Transportador de membrana / canal de iones
Los inhibidores de transportadores de membrana y canales iónicos son compuestos que bloquean la función de proteínas responsables del transporte de iones, nutrientes y otras moléculas a través de las membranas celulares. Estos inhibidores son cruciales para estudiar la regulación de la homeostasis celular, la transducción de señales y la neurotransmisión. Los inhibidores de transportadores de membrana y canales iónicos también son importantes para desarrollar tratamientos para trastornos como la epilepsia, las enfermedades cardiovasculares y los síndromes metabólicos. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de transportadores de membrana y canales iónicos para apoyar su investigación en fisiología, neurociencia y farmacología.
Subcategorías de "Transportador de membrana / canal de iones"
- ABC(3 productos)
- ATPasa(93 productos)
- Receptor de adiponectina(5 productos)
- CFTR(64 productos)
- Receptor CGRP(51 productos)
- Canal de calcio(493 productos)
- Canal de cloruro(49 productos)
- Receptor GABA(336 productos)
- Transportador de monoamina(23 productos)
- Transportador de monocarboxilato(17 productos)
- NKCC(2 productos)
- NPC1L1(3 productos)
- Cotransportador de Na-K-Cl(8 productos)
- OAT(27 productos)
- OCT(7 productos)
- P-gp(53 productos)
- Canal de potasio(276 productos)
- Bomba de protones(39 productos)
- SGLT(30 productos)
- Canal de sodio(202 productos)
- Canal TRP / TRPV(92 productos)
Mostrar 13 subcategorías más
Se han encontrado 2270 productos de "Transportador de membrana / canal de iones"
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Aglafoline
CAS:<p>Aglafoline inhibits in a concentration-dependent manner the aggregation and ATP release reaction induced in washed rabbit platelets by PAF (platelet-activating</p>Fórmula:C28H28O8Forma y color:SolidPeso molecular:492.52LY393615
<p>LY393615 (NCC1048) is a novel blocker of both neuronal Ca²⁺ (calcium) and Na⁺ (sodium) channels, exhibiting half-maximal inhibitory concentrations (IC₅₀) of 1.9</p>Pureza:98%Forma y color:Odour SolidVerruculogen
CAS:<p>Verruculogen, a toxin from Penicillium/Aspergillus, blocks Ca2+-K+ channels and halts mammalian M phase.</p>Fórmula:C27H33N3O7Pureza:98%Forma y color:White PowderPeso molecular:511.57GABA-A Receptor Ligand-1
<p>GABA-A Receptor Ligand-1 (Compound 4) is a ligand for the GABA-A receptor with a pKi of 7.27. It alleviates mitochondrial dysfunction, promotes neurite outgrowth and neuronal regeneration, and demonstrates neuroprotective effects in a rat ischemic stroke model.</p>Fórmula:C20H20FN3OForma y color:SolidPeso molecular:337.391Bafilomycin B1
CAS:<p>Bafilomycin B1, a Streptomyces-derived macrolide, inhibits E. coli ATPase and fights Gram-positive bacteria and fungi.</p>Fórmula:C44H65NO13Pureza:98%Forma y color:White PowderPeso molecular:815.998Apamin
CAS:<p>Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.</p>Fórmula:C79H131N31O24S4Pureza:98%Forma y color:SolidPeso molecular:2027.34BeKm-1
CAS:<p>Potent, selective hERG (KV11.1) blocker; doesn't affect 14 other K+ channels; extends QTc in rabbit heart dose-dependently.</p>Fórmula:C174H261N51O52S6Pureza:98%Forma y color:SolidPeso molecular:4091.65Cyclic ADP-ribose ammonium
<p>cADPR ammonium is a second messenger that boosts cytosolic calcium via Ryanodine receptors and TRPM2 channels.</p>Forma y color:LiquidCamegliptin
