. The binding of TNF-α to TNFR2 leads to activation</p>

<p>RNA Binding Motif Protein 3 (RBMY3) is a high-quality research peptide that is commonly used in scientific studies. It is a recombinant protein derived from Escherichia Coli. RBMY3 plays a crucial role in RNA metabolism and regulation, specifically in the binding and processing of RNA molecules. This protein is highly purified and has been extensively tested for its quality and functionality. Researchers rely on RBMY3 to study various cellular processes, including gene expression, mRNA splicing, and post-transcriptional modifications. With its exceptional purity and reliability, RBMY3 is an essential tool for any laboratory conducting cutting-edge research in the field of RNA biology.</p>

<p>High quality, quantitated heavy/light peptide calibrator for angiotensinogen in Mass Spectroscopy research</p>

<p>Anti Nociceptin / Orphanin FQ (Human, Rat) Serum is a peptide that belongs to the family of orphanin FQ peptides. It has been shown to activate ion channels and ligand-gated channels. Anti Nociceptin / Orphanin FQ (Human, Rat) Serum is a high purity, pharmacology research tool for use in cell biology and receptor studies.</p>

<p>TNF-α is a cytokine that is produced by many cells, including macrophages, T cells, mast cells, and synovial cells. It is a pleiotropic proinflammatory cytokine that has been implicated in cancer and other inflammatory diseases. TNF-α is a potent inducer of cell death through activation of the Fas-FasL death pathway or induction of apoptosis. In addition to its role as an anti-tumor agent, TNF-α has been shown to be important in the regulation of immune responses and inflammation. It also plays an important role in bacterial sepsis by suppressing the production of proinflammatory cytokines such as IL-1β and IL-12 by macrophages.</p>

<p>Ferredoxin-1 is a peptide that belongs to the group of activators. It can be used as an inhibitor, or as a receptor or ligand in pharmacological experiments. Ferredoxin-1 has been shown to inhibit ion channels and protein interactions. This protein may also have implications for cell biology and is used as a research tool for life science. The CAS number for ferredoxin-1 is 107899-38-2.</p>

<p>Lipidated Oxytocin analog with long-lasting activities. Product has the following disulfide bonds: Cys1-Cys6 and is available as a 0.5mg vial.</p>

<p>Catestatin is a peptide that belongs to the family of activators. Catestatin is an activator of potassium channels and can be used as a research tool. It has been shown to bind to the Kv1.2 receptor, which is expressed in human heart and skeletal muscle cells. This peptide also inhibits calcium-activated potassium channels, thereby blocking the transmission of nerve impulses. Catestatin has been shown to inhibit protein interactions with G protein-coupled receptors (GPCRs) and ion channels, thereby regulating cellular signaling pathways involved in cell growth and differentiation.</p>

<p>MAL-dPEG®3-Lipoamide is a PEG molecule conjugated with a lipid moiety. MAL-dPEG®3-Lipoamide, conjugated to this lipid constituent, is very important especially in drug delivery and vaccine development as it helps improve the stability and circulation time of lipid nanoparticles (LNPs) and liposomes.</p>

<p>Peptide H-WLGFIAGLIAIVMVT-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>This product is produced via the activation of mariculture Keyhole Limpet (Megathura crenulata) Hemocyanin with a maleimide group.  The activated material will readily bind free sulfhydryl groups present in solution.KLH is a highly antigenic protein with a high molecular mass (4.5 x 105 - 1.3 x 107 Daltons, in aggregates of 350 and 390 kDa subunits) that elicits a strong immune response when used to immunize animals.As many as 400 moles of Cysteine-containing peptide can bind to one mole of maleimide-activated KLH.</p>

<p>Insulin-like 5 (INSL5) is a protein that in humans is encoded by the INSL5 gene. It belongs to the insulin family of proteins and has been shown to have a role in various biological functions. INSL5 binds to the insulin receptor, which induces apoptosis in cancer cells by inhibiting cyclin-dependent kinase activity and inducing cell cycle arrest. The expression of INSL5 can be used as a diagnostic marker for cervical cancer and may also be used as a potential biomarker for cancer tissues.</p>

<p>Please enquire for more information about Amyloid β (1-42) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Anti Atrial Natriuretic Peptide (ANP) (Rat) Serum is a research tool for studying the pharmacology of ANP. It is an activator of ion channels and the receptor for ANP, which regulates water balance in the body. It has also been shown to be a ligand for antibody, used in pharmacology to study protein interactions. This serum is used as a research tool in Cell Biology to study the effects of ligands on membrane ion channels and receptors. Anti Atrial Natriuretic Peptide (ANP) (Rat) Serum is purified from rat serum with high purity.</p>

