Transportador de membrana / canal de iones
Los inhibidores de transportadores de membrana y canales iónicos son compuestos que bloquean la función de proteínas responsables del transporte de iones, nutrientes y otras moléculas a través de las membranas celulares. Estos inhibidores son cruciales para estudiar la regulación de la homeostasis celular, la transducción de señales y la neurotransmisión. Los inhibidores de transportadores de membrana y canales iónicos también son importantes para desarrollar tratamientos para trastornos como la epilepsia, las enfermedades cardiovasculares y los síndromes metabólicos. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de transportadores de membrana y canales iónicos para apoyar su investigación en fisiología, neurociencia y farmacología.
Subcategorías de "Transportador de membrana / canal de iones"
- ABC(3 productos)
- ATPasa(93 productos)
- Receptor de adiponectina(5 productos)
- CFTR(64 productos)
- Receptor CGRP(51 productos)
- Canal de calcio(493 productos)
- Canal de cloruro(49 productos)
- Receptor GABA(336 productos)
- Transportador de monoamina(23 productos)
- Transportador de monocarboxilato(17 productos)
- NKCC(2 productos)
- NPC1L1(3 productos)
- Cotransportador de Na-K-Cl(8 productos)
- OAT(27 productos)
- OCT(7 productos)
- P-gp(53 productos)
- Canal de potasio(276 productos)
- Bomba de protones(39 productos)
- SGLT(30 productos)
- Canal de sodio(202 productos)
- Canal TRP / TRPV(92 productos)
Mostrar 13 subcategorías más
Se han encontrado 2270 productos de "Transportador de membrana / canal de iones"
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6,2'-Dihydroxyflavone
CAS:<p>6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor.</p>Fórmula:C15H10O4Pureza:99.44% - 99.67%Forma y color:SolidPeso molecular:254.24MK-2295
CAS:<p>MK-2295 is a potent TRPV1 antagonist. MK-2295 can be used in studies about the treatment of chronic pain.</p>Fórmula:C27H31FN6O2Pureza:98.83% - 99.44%Forma y color:SolidPeso molecular:490.57XR9051
CAS:<p>XR9051, a synthetic derivative of a natural compound, potently reverses P-glycoprotein MDR (EC50 = 1.4 nM) by inhibiting cytotoxic binding.</p>Fórmula:C39H38N4O5Forma y color:SolidPeso molecular:642.74Ritivixibat
CAS:<p>Ritivixibat inhibits IBAT and modulates bile acids, used in research for cardiovascular, metabolic, GI, and liver diseases.</p>Fórmula:C26H36N2O5S2Forma y color:SolidPeso molecular:520.7MK-8153
CAS:<p>MK-8153: Selective, potent ROMK inhibitor, orally active, IC50: ROMK EP 5 μM, hERG EP 34 μM; potential diuretic.</p>Fórmula:C24H28N2O6Forma y color:SolidPeso molecular:440.49Lingdolinurad
CAS:<p>Lingdolinurad is a uric acid transporter protein inhibitor targeting hURAT1 for the study of hyperuricemia or gout.</p>Fórmula:C17H12BrN3O2Pureza:96.26%Forma y color:SolidPeso molecular:370.2JYL-1511
CAS:<p>JYL-1511 is the TRPV1 channel partial agonist.</p>Fórmula:C21H29N3O3S2Pureza:98%Forma y color:SolidPeso molecular:435.6D-erythro-Sphingosine hydrochloride
CAS:<p>D-erythro-Sphingosine HCl activates TRPM3 and dephosphorylates retinoblastoma protein.</p>Fórmula:C18H38ClNO2Forma y color:SolidPeso molecular:335.95TPA 023
CAS:<p>TPA 023 is a selective agonist of GABAA α2/α3 subtype (Kis = 0.19 - 0.41 nM).</p>Fórmula:C20H22FN7OPureza:99.75%Forma y color:SolidPeso molecular:395.43NO-711ME
CAS:<p>NO-711ME (N-O711 Methyl ester) is a prodrug of NO-711. It also is a potent and selective GABA uptake inhibitor.</p>Fórmula:C22H24N2O3Pureza:99.54%Forma y color:SolidPeso molecular:364.44Kv3 modulator 2
CAS:<p>Kv3 modulator 2 is a potent Kv3 channels modulator.has analgesic activity and is used in the prophylaxis or treatment of related disorders.</p>Fórmula:C21H21N3O4Pureza:98%Forma y color:SolidPeso molecular:379.41TRPC5-IN-3
CAS:<p>TRPC5-IN-3 is a potent TRPC5 inhibitor (IC50= 10.75 nM).</p>Fórmula:C18H15ClF3N5OForma y color:SolidPeso molecular:409.79NS1219
CAS:<p>NS1219, an isomer of NS1209, is a selective AMPA antagonist for studying stroke, neuropathic pain, and epilepsy.</p>Fórmula:C24H28N4O7SForma y color:SolidPeso molecular:516.57Budiodarone
CAS:<p>Budiodarone (ATI-2042) resembles amiodarone, potentially preventing atrial fibrillation.</p>Fórmula:C27H31I2NO5Forma y color:SolidPeso molecular:703.35Kv3 modulator 3
CAS:<p>Kv3 modulator 3 is a selective modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 channels .has analgesic activity for use in the prophylaxis o or treatment of pain.</p>Fórmula:C19H18N4O3Pureza:98%Forma y color:SolidPeso molecular:350.37CGP36216 hydrochloride
CAS:<p>CGP36216 hydrochloride acts as a selective antagonist at the presynaptic GABA receptor, specifically binding to the GABAB receptor with a Ki value of 0.3 μM. This compound is leveraged in research focused on anxiety and trauma-related disorders [1] [2].</p>Fórmula:C5H15ClNO2PForma y color:SolidPeso molecular:187.6(R)-Vanzacaftor
CAS:<p>(R)-Vanzacaftor ((R)-VX-121) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator [1].</p>Fórmula:C32H39N7O4SForma y color:SolidPeso molecular:617.76Oct4 inducer-2
CAS:<p>Oct4 Inducer-2, an OCT4 inducer, sustains hiPSC formation by enhancing endogenous OCT4 expression and has applications in anti-aging research [1].</p>Fórmula:C14H16N2O2SForma y color:SolidPeso molecular:276.35VU0463271
CAS:<p>VU0463271: KCC2 antagonist, IC50 61 nM, >100x selective over NKCC1, inactive on other GPCRs, channels, transporters.</p>Fórmula:C19H18N4OS2Pureza:97.84% - 99.55%Forma y color:SolidPeso molecular:382.5PZ-II-029
CAS:<p>PZ-II-029 is a modulator of α6β3γ2-selective GABAA channel.</p>Fórmula:C18H15N3O3Pureza:99.79%Forma y color:SolidPeso molecular:321.33Diproqualone
CAS:<p>Diproqualone, analogous to methaqualone, exhibits sedative, anxiolytic, anti-inflammatory, and analgesic properties [1].</p>Fórmula:C12H14N2O3Forma y color:SolidPeso molecular:234.255Naltiazem