CAS:<p>Cameglipti, a dipeptidyl peptidase IV (DPP-4) inhibitor, is used potentially for the treatment of type 2 diabetes.</p>Fórmula:C20H28FN3O3Forma y color:SolidPeso molecular:377.45NMDA receptor antagonist 2
CAS:<p>Potent, oral NR2B-selective NMDA receptor antagonist; IC50 of 1.0 nM, Ki of 0.88 nM; used for neuropathic pain and Parkinson's research.</p>Fórmula:C20H21N7OForma y color:SolidPeso molecular:375.436Homocarnosine TFA
<p>Homocarnosine TFA: brain-exclusive GABA-histidine dipeptide, neuronal, anticonvulsant, antioxidant, anti-inflammatory.</p>Fórmula:C12H17F3N4O5Forma y color:SolidPeso molecular:354.28NSC799462
<p>NSC799462, a triazole inhibitor, specifically targets p97 ATPase, exerting its effect by binding to a designated site on the p97 enzyme. This interaction induces localized structural alterations in p97, effectively inhibiting its ATPase activity with an IC 50 value of 15 nM.</p>Fórmula:C30H32F2N6O3SForma y color:SolidPeso molecular:594.68TET-13
<p>TET-13 is a positive allosteric modulator of the GABAA receptor with an EC50 of 5.65 μM, which is more potent than Etomidate (EC50: 9.29 μM). It exhibits strong anesthetic effects in both mice and rats, with an ED50 of 0.48 mg/kg in mice and 0.69 mg/kg in rats.</p>Fórmula:C15H16N2O3SForma y color:SolidPeso molecular:304.36Idrevloride
CAS:<p>Idrevloride (WO2016133967) inhibits ENaC, used in skin disorder research.</p>Fórmula:C30H49ClN8O7Forma y color:SolidPeso molecular:669.223-Aminopropylphosphonic Acid
CAS:<p>3-aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding</p>Fórmula:C3H10NO3PPureza:99.84%Forma y color:Light Yellow LiquidPeso molecular:139.09NSC265473
CAS:<p>NSC265473 is an ABCG2 substrate.</p>Fórmula:C21H35N3O4SForma y color:SolidPeso molecular:425.58Bendroflumethiazide
CAS:<p>Bendroflumethiazide (Naturetin) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)</p>Fórmula:C15H14F3N3O4S2Pureza:98% - >99.99%Forma y color:Crystals From Dioxane SolidPeso molecular:421.41Dihydroisopimaric acid
CAS:<p>Dihydroisopimaric acid opens BKαβ1 channels - large Ca²⁺-activated K⁺ conductors, verified by whole-cell voltage clamp.</p>Fórmula:C20H32O2Forma y color:SolidPeso molecular:304.47Antidepressant agent 3
<p>Agent 3: orally active, antidepressant, anxiolytic, boosts performance and cognition.</p>Fórmula:C17H30ClN5O2SForma y color:SolidPeso molecular:403.97PF-04745637
CAS:<p>PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].</p>Fórmula:C27H32ClF3N2O2Pureza:98.88% - 99.3%Forma y color:SolidPeso molecular:509(R)-AMPA
CAS:<p>inactive enantiomer of AMPA</p>Fórmula:C7H10N2O4Pureza:98%Forma y color:SolidPeso molecular:186.17kCAL01
CAS:<p>kCAL01 is a CAL inhibitor with a Ki value of 2.3 μM and holds potential for research in cystic fibrosis (CF).</p>Fórmula:C36H57N11O9Forma y color:SolidPeso molecular:787.91CFTR activator 2
CAS:<p>CFTR activator 2 (WAY-326769) is an activator of mutant CFTR (cystic fibrosis transmembrane conductance regulator), which increases ion transport activity and can be used for research into cystic fibrosis (CF).</p>Fórmula:C27H27N3O3Pureza:99.70%Forma y color:SolidPeso molecular:441.52Chlorpropylate
CAS:<p>Chlorpropylate is an insecticide.</p>Fórmula:C17H16Cl2O3Pureza:98%Forma y color:SolidPeso molecular:339.21ETD001
CAS:<p>ETD001 is a long-acting ENaC inhibitor with an IC50 value of 57.5 nM in HBE cells. It is applicable for research in cystic fibrosis.</p>Fórmula:C41H57F6N9O16Forma y color:SolidPeso molecular:1045.9318β-Glycyrrhetyl-3-O-sulfate
