Transportador de membrana / canal de iones
Los inhibidores de transportadores de membrana y canales iónicos son compuestos que bloquean la función de proteínas responsables del transporte de iones, nutrientes y otras moléculas a través de las membranas celulares. Estos inhibidores son cruciales para estudiar la regulación de la homeostasis celular, la transducción de señales y la neurotransmisión. Los inhibidores de transportadores de membrana y canales iónicos también son importantes para desarrollar tratamientos para trastornos como la epilepsia, las enfermedades cardiovasculares y los síndromes metabólicos. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de transportadores de membrana y canales iónicos para apoyar su investigación en fisiología, neurociencia y farmacología.
Subcategorías de "Transportador de membrana / canal de iones"
- ABC(3 productos)
- ATPasa(93 productos)
- Receptor de adiponectina(5 productos)
- CFTR(64 productos)
- Receptor CGRP(51 productos)
- Canal de calcio(493 productos)
- Canal de cloruro(49 productos)
- Receptor GABA(336 productos)
- Transportador de monoamina(23 productos)
- Transportador de monocarboxilato(17 productos)
- NKCC(2 productos)
- NPC1L1(3 productos)
- Cotransportador de Na-K-Cl(8 productos)
- OAT(27 productos)
- OCT(7 productos)
- P-gp(53 productos)
- Canal de potasio(276 productos)
- Bomba de protones(39 productos)
- SGLT(30 productos)
- Canal de sodio(202 productos)
- Canal TRP / TRPV(92 productos)
Mostrar 13 subcategorías más
Se han encontrado 2270 productos de "Transportador de membrana / canal de iones"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
(RS)-AMPA hydrobromide
CAS:<p>AMPAR agonist</p>Fórmula:C7H11BrN2O4Pureza:98%Forma y color:SolidPeso molecular:267.08KV1.3-IN-2
CAS:<p>KV1.3-IN-2 (Compound I) selectively inhibits the kv1.3 potassium channel without affecting the hERG channel. It is applicable in research related to immune-associated diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.</p>Fórmula:C16H23ClN2O4Forma y color:SolidPeso molecular:342.818Opakalim
CAS:<p>Opakalim is an activator of potassium channels (potassium channel) and exhibits anticonvulsant activity.</p>Fórmula:C18H22F2N4OForma y color:SolidPeso molecular:348.39WS-898
<p>WS-898 boosts paclitaxel efficacy in resistant cells by inhibiting ABCB1; IC50: SW620/Ad300 - 5.0 nM, KB-C2 - 3.67 nM, HEK293/ABCB1 - 3.68 nM.</p>Fórmula:C33H25N7OSForma y color:SolidPeso molecular:567.66Blixeprodil
CAS:<p>Blixeprodil (GM-1020) is an orally active NMDA receptor antagonist with an affinity of Ki = 3.25 µM in rat cortical tissue. It inhibits NR1/2A-NMDAR-mediated currents in HEK293 cells with an IC50 of 1.192 µM. Blixeprodil demonstrates antidepressant effects in rat models and exhibits blood-brain barrier permeability.</p>Fórmula:C13H16FNOForma y color:SolidPeso molecular:221.271IAA65
CAS:<p>IAA65 is a potent inhibitor of T-type calcium channels, exhibiting an IC50 value of 18.9 μM, and holds potential for use in epilepsy research [1].</p>Fórmula:C16H13F6NO2Forma y color:SolidPeso molecular:365.27VU0463271 quarterhydrate
<p>VU0463271 quarterhydrate is a potent KCC2 antagonist, with an IC 50 of 61 nM [1].</p>Fórmula:C19H20N4O2S2Forma y color:SolidPeso molecular:387V-ATPase-IN-1
CAS:<p>V-ATPase-IN-1 (Compound 3b-03) is an inhibitor of Vacuolar-type H+-ATPases (V-ATPase), exhibiting an inhibition constant (IC50) of 194.80 μM and effectively targeting the V-ATPase subunit A with a dissociation constant (Kd) of 0.803 μM. This compound demonstrates insecticidal activity against M. separata (LC50 = 2.64 mM), aiding in the development of chemical insecticides.</p>Fórmula:C21H20ClNO2Forma y color:SolidPeso molecular:353.84(S)-Albuterol
