Transportador de membrana / canal de iones
Los inhibidores de transportadores de membrana y canales iónicos son compuestos que bloquean la función de proteínas responsables del transporte de iones, nutrientes y otras moléculas a través de las membranas celulares. Estos inhibidores son cruciales para estudiar la regulación de la homeostasis celular, la transducción de señales y la neurotransmisión. Los inhibidores de transportadores de membrana y canales iónicos también son importantes para desarrollar tratamientos para trastornos como la epilepsia, las enfermedades cardiovasculares y los síndromes metabólicos. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de transportadores de membrana y canales iónicos para apoyar su investigación en fisiología, neurociencia y farmacología.
Subcategorías de "Transportador de membrana / canal de iones"
- ABC(3 productos)
- ATPasa(98 productos)
- Receptor de adiponectina(5 productos)
- CFTR(66 productos)
- Receptor CGRP(53 productos)
- Canal de calcio(525 productos)
- Canal de cloruro(51 productos)
- Receptor GABA(355 productos)
- Transportador de monoamina(26 productos)
- Transportador de monocarboxilato(18 productos)
- NKCC(2 productos)
- NPC1L1(3 productos)
- Cotransportador de Na-K-Cl(9 productos)
- OAT(28 productos)
- OCT(7 productos)
- P-gp(52 productos)
- Canal de potasio(280 productos)
- Bomba de protones(40 productos)
- SGLT(31 productos)
- Canal de sodio(202 productos)
- Canal TRP / TRPV(94 productos)
Mostrar 13 subcategorías más
Se han encontrado 2430 productos de "Transportador de membrana / canal de iones"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
KCC2 Modulator-2
CAS:<p>KCC2 Modulator-2 (example 53) is a regulator of KCC2 with an EC50 of 0.215 μM. It is used in the research of neurological diseases.</p>Fórmula:C35H45N5O3Forma y color:SolidPeso molecular:583.76N-Depropylpropafenone
CAS:N-Depropylpropafenone, an active metabolite of Propafenone, is produced through the metabolism by the CYP450 enzyme system (primarily CYP2D6). It functions by blocking sodium ion channels, thereby delaying the depolarization process in myocardial cells and exhibiting antiarrhythmic properties.Fórmula:C18H21NO3Forma y color:SolidPeso molecular:299.36Desmethylflunitrazepam
CAS:Desmethylflunitrazepam (Norflunitrazepam) is a benzodiazepine derivative and an active metabolite of Flunitrazepam.Fórmula:C15H10FN3O3Forma y color:SolidPeso molecular:299.26Tizolemide
CAS:<p>Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.</p>Fórmula:C11H14ClN3O3S2Forma y color:SolidPeso molecular:335.83cis-KV1.3-IN-1
CAS:cis-KV1.3-IN-1, also known as Compound cis-18, is the cis-isomer of KV1.3-IN-1 and functions as an inhibitor of the KV1.3 channel. In Xenopus laevis oocytes expressing human hKV1.3, cis-KV1.3-IN-1 (10 μM) achieves an inhibition rate of 25.53% against KV1.3.Fórmula:C23H30N2O4SForma y color:SolidPeso molecular:430.56Lu AF90103
CAS:<p>Lu AF90103 (Compound 42e) is the methyl ester prodrug of compound 42d, capable of crossing the blood-brain barrier. Compound 42d acts as a partial agonist of the GluN1/GluN2B complex, with an efficacy of 24% and an EC50 value of 78 nM. Lu AF90103 plays a significant role in neuropsychiatric disorder research.</p>Fórmula:C13H15N3O3SForma y color:SolidPeso molecular:293.342Cav 2.2/3.2 blocker 1