CAS:<p>Naltiazem, a calcium channel antagonist, is used potentially for the treatment of arrhythmias, hypertension and myocardial infarction.</p>Fórmula:C26H28N2O4SPureza:98%Forma y color:SolidPeso molecular:464.58NPBA
CAS:<p>NPBA, a potassium K2P channel TASK-3 (KCNK9) agonist, concurrently functions as a blocker of the tandem pore domain weak inward rectifying K+ channel (TWIK2). This compound effectively inhibits NLRP3 inflammasome activation in macrophages [1].</p>Fórmula:C16H14F3N3O3Forma y color:SolidPeso molecular:353.3Nalanthalide
CAS:<p>Nalanthalide, serving as a voltage-gated potassium channel Kv1.3 blocker (IC50 = 3.9 µM) with potential immunosuppressive properties, is applicable in the research of inflammatory immune diseases including neuroinflammation [1] [2].</p>Fórmula:C30H44O5Forma y color:SolidPeso molecular:484.67CRF1 receptor antagonist-1
CAS:<p>CRF1 Receptor Antagonist-1 (Compound 2), a CRF1 receptor antagonist, is utilized in research pertaining to congenital adrenal hyperplasia (CAH) [1].</p>Fórmula:C27H28ClFN2O2SPureza:98%Forma y color:SolidPeso molecular:499.04Kv3 modulator 4
CAS:<p>Kv3 modulator 4 is a Kv3.1 (pEC50=5.45) and Kv3.2 modulator .Cyclobutyl structure.</p>Fórmula:C20H24N2O4Pureza:98%Forma y color:SolidPeso molecular:356.42SN40 hydrochloride
CAS:<p>SN40 hydrochloride is a potent inhibitor of amino acid transport (AAT), exhibiting inhibitory constants (Kis) of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM, and 5.55 μM for rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1, and EAAT5, respectively. It is utilized in cancer research. [1]</p>Fórmula:C18H21ClN2O2Forma y color:SolidPeso molecular:332.82COR659
CAS:<p>COR659: suppresses alcohol/chocolate intake in rats; enhances GABAB receptor, blocks CB1 receptor.</p>Fórmula:C16H16ClNO3SPureza:99.75%Forma y color:SolidPeso molecular:337.82BMT-108908
CAS:<p>BMT-108908 is a Negative Allosteric Modulator. It is selective for the NR2B Subtype of The NMDA Receptor Impair Cognition in Multiple Domains.</p>Fórmula:C22H25FN2O2Forma y color:SolidPeso molecular:368.44Ebio1
CAS:<p>Ebio1, a selective activator of the voltage-gated potassium channel KCNQ2, enhances channel conductance by promoting the formation of an expanded gate at a saturation voltage of +50 mV, leading to increased channel activity [1].</p>Fórmula:C19H14FNOForma y color:SolidPeso molecular:291.32Coelenterazine h
CAS:<p>Coelenterazine H, a Ca2+ sensitive synthetic derivative, is a luminescent biomolecule used to measure Ca2+ changes.</p>Fórmula:C26H21N3O2Pureza:99.49%Forma y color:Yellow To Brownish PowderPeso molecular:407.46Etidocaine Hydrochloride
CAS:<p>Etidocaine Hydrochloride (W19053) is a long-acting anesthetic and a blocker of the voltage-gated sodium channel.</p>Fórmula:C17H29ClN2OPureza:99.86%Forma y color:SolidPeso molecular:312.88α,β-Methylene-ATP
CAS:<p>α,β-Methylene ATP，一种ATP的膦酸酯类似物，充当P2X3和P2X7受体的配体。该化合物对P2X1和P2X3表现出高选择性激动剂活性，而在P2X2, 4, 7受体上无活性。</p>Fórmula:C11H18N5O12P3Forma y color:SolidPeso molecular:505.21URAT1 inhibitor 6
CAS:<p>URAT1 inhibitor 6 (Compound 1h), with an IC50 of 35 nM for hURAT1, demonstrates 200-fold and 8-fold greater potency compared to Lesinurad and Benzbromarone,</p>Fórmula:C9H7BrN3NaO2S2Forma y color:SolidPeso molecular:356.2Glibornuride
CAS:<p>Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75).</p>Fórmula:C18H26N2O4SPureza:99.5%Forma y color:SolidPeso molecular:366.48PF-05241328
CAS:<p>PF-05241328 is an effective and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (IC50: 31 nM).</p>Fórmula:C19H21ClN4O4SPureza:98%Forma y color:SolidPeso molecular:436.91VMAT2-IN-I HCl
CAS:<p>VMAT2-IN-I HCl is an inhibitor of vesicular monoamine transporter-2. It also has 15- fold greater affinity than GZ- 793A.</p>Fórmula:C25H32ClF4NO4Pureza:98%Forma y color:SolidPeso molecular:521.97GSK 2833503A
CAS:<p>GSK 2833503A: potent TRPC6/3 antagonist; IC50: 3-16/21-100 nM; >63x selective; inhibits cardiac hypertrophy signaling.</p>Fórmula:C18H21ClFN3OSForma y color:SolidPeso molecular:381.9PHP 501 trifluoroacetate
CAS:<p>GABAA antagonist</p>Fórmula:C20H21N3OPureza:98%Forma y color:SolidPeso molecular:319.4UBP316
CAS:<p>GluR5-containing kainate receptor antagonist</p>Fórmula:C20H19N3O6SPureza:98%Forma y color:SolidPeso molecular:429.45ADCI
CAS:<p>ADCI inhibits voltage-activated sodium and NMDA channels; boosts dopamine metabolism in prefrontal cortex and nucleus accumbens.</p>Fórmula:C16H14N2OPureza:98%Forma y color:SolidPeso molecular:250.3TCS 46b
CAS:<p>TCS 46b is a NR1A/NR2B NMDA receptor antagonist with oral activity.</p>Fórmula:C22H23N3OPureza:99.78% - 99.78%Forma y color:SolidPeso molecular:345.4411-deoxy-PGF2a
CAS:<p>11-deoxy-PGF2a is a thromboxane A2 receptor agonist that partially alleviates crowding in Lpar3(−/−) female embryos and induces smooth muscle contraction</p>Fórmula:C20H34O4Forma y color:SolidPeso molecular:338.48Zelquistinel
CAS:<p>Zelquistinel, an NMDA receptor agonist, aids research on depression, anxiety, and psychiatric disorders.</p>Fórmula:C15H25N3O5Forma y color:SolidPeso molecular:327.38(+)-Bicuculline methiodide
CAS:<p>(+)-Bicuculline methiodide is a GABAA receptor blocker that blocks epileptogens and may be used in the study of neurological disorders.</p>Fórmula:C21H20INO6Pureza:99.24%Forma y color:SolidPeso molecular:509.29ARN 11391
CAS:<p>ARN 11391 enhances the function of the IP3-gated calcium channel ITPR1 (Inositol 1,4,5-trisphosphate (IP3) receptor type 1), boosting intracellular calcium ion</p>Fórmula:C22H29N3O3Forma y color:SolidPeso molecular:383.49JYL-273
CAS:<p>JYL-273 is a TRPV1 agonist.</p>Fórmula:C28H39NO4SForma y color:SolidPeso molecular:485.68AMPA-IN-1
CAS:<p>AMPA-IN-1: Potent AMPA receptor inhibitor; key in regulating brain excitatory transmission and plasticity.</p>Fórmula:C23H12F2N4O2Forma y color:SolidPeso molecular:414.36KCa1.1 channel activator-1
<p>A selective vascular KCa1.1 channel stimulator with CaV1.2 blocking ability and mild myorelaxant effects.</p>Fórmula:C25H16O10Forma y color:SolidPeso molecular:476.39L-822179