<p>Oxytocin is a peptide hormone and neurotransmitter. It is primarily used in the brain to regulate social behavior, such as maternal behaviour, sexual arousal and romantic attachment. Oxytocin is also used for uterine contractions during childbirth and to induce labour. Oxytocin can be administered by injection or as nasal spray. It has a half-life of about two minutes in the blood stream and its effects last up to one hour. Oxytocin is a nonapeptide with the amino acid sequence: Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Arg-Gly-Leu-Met-(OH). The oxytocin receptor (OXTR) belongs to G protein coupled receptors (GPCR), which are known for their roles in cell signaling, oncogenesis, immunity, inflammation, pain sensation and endocrine regulation. The OXTR is expressed throughout the body including the uterus and vagina.</p>

<p>Z-Gly-Pro-Leu is a bacterial enzyme that belongs to the group of carboxypeptidases. It has an optimal pH of neutral ph, and can be found in ascidian tissue. Z-Gly-Pro-Leu is a synthetic substrate, and its sequences have been determined. Functional groups of this enzyme are carboxylic acid, hydroxyl, amine and thiol. This enzyme is used in the production of synthetic peptides and it has been shown to have a high level of activity on homogenates. It has also been shown to have an effector function in pancreatic tissue when injected subcutaneously.</p>

<p>Please enquire for more information about IgA1 Hinge Region Peptide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>L-Methionylglycyl-L-methionyl-L-methionine trifluoroacetate is a medicinal compound that has shown promise as an anticancer agent. It is an analog of a naturally occurring tripeptide found in human urine and has been shown to inhibit the activity of certain kinases, which are enzymes that play a key role in cancer cell growth and survival. L-Methionylglycyl-L-methionyl-L-methionine trifluoroacetate induces apoptosis, or programmed cell death, in cancer cells by inhibiting the activity of these kinases. This inhibitor has demonstrated potent anticancer activity against various human tumor types, including breast and lung cancer. The compound shows favorable pharmacokinetic properties and good tolerability in preclinical studies, making it a promising candidate for further development as an anticancer therapy.</p>

<p>GaTx2 is a costimulatory molecule that binds to the B7-1 and B7-2 receptors on the surface of antigen-presenting cells. GaTx2 has been shown to regulate transcriptional regulation, cellular growth, and physiological function in heart tissue. It is also involved in the development of cancer and autoimmune diseases. GaTx2 has biological properties that are similar to those of T lymphocyte growth factor (TGF) and basic fibroblast growth factor (bFGF). GaTx2 is also a whole-cell voltage clamp that can be used in tissue culture.</p>

<p>Huwentoxin XVI is a synthetic molecule that inhibits the transmission of pain signals. It does this by inhibiting the release of neurotransmitters from dorsal root ganglia cells in the spinal cord. Huwentoxin XVI has been shown to inhibit the cancer-associated inflammatory response, which may be due to its ability to inhibit chronic pain. In addition, Huwentoxin XVI has been shown to have an inhibitory effect on adipose tissue and is thought to be a potential treatment for obesity-associated chronic pain. Huwentoxin XVI also blocks A-type potassium channels, which are responsible for neuronal transmission and are found in neurons and glial cells in the dorsal root ganglia. This inhibition can lead to neuropathic pain or chronic pain caused by nerve damage.</p>

<p>Anti IL-1alpha (Rat) Serum is a serum that provides an inhibitor for IL-1alpha. The serum is used in the study of peptides and cell biology. This serum is made from high purity, life science grade material and has been shown to be effective in inhibiting the activation of ion channels.</p>

<p>GalNAc modified hinge region peptide.  Supplied as the TFA salt.Soluble in water, 0.1mM.</p>

<p>Please enquire for more information about TentaGel® Macrobead RAM particle size: 140 - 170 µm including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>An Apolipoprotein B light tryptic peptide standard for use in protein identification and quantitation studies. Apolipoprotein B is responsibly for carrying lipids such as low density lipoprotein (LDL), chylomicrons, intermediate-density lipoprotein, very low-density lipoprotein and lipoprotein (a).</p>

<p>Apolipoprotein A1 light tryptic peptide standard for protein identification and quantitation studies. Apolipoprotein A1 is a structural component of high density lipoprotein (HDL) and is involved in cellular cholesterol homeostasis and reverse cholesterol transport.</p>

<p>A Ceruloplasmin Light Tryptic Peptide Standard for use in protein identification and quantitation studies. Ceruloplasmin is a serum ferroxidase key to transporting copper in the blood. It also plays a role in iron metabolism regulation and the pathogenesis of Wilson disease. Furthermore it has been found in elevated levels during inflammation.</p>