<p>Compound 9e is a Cav 2.2/3.2 blocker; IC50: 1.22 μM & 80 μM, respectively; penetrates CNS.</p>Fórmula:C28H30N2O3Forma y color:SolidPeso molecular:442.55Ro-51
CAS:dual P2X3 and P2X2/3 antagonistFórmula:C17H23IN4O4Pureza:98%Forma y color:SolidPeso molecular:474.29Quinacainol dihydrochloride
CAS:<p>Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.</p>Fórmula:C21H32Cl2N2OForma y color:SolidPeso molecular:399.398IAB15
CAS:IAB15 is a potent inhibitor of T-type calcium channel that can be used in the research of epilepsy [1].Fórmula:C15H14F3NO2Forma y color:SolidPeso molecular:297.27SGE-516
CAS:<p>SGE516: neuroactive steroid, enhances GABAA, lowers neuronal activity, protects from seizures.</p>Fórmula:C23H35N3O2Pureza:98%Forma y color:SolidPeso molecular:385.54TTA-P1
CAS:TTA-P1: potent T-type calcium channel inhibitor; impacts neuron firing, hormone secretion, cell growth; potential in absence epilepsy research.Fórmula:C19H27Cl2FN2OForma y color:SolidPeso molecular:389.33YY-23
CAS:<p>YY-23 is a selective NMDAR (containing GluN2C or GluN2D) inhibitor. By inhibiting NMDARs with GluN2D on GABAergic interneurons in the prefrontal cortex, YY-23 suppresses GABAergic neurotransmission and enhances excitatory transmission. YY-23 exhibits antidepressant activity and is useful for neurological disease research.</p>Fórmula:C33H54O8Forma y color:SolidPeso molecular:578.777LY3130481
CAS:LY3130481: TARP γ-8 dependent AMPA receptor blocker; selectively targets AMPA/TARP γ-8 with 65 nM IC50.Fórmula:C19H18N4O3SForma y color:SolidPeso molecular:382.44Cav 3.2 inhibitor 2
Cav 3.2 inhibitor 2 blocks T-type Ca2+ channels (IC50=0.09339 μM) and reduces mouse somatic/visceral pain. Used for intractable pain studies.Fórmula:C32H37F2N3OForma y color:SolidPeso molecular:517.65MSK-195
CAS:MSK-195 is an effective TRPV1 agonist.Fórmula:C28H40N2O5Pureza:98%Forma y color:SolidPeso molecular:484.63Kv7.2/Kv7.3 modulator-1
CAS:Kv7.2/Kv7.3 modulator-1 (compound 6a) acts as a modulator for Kv7.2/Kv7.3 channels, with a pEC50 value of 7.96 for opening these channels. Kv7.2/Kv7.3 modulator-1 is applicable in research related to epilepsy, depression, brain injury, and pain.Fórmula:C20H21F4N3O3Forma y color:SolidPeso molecular:427.393SR 33805 oxalate
CAS:Ca2+ channel antagonistFórmula:C34H42N2O9SPureza:98%Forma y color:SolidPeso molecular:654.77T-Type calcium channel inhibitor 2
Compound 6g inhibits T-type Ca channels (IC50: Cav3.1-31μM, Cav3.2-83μM), cytotoxic to A549 (IC50: 5μM) & HCT-116 cells (IC50: 6.4μM).Fórmula:C36H39FN4OSForma y color:SolidPeso molecular:594.78ATP synthase inhibitor 2
CAS:<p>ATP synthase inhibitor 2 blocks P. aeruginosa ATP synthase; IC50=10 μg/mL, fully inhibits at 128 μg/mL.</p>Fórmula:C21H22N2O3SForma y color:SolidPeso molecular:382.48264W94
CAS:264W94 robustly inhibits IBAT, induces CYP7A1, and significantly reduces cholesterol.Fórmula:C23H31NO4SPureza:98%Forma y color:SolidPeso molecular:417.56CFTR corrector 18
CAS:<p>CFTRcorrector 18 (Compound I-99) acts as a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It enhances the processing and trafficking of CFTR, thereby increasing the amount of CFTR present on the cell surface. CFTRcorrector 18 holds potential for research in cystic fibrosis (CF).</p>Fórmula:C38H40N6O5SForma y color:SolidPeso molecular:692.826P2X4-IN-1
