Peptides

Sarafotoxin S6c, sourced from the venom of the Atractaspis engaddensis snake family, is one of four (S6a-d) isopeptides of the Sarafotoxins. This product is a synthetically produced toxin, containing disulfide bonds between Cys1-Cys15 and Cys3-Cys11. Due to their structural and functional homology to the endothelin peptides, Sarafotoxins can enhance vasoconstriction through stimulating the class A G-protein-coupled, endothelin ETA and ETB receptors. This in turn leads to left ventricular dysfunction and bronchoconstriction. Compared to the sarafotoxin isopeptide S6b, S6c is less toxic with a 100 to 10,000-fold reduced affinity for the ETA receptor, therefore acts as a selective agonist to the ETB receptor. One study demonstrated that when sarafotoxin 6c was used to activate ETB receptors in rats there was an increase in arterial pressure, known as S6c-induced hypertension. As the upregulation of Endothelin-1 (ET-1) is related to circulatory-system diseases, the interaction between ET-1 and its receptors is highly important for development of endothelin receptor antagonist treatments. Sarafotoxin S6c can be used as a pharmacological reagent to study these interactions.

Z-Gln-Gly is a protected dipeptide, which is commonly used as an intermediate in peptide synthesis. It is derived from the amino acids glutamine and glycine, with the N-terminal glutamine being protected by a benzyloxycarbonyl (Z or Cbz) group. This protective group is essential for preventing undesirable reactions at the amine site during peptide chain elongation.The primary mode of action for Z-Gln-Gly involves its use in solid-phase peptide synthesis, where the Z-group safeguards the amine functionality. This protection allows for selective reactions at other sites of the molecule until the final deprotection step, facilitating the sequential addition of amino acids.Z-Gln-Gly is used predominantly in research and development within biochemical and pharmaceutical laboratories. Its applications are critical in the synthesis of longer peptide chains and peptide-based drugs, where precision and control over the peptide structure are paramount for investigating biological processes and therapeutic functions.

Hepcidin-20 consists of the disulfide Bonds: Cys2-Cys18, Cys5-Cys8, Cys6-Cys14, and Cys9-Cys17 and is available in the trifluoroacetate salt form. Hepcidin-20 is a truncated form of the peptide hormone hepcidin-25, which plays a key role in the regulation of iron metabolism in the body. It is produced by the liver and is secreted into the bloodstream. Hepcidin has the ability to regulate the activity of ferroportin, a protein that facilitates the export of iron from cells into the bloodstream. It binds to ferroportin and inhibits its activity, leading to decreased iron absorption from the diet and reduced iron release from cells. The biological significance of hepcidin-20 is still being studied, but it may be involved in the regulation of iron metabolism in certain situations, such as inflammation or certain disease states. Like hepcidin-25, hepcidin-20 is a target for the development of treatments for iron-related disorders, such as anemia of chronic disease and hemochromatosis.

Peptide H-FVEGLPINDFSR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

H-Ser-Leu-Ile-Gly-Lys-Val-NH2 is a synthetic peptide that is a cyclase inhibitor. It binds to the receptor for neurokinin 1, which has been shown to inhibit lacrimal gland function in rats. The compound also inhibits the synthesis of epidermal growth factor and has been shown to have anti-inflammatory effects in mouse models. H-Ser-Leu-Ile-Gly-Lys-Val-NH2 has also been shown to inhibit protease activity in rat prostate cells and can be used as a chemical inhibitor for proteases.

Peptide H-ELLETVVNR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

Peptide H-FVEEIIEETK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

Fmoc-D-Cys(Trt)-OH is a synthetic peptide that can be used as a research tool in cell biology and pharmacology. It has an ion channel blocking effect and is a potent activator of the receptor GPR75. Fmoc-D-Cys(Trt)-OH is soluble in water and displays high purity, with a CAS No. 167015-11-4. This product can be used to study protein interactions, ion channels, and receptors. Fmoc-D-Cys(Trt)-OH can also be used as an antibody or cell biology reagent, as well as an inhibitor for certain enzymes such as tyrosine hydroxylase.

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Peptide H-DLPMSPR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

COMU reagent is a copper-containing, natural compound that can be used in intrauterine diagnosis. The COMU reagent has been shown to have potent antagonistic activity against the CB2 receptor and hydrogen bond donor site. This product also can be used to detect the presence of peptide hormones, such as LH and FSH, in urine samples. The COMU reagent has been shown to bind to integrin receptors on cells, which are involved in cell adhesion and migration. The conformational properties of this compound allow it to form a complex with cyclic peptides that are found in human liver cells infected with hepatitis C virus (HCV).

Peptide H-FFEILSPVYR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

PyClocK® is a monoclonal antibody that binds to the HIV-1 surface protein, gp120. It is used in diagnostic immunoassays for the detection of anti-HIV antibodies and in preparative high performance liquid chromatography (HPLC) of glycopeptides, which are cyclic peptides that are produced by bacteria. PyClocK® also has been shown to bind to vasoactive intestinal peptide and cyclic peptide receptors, which may be involved in autoimmune diseases or metabolic disorders. The conformational properties of this antibody have been determined using X-ray crystallography on the monoclonal antibody.

Peptide H-DIYETDYYR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

The V5 tag is derived from a small epitope (Pk) found on the P and V proteins of the paramyxovirus (of the simian virus 5 (SV5) family) and is extensively used as a general epitope tag in expression vectors.