CAS:<p>18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)), a major metabolite of Glycyrrhetinic acid (GA), serves as a potent inhibitor of type 2</p>Fórmula:C30H46O7SForma y color:SolidPeso molecular:550.75ANO1-IN-4
CAS:<p>ANO1-IN-4 (Compound 10bm) is a reversible inhibitor of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1), with an IC50 of 0.030 µM. It demonstrates good metabolic stability in rat liver microsomes and can inhibit spontaneous contractions in isolated mouse ileum.</p>Fórmula:C19H19BrF2N2O2SForma y color:SolidPeso molecular:457.33Tertiapin LQ
<p>Kir1.1 channel blocker, 250x selective; Kd: Kir1.1 (1.1 nM), Kir3.1/3.2 (274 nM), Kir3.1/3.4 (361 nM). Tertiapin-Q derivative.</p>Fórmula:C106H179N33O24S4Pureza:98%Forma y color:SolidPeso molecular:2428.03Vesnarinone HCl
<p>Vesnarinone HCl is an oral PDE3 inhibitor improving heart contractility, affecting calcium and potassium flux. Used in heart failure research.</p>Fórmula:C22H26ClN3O4Pureza:99.17%Forma y color:SoildPeso molecular:431.91Vanzacaftor
CAS:<p>Vanzacaftor is a CFTR modulator improving protein processing and surface trafficking, restoring chloride transport and aiding cystic fibrosis therapy research.</p>Fórmula:C32H39N7O4SPureza:99.14%Forma y color:SolidPeso molecular:617.764-Hydroxytolbutamide
CAS:<p>4-Hydroxytolbutamide is a drug metabolite derived from the metabolism of Tolbutamide by CYP2C8 and CYP2C9 a sulfonylurea hypoglycemic agent.</p>Fórmula:C12H18N2O4SPureza:98%Forma y color:White To Off-WhitePeso molecular:286.35Detajmium bitartrate
CAS:<p>Detajmium bitartrate is used as an antiarrhythmic drug.</p>Fórmula:C31H47N3O9Forma y color:SolidPeso molecular:605.72S-WJM992
<p>S-WJM992 (compound 10ahb) serves as an antiparasitic agent, effectively inhibiting ATPase activity in high [Na+] environments. It also significantly counteracts parasites resistant to PfATP4 inhibitors. Additionally, S-WJM992 acts as a potential transmission blocker by impeding gamete development and halting the transmission of parasites to mosquitoes during blood feeding.</p>Fórmula:C22H18ClFN6O3Forma y color:SolidPeso molecular:468.87L-R4W2
CAS:<p>Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.</p>Fórmula:C46H71N21O6Pureza:98%Forma y color:SolidPeso molecular:1014.2Antimalarial agent 41
<p>Antimalarial agent 41 (Compound 17) exhibits antimalarial activity by inhibiting the malaria parasite Plasmodium falciparum, with IC50 values of 40 nM for NF54 strain and 76 nM for K1 strain. This compound acts as an inhibitor of P. falciparum phosphatidylinositol-4-kinase β (PfPI4K) and hERG channels, with IC50 values of 53 nM and 3 μM, respectively. Additionally, Antimalarial agent 41 shows cytotoxicity against CHO cells, with an IC50 of 34 μM. It can improve malaria infections and demonstrates favorable pharmacokinetic properties in mouse models.</p>Fórmula:C19H18F3N5Peso molecular:373.15143Hyp9
CAS:<p>Hyp9, a specific agonist for the transient receptor potential canonical 6 (TRPC6) channel, is utilized in spinal cord injury (SCI) research [1].</p>Fórmula:C18H26O5Forma y color:SolidPeso molecular:322.40(±)17-HETE
CAS:<p>Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.</p>Fórmula:C20H32O3Forma y color:SolidPeso molecular:320.473AChE/Aβ-IN-1
<p>AChE/Aβ-IN-1 (compound 32) is a potent, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 86 nM and an NMDA receptor antagonist targeting the</p>Fórmula:C20H25BrN4Forma y color:SolidPeso molecular:401.34AChE/Aβ-IN-2