CAS:P2X4-IN-1 is an orally active P2X4 inhibitor. P2X4-IN-1 is applicable in research focused on disease prevention.Fórmula:C18H14ClN5O3SForma y color:SolidPeso molecular:415.85ML-SI1
CAS:ML-SI1, a racemic mixture of diastereoisomers, is a TRPML inhibitor and acts on TRPML1 (IC50: 15 μM).Fórmula:C23H26Cl2N2O3Forma y color:SolidPeso molecular:449.373-Bromoamphetamine hydrochloride
CAS:3-Bromoamphetamine hydrochloride is a para-substituted amphetamine that functions as a monoamine releaser.Fórmula:C9H13BrClNForma y color:SolidPeso molecular:250.563PF-06305591 dihydrate
PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker (IC 50 = 15 nM) with an excellent preclinical in vitro ADMEFórmula:C15H26N4O3Forma y color:SolidPeso molecular:310.39Mibefradil dihydrochloride hydrate
CAS:<p>Mibefradil dihydrochloride hydrate is a long-acting antihypertensive blocking high-voltage L calcium channels.</p>Fórmula:C29H42Cl2FN3O4Forma y color:SolidPeso molecular:586.57LY 235959
CAS:LY 235959 is a NMDA receptor antagonist.Fórmula:C11H20NO5PPureza:98%Forma y color:SolidPeso molecular:277.25CRM1 degrader 1
<p>CRM1 degrader 1 (1l) is a low-toxic CRM1 degrader that induces apoptosis in gastric carcinoma and selectively inhibits the proliferation of gastric cancer[1].</p>Fórmula:C16H20O3Forma y color:SolidPeso molecular:260.33PDE2 inhibitor 6
CAS:<p>PDE2 inhibitor6 (Compound 1) is an orally active phosphodiesterase (PDE) inhibitor, effectively inhibiting PDE2A, PDE3B, and PDE10A2 with IC50 values of 0.95 nM, 6.17 μM (pIC50=5.21), and 87.1 nM (pIC50=7.06), respectively. It modulates AMPA receptor activity, enhances synaptic plasticity, and improves learning and memory in rat models. Furthermore, PDE2 inhibitor6 possesses blood-brain barrier permeability.</p>Fórmula:C20H22F2N6OForma y color:SolidPeso molecular:400.425Metaphit methylsulfate
CAS:<p>Metaphit methylsulfate is a specific PCP antagonist and an acylating agent for the [3H] phencyclidine binding site in rat brain homogenate. It inhibits PCP-induced motor activity through a presynaptic mechanism.</p>Fórmula:C19H28N2O3S2Forma y color:SolidPeso molecular:396.567URAT1 inhibitor 3
URAT1 inhibitor 3: potent oral URAT1 blocker, IC50=0.8 nM, for gout/hyperuricemia study.Fórmula:C14H8Cl2N2O2Forma y color:SolidPeso molecular:307.13Unoprostone
CAS:Unoprostone is a prostaglandin F2α analogs (PGAs), and reduces intraocular pressure and is used topically for glaucoma or ocular hypertension.Fórmula:C22H38O5Pureza:98%Forma y color:SolidPeso molecular:382.53S-8510 phosphate
CAS:S-8510 phosphate is an agonist of inverse Benzodiazepine (BDZ) receptor(Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively).Fórmula:C12H13N4O6PPureza:98%Forma y color:SolidPeso molecular:340.23Gabaculine HCl
CAS:<p>Gabaculine, an irreversible GABA-T inhibitor (Ki: 2.9 μM), impacts plastid development and affects DPOR/GluTR levels.</p>Fórmula:C7H10ClNO2Forma y color:SolidPeso molecular:175.61RO-275
CAS:RO-275 is an HCN1 inhibitor that also inhibits HCN2, HCN3, and HCN4, improving working memory deficits and being used in research on cognitive disorders.Fórmula:C18H14ClN5OPureza:98.12% - 98.3%Forma y color:SolidPeso molecular:351.79EMD-95885