CAS:<p>L-822179 (α5IA) is a selective inverse agonist for the Α5 subtype of GABAA receptor with higher intrinsic activity at the A5 subtype than other drugs.</p>Fórmula:C17H14N8O2Pureza:98.5% - 99.61%Forma y color:SolidPeso molecular:362.35GABAA receptor agent 2 TFA
CAS:<p>Potent GABAA antagonist; IC50: 24 nM (α1β2γ2), Ki: 28 nM (rat); inactive on human GABA transporters.</p>Fórmula:C22H22F3N3O3Forma y color:SolidPeso molecular:433.426-Iodoamiloride
CAS:<p>6-Iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (ASIC1), exhibiting an IC50 value of 88 nM.</p>Fórmula:C6H8IN7OPureza:98%Forma y color:SolidPeso molecular:321.08A 425619
CAS:<p>A 425619 (1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA) is a potent TRPV1 antagonist</p>Fórmula:C18H14F3N3OPureza:99.75%Forma y color:SolidPeso molecular:345.32APS3
CAS:<p>APS3 is an inhibitor of GABA and nACh receptors, exhibiting an LC50 value of 7.2423 μg/mL against Plutella xylostella [1].</p>Fórmula:C18H7Cl2F6N5O5S2Forma y color:SolidPeso molecular:622.31Potassium Channel Activator 1
CAS:<p>Potassium Channel Activator 1 aids treatment of ADHD, schizophrenia, and mood disorders by targeting the dopaminergic system.</p>Fórmula:C19H23N3O3Pureza:99.86%Forma y color:SolidPeso molecular:341.4L 663581
CAS:<p>L 663581 is the benzodiazepine receptor partial agonist.</p>Fórmula:C17H16ClN5O2Pureza:98%Forma y color:SolidPeso molecular:357.79Bupivacaine hydrochloride monohydrate
CAS:<p>Bupivacaine hydrochloride monohydrate is an NMDA receptor inhibitor that inhibits SCN5A channels and is commonly used in the study of chronic pain.</p>Fórmula:C18H31ClN2O2Pureza:99.91%Forma y color:SolidPeso molecular:342.9Funapide
CAS:<p>Funapide (TV 45070) is a potent Nav1.7 inhibitor, potentially treating inflammation and various pains.</p>Fórmula:C22H14F3NO5Pureza:99.91%Forma y color:SolidPeso molecular:429.35Maralixibat Chloride
CAS:<p>Maralixibat Chloride (LUM001 chloride), an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid recirculation.</p>Fórmula:C40H56ClN3O4SPureza:99.19% - 99.65%Forma y color:SolidPeso molecular:710.41C 101248
CAS:<p>C 101248 (KCNK13-IN-1) is a selective and potent tandem pore halogen inhibitor of K+ channel 1 (THIK-1) inhibitor and a human and mouse KCNK13 inhibitor.</p>Fórmula:C15H12N6OPureza:99.14% - 99.31%Forma y color:SolidPeso molecular:292.3VGSCs-IN-1
CAS:<p>VGSCs-IN-1, a VGSC inhibitor and Riluzole analog, exhibits good blocking activity on Nav1.4 and can be used to study cellular excitability disorders.</p>Fórmula:C12H12F3N3OSPureza:99.88%Forma y color:SolidPeso molecular:303.3CE-224535
CAS:<p>CE-224535 (PF-04905428) is a selective antagonist of P2X7 receptor. CE-224535 can be used in disease-modifying antirheumatic studies.</p>Fórmula:C22H29ClN4O6Pureza:99.68%Forma y color:SolidPeso molecular:480.94LE135
CAS:<p>LE135: RARα/RARβ antagonist (Ki: 1.4 μM/220 nM), favors RARβ, selective vs RARγ/RXRs; also activates TRPV1/TRPA1 (EC50s: 2.5/20 μM).</p>Fórmula:C29H30N2O2Pureza:97.94%Forma y color:SolidPeso molecular:438.56AMG-0347
CAS:<p>AMG-0347 inhibits TRPA1 ion channels in sensory neurons, blocking pain perception.</p>Fórmula:C24H26F3N3O2Pureza:99.93%Forma y color:SolidPeso molecular:445.48Kv3 modulator 1
CAS:<p>Kv3 modulator 1 is a voltage-gated potassium channel Kv3 modulator that can be used to study neurologic-level diseases.</p>Fórmula:C20H20N4O4Pureza:99.41%Forma y color:SolidPeso molecular:380.4CFTR corrector 4
CAS:<p>Potent, oral CFTR corrector 4 targets cystic fibrosis, increasing cell surface CFTR levels.</p>Fórmula:C29H27F2NO7Pureza:99.32%Forma y color:SolidPeso molecular:539.52MCT1-IN-3
CAS:<p>MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor.</p>Fórmula:C22H19N3O4Pureza:99.35%Forma y color:SoildPeso molecular:389.4Soraprazan
CAS:<p>BS3 Crosslinker (Bis(sulfosuccinimidyl)suberate) is an ADC linker that can be used to synthesize antibody-coupled active molecules.</p>Fórmula:C21H25N3O3Pureza:97.69% - 99.84%Forma y color:SolidPeso molecular:367.44L-DABA hydrobromide
CAS:<p>L-DABA hydrobromide (L-2,4-Diaminobutyric acid hydrobromide) , GABA transaminase inhibitor with antitumor and anticonvulsant activity.</p>Fórmula:C4H11BrN2O2Pureza:99.11%Forma y color:SolidPeso molecular:199.05Aneratrigine hydrochloride
CAS:<p>Aneratrigine hydrochloride is a Nav 1.9 blocker that may be used to prevent or treat sodium channel blocker-related disorders.</p>Fórmula:C19H21Cl2F2N5O2S2Pureza:98.37% - 99.16%Forma y color:SolidPeso molecular:524.43EMD57033
CAS:<p>EMD57033 activates cardiac troponin C, enhances Ca2+ sensitivity to boost heart contraction.</p>Fórmula:C22H23N3O4SPureza:99.72% - >99.99%Forma y color:SolidPeso molecular:425.5Reldesemtiv
CAS:<p>Reldesemtiv (CK-2127107) boosts exercise capacity, targeting fast muscle troponin, EC50 3.4 μM.</p>Fórmula:C19H18F2N6OPureza:97.27%Forma y color:SolidPeso molecular:384.38AMG2850
CAS:<p>AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).</p>Fórmula:C19H17F6N3OPureza:99.84%Forma y color:SolidPeso molecular:417.353-Methoxy PCE hydrochloride
CAS:<p>3-Methoxy PCE (3-MEO PCE) hydrochloride is an arylcyclohexylamine compound that functions as an NMDA receptor antagonist with a pKi value of 7.22.</p>Fórmula:C15H24ClNOForma y color:SolidPeso molecular:269.81Butein tetramethyl ether
CAS:<p>Butein tetramethyl ether (Compound 20) is a potent and selective inhibitor of breast cancer resistance protein / ATP-binding cassette sub-family G member 2 (BCRP/ABCG2). It inhibits MCF-7 MX and MDCKBCRP cells with IC50 values of 2.2 μM and 1.03 μM, respectively. Butein tetramethyl ether holds potential for cancer research.</p>Fórmula:C19H20O5Forma y color:SolidPeso molecular:328.359Leualacin
CAS:<p>Leualacin is a novel calcium blocker from Hapsidospora irregularis.</p>Fórmula:C31H47N3O7Pureza:98%Forma y color:SolidPeso molecular:573.72Tamitinol