<p>Ac-YVAD-pNA is a synthetic tetrapeptide inhibitor, which is primarily derived from specific peptide sequences designed to selectively inhibit cysteine protease activity. It acts by mimicking the natural substrates of the enzyme caspase-1 and competitively inhibiting its activity. The acetylated N-terminus (Ac-) and para-nitroanilide (pNA) group at the C-terminus facilitate the penetration across cell membranes and spectrophotometric measurement, respectively.Ac-YVAD-pNA is extensively utilized in biochemical research to investigate the role of caspase-1, which is a key player in inflammatory processes and apoptosis. By inhibiting caspase-1, researchers can study its involvement in the maturation of pro-inflammatory cytokines such as IL-1β and IL-18. The use of this inhibitor is crucial in elucidating the mechanisms of pyroptosis, a form of programmed cell death associated with inflammation. This tool aids in dissecting the pathways implicated in various diseases, including autoimmune disorders, neurodegenerative diseases, and infections, providing insights into potential therapeutic targets.</p>

<p>Please enquire for more information about Atrial natriuretic factor (1-28) (human) acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Peptide H-NVEDLSGGELQR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Hydroxyacyl-Coenzyme A Dehydrogenase is an enzyme that catalyzes the oxidation of hydroxyacyl-CoA to form acetyl-CoA. It is a member of the short-chain dehydrogenases/reductases (SDR) superfamily. Hydroxyacyl-Coenzyme A Dehydrogenase is expressed in many tissues and has been shown to be essential for fatty acid synthesis and catabolism, as well as for the conversion of ketone bodies to acetyl-CoA. It also plays a role in cellular respiration and energy production.</p>

<p>An Alpha-2-Macroglobulin light tryptic peptide standard for protein identification and quantitation studies. Alpha-2-Macroglobulin is a broad spectrum protease inhibitor which also plays roles in cell migration and in the binding of growth factors and cytokines.</p>

<p>α 1 Antitrypsin Human is a research tool that can be used in the study of protein interactions. It is a high-purity, recombinant, human α 1 antitrypsin with an N-terminal hexahistidine tag. It has been specifically designed for use in antibody production and as a pharmacological agent to inhibit trypsin-like enzymes.</p>

<p>TFP-dPEG®4-Biotinidase Resistant Biotin is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. TFP-dPEG®4-Biotinidase Resistant Biotin is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Conantokin G trifluoroacetic acid is a peptide that is derived from the conantokins. It has been shown to have neuroprotective properties and inhibitory properties. Conantokin G trifluoroacetic acid binds to calcium in neuronal cells, which leads to the inhibition of glutamate-induced neuronal death and brain infarction. The binding of this peptide to calcium also inhibits intracellular signalling pathways, leading to an anti-inflammatory response. In addition, this compound may be a potential therapeutic agent for chronic oral toxicity due to its ability to bind with glutamate receptors and prevent activation.</p>

<p>Human Hepcidin IDxâ„¢ ELISA (1ea) is a microwell plate that can be used to measure the concentration of human hepcidin in serum. The test uses antibodies and biotinylated secondary antibodies to detect the presence of hepcidin in the sample. Diluent is provided with the kit, and a polypropylene plate is included. This product requires a blood sample from humans, as well as a diluent.</p>

<p>Modified H-2kb tetramer peptide for further modification (e.g. addition of N-term tag)</p>

<p>This is a Von Willebrand Factor Light Tryptic Peptide Standard for use in protein identification and quantitation. Von Wilebrand Factor is a glycoprotein involved in platelet adhesion and when it is deficient in the body it can result in diseases such as von Willebrand disease.</p>

<p>Boc-Gly-Arg-Arg-AMC trifluoroacetate is a potent inhibitor of kinases, which are enzymes that play a crucial role in various cellular processes. It has been shown to effectively inhibit the activity of both Chinese and human kinases. This inhibitor has also demonstrated its efficacy as an anticancer agent by inducing apoptosis in cancer cells. Boc-Gly-Arg-Arg-AMC trifluoroacetate is a medicinal protein analog that can be used for the development of novel inhibitors with improved potency and selectivity. Its potential therapeutic applications make it a promising candidate for cancer treatment. Additionally, this compound can be detected in urine, making it an excellent biomarker for kinase activity in vivo.</p>