CAS:<p>EMD-95885 is a selective antagonist of NMDA receptors containing NR2B subunits, with an IC50 of 3.9 nM. It does not interact with other sites on the NMDA receptor.</p>Fórmula:C22H23FN2O3Forma y color:SolidPeso molecular:382.428Olorigliflozin
CAS:<p>Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.</p>Fórmula:C23H27ClO7Forma y color:SolidPeso molecular:450.909ARN23765
CAS:<p>ARN23765 is an F508del-CFTR corrector with an EC50 of 38 pM in human bronchial epithelial cells. It enhances the maturation and function of F508del-CFTR at the cell membrane, influencing ion transport and secretion, thereby addressing the pathological mechanisms of cystic fibrosis (CF).</p>Fórmula:C30H22F5N3O6Forma y color:SolidPeso molecular:615.504Pyrimidinone 8
CAS:<p>Pyrimidinone 8 is a reversible, linear non-competitive inhibitor of divalent metal transporter 1 (DMT1) with a Ki of 20 μM (hDMT1). It does not affect the surface expression of hDMT1 and is not influenced by extracellular pH. Pyrimidinone 8 inhibits hDMT1-mediated iron uptake, with an IC50 of 13.8 μM.</p>Fórmula:C10H12N4OForma y color:SolidPeso molecular:204.229GABA-IN-4
CAS:GABA-IN-4 (Compound 17) is a derivative of N-(indol-3-ylglyoxylyl)benzylamine. It exhibits high affinity for the benzodiazepine receptor (BzR), the binding site within the GABAA receptor complex, with a Ki value of 67 nM. Benzodiazepines are widely used as anxiolytic, sedative-hypnotic, and anticonvulsant agents.Fórmula:C17H13ClN2O2Forma y color:SolidPeso molecular:312.75Zilvetrigine
CAS:<p>Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.</p>Fórmula:C20H20ClN3O2Forma y color:SolidPeso molecular:369.845NMDA agonist 1
CAS:<p>NMDA agonist 1 (compound 42d) is a potent NMDA agonist with a Ki value of 96 nM. It acts as a partial agonist of the GluN1/GluN2B complex, exhibiting an EC50 value of 78 nM.</p>Fórmula:C12H13N3O3SForma y color:SolidPeso molecular:279.315Antidepressant agent 9
CAS:<p>Antidepressant agent 9 (Compound 24) is an orally active inhibitor of NMDAR and SERT, with IC50 values of 3.50 μM and 1044 nM, respectively. It exhibits good metabolic stability and plasma exposure, and demonstrates antidepressant-like effects in the forced swim test in mice.</p>Fórmula:C17H24N2Forma y color:SolidPeso molecular:256.386SGC-CAMKK2-1
CAS:<p>SGC-CAMKK2-1 is a selective inhibitor of calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) with an IC50 of 30 nM. It effectively inhibits AMPK phosphorylation in C4-2 cells, exhibiting an IC50 value of 1.6 µM.</p>Fórmula:C26H23NO3Forma y color:SolidPeso molecular:397.466O4I4
CAS:O4I4 is an OCT4-inducing compound capable of activating endogenous OCT4 and its associated signaling pathways, shown anti-aging effects.Fórmula:C15H20N2SPureza:99.74%Forma y color:SolidPeso molecular:260.4Antidepressant agent 8
CAS:<p>Antidepressant agent 8 (Compound 1f) acts as a selective antagonist for the NMDA receptor GluN1/2A (NMDA receptorGluN1/2A), with an IC50 of 2.94 μmol/L. In a hydrocortisone-induced zebrafish depression model, it demonstrates antidepressant-like effects and shows good blood-brain barrier penetration.</p>Fórmula:C18H23FN4OS2Forma y color:SolidPeso molecular:394.53LY503430