CAS:<p>Tamitinol is a neurotropic drug. It has been found to help symptoms of obsessive rumination in conjunction with maprotiline.</p>Fórmula:C12H20N2OSPureza:98%Forma y color:SolidPeso molecular:240.37EF1502 free base
CAS:<p>EF1502 is a potent and selective GABA transporter inhibitor.</p>Fórmula:C22H26N2O2S2Pureza:98%Forma y color:SolidPeso molecular:414.58(R)-KMH-233
CAS:<p>(R)-KMH-233 is an isomer of KMH-233, which can serve as a reference compound in experiments. KMH-233 functions as a potent, reversible, and selective inhibitor of L-type amino acid transporter 1 (LAT1), effectively hindering the uptake of LAT1 substrate, l-leucine (IC50=18 μM), and also inhibiting cell growth. Even at a low concentration of 25 μM, KMH-233 significantly enhances the efficacy of Bestatin and cisplatin.</p>Fórmula:C32H25N7O5Peso molecular:587.58Caged MK801
CAS:<p>Caged MK801 (cMK801) is a selective, noncompetitive, and irreversible blocker of the NMDA receptor open channel. The NVOC cage is compatible in neuropharmacology and does not alter the intrinsic activity of the molecule.</p>Fórmula:C26H24N2O6Forma y color:SolidPeso molecular:460.48CFTR corrector 17
CAS:<p>CFTRcorrector 17 (example 17) is a regulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It is utilized in the study of diseases mediated by CFTR.</p>Fórmula:C18H15FN2O2Forma y color:SolidPeso molecular:310.32BGT1-IN-1
CAS:<p>BGT1-IN-1 (compound 9) is an effective inhibitor of BGT1, demonstrating IC50 values of 13.9 µM for hBGT1 and 58.3 µM for GAT3. It exhibits no cytotoxic effects and possesses neuroprotective activity.</p>Fórmula:C6H9NO2Forma y color:SolidPeso molecular:127.14S9-A13
CAS:<p>S9-A13 is a potent and selective inhibitor of SLC26A9, exhibiting an IC50 of 90.9 nM without inhibiting other members of the SLC26 family, such as SLC26A3, SLC26A4, and SLC26A6. It also inhibits the SLC26A9 Cl- current in cells lacking CFTR expression.</p>Fórmula:C20H18ClN3O2SForma y color:SolidPeso molecular:399.89H052
CAS:<p>H052 is a selective inhibitor of Staphylococcus aureus α-hemolysin (Hla). It binds to the Hla monomer, disrupting its interaction with the host cell membrane, thereby blocking pore formation and inhibiting calcium influx, cytotoxicity, and inflammatory response. H052 exhibits inhibitory activity against Hla-induced calcium influx (EC50 = 30 nM in U937 cells) and holds potential for research into lung infections caused by S. aureus.</p>Fórmula:C21H15ClFN3O4SForma y color:SolidPeso molecular:459.88EU 1622-240
CAS:<p>EU 1622-240 is an allosteric modulator with a preference for GluN2B, GluN2C, and GluN2D, exhibiting EC50 values of 0.57, 0.82, and 1.1 μM, respectively. It possesses favorable physicochemical properties, along with in vitro stability and permeability.</p>Fórmula:C20H14BrF2N3O2SForma y color:SolidPeso molecular:478.31Cyproflanilide
CAS:<p>Cyproflanilide is a GABAR antagonist that exhibits high activity against a variety of pests, including those from the Lepidoptera, Coleoptera, and Thysanoptera orders.</p>Fórmula:C28H17BrF12N2O2Forma y color:SolidPeso molecular:721.33Vormatrigine
CAS:<p>Vormatrigine effectively inhibits sodium channels (sodium channel).</p>Fórmula:C16H12F6N4O2Forma y color:SolidPeso molecular:406.28Kv7.2/Kv7.3 agonist 1
CAS:<p>Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.</p>Fórmula:C14H14FN3O2Forma y color:SolidPeso molecular:275.28NMD670
CAS:<p>NMD670 is an orally active, partial inhibitor of the skeletal muscle-specific chloride channel ClC-1. It enhances muscle excitability and neuromuscular transmission, restoring muscle function and mobility. NMD670 has a favorable safety profile and improves muscle function in rats, particularly in an MG rat model [1].</p>Fórmula:C12H10BrNO4Forma y color:SolidPeso molecular:312.12CRM1-IN-3
CAS:<p>CRM1-IN-3 (B28), a noncovalent inhibitor of CRM1, is utilized in the research of protein localization and tumor studies [1].</p>Fórmula:C26H26ClN3O3Forma y color:SolidPeso molecular:463.96Sp-8-Br-cGMPS
CAS:<p>Sp-8-Br-cGMPS, an analogue of cGMP, acts as an agonist for cGMP gated cation channels (CNG channels) with an EC50 of 106.5 μM. While Sp-8-Br-cGMPS can induce currents, it does not stabilize channel open states as effectively as a full agonist.</p>Fórmula:C10H11BrN5O6PSForma y color:SolidPeso molecular:440.17TRPV1 antagonist 10
CAS:<p>TRPV1 antagonist 10 is a potent, orally active TRPV1 antagonist with an IC50 of 33.06 nM and serves as a moderate to weak inhibitor of URAT1 (IC50 = 22.51 μM) and GLUT9 (inhibition of 60.25% at 50 μM). It exhibits analgesic and urate-lowering properties and is applicable for research in hyperuricemia and inflammatory pain.</p>Fórmula:C16H14N2O5Forma y color:SolidPeso molecular:314.293TRPA1 Antagonist 1
CAS:<p>TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.</p>Fórmula:C24H20F6N5Na2O7PSPureza:98%Forma y color:SolidPeso molecular:713.45pan-HCN-IN-1
CAS:<p>Pan-HCN-IN-1 (Compound J&J12e) is an inhibitor of the hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channel, with an IC50 of 58 nM. Pan-HCN-IN-1 reduces the voltage sag response and enhances EPSP summation in ex vivo rat brain slices [1].</p>Fórmula:C23H37N3O2Forma y color:SolidPeso molecular:387.56Sesamodil
CAS:<p>Sesamodil (SD 3211) is a novel calcium antagonist that can be used to study hypertension.</p>Fórmula:C29H32N2O6SPureza:98.58% - 99.01%Forma y color:SolidPeso molecular:536.64ABCA1 inducer 2
CAS:<p>ABCA1 inducer 2 is a non-lipogenic inducer of ABCA1. It increases the expression of ABCA1 by targeting the LXR pathway, thereby reducing lipid accumulation induced by ox-LDL and inhibiting foam cell formation. ABCA1 inducer 2 holds potential as an anti-atherosclerotic agent.</p>Fórmula:C16H11BrN2OForma y color:SolidPeso molecular:327.175MRS4738
<p>MRS4738 is a potent antagonist with high affinity for the P2Y14R receptor. It demonstrates in vivo anti-hyperallodynic and antiasthmatic activity [1].</p>Fórmula:C30H24F3NO2Forma y color:SolidPeso molecular:487.51GABAA receptor agonist 1