<p>For Protein Identification and Quantitation</p>

<p>Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu is a peptide that has been shown to activate potassium channels in the central nervous system. It has been suggested as a potential treatment for epilepsy and Parkinson's disease. Myr Ser Ile Tyr Arg Arg Gly Ala Arg Arg Trp Arg Lys Leu is also an inhibitor of ligand binding to the GABA receptor, which may be useful in the treatment of anxiety disorders.</p>

<p>m-dPEG®8-Azide (Azido-m-dPEG®8) is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®8-Azide (Azido-m-dPEG®8) is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>This is a recombinant human Leukocyte-Associated Ig-Like Receptor 2 (LAIR2) protein. It is an activator of the LAIR2 receptor, which is a member of the immunoglobulin superfamily. LAIR2 is expressed on activated T cells and NK cells. This protein also can interact with other receptors, such as CD4 and FcRγ, to inhibit ion channels and activate cell signaling pathways. LAIR2 has been shown to be involved in immune responses, including antibody production and cytokine release by activated lymphocytes.</p>

<p>Blocker of P/Q-type calcium channel (Cav2.1)</p>

<p>ASIC1a/1b agonist</p>

<p>Follicle Stimulating Hormone (FSH) is a protein hormone that plays a crucial role in the reproductive cycle. It stimulates the growth and development of follicles in the ovaries, which produce estrogen and progesterone. FSH also regulates spermatogenesis in men. Studies have shown that FSH has inhibitory activity on cyclin-dependent kinases, which are enzymes that regulate the cell cycle. This inhibitory activity leads to decreased cell proliferation and growth, making it a potential treatment for cancer. In vitro studies have demonstrated its effectiveness against breast and lung cancer cells lines when combined with kinase inhibitors. Additionally, FSH has been found to stimulate protein kinase activity, which may be useful in developing therapies for other diseases such as diabetes and osteoporosis.</p>

<p>Slowing of Nav1.2, Nav1.4 and Nav1.7 channels' inactivation</p>

<p>Biotin-MAGE-A1 (278-286) is the N-ter biotinylated version of MAGE-A1 (278-286). Biotin-MAGE-A1 (278-286) can be used in the analysis of antigen-specific T cells. MAGE-A1 protein:<br>MAGE-A1 (278-286) is an epitope of Melanoma Antigen Gene A1 expressed by tumors of different histological types such as on the surface of breast carcinoma cell and is a Cancer/Testis Antigens (CTA). MAGE-A1 is a tumor antigen expressed in 40% of melanoma and contains epitope for binding HLA-A*02:01 molecules and that are recognized by cytotoxic T cells.<br>Applications of MAGE-A1 (278-286):<br>MAGE-A1 (278-286) is used to stimulate specific cytotoxic T cells in PBMCs and to analyze by ELISPOT peptide epitope specificity and cytokine production like IFN-γ. Immunogenicity of MAGE-A1 (278-286) raised the possibility of developing anticancer immunotherapies or vaccinations. MAGE-A1 is also expressed in lung adenocarcinoma and studies suggest that MAGE-A1 may serve to develop Chimeric Antigen Receptor (CAR) T cell therapy using lentiviral vector and show an encouraging tumor-inhibitory efficacy.<br>Sequence: Biotin-KVLEYVIKV</p>

<p>Cyclotide</p>

<p>Selective blocker of muscular nACh receptors</p>

<p>Human beta-defensin-2 (hBD-2), also known as skin-antimicrobial peptide 1 (SAP1) is a cysteine-rich cationic antimicrobial peptide of 41 amino acids. It was originally isolated from skin cells of psoriasis patients. hBD-2, which belongs to the defensin family, is implicated in the innate immunity thanks to its antimicrobial activity. Thus, β-defensins can play a role at the cutaneous level by limiting the use of antibiotics in severe burns and disease like psoriasis. Moreover, at the pulmonary level, defensins might be involved in the resorption of the infection in cases of cystic fibrosis.<br>hBD-2 is produced after stimulation of epithelial cells following their contact with some organisms like Gram-negative bacteria and Candida Albicans, fungus or cytokines such as TNF-alpha and IL-1 beta. This antimicrobial activity was shown to be microbicidal at concentrations greater than 1 µM and was lethal for E.Coli and pseudomonas (LD90 : 10 mg/mL) and Candida Albicans (LD90 : 25 mg/mL). Besides its antimicrobial activity, hBD-2 also exhibits proinflammatory properties as chemoattractants for memory T-cells, immature dendritic cells, mast cells and neutrophils.<br>hBD-2 has also demonstrated inhibitory activity of the voltage-gated potassium channel Kv1.3 at picomolar concentration. Kv1.3 are overexpressed by T-cells in case of autoimmune disorders.</p>