CAS:<p>(S)-Albuterol functions as a muscarinic receptor and phospholipase C activator, enhancing the intracellular free calcium concentration in airway smooth muscle cells.</p>Fórmula:C13H21NO3Forma y color:SolidPeso molecular:239.311Lubeluzole dihydrochloride
CAS:<p>Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.</p>Fórmula:C22H27Cl2F2N3O2SForma y color:SolidPeso molecular:506.44Kv7.2/Kv7.3 activator-1
CAS:<p>Kv7.2/Kv7.3 Activator-1 (compound 517) serves as a powerful activator of the Kv7.2/Kv7.3 channels, exhibiting an EC50 value of less than 1 µM. It holds potential for use in neurological disease research.</p>Fórmula:C19H22F2N4OForma y color:SolidPeso molecular:360.40PF-05661014
CAS:<p>PF-05661014, a demethylated analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing the inactivated state through interaction with the D4 VSD. This compound is utilized in research focused on sodium channel modulation.</p>Fórmula:C17H16N4O3S2Forma y color:SolidPeso molecular:388.46CFTR corrector 16
CAS:<p>CFTRcorrector 16 (Compound 39) is a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR), utilized in the research of cystic fibrosis disease.</p>Fórmula:C27H26ClN5O2SForma y color:SolidPeso molecular:520.05SP100030 analogue 1
CAS:<p>SP100030 analogue 1 (compound 11) is a selective transcription activation (SITA) inhibitor within the SP100030 class, capable of inhibiting XPO1-dependent upregulation of IL2 in a Jurkat-based IL2-Luc reporter assay, with an EC50 of 137 nM.</p>Fórmula:C13H5ClF7N3OForma y color:SolidPeso molecular:387.64CFTR corrector 15
CAS:<p>CFTR Corrector 15 (Compound 4172) serves as a corrector for cystic fibrosis transmembrane conductance regulator (CFTR). When used in combination with VX-809, it addresses the folding defects of F508del-CFTR. CFTR Corrector 15 is also applicable in the research of cystic fibrosis.</p>Fórmula:C24H22ClN5O2SForma y color:SolidPeso molecular:479.98(2S,3S,11bR)-Dihydrotetrabenazine
CAS:<p>(2S,3S,11bR)-Dihydrotetrabenazine ((2S,3S,11bR)-DHTBZ) is a highly selective inhibitor of vesicular monoamine transporter 2 (VMAT2) with a Ki value of 593 nM. It suppresses the vesicular transport of monoamine neurotransmitters, such as dopamine and serotonin, leading to reduced release into the synaptic cleft. This compound holds potential for research in Huntington's disease and other hyperkinetic movement disorders.</p>Fórmula:C19H29NO3Forma y color:SolidPeso molecular:319.44S 0960
CAS:<p>S 0960 is a dimeric bile acid analogue, a specific inhibitor of the sodium-dependent bile salt transporter in the ileum, used in metabolic disease research.</p>Fórmula:C48H79NO8Pureza:99.32% - >99.99%Forma y color:SolidPeso molecular:798.14Caramboxin
CAS:<p>Caramboxin, a neurotoxin, can induce acute kidney injury.</p>Fórmula:C11H13NO6Forma y color:SolidPeso molecular:255.22Dehydroindapamide
CAS:<p>Dehydroindapamide, an indole form of Indapamide, is utilized to quantify the turnover rate of Indapamide in CYP3A4, which is approximately 10 times higher than that of Indoline, with slightly enhanced affinity for CYP3A4.</p>Fórmula:C16H14ClN3O3SForma y color:SolidPeso molecular:363.82Perfluoroheptanesulfonic acid
CAS:<p>Perfluoroheptanesulfonic acid (1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid) is a perfluoroalkyl substance (PFAS). This compound has been detected in landfill leachate and has been shown to induce deformities in zebrafish larvae (EC50=168.1 μM). Exposure to PFHpS in fetuses can lead to reduced birth weight.</p>Fórmula:C7HF15O3SForma y color:SolidPeso molecular:450.12ZK 93426 hydrochloride
CAS:<p>benzodiazepine receptor antagonist,competitive</p>Fórmula:C18H21ClN2O3Pureza:98%Forma y color:SolidPeso molecular:348.82CAD204520