<p>Compound 3e, a potent GABAA agonist, targets GABA sites and has potential anti-depressive effects in mice.</p>Fórmula:C20H30O3Forma y color:SolidPeso molecular:318.45DAD dichloride
<p>DAD dichloride is a 3rd-gen photoelectric switch, blocks K+ channels, and helps in visual function research.</p>Fórmula:C26H42Cl2N6OForma y color:SolidPeso molecular:525.56NSC73306
CAS:<p>NSC73306 is a thiosemicarbazone known for its role as a cell-permeable agent, exhibiting increased toxicity towards cells expressing p-glycoprotein.</p>Fórmula:C16H14N4O2SForma y color:SolidPeso molecular:326.373Unoprostone isopropyl
CAS:<p>Unoprostone isopropyl, a prostanoid and synthetic docosanoid, is approved for the treatment of ocular hypertension and open-angle glaucoma.</p>Fórmula:C25H44O5Pureza:98%Forma y color:SolidPeso molecular:424.618-Prenylchrysin
CAS:<p>8-Prenylchrysin is a C8-isopentenyl flavonoid compound. It acts as an inhibitor of P-glycoprotein (P-gp) and can be utilized in cancer research.</p>Fórmula:C20H18O4Forma y color:SolidPeso molecular:322.354(RS)-AMPA monohydrate
CAS:<p>(RS)-AMPA monohydrate, potent glutamate analogue, selectively activates L-glutamic acid without affecting kainic acid or NMDA receptors.</p>Fórmula:C7H12N2O5Forma y color:SolidPeso molecular:204.182Probenecid sodium
CAS:<p>Probenecid sodium is the sodium salt of Probenecid, a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Additionally, Probenecid acts as an inhibitor of pannexin 1 channels.</p>Fórmula:C13H18NNaO4SForma y color:SolidPeso molecular:307.341TRPC4/5-IN-1
<p>TRPC4/5-IN-1, a TRPC5/4 inhibitor with IC50s 0.54 μM/2.06 μM, targets skin inflammation and proteinuric kidney diseases.</p>Fórmula:C21H21N3OForma y color:SolidPeso molecular:331.41hURAT1 inhibitor 2
CAS:<p>hURAT1 inhibitor 2 (Compound 5) is an inhibitor of hURAT1 (uric acid transporter 1, SLC22A12) with an IC50 of 18 nM. It also exhibits some inhibitory activity against OATP1B1, with an IC50 of 0.73 μM. hURAT1 inhibitor 2 can be used in research related to hyperuricemia, gout, and other diseases associated with abnormal uric acid metabolism.</p>Fórmula:C17H11Br2FO3Forma y color:SolidPeso molecular:442.074P-gp modulator 2
<p>P-gp modulator 2 (Compound 27) is a potent competitive and metabotropic P-glycoprotein (P-gp) modulator.</p>Fórmula:C22H20BrN3O4Forma y color:SolidPeso molecular:470.32GABAA receptor agonist 2
<p>Compound 4c, a potent GABAA agonist with anti-depressive effects in mouse FST/TST, shows promise in depression research.</p>Fórmula:C22H36O5Forma y color:SolidPeso molecular:380.52Dehydelone
CAS:<p>Dehydelone(KOS-1584, R-1645, SK-10088) is a microtubule stabilizer that may be used in the treatment of non-small cell lung cancer.</p>Fórmula:C27H39NO5SForma y color:SolidPeso molecular:489.67P-gp inhibitor 2
CAS:<p>Potent P-gp inhibitor 2 reverses Doxorubicin resistance in colorectal carcinoma cells with IC50 of 0.22 µM.</p>Fórmula:C29H26N2O6Forma y color:SolidPeso molecular:498.53INCB-056868
CAS:<p>INCB-056868 is the metabolite M11 of Epacadostat. It serves as a substrate for BCRP and holds potential for use in the study of metabolic diseases.</p>Fórmula:C11H13BrFN7O3SForma y color:SolidPeso molecular:422.23NMDA receptor antagonist-3
<p>NMDA antagonist-3: recovery rate 40% at 100 μM, low toxicity in SH-SY5Y, human stem cells.</p>Fórmula:C13H19N3O6Forma y color:SolidPeso molecular:313.31BMS-986163
CAS:<p>BMS-986163, a prodrug, quickly becomes BMS-986169, a GluN2B inhibitor (Ki=4 nM, IC50=24 nM).</p>Fórmula:C23H28FN2O5PPureza:98%Forma y color:SolidPeso molecular:462.45Coleon-U-quinone
CAS:<p>Coleon-U-quinone, a P-gp inhibitor, reduces cancer cell viability and enhances Doxorubicin sensitivity in resistant cells.</p>Fórmula:C20H24O5Forma y color:SolidPeso molecular:344.4DFBTA
<p>DFBTA inhibits ANO1 with IC50 of 24 nM, effectively treating inflammatory pain orally.</p>Fórmula:C18H10ClF2NO3SForma y color:SolidPeso molecular:393.79KCa2 channel modulator 2
<p>Compound 2q is a potent, subtype-selective K/Ca 2 modulator, effective on human K Ca 2.3 and rat K Ca 2.2a with EC50s of 0.60 μM and 0.64 μM.</p>Fórmula:C16H15ClFN5Forma y color:SolidPeso molecular:331.78TRPV1 antagonist 3
<p>TRPV1 antagonist 3 (7q) strongly blocks TRPV1 at 2.66 nM IC50, is selective, 60% bioavailable, and crosses the blood-brain barrier.</p>Fórmula:C23H25N3OSForma y color:SolidPeso molecular:391.53Ro 0437626
CAS:<p>P2X1 purinergic receptor antagonist</p>Fórmula:C27H35N5O4SPureza:98%Forma y color:SolidPeso molecular:525.66NYX-2925
CAS:<p>NYX-2925, an oral NMDAR modulator, enhances Src in mPFC. No CAMKII impact or addictive/sedative effects. Useful for CNS disorder studies.</p>Fórmula:C14H23N3O4Forma y color:SolidPeso molecular:297.35(RS)-AMPA
CAS:<p>(RS)-AMPA ((±)-AMPA) is a glutamate analog. (RS)-AMPA is an agonist of effective and selective excitatory neurotransmitter L-glutamic acid.</p>Fórmula:C7H10N2O4Pureza:98%Forma y color:SolidPeso molecular:186.17Onfasprodil
CAS:<p>Onfasprodil, NR2B inhibitor & GABA regulator, potential for Alzheimer's research. (Patent CN111481543A)</p>Fórmula:C20H23FN2O3Forma y color:SolidPeso molecular:358.41Valbenazine tosylate
CAS:<p>Valbenazine tosylate, the tosylate salt of valbenazine, is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki value of 150 nM while displaying no</p>Fórmula:C38H54N2O10S2Pureza:98%Forma y color:SolidPeso molecular:762.974α-PDD
CAS:<p>4alpha-PDD activates transient receptor potential vanilloid 4 (TRPV4) channels and is inactive for signaling through PKC.</p>Fórmula:C40H64O8Forma y color:SolidPeso molecular:672.93DS88790512
CAS:<p>DS88790512, IC50 at 11 nM, is an effective, selective, oral bioeffective TRPC6 inhibitor.</p>Fórmula:C22H29N3O2Pureza:98%Forma y color:SolidPeso molecular:367.48KPH2f
CAS:<p>KPH2f: dual URAT1/GLUT9 inhibitor, orally active, IC50: 0.24μM (URAT1), 9.37μM (GLUT9), minimal OAT1/ABCG2 impact.</p>Fórmula:C24H16N3NaO2SForma y color:SolidPeso molecular:433.46Cav 3.2 inhibitor 3