<p>AChE/Aβ-IN-2 (compound 33) is a powerful, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 135 nM.</p>Fórmula:C20H25ClN4Forma y color:SolidPeso molecular:356.89N-hydroxy Riluzole
CAS:<p>N-hydroxy Riluzole, a metabolite of riluzole, is mainly produced by CYP1A2 in human liver.</p>Fórmula:C8H5F3N2O2SForma y color:SolidPeso molecular:250.20ω-Conotoxin MVIIC
CAS:<p>Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.</p>Fórmula:C106H178N40O32S7Pureza:98%Forma y color:White Lyophilised SolidPeso molecular:2749NF110
CAS:<p>P2X3 antagonist</p>Fórmula:C41H32N6NaO17S4Pureza:98%Forma y color:SolidPeso molecular:1031.97TRPV4 antagonist 3
CAS:<p>TRPV4 antagonist 3 is a TRPV4 antagonist (p IC 50 = 8.4).</p>Fórmula:C20H18F4N4O3SForma y color:SolidPeso molecular:470.44Venturicidin A
CAS:<p>Venturicidin A is a macrolide antibiotic.</p>Fórmula:C41H67NO11Pureza:98%Forma y color:SolidPeso molecular:749.97Brevetoxin B
CAS:<p>Brevetoxin B, a polyketide neurotoxin from Karenia, affects sodium channels causing neurotoxic shellfish poisoning. IC50=15nM.</p>Fórmula:C50H70O14Forma y color:SolidPeso molecular:895.096Furosemide
CAS:<p>Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used for edema and chronic renal insufficiency.</p>Fórmula:C12H11ClN2O5SPureza:99.32% - 99.89%Forma y color:Crystals From Aqueous Ethanol Tasteless (Ntp 1992)Peso molecular:330.74412,14-Dichlorodehydroabietic acid
CAS:<p>12,14-Dichlorodehydroabietic acid activates BK channels, blocks GABA A receptors, and increases calcium and neurotransmitter release.</p>Fórmula:C20H26Cl2O2Forma y color:SolidPeso molecular:369.33URAT1/GLUT9-IN-1
<p>URAT1/GLUT9-IN-1 (compound 29) effectively inhibits urate transporter 1 (URAT1) with an IC50 value of 2.01 μM and glucose transporter 9 (GLUT9) with an IC50 of 18.21 μM. This compound exhibits favorable pharmacokinetic properties and oral bioavailability, making it useful for research in gout and hyperuricemia.</p>Foslevcromakalim
CAS:<p>Foslevcromakalim (QLS-101), an ATP-sensitive potassium channel opener, serves as a proagent for ocular hypotensive effects [1] [2].</p>Fórmula:C16H19N2O6PForma y color:SolidPeso molecular:366.31SG-094
CAS:<p>SG-094 inhibits TPC2, halts RIL175 cell growth, IC50: 3.7 μM for cancer research.</p>Fórmula:C30H29NO3Pureza:97.06%Forma y color:SoildPeso molecular:451.56S-Bioallethrin
CAS:<p>S-Bioallethrin is a pure S-form of Bioallethrin.</p>Fórmula:C19H26O3Pureza:98%Peso molecular:302.41AZD-3161
CAS:<p>AZD-3161 is a sodium channel regulator for pain.</p>Fórmula:C23H21F3N4O4Forma y color:SolidPeso molecular:474.43α-Amylase/α-Glucosidase-IN-10
<p>α-Amylase/α-Glucosidase-IN-10 (compound 5d) is an inhibitor of α-amylase and α-glucosidase, with IC50 values of 30.39 μM and 65.1 μM, respectively, indicating potential antidiabetic properties. In ADMET (absorption, distribution, metabolism, excretion, and toxicity) predictions, it shows high gastrointestinal (GI) absorption but functions as a substrate for P-glycoprotein (P-gp) and does not cross the blood-brain barrier (BBB), which may pose a risk of central nervous system side effects.</p>Fórmula:C33H40ClN5O5Peso molecular:621.2718Desalkylgidazepam
CAS:<p>Desalkylgidazepam, a benzodiazepine compound, is a metabolite of gidazepam. It is capable of activating both GABA A-type receptors and the translocator protein (TSPO).</p>Fórmula:C15H11BrN2OForma y color:SolidPeso molecular:315.17ω-Agatoxin TK