CAS:<p>CAD204520 functions as an inhibitor of SERCA (IC50 = 0.34 μM), specifically targeting mutations in the wild-type NOTCH1 protein associated with T-cell acute lymphoblastic leukemia (T-ALL) and mantle cell lymphoma (MCL).</p>Fórmula:C23H32F3N3O2Forma y color:SolidPeso molecular:439.51AP-6
CAS:<p>AP-6, a selective TMEM175 inhibitor, enhances lysosomal macromolecular catabolism by acutely inhibiting TMEM175, thus speeding up macrophage and other digestive activities. This compound holds potential for use in Parkinson's disease research due to its role in modulating lysosomal function.</p>Fórmula:C16H14N4Forma y color:SolidPeso molecular:262.31AN-988
CAS:<p>AN-988 (compound 6) is a covalent CRM1 inhibitor.</p>Fórmula:C22H22N2O4SForma y color:SolidPeso molecular:410.49Fletazepam
CAS:<p>Fletazepam, a benzodiazepine derivative, exhibits sedative, anti-anxiety, and muscle-relaxant properties. It is utilized in neurological research.</p>Fórmula:C17H13ClF4N2Forma y color:SolidPeso molecular:356.74SOAT-IN-1
CAS:<p>SOAT-IN-1 (compound 40) is a potent and selective inhibitor targeting the sodium-dependent organic anion transporter (SOAT), exhibiting IC50 values of 1.6 µM for SOAT and 14.3 µM for NTCP.</p>Fórmula:C20H16ClN3O6SForma y color:SolidPeso molecular:461.88LY 215490
CAS:<p>LY 215490 is a selective AMPA receptor antagonist with neuroprotective properties in rat ischemia.</p>Fórmula:C13H21N5O2Pureza:98%Forma y color:SolidPeso molecular:279.34Lorajmine
CAS:<p>Lorajmine, a monochloroacetyl derivative of ajmaline, is a class Ia antiarrhythmic agent that is rapidly hydrolyzed to ajmaline by plasma and tissue esterases.</p>Fórmula:C22H27ClN2O3Pureza:98%Forma y color:SolidPeso molecular:402.91PD-217014
CAS:<p>PD-217014 is an α2δ ligand that exhibits visceral analgesic activity and can suppress visceral hypersensitivity. Its antihyperalgesic effects are dose-dependent.</p>Fórmula:C10H17NO2Forma y color:SolidPeso molecular:183.25ABCG2-IN-4
CAS:<p>ABCG2-IN-4 (Compound K31) is an orally active ABCG2 inhibitor that reduces the release of Protoporphyrin IX (PPIX) from red blood cells into the plasma and prevents phototoxicity. In mouse models, ABCG2-IN-4 also demonstrates anti-inflammatory and antioxidant properties.</p>Fórmula:C24H32N4O4Forma y color:SolidPeso molecular:440.535Detajmium
CAS:<p>Detajmium is an anti-arrhythmia compound. It is an Na(+)-channel-blocking drug with an extremely long recovery from use-dependent sodium channel block.</p>Fórmula:C27H42N3O3Pureza:98%Forma y color:SolidPeso molecular:456.64(+)-Tetrabenazine
CAS:<p>(+)-Tetrabenazine ((3R,11bR)-Tetrabenazine) is a reversible vesicular monoamine transporter 2 (VMAT-2) inhibitor, inhibits transport by VMAT2 with 10-fold</p>Fórmula:C19H27NO3Pureza:98.31%Forma y color:SolidPeso molecular:317.42SDZ 220-040
CAS:<p>SDZ 220-040 是一种选择性哺乳动物 NMDA 受体拮抗剂，可诱导根系生长的部分无重力模式 。</p>Fórmula:C16H16Cl2NO6PPureza:98.13%Forma y color:SolidPeso molecular:420.18SYM2206
CAS:<p>SYM2206 is a low affinity non-competitive AMPA receptor antagonist with an IC50 value of 1.6 μM.SYM2206 exhibits anticancer activity by blocking Nav1.6-mediated</p>Fórmula:C20H22N4O3Pureza:99.88%Forma y color:SolidPeso molecular:366.41Suzetrigine
CAS:<p>Suzetrigine (VX-548) is an oral NaV1.8 inhibitor with analgesic properties for acute pain research.</p>Fórmula:C21H20F5N3O4Pureza:98.08% - 99.27%Forma y color:SolidPeso molecular:473.39Odevixibat
CAS:<p>Odevixibat (A4250) is a selective oral inhibitor for ileal bile acid transport, potentially treating primary biliary cirrhosis.</p>Fórmula:C37H48N4O8S2Pureza:99.53% - 99.83%Forma y color:SolidPeso molecular:740.935-Hydroxylansoprazole
CAS:<p>5-Hydroxylansoprazole (AG1908) is the active metabolite of plasma Lansoprazole, inhibits the proton pump, and is used in the study of peptic ulcers.</p>Fórmula:C16H14F3N3O3SPureza:99.00%Forma y color:SolidPeso molecular:385.36(-)-Bicuculline methobromide