<p>Cav 3.2 inhibitor 3 is a potent inhibitor of the Cav3.2 T-type Ca2+channel (IC50: 0.1534 μM) and has a low binding affinity for D2 receptors.</p>Fórmula:C32H37N3O2Forma y color:SolidPeso molecular:495.66P-gp modulator 1
CAS:<p>P-gp modulator 1 is a high affinity and orally available P-glycoprotein (Pgp) modulator</p>Fórmula:C41H72N2O6Pureza:98%Forma y color:SolidPeso molecular:689.02P-gp modulator 3
<p>P-gp modulator 3 (Compound 37) is a potent, competitive, metabotropic P-glycoprotein (P-gp) modulator.</p>Fórmula:C31H37N3O5Forma y color:SolidPeso molecular:531.64(R)-Duloxetine
CAS:<p>(R)-Duloxetine, an isomer of Duloxetine, induces tonic and use-dependent blockade of neuronal Na+ channels. This compound is utilized in pain research.</p>Fórmula:C18H19NOSForma y color:SolidPeso molecular:297.42Cav 3.2 inhibitor 1
<p>Cav 3.2 inhibitor 1 targets T-type calcium channels, weakly binds D2 receptors, and aids physical and visceral pain research.</p>Fórmula:C32H39N3OForma y color:SolidPeso molecular:481.67TP003
CAS:<p>TP003 is a novel non-selective GABAA receptor benzodiazepine site agonist with affinity for α1β2gam2, α2β3gam2, α3β3gam2, α5β2gam2, EC50 of 20.3, 10.6, 3.24, 5.</p>Fórmula:C23H16F3N3OPureza:99.17%Forma y color:SolidPeso molecular:407.39DAD
<p>DAD is an ion channel blocker (blocks voltage-gated potassium channels) and is a third generation photoelectric switch that responds to visible light.</p>Fórmula:C26H40N6OForma y color:SolidPeso molecular:452.64P-gp/BCRP-IN-1
CAS:<p>P-gp/BCRP-IN-1, safe and oral, inhibits P-gp/BCRP transporters, enhancing Paclitaxel bioavailability.</p>Fórmula:C27H25ClN4O3Forma y color:SolidPeso molecular:488.97TRPC5-IN-4
CAS:<p>TRPC5-IN-4: Potent, safe inhibitor; IC50 14.07 nM (TRPC5), 65 nM (TRPC4); non-toxic to liver/kidney cells; for CKD research.</p>Fórmula:C18H11ClF4N4O3Forma y color:SolidPeso molecular:442.75Suloctidil HCl
CAS:<p>Suloctidil HCl is a peripheral vascular dilator.</p>Fórmula:C20H36ClNOSForma y color:SolidPeso molecular:374.02SC-435 mesylate
CAS:<p>SC-435 is an ileal apical sodium co-dependent bile acid transporter (ASBT). SC-435 inhibits plasma cholesterol.</p>Fórmula:C37H59N3O7S2Pureza:98%Forma y color:SolidPeso molecular:722.01Tuclazepam
CAS:<p>Tuclazepam (KC 1956) is a derivative of the benzodiazepine class of drugs, exhibiting anti-anxiety and sedative properties.</p>Fórmula:C17H16Cl2N2OForma y color:SolidPeso molecular:335.23KCC2 Modulator-2
CAS:<p>KCC2 Modulator-2 (example 53) is a regulator of KCC2 with an EC50 of 0.215 μM. It is used in the research of neurological diseases.</p>Fórmula:C35H45N5O3Forma y color:SolidPeso molecular:583.76N-Depropylpropafenone
CAS:<p>N-Depropylpropafenone, an active metabolite of Propafenone, is produced through the metabolism by the CYP450 enzyme system (primarily CYP2D6). It functions by blocking sodium ion channels, thereby delaying the depolarization process in myocardial cells and exhibiting antiarrhythmic properties.</p>Fórmula:C18H21NO3Forma y color:SolidPeso molecular:299.36Desmethylflunitrazepam
CAS:<p>Desmethylflunitrazepam (Norflunitrazepam) is a benzodiazepine derivative and an active metabolite of Flunitrazepam.</p>Fórmula:C15H10FN3O3Forma y color:SolidPeso molecular:299.26Tizolemide
CAS:<p>Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.</p>Fórmula:C11H14ClN3O3S2Forma y color:SolidPeso molecular:335.83cis-KV1.3-IN-1
CAS:<p>cis-KV1.3-IN-1, also known as Compound cis-18, is the cis-isomer of KV1.3-IN-1 and functions as an inhibitor of the KV1.3 channel. In Xenopus laevis oocytes expressing human hKV1.3, cis-KV1.3-IN-1 (10 μM) achieves an inhibition rate of 25.53% against KV1.3.</p>Fórmula:C23H30N2O4SForma y color:SolidPeso molecular:430.56Cyazofamid
CAS:<p>Cyazofamid functions as a fungicide by impairing the production of ATP. It inhibits Organic Cation Transporter 3 (OCT3) and OAT1 with IC50 values of 1.54 and 17.3 μM, respectively.</p>Fórmula:C13H13ClN4O2SForma y color:SolidPeso molecular:324.79Lu AF90103
CAS:<p>Lu AF90103 (Compound 42e) is the methyl ester prodrug of compound 42d, capable of crossing the blood-brain barrier. Compound 42d acts as a partial agonist of the GluN1/GluN2B complex, with an efficacy of 24% and an EC50 value of 78 nM. Lu AF90103 plays a significant role in neuropsychiatric disorder research.</p>Fórmula:C13H15N3O3SForma y color:SolidPeso molecular:293.342Cav 2.2/3.2 blocker 1
<p>Compound 9e is a Cav 2.2/3.2 blocker; IC50: 1.22 μM & 80 μM, respectively; penetrates CNS.</p>Fórmula:C28H30N2O3Forma y color:SolidPeso molecular:442.55Ro-51
CAS:<p>dual P2X3 and P2X2/3 antagonist</p>Fórmula:C17H23IN4O4Pureza:98%Forma y color:SolidPeso molecular:474.29Quinacainol dihydrochloride
CAS:<p>Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.</p>Fórmula:C21H32Cl2N2OForma y color:SolidPeso molecular:399.398IAB15
CAS:<p>IAB15 is a potent inhibitor of T-type calcium channel that can be used in the research of epilepsy [1].</p>Fórmula:C15H14F3NO2Forma y color:SolidPeso molecular:297.27SGE-516
CAS:<p>SGE516: neuroactive steroid, enhances GABAA, lowers neuronal activity, protects from seizures.</p>Fórmula:C23H35N3O2Pureza:98%Forma y color:SolidPeso molecular:385.54TTA-P1
CAS:<p>TTA-P1: potent T-type calcium channel inhibitor; impacts neuron firing, hormone secretion, cell growth; potential in absence epilepsy research.</p>Fórmula:C19H27Cl2FN2OForma y color:SolidPeso molecular:389.33YY-23
CAS:<p>YY-23 is a selective NMDAR (containing GluN2C or GluN2D) inhibitor. By inhibiting NMDARs with GluN2D on GABAergic interneurons in the prefrontal cortex, YY-23 suppresses GABAergic neurotransmission and enhances excitatory transmission. YY-23 exhibits antidepressant activity and is useful for neurological disease research.</p>Fórmula:C33H54O8Forma y color:SolidPeso molecular:578.777LY3130481
