STAT
Las proteínas STAT son componentes críticos de la vía de señalización JAK/STAT, que transmite señales extracelulares de citoquinas y factores de crecimiento al núcleo celular, influyendo en la expresión génica. Las proteínas STAT están involucradas en la regulación de respuestas inmunitarias, crecimiento celular, diferenciación y supervivencia. La desregulación de la señalización STAT está implicada en diversas enfermedades, incluido el cáncer, trastornos autoinmunes e inflamación crónica. En CymitQuimica, ofrecemos una amplia gama de moduladores de la vía STAT para apoyar su investigación en transducción de señales, inmunología y desarrollo terapéutico.
Se han encontrado 98 productos de "STAT"
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L002
CAS:<p>L002 is a potent inhibitor of acetyltransferase p300 with an IC50 of 1.98 μM, blocking histone and p53 acetylation, and may treat cardiac hypertrophy.</p>Fórmula:C15H15NO5SPureza:98.59%Forma y color:SolidPeso molecular:321.35Niclosamide
CAS:<p>Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.</p>Fórmula:C13H8Cl2N2O4Pureza:98.47% - 99.1%Forma y color:Pale Yellow Crystals SolidPeso molecular:327.12Fludarabine
CAS:<p>Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation.</p>Fórmula:C10H12FN5O4Pureza:99.65% - 99.89%Forma y color:White SolidPeso molecular:285.23Nifuroxazide
CAS:<p>Nifuroxazide (Diarlidan), an oral nitrofuran antidiarrheal, blocks STAT1/3/5 activation.</p>Fórmula:C12H9N3O5Pureza:99.79% - 99.95%Forma y color:Yellow SolidPeso molecular:275.22Garcinone C
CAS:<p>Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.</p>Fórmula:C23H26O7Pureza:99.13% - 99.92%Forma y color:SolidPeso molecular:414.45UC-514321
CAS:<p>UC-514321 directly targets STAT3/5 and represses TET1 expression.</p>Fórmula:C26H35NO5Pureza:98.50%Forma y color:SolidPeso molecular:441.56STAT3-IN-1
CAS:<p>STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor</p>Fórmula:C28H29NO6Pureza:95.89% - 95.89%Forma y color:SolidPeso molecular:475.53Artesunate
CAS:<p>Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria.</p>Fórmula:C19H28O8Pureza:97.67% - 99.9%Forma y color:White Crystalline PowderPeso molecular:384.42Niclosamide olamine
CAS:<p>Niclosamide olamine (Niclosamide Ethanolamine salt) is an Repellent, Insect Attractant and Chemosterilant.</p>Fórmula:C15H15Cl2N3O5Pureza:99.89%Forma y color:Bright Yellow Crystalline Physical Description Yellow Solid Insoluble In Water (Ntp 1992)Peso molecular:388.20Diosgenin
CAS:<p>Diosgenin (Nitogenin) is a spirostan found in DIOSCOREA and other plants.</p>Fórmula:C27H42O3Pureza:98.87% - 99.87%Forma y color:Flaky Or Needle CrystalPeso molecular:414.62STAT3-IN-41
<p>STAT3-IN-41 (Compound 16) is a prodrug of compound 1. It gradually releases compound 1, which inhibits the STAT3 signaling pathway. STAT3-IN-41 exhibits antitumor activity against lung cancer, hepatocellular carcinoma, and pancreatic cancer.</p>Fórmula:C22H30F3NO7Forma y color:SolidPeso molecular:477.471Eflepedocokin alfa
CAS:<p>Eflepedocokin alfa is a recombinant IL-22/IgG2-Fc protein, potentially protecting cells and enhancing immune function and tissue repair.</p>Forma y color:LiquidEupalinolide K
CAS:<p>Eupalinolide K is a natural product</p>Fórmula:C20H26O6Pureza:98%Forma y color:SolidPeso molecular:362.42MNK8
CAS:<p>MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.</p>Fórmula:C15H12N2O2Pureza:99.74%Forma y color:SolidPeso molecular:252.27STAT4-IN-1
<p>STAT4-IN-1 is a STAT4 inhibitor with a Ki of 0.35 μM. It holds promise for research into autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes.</p>Forma y color:Odour SolidCMD178
<p>CMD178 is an important polypeptide that consistently reduces the expression of Foxp3 and STAT5 by inhibiting the IL-2/s IL-2Rα signaling pathway.</p>Fórmula:C46H59N9O7Pureza:98%Forma y color:SolidPeso molecular:850.03STAT5-IN-3
<p>STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.</p>Fórmula:C25H27N5OForma y color:SolidPeso molecular:413.51STAT3-IN-34
<p>STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.</p>Fórmula:C19H16N2O4SForma y color:SolidPeso molecular:368.41STAT3-IN-31
<p>STAT3-IN-31 (compound K2071), derived from STATtic, acts as an inhibitor of both STAT3 and mitotic processes. This compound interrupts mitotic progression and impacts the formation of the mitotic spindle. Additionally, STAT3-IN-31 hampers migration in glioblastoma cells, suppresses cellular proliferation within tumor spheroids, induces senescence in glioblastoma, and inhibits the growth of Temozolomide-resistant cells while reducing the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein (MCP-1).</p>Fórmula:C16H15NO3SForma y color:SolidPeso molecular:301.36JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Forma y color:Odour Solid