CAS:<p>(-)-Bicuculline methobromide is a potent antagonist of GABAA receptor .</p>Fórmula:C21H20BrNO6Forma y color:WhitePeso molecular:462.29Umbellulone
CAS:<p>Umbellulone is a natural product isolated from Umbellularia californica, and stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism.</p>Fórmula:C10H14OPureza:98%Forma y color:SolidPeso molecular:150.22A-887826
CAS:<p>A-887826 is a selective, orally bioavailable, and voltage-dependent Na(v1.8) channel blocker (IC50: 11 nM). It attenuates neuropathic tactile allodynia in vivo.</p>Fórmula:C26H29ClN4O3Forma y color:SolidPeso molecular:480.99Indapamide
CAS:<p>Indapamide (Noranat) is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.</p>Fórmula:C16H16ClN3O3SPureza:98.97% - 99.83%Forma y color:SolidPeso molecular:365.83Ref: TM-T1498
Producto descatalogadoApcin A HCL
CAS:<p>Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to synthesize the PROTAC CP5V [1].</p>Fórmula:C10H15Cl4N5O2Pureza:99.30%Forma y color:SolidPeso molecular:379.07Verapamil EP Impurity C hydrochloride
CAS:<p>NSC-609249 hydrochloride, an impurity of Verapamil, is a calcium channel blocker with potent orally active properties. It also functions as a first-generation P-glycoprotein (P-gp) inhibitor.</p>Fórmula:C12H20ClNO2Forma y color:SolidPeso molecular:245.75PF-06761281
CAS:<p>PF-06761281 is a partially selective sodium-coupled citrate transporter protein (NaCT/SLC13A5) inhibitor, oral, reducing plasma glucose concentration.</p>Fórmula:C13H17NO6Forma y color:SolidPeso molecular:283.28GNE-9278
CAS:<p>GNE-9278 is a highly selective NMDAR orthosteric modulator that targets the GluN1 transmembrane structural domain (TMD), enhancing peak current and agonist affinity in activated NMDAR.</p>Fórmula:C21H27N5O3SForma y color:SolidPeso molecular:429.54Zastaprazan
CAS:<p>Zastaprazan (JP-1366, compound 6) is a potassium-competitive acid blocker and proton pump inhibitor that suppresses gastric acid secretion, indicated for GERD.</p>Fórmula:C22H26N4OPureza:99.97%Forma y color:SolidPeso molecular:362.48Filapixant
CAS:<p>Filapixant, a purinoreceptor antagonist. This compound serves as the active reference substance for Eliapixant.</p>Fórmula:C24H26F3N5O3SForma y color:SolidPeso molecular:521.562-AEMP TFA
CAS:<p>2-AEMP TFA is a potent and rapidly acting antagonist of GABA(A)-ρ1 receptors. 2-AEMP is an analog of GABA.</p>Fórmula:C3H10NO3PPureza:98%Forma y color:SolidPeso molecular:139.091(±)-Vasicine
CAS:<p>(±)-Vasicine, the racemate of Vasicine, is isolated from Peganum harmala seeds and exhibits anti-ulcer activity.</p>Fórmula:C11H12N2OPureza:98%Forma y color:SolidPeso molecular:188.23(Rac)-Lanicemine
CAS:<p>(Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker with a Ki of 0.56-2.1 μM for the NMDA receptor and IC50 values of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively. Lanicemine shows antidepressant effects [1].</p>Fórmula:C13H14N2Forma y color:SolidPeso molecular:198.26L-Cysteine S-sulfate sodium salt sesquihydrate
CAS:<p>L-Cysteine S-sulfate sodium salt sesquihydrate is a useful organic compound for research related to life sciences. The catalog number is T64782 and the CAS number is 150465-29-5.</p>Fórmula:C9H25N3Na3O17S6Forma y color:SolidPeso molecular:708.63Indoxacarb
CAS:<p>Indoxacarb is an Oxadiazine insecticide.</p>Fórmula:C22H17ClF3N3O7Pureza:98%Forma y color:SolidPeso molecular:527.833-Methylglutaconic acid
CAS:<p>3-Methylglutaconic acid, a primary metabolite accumulating in 3-Methylglutaconic aciduria (MGTA), induces lipid and protein oxidation, while diminishing non-enzymatic antioxidant defenses in cerebral cortex supernatants, thereby promoting oxidative stress in the cerebral cortex. This compound is utilized in research concerning brain damage diseases [1].</p>Fórmula:C6H8O4Pureza:98%Forma y color:SolidPeso molecular:144.13Alfadolone acetate