CAS:<p>LY3130481: TARP γ-8 dependent AMPA receptor blocker; selectively targets AMPA/TARP γ-8 with 65 nM IC50.</p>Fórmula:C19H18N4O3SForma y color:SolidPeso molecular:382.44Cav 3.2 inhibitor 2
<p>Cav 3.2 inhibitor 2 blocks T-type Ca2+ channels (IC50=0.09339 μM) and reduces mouse somatic/visceral pain. Used for intractable pain studies.</p>Fórmula:C32H37F2N3OForma y color:SolidPeso molecular:517.65MSK-195
CAS:<p>MSK-195 is an effective TRPV1 agonist.</p>Fórmula:C28H40N2O5Pureza:98%Forma y color:SolidPeso molecular:484.63Kv7.2/Kv7.3 modulator-1
CAS:<p>Kv7.2/Kv7.3 modulator-1 (compound 6a) acts as a modulator for Kv7.2/Kv7.3 channels, with a pEC50 value of 7.96 for opening these channels. Kv7.2/Kv7.3 modulator-1 is applicable in research related to epilepsy, depression, brain injury, and pain.</p>Fórmula:C20H21F4N3O3Forma y color:SolidPeso molecular:427.393SR 33805 oxalate
CAS:<p>Ca2+ channel antagonist</p>Fórmula:C34H42N2O9SPureza:98%Forma y color:SolidPeso molecular:654.77T-Type calcium channel inhibitor 2
<p>Compound 6g inhibits T-type Ca channels (IC50: Cav3.1-31μM, Cav3.2-83μM), cytotoxic to A549 (IC50: 5μM) & HCT-116 cells (IC50: 6.4μM).</p>Fórmula:C36H39FN4OSForma y color:SolidPeso molecular:594.78ATP synthase inhibitor 2
CAS:<p>ATP synthase inhibitor 2 blocks P. aeruginosa ATP synthase; IC50=10 μg/mL, fully inhibits at 128 μg/mL.</p>Fórmula:C21H22N2O3SForma y color:SolidPeso molecular:382.48264W94
CAS:<p>264W94 robustly inhibits IBAT, induces CYP7A1, and significantly reduces cholesterol.</p>Fórmula:C23H31NO4SPureza:98%Forma y color:SolidPeso molecular:417.56CFTR corrector 18
CAS:<p>CFTRcorrector 18 (Compound I-99) acts as a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It enhances the processing and trafficking of CFTR, thereby increasing the amount of CFTR present on the cell surface. CFTRcorrector 18 holds potential for research in cystic fibrosis (CF).</p>Fórmula:C38H40N6O5SForma y color:SolidPeso molecular:692.826P2X4-IN-1
CAS:<p>P2X4-IN-1 is an orally active P2X4 inhibitor. P2X4-IN-1 is applicable in research focused on disease prevention.</p>Fórmula:C18H14ClN5O3SForma y color:SolidPeso molecular:415.85ML-SI1
CAS:<p>ML-SI1, a racemic mixture of diastereoisomers, is a TRPML inhibitor and acts on TRPML1 (IC50: 15 μM).</p>Fórmula:C23H26Cl2N2O3Forma y color:SolidPeso molecular:449.373-Bromoamphetamine hydrochloride
CAS:<p>3-Bromoamphetamine hydrochloride is a para-substituted amphetamine that functions as a monoamine releaser.</p>Fórmula:C9H13BrClNForma y color:SolidPeso molecular:250.563PF-06305591 dihydrate
<p>PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker (IC 50 = 15 nM) with an excellent preclinical in vitro ADME</p>Fórmula:C15H26N4O3Forma y color:SolidPeso molecular:310.39Mibefradil dihydrochloride hydrate
CAS:<p>Mibefradil dihydrochloride hydrate is a long-acting antihypertensive blocking high-voltage L calcium channels.</p>Fórmula:C29H42Cl2FN3O4Forma y color:SolidPeso molecular:586.57LY 235959
CAS:<p>LY 235959 is a NMDA receptor antagonist.</p>Fórmula:C11H20NO5PPureza:98%Forma y color:SolidPeso molecular:277.25CRM1 degrader 1
<p>CRM1 degrader 1 (1l) is a low-toxic CRM1 degrader that induces apoptosis in gastric carcinoma and selectively inhibits the proliferation of gastric cancer[1].</p>Fórmula:C16H20O3Forma y color:SolidPeso molecular:260.33PDE2 inhibitor 6
CAS:<p>PDE2 inhibitor6 (Compound 1) is an orally active phosphodiesterase (PDE) inhibitor, effectively inhibiting PDE2A, PDE3B, and PDE10A2 with IC50 values of 0.95 nM, 6.17 μM (pIC50=5.21), and 87.1 nM (pIC50=7.06), respectively. It modulates AMPA receptor activity, enhances synaptic plasticity, and improves learning and memory in rat models. Furthermore, PDE2 inhibitor6 possesses blood-brain barrier permeability.</p>Fórmula:C20H22F2N6OForma y color:SolidPeso molecular:400.425Metaphit methylsulfate
CAS:<p>Metaphit methylsulfate is a specific PCP antagonist and an acylating agent for the [3H] phencyclidine binding site in rat brain homogenate. It inhibits PCP-induced motor activity through a presynaptic mechanism.</p>Fórmula:C19H28N2O3S2Forma y color:SolidPeso molecular:396.567URAT1 inhibitor 3
<p>URAT1 inhibitor 3: potent oral URAT1 blocker, IC50=0.8 nM, for gout/hyperuricemia study.</p>Fórmula:C14H8Cl2N2O2Forma y color:SolidPeso molecular:307.13Unoprostone
CAS:<p>Unoprostone is a prostaglandin F2α analogs (PGAs), and reduces intraocular pressure and is used topically for glaucoma or ocular hypertension.</p>Fórmula:C22H38O5Pureza:98%Forma y color:SolidPeso molecular:382.53S-8510 phosphate
CAS:<p>S-8510 phosphate is an agonist of inverse Benzodiazepine (BDZ) receptor(Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively).</p>Fórmula:C12H13N4O6PPureza:98%Forma y color:SolidPeso molecular:340.23Gabaculine HCl
CAS:<p>Gabaculine, an irreversible GABA-T inhibitor (Ki: 2.9 μM), impacts plastid development and affects DPOR/GluTR levels.</p>Fórmula:C7H10ClNO2Forma y color:SolidPeso molecular:175.61EMD-95885
CAS:<p>EMD-95885 is a selective antagonist of NMDA receptors containing NR2B subunits, with an IC50 of 3.9 nM. It does not interact with other sites on the NMDA receptor.</p>Fórmula:C22H23FN2O3Forma y color:SolidPeso molecular:382.428RO-275
CAS:<p>RO-275 is an HCN1 inhibitor that also inhibits HCN2, HCN3, and HCN4, improving working memory deficits and being used in research on cognitive disorders.</p>Fórmula:C18H14ClN5OPureza:98.12% - 98.3%Forma y color:SolidPeso molecular:351.79Olorigliflozin
CAS:<p>Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.</p>Fórmula:C23H27ClO7Forma y color:SolidPeso molecular:450.909ARN23765
CAS:<p>ARN23765 is an F508del-CFTR corrector with an EC50 of 38 pM in human bronchial epithelial cells. It enhances the maturation and function of F508del-CFTR at the cell membrane, influencing ion transport and secretion, thereby addressing the pathological mechanisms of cystic fibrosis (CF).</p>Fórmula:C30H22F5N3O6Forma y color:SolidPeso molecular:615.504Pyrimidinone 8