CAS:<p>LY503430: Oral AMPA enhancer with nootropic, neuroprotective properties, mitigates 6-OHDA/MPTP brain damage.</p>Fórmula:C20H25FN2O3SPureza:98%Forma y color:SolidPeso molecular:392.49Antimalarial agent 7
Antimalarial agent 7 is a potent and effective inhibitor of PfATP4. Antimalarial agent 7 has potential for the study of the human plasmodium falciparum.Fórmula:C23H22F2N4O3Forma y color:SolidPeso molecular:440.44Olisutrigine bromide
CAS:<p>Olisutrigine bromide is a sodium channel blocker used as an analgesic.</p>Fórmula:C25H35BrN2Forma y color:SolidPeso molecular:443.463ErSO-TFPy
CAS:ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.Fórmula:C19H13F7N2O2Forma y color:SolidPeso molecular:434.307Moxetomidate
CAS:<p>Moxetomidate is a GABAA receptor (GABAA receptor) agonist with hypnotic properties.</p>Fórmula:C15H18N2O3Forma y color:SolidPeso molecular:274.315Crinecerfont tosylate
CAS:<p>Crinecerfont tosylate is an effective oral CRF1 receptor antagonist. It is applicable to studies involving congenital adrenal hyperplasia (CAH).</p>Fórmula:C34H36ClFN2O4S2Forma y color:SolidPeso molecular:655.242(3S,6R)-NML
CAS:<p>(3S,6R)-NML is an NMDA receptor antagonist with pIC50 values of 4.8 [GluN1-GluN2A], 4.6 [GluN1-GluN2B], 5.0 [GluN1-GluN2C], and 5.0 [GluN1-GluN2D]. It is applicable in the study of depression.</p>Fórmula:C20H27NOForma y color:SolidPeso molecular:297.435URAT1 inhibitor 2
URAT1 inhibitor 2: oral URAT1/CYP blocker, IC50 of 1.36μM (URAT1), 16.97μM (CYP1A2), 5.22μM (CYP2C9); potential gout treatment.Fórmula:C21H18BrN3O2SForma y color:SolidPeso molecular:456.36Insecticidal agent 21
CAS:Insecticidal agent 21 (Compound 6) is an insecticide targeting Culex pipiens larvae with an LC50 of 0.4 μg/mL. It achieves multi-target neurotoxicity by inhibiting acetylcholinesterase (AChE) and simultaneously targeting other neural receptors, including nicotinic acetylcholine receptors (nAChR), voltage-gated sodium channels (VGSC), and γ-aminobutyric acid receptors (GABAAR). Insecticidal agent 21 shows potent insecticidal activity and can be utilized in the development of new insecticides to combat mosquito resistance to conventional agents.Fórmula:C37H40ClN3O2Forma y color:SolidPeso molecular:594.185ATPase-IN-5
CAS:<p>ATPase-IN-5 (Compound 11) is an antifungal Pma1p (H+ -ATPase) inhibitor (IC50 = 12.7 μM) that inhibits the growth of Candida albicans and Saccharomyces cerevisiae.</p>Fórmula:C10H10N4O3SPureza:99.19%Forma y color:SolidPeso molecular:266.28PDE1-IN-4
PDE1-IN-4: inhibits PDE1C/A/B with IC50s 10/145/354 nM, may help study idiopathic pulmonary fibrosis.Fórmula:C33H33N3O4Forma y color:SolidPeso molecular:535.63P2X receptor-1
P2X receptor-1 is a potential inhibitor of P2X receptor for the treatment of pain and inflammation.Fórmula:C14H14ClN3O3S2Forma y color:SolidPeso molecular:371.865-O-Desmethyl donepezil
CAS:<p>5-O-Desmethyl donepezil is a metabolite of Donepezil that acts as an inhibitor of hERG channels, with an IC50 of 1.5 μM.</p>Fórmula:C23H27NO3Forma y color:SolidPeso molecular:365.465ICA-105665
CAS:ICA-105665 is an orally active Kv7.2/7.3/7.5 channel opener, CNS-penetrant with antiseizure effects, and low hepatocyte cytotoxicity.Fórmula:C19H15F2N3O2Pureza:98%Forma y color:SolidPeso molecular:355.34GNE-616