CAS:<p>Alfadolone acetate is a gamma-aminobutyric acid (GABA) receptor agonist.</p>Fórmula:C23H34O5Forma y color:SolidPeso molecular:390.51Phenamil methanesulfonate
CAS:<p>TRPP3 channel inhibitor</p>Fórmula:C13H16ClN7O4SPureza:98%Forma y color:SolidPeso molecular:401.83CGP 44532
CAS:<p>CGP 44532 a GABAB receptor agonist.</p>Fórmula:C4H12NO3PPureza:98%Forma y color:SolidPeso molecular:153.12CMPDA
CAS:<p>CMPDA is a positive allosteric modulator of AMPA receptors [EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor].</p>Fórmula:C16H28N2O4S2Pureza:98%Forma y color:SolidPeso molecular:376.53Fostedil
CAS:<p>Fostedil enhances heart function, maintains blood flow during partial/total coronary occlusions, and lowers aortic pressure.</p>Fórmula:C18H20NO3PSPureza:98%Forma y color:SolidPeso molecular:361.4Gacyclidine
CAS:<p>Gacyclidine (OTO311), an NMDA receptor blocker, treats tinnitus and injuries in the brain and spinal cord.</p>Fórmula:C16H25NSPureza:99.85% - 99.92%Forma y color:SolidPeso molecular:263.44Pipequaline
CAS:<p>Pipequaline (PK-8165) is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It possesses a novel chemical structure that is not closely related to other drugs of this type. The drug has a similar pharmacological profile to the benzodiazepine family of drugs, but with mainly anxiolytic properties and very little sedative, amnestic or anticonvulsant effects, and so is classified as a nonbenzodiazepine anxiolytic.</p>Fórmula:C22H24N2Pureza:98%Forma y color:SolidPeso molecular:316.44Ref: TM-T4655
Producto descatalogadoTifenazoxide
CAS:<p>Tifenazoxide is an effective and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has an anti-diabetic effect, can inhibit glucose-stimulated insulin release in vitro and in vivo.</p>Fórmula:C9H10ClN3O2S2Pureza:98%Forma y color:SolidPeso molecular:291.78Pazinaclone
CAS:<p>Pazinaclone is a non-benzodiazepine (GABAA) partial agonist with sedative and anxiolytic activity.</p>Fórmula:C25H23ClN4O4Pureza:97.79% - 99.07%Forma y color:SolidPeso molecular:478.93T16A(inh)-C01
CAS:<p>T16A(inh)-C01 is the Ca(2+)-activated Cl(-) Channel, Ano1 class C inhibitor.</p>Fórmula:C18H16O5Pureza:98%Forma y color:SolidPeso molecular:312.32LFS-1107
CAS:<p>LFS-1107, a reversible CRM1 inhibitor (Kd: 12.5 pM), selectively targets and eliminates ENKTL cells, offering potential for cancer research applications [1].</p>Fórmula:C12H11N5OS2Pureza:98%Forma y color:SolidPeso molecular:305.38VMAT2-IN-2 tosylate
CAS:<p>VMAT2-IN-2 tosylate is a potent inhibitor of VMAT2 and is applicable in the research of tardive dyskinesia [1].</p>Fórmula:C27H36F3NO6SPureza:98%Forma y color:SolidPeso molecular:559.64Ref: TM-T79061
Producto descatalogadoXilmenolone
CAS:<p>Xilmenolone acts as a positive allosteric modulator of the GABA_A receptor [1].</p>Fórmula:C26H37N3O2Pureza:98%Forma y color:SolidPeso molecular:423.59Ref: TM-T78670
Producto descatalogadoHMR 1556
CAS:<p>HMR 1556 is a chromanol derivative and is an IKs blocker (IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively).</p>Fórmula:C17H24F3NO5SForma y color:SolidPeso molecular:411.44Belfosdil
CAS:<p>Belfosdil is a blocker of antihypertensive calcium channel.</p>Fórmula:C27H50O7P2Pureza:98%Forma y color:SolidPeso molecular:548.63CGP 56999A
CAS:<p>CGP 56999A is a GABA(B) receptor antagonist; it boosts BDNF and reduces dopamine loss in rat striatum.</p>Fórmula:C19H30NO5PPureza:98%Forma y color:SolidPeso molecular:383.42Bumetanide sodium
CAS:<p>Bumetanide sodium, a potent diuretic, blocks NKCC1 (IC50: 0.68 μM) and NKCC2 (IC50: 4.0 μM).</p>Fórmula:C17H19N2NaO5SForma y color:SolidPeso molecular:386.4