CAS:<p>Pyrimidinone 8 is a reversible, linear non-competitive inhibitor of divalent metal transporter 1 (DMT1) with a Ki of 20 μM (hDMT1). It does not affect the surface expression of hDMT1 and is not influenced by extracellular pH. Pyrimidinone 8 inhibits hDMT1-mediated iron uptake, with an IC50 of 13.8 μM.</p>Fórmula:C10H12N4OForma y color:SolidPeso molecular:204.229GABA-IN-4
CAS:<p>GABA-IN-4 (Compound 17) is a derivative of N-(indol-3-ylglyoxylyl)benzylamine. It exhibits high affinity for the benzodiazepine receptor (BzR), the binding site within the GABAA receptor complex, with a Ki value of 67 nM. Benzodiazepines are widely used as anxiolytic, sedative-hypnotic, and anticonvulsant agents.</p>Fórmula:C17H13ClN2O2Forma y color:SolidPeso molecular:312.75Zilvetrigine
CAS:<p>Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.</p>Fórmula:C20H20ClN3O2Forma y color:SolidPeso molecular:369.845NMDA agonist 1
CAS:<p>NMDA agonist 1 (compound 42d) is a potent NMDA agonist with a Ki value of 96 nM. It acts as a partial agonist of the GluN1/GluN2B complex, exhibiting an EC50 value of 78 nM.</p>Fórmula:C12H13N3O3SForma y color:SolidPeso molecular:279.315Antidepressant agent 9
CAS:<p>Antidepressant agent 9 (Compound 24) is an orally active inhibitor of NMDAR and SERT, with IC50 values of 3.50 μM and 1044 nM, respectively. It exhibits good metabolic stability and plasma exposure, and demonstrates antidepressant-like effects in the forced swim test in mice.</p>Fórmula:C17H24N2Forma y color:SolidPeso molecular:256.386SGC-CAMKK2-1
CAS:<p>SGC-CAMKK2-1 is a selective inhibitor of calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) with an IC50 of 30 nM. It effectively inhibits AMPK phosphorylation in C4-2 cells, exhibiting an IC50 value of 1.6 µM.</p>Fórmula:C26H23NO3Forma y color:SolidPeso molecular:397.466Antidepressant agent 8
CAS:<p>Antidepressant agent 8 (Compound 1f) acts as a selective antagonist for the NMDA receptor GluN1/2A (NMDA receptorGluN1/2A), with an IC50 of 2.94 μmol/L. In a hydrocortisone-induced zebrafish depression model, it demonstrates antidepressant-like effects and shows good blood-brain barrier penetration.</p>Fórmula:C18H23FN4OS2Forma y color:SolidPeso molecular:394.53O4I4
CAS:<p>O4I4 is an OCT4-inducing compound capable of activating endogenous OCT4 and its associated signaling pathways, shown anti-aging effects.</p>Fórmula:C15H20N2SPureza:99.74%Forma y color:SolidPeso molecular:260.4LY503430
CAS:<p>LY503430: Oral AMPA enhancer with nootropic, neuroprotective properties, mitigates 6-OHDA/MPTP brain damage.</p>Fórmula:C20H25FN2O3SPureza:98%Forma y color:SolidPeso molecular:392.49Antimalarial agent 7
<p>Antimalarial agent 7 is a potent and effective inhibitor of PfATP4. Antimalarial agent 7 has potential for the study of the human plasmodium falciparum.</p>Fórmula:C23H22F2N4O3Forma y color:SolidPeso molecular:440.44Olisutrigine bromide
CAS:<p>Olisutrigine bromide is a sodium channel blocker used as an analgesic.</p>Fórmula:C25H35BrN2Forma y color:SolidPeso molecular:443.463ErSO-TFPy
CAS:<p>ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.</p>Fórmula:C19H13F7N2O2Forma y color:SolidPeso molecular:434.307Moxetomidate
CAS:<p>Moxetomidate is a GABAA receptor (GABAA receptor) agonist with hypnotic properties.</p>Fórmula:C15H18N2O3Forma y color:SolidPeso molecular:274.315Crinecerfont tosylate
CAS:<p>Crinecerfont tosylate is an effective oral CRF1 receptor antagonist. It is applicable to studies involving congenital adrenal hyperplasia (CAH).</p>Fórmula:C34H36ClFN2O4S2Forma y color:SolidPeso molecular:655.242(3S,6R)-NML
CAS:<p>(3S,6R)-NML is an NMDA receptor antagonist with pIC50 values of 4.8 [GluN1-GluN2A], 4.6 [GluN1-GluN2B], 5.0 [GluN1-GluN2C], and 5.0 [GluN1-GluN2D]. It is applicable in the study of depression.</p>Fórmula:C20H27NOForma y color:SolidPeso molecular:297.435URAT1 inhibitor 2
<p>URAT1 inhibitor 2: oral URAT1/CYP blocker, IC50 of 1.36μM (URAT1), 16.97μM (CYP1A2), 5.22μM (CYP2C9); potential gout treatment.</p>Fórmula:C21H18BrN3O2SForma y color:SolidPeso molecular:456.36Insecticidal agent 21
CAS:<p>Insecticidal agent 21 (Compound 6) is an insecticide targeting Culex pipiens larvae with an LC50 of 0.4 μg/mL. It achieves multi-target neurotoxicity by inhibiting acetylcholinesterase (AChE) and simultaneously targeting other neural receptors, including nicotinic acetylcholine receptors (nAChR), voltage-gated sodium channels (VGSC), and γ-aminobutyric acid receptors (GABAAR). Insecticidal agent 21 shows potent insecticidal activity and can be utilized in the development of new insecticides to combat mosquito resistance to conventional agents.</p>Fórmula:C37H40ClN3O2Forma y color:SolidPeso molecular:594.185ATPase-IN-5
CAS:<p>ATPase-IN-5 (Compound 11) is an antifungal Pma1p (H+ -ATPase) inhibitor (IC50 = 12.7 μM) that inhibits the growth of Candida albicans and Saccharomyces cerevisiae.</p>Fórmula:C10H10N4O3SPureza:99.19%Forma y color:SolidPeso molecular:266.28PDE1-IN-4
<p>PDE1-IN-4: inhibits PDE1C/A/B with IC50s 10/145/354 nM, may help study idiopathic pulmonary fibrosis.</p>Fórmula:C33H33N3O4Forma y color:SolidPeso molecular:535.63P2X receptor-1
<p>P2X receptor-1 is a potential inhibitor of P2X receptor for the treatment of pain and inflammation.</p>Fórmula:C14H14ClN3O3S2Forma y color:SolidPeso molecular:371.865-O-Desmethyl donepezil
CAS:<p>5-O-Desmethyl donepezil is a metabolite of Donepezil that acts as an inhibitor of hERG channels, with an IC50 of 1.5 μM.</p>Fórmula:C23H27NO3Forma y color:SolidPeso molecular:365.465ICA-105665
CAS:<p>ICA-105665 is an orally active Kv7.2/7.3/7.5 channel opener, CNS-penetrant with antiseizure effects, and low hepatocyte cytotoxicity.</p>Fórmula:C19H15F2N3O2Pureza:98%Forma y color:SolidPeso molecular:355.34GNE-616
CAS:<p>GNE-616: a potent, stable, oral Nav1.7 inhibitor; Ki: 0.79 nM, Kd: 0.38 nM; for chronic pain.</p>Fórmula:C24H23F4N5O3SPureza:98%Forma y color:SolidPeso molecular:537.53