CAS:<p>GNE-616: a potent, stable, oral Nav1.7 inhibitor; Ki: 0.79 nM, Kd: 0.38 nM; for chronic pain.</p>Fórmula:C24H23F4N5O3SPureza:98%Forma y color:SolidPeso molecular:537.53(RS)-AMPA hydrobromide
CAS:AMPAR agonistFórmula:C7H11BrN2O4Pureza:98%Forma y color:SolidPeso molecular:267.08KV1.3-IN-2
CAS:<p>KV1.3-IN-2 (Compound I) selectively inhibits the kv1.3 potassium channel without affecting the hERG channel. It is applicable in research related to immune-associated diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.</p>Fórmula:C16H23ClN2O4Forma y color:SolidPeso molecular:342.818Opakalim
CAS:<p>Opakalim is an activator of potassium channels (potassium channel) and exhibits anticonvulsant activity.</p>Fórmula:C18H22F2N4OForma y color:SolidPeso molecular:348.39WS-898
<p>WS-898 boosts paclitaxel efficacy in resistant cells by inhibiting ABCB1; IC50: SW620/Ad300 - 5.0 nM, KB-C2 - 3.67 nM, HEK293/ABCB1 - 3.68 nM.</p>Fórmula:C33H25N7OSForma y color:SolidPeso molecular:567.66Blixeprodil
CAS:<p>Blixeprodil (GM-1020) is an orally active NMDA receptor antagonist with an affinity of Ki = 3.25 µM in rat cortical tissue. It inhibits NR1/2A-NMDAR-mediated currents in HEK293 cells with an IC50 of 1.192 µM. Blixeprodil demonstrates antidepressant effects in rat models and exhibits blood-brain barrier permeability.</p>Fórmula:C13H16FNOForma y color:SolidPeso molecular:221.271IAA65
CAS:<p>IAA65 is a potent inhibitor of T-type calcium channels, exhibiting an IC50 value of 18.9 μM, and holds potential for use in epilepsy research [1].</p>Fórmula:C16H13F6NO2Forma y color:SolidPeso molecular:365.27VU0463271 quarterhydrate
VU0463271 quarterhydrate is a potent KCC2 antagonist, with an IC 50 of 61 nM [1].Fórmula:C19H20N4O2S2Forma y color:SolidPeso molecular:387V-ATPase-IN-1
CAS:<p>V-ATPase-IN-1 (Compound 3b-03) is an inhibitor of Vacuolar-type H+-ATPases (V-ATPase), exhibiting an inhibition constant (IC50) of 194.80 μM and effectively targeting the V-ATPase subunit A with a dissociation constant (Kd) of 0.803 μM. This compound demonstrates insecticidal activity against M. separata (LC50 = 2.64 mM), aiding in the development of chemical insecticides.</p>Fórmula:C21H20ClNO2Forma y color:SolidPeso molecular:353.84(S)-Albuterol
CAS:<p>(S)-Albuterol functions as a muscarinic receptor and phospholipase C activator, enhancing the intracellular free calcium concentration in airway smooth muscle cells.</p>Fórmula:C13H21NO3Forma y color:SolidPeso molecular:239.311ATPase-IN-6
CAS:ATPase-IN-6 is an inhibitor of H+/K+-ATPase (ATPase) and a derivative of imidazopyridine. It exhibits significant antiviral activity against various viruses, such as HIV-1 and SARS-CoV-2. ATPase-IN-6 is applicable in antiviral infection research.Fórmula:C29H25N3O4SForma y color:SolidPeso molecular:511.59AqF026
CAS:AqF026 is an AQP1 agonist that enhances AQP1-mediated water transport. It is utilized in research related to peritoneal dialysis and diseases associated with local water metabolism defects, such as subretinal edema and cerebral edema.Fórmula:C20H19ClN2O5SForma y color:SolidPeso molecular:434.89PF-06462894
CAS:PF-06462894: morpholinopyrimidone, mGlu5 antagonist (Ki=6nM), no immune activation in mouse model.Fórmula:C18H23N3O3Pureza:98%Forma y color:SolidPeso molecular:329.392-PPA
CAS:2-PPA serves as a selective TMEM175 inhibitor (IC 50 =32 μM), primarily influencing lysosomal activity. Through acute inhibition of TMEM175, 2-PPA enhances lysosomal macromolecular catabolism, which in turn boosts macrophage activity and other digestive processes. This compound holds significance in Parkinson's disease research.Fórmula:C11H10N2Forma y color:SolidPeso molecular:170.21Thiomuscimol hydrobromide
CAS:Thiomuscimol hydrobromide is an agonist of GABAA receptor.Fórmula:C4H6N2OSPureza:98%Forma y color:SolidPeso molecular:130.17URAT1-IN-14
CAS:URAT1-IN-14 is a potent and orally active inhibitor of uric acid transporter 1 (URAT1). It demonstrates an IC50 value of 0.72 μM for inhibiting human URAT1 in HEK293 cells and exhibits low cytotoxicity in Hep-G2 cells. URAT1-IN-14 reduces uric acid levels in a hyperuricemia mouse model and is applicable in research on hyperuricemia and gout.Fórmula:C19H19NO3SForma y color:SolidPeso molecular:341.42Kv3 modulator 5
CAS:Kv3 modulator 5 (Example 5), a Kv3 channel modulator, enhances the Kv3.2 current and may be employed in research of hearing disorders [1].Fórmula:C20H20N4O4Forma y color:SolidPeso molecular:380.4SW016789
CAS:SW016789 is a potent high-secretion inducer targeting VDAC1, which directly stimulates insulin secretion and calcium ion influx in β cells. It transiently induces endoplasmic reticulum stress (ER stress) without causing β cell death. The response it triggers is reversible and non-apoptotic, making SW016789 useful for studying β cell dysfunction in type 2 diabetes (T2DM).Fórmula:C20H19N3OSForma y color:SolidPeso molecular:349.45Caramboxin
CAS:Caramboxin, a neurotoxin, can induce acute kidney injury.Fórmula:C11H13NO6Forma y color:SolidPeso molecular:255.22Dehydroindapamide
CAS:Dehydroindapamide, an indole form of Indapamide, is utilized to quantify the turnover rate of Indapamide in CYP3A4, which is approximately 10 times higher than that of Indoline, with slightly enhanced affinity for CYP3A4.Fórmula:C16H14ClN3O3SForma y color:SolidPeso molecular:363.82Refisolone
CAS:Refisolone is an antagonist of the GABAA receptor.Fórmula:C18H24O3Peso molecular:288.381Lubeluzole dihydrochloride
CAS:<p>Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.</p>Fórmula:C22H27Cl2F2N3O2SForma y color:SolidPeso molecular:506.44Perfluoroheptanesulfonic acid
CAS:Perfluoroheptanesulfonic acid (1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid) is a perfluoroalkyl substance (PFAS). This compound has been detected in landfill leachate and has been shown to induce deformities in zebrafish larvae (EC50=168.1 μM). Exposure to PFHpS in fetuses can lead to reduced birth weight.Fórmula:C7HF15O3SForma y color:SolidPeso molecular:450.12Lafadofensine (D-(-)-Mandelic acid)
Lafadofensine D-(-)-Mandelic acid is a monoamines reuptake inhibitor with adequate effects when administered short-term.Fórmula:C32H32F2N2O6Forma y color:SolidPeso molecular:578.6Kv7.2/Kv7.3 activator-1
CAS:<p>Kv7.2/Kv7.3 Activator-1 (compound 517) serves as a powerful activator of the Kv7.2/Kv7.3 channels, exhibiting an EC50 value of less than 1 µM. It holds potential for use in neurological disease research.</p>Fórmula:C19H22F2N4OForma y color:SolidPeso molecular:360.40PF-05661014
CAS:<p>PF-05661014, a demethylated analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing the inactivated state through interaction with the D4 VSD. This compound is utilized in research focused on sodium channel modulation.</p>Fórmula:C17H16N4O3S2Forma y color:SolidPeso molecular:388.46CFTR corrector 16
CAS:<p>CFTRcorrector 16 (Compound 39) is a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR), utilized in the research of cystic fibrosis disease.</p>Fórmula:C27H26ClN5O2SForma y color:SolidPeso molecular:520.05SP100030 analogue 1
CAS:SP100030 analogue 1 (compound 11) is a selective transcription activation (SITA) inhibitor within the SP100030 class, capable of inhibiting XPO1-dependent upregulation of IL2 in a Jurkat-based IL2-Luc reporter assay, with an EC50 of 137 nM.Fórmula:C13H5ClF7N3OForma y color:SolidPeso molecular:387.64(+)-Tetrabenazine
CAS:(+)-Tetrabenazine ((3R,11bR)-Tetrabenazine) is a reversible vesicular monoamine transporter 2 (VMAT-2) inhibitor, inhibits transport by VMAT2 with 10-foldFórmula:C19H27NO3Pureza:98.69%Forma y color:SolidPeso molecular:317.42Odevixibat
CAS:Odevixibat (A4250) is a selective oral inhibitor for ileal bile acid transport, potentially treating primary biliary cirrhosis.Fórmula:C37H48N4O8S2Pureza:99.53% - 99.83%Forma y color:SolidPeso molecular:740.93SDZ 220-040
CAS:<p>SDZ 220-040 是一种选择性哺乳动物 NMDA 受体拮抗剂，可诱导根系生长的部分无重力模式 。</p>Fórmula:C16H16Cl2NO6PPureza:98.13%Forma y color:SolidPeso molecular:420.18Suzetrigine
CAS:Suzetrigine (VX-548) is an oral NaV1.8 inhibitor with analgesic properties for acute pain research.Fórmula:C21H20F5N3O4Pureza:98.08% - 99.27%Forma y color:SolidPeso molecular:473.39SYM2206
CAS:<p>SYM2206 is a low affinity non-competitive AMPA receptor antagonist with an IC50 value of 1.6 μM.SYM2206 exhibits anticancer activity by blocking Nav1.6-mediated</p>Fórmula:C20H22N4O3Pureza:99.88%Forma y color:SolidPeso molecular:366.415-Hydroxylansoprazole
CAS:5-Hydroxylansoprazole (AG1908) is the active metabolite of plasma Lansoprazole, inhibits the proton pump, and is used in the study of peptic ulcers.Fórmula:C16H14F3N3O3SPureza:99.00%Forma y color:SolidPeso molecular:385.36A-887826
CAS:A-887826 is a selective, orally bioavailable, and voltage-dependent Na(v1.8) channel blocker (IC50: 11 nM). It attenuates neuropathic tactile allodynia in vivo.Fórmula:C26H29ClN4O3Forma y color:SolidPeso molecular:480.99(-)-Bicuculline methobromide
CAS:(-)-Bicuculline methobromide is a potent antagonist of GABAA receptor .Fórmula:C21H20BrNO6Forma y color:WhitePeso molecular:462.29Umbellulone
CAS:Umbellulone is a natural product isolated from Umbellularia californica, and stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism.Fórmula:C10H14OPureza:98%Forma y color:SolidPeso molecular:150.22(Rac)-Lanicemine
CAS:<p>(Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker with a Ki of 0.56-2.1 μM for the NMDA receptor and IC50 values of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively. Lanicemine shows antidepressant effects [1].</p>Fórmula:C13H14N2Forma y color:SolidPeso molecular:198.26L-Cysteine S-sulfate sodium salt sesquihydrate
CAS:L-Cysteine S-sulfate sodium salt sesquihydrate is a useful organic compound for research related to life sciences. The catalog number is T64782 and the CAS number is 150465-29-5.Fórmula:C9H25N3Na3O17S6Forma y color:SolidPeso molecular:708.63