CAS:<p>Selective blocker of CaV2.1 P/Q-type calcium channels.</p>Fórmula:C215H337N65O70S10Pureza:98%Forma y color:SolidPeso molecular:5273.02Anisatin
<p>Anisatin is a useful organic compound for research related to life sciences and the catalog number is T124719.</p>Fórmula:C15H20O8Forma y color:SolidPeso molecular:328.317CHET3
CAS:<p>CHET3 is a highly selective allosteric activator for TASK-3-containing K2P channels. CHET3 has shown potent in vivo analgesic effects. Cost-effective and quality-assured.</p>Fórmula:C21H21N5O3SPureza:99.64% - >99.99%Forma y color:SoildPeso molecular:423.49SC 4453
CAS:<p>SC 4453 is a digoxin analog and a cardiac glycoside derivative.</p>Fórmula:C41H64N2O12Forma y color:SolidPeso molecular:776.965Transdermal Peptide Disulfide
CAS:<p>TD 1 peptide, an 11-amino acid, binds ATP1B1's C-terminus, enhancing transdermal drug delivery.</p>Fórmula:C40H64N14O16S2Pureza:98%Forma y color:SolidPeso molecular:1061.15GSK2332255B
CAS:<p>GSK2332255B: potent TRPC3/6 antagonist; IC50 5 nM (TRPC3), 4 nM (TRPC6); over 100-fold selectivity vs other Ca2+ channels.</p>Fórmula:C18H19ClFN3O3SForma y color:SolidPeso molecular:411.88Nav1.7-IN-8
CAS:<p>Nav1.7-IN-8 selectively inhibits NaV1.7 over hNaV1.1/1.5, affects CYP2C9/3A4 (IC50: 0.17/0.077 μM), and provides rodent pain relief.</p>Fórmula:C21H12ClF2N5O4S2Forma y color:SolidPeso molecular:535.93Endosulfan I
CAS:<p>Endosulfan I is one of the two major stereoisomers of the broad-spectrum insecticide Endosulfan inhibi the GABA/benzodiazepine/picrotoxin complex</p>Fórmula:C9H6Cl6O3SPureza:99.86%Forma y color:SolidPeso molecular:406.93µ-Conotoxin-CnIIIC acetate
<p>µ-Conotoxin-CnIIIC acetate is a NaV1.4 sodium channel antagonist, a conotoxin peptide consisting of 22 amino acids, used for muscle relaxation and pain relief.</p>Fórmula:C92H139N35O28S6·xC2H4O2Pureza:99.94%Forma y color:SolidPeso molecular:2375.70 (free base)Jingzhaotoxin-IX
<p>Jingzhaotoxin-IX is a C-terminally amidated peptide neurotoxin consisting of 35 amino acid residues.</p>Fórmula:C171H251N49O48S6Pureza:98%Forma y color:SolidPeso molecular:3953.51AZ1422
<p>AZ1422 is a selective MCT4 inhibitor, applicable for cancer research.</p>Fórmula:C31H40N2O6Peso molecular:536.28864Anticancer agent 108
<p>Anticancer Agent 108 (Compound 3.10) serves as a potent P-gp inhibitor exhibiting considerable antitumor properties while maintaining reduced toxicity to both</p>Fórmula:C18H9NO5S2Forma y color:SolidPeso molecular:383.4Yaddle1
<p>Yaddle1 is an agonist of the mechanically sensitive ion channel protein Piezo1, with a half-maximal effective concentration (MEC50) of 0.40 μM. It significantly induces Ca2+ influx in T cells, prompting T cell activation responses. Yaddle1 is applicable in vaccine adjuvant research.</p>Fórmula:C14H8ClF3N4OSPeso molecular:372.00594Lyso-Globotriaosylceramide (d18:1)
CAS:<p>Lyso-Gb3, lacking fatty acyl, binds Stx1 with cholesterol and phosphatidylcholine, not Stx2; lowers neutrophil viability; accumulates in Fabry disease.</p>Fórmula:C36H67NO17Forma y color:SolidPeso molecular:785.922GpTx-1 TFA
<p>GpTx-1 TFA is a polypeptide NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It exhibits potent inhibitory activity on the NaV1.7 channel with an IC50 value of 10 nM, demonstrating excellent selectivity over NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM) with >20-fold and >950-fold selectivity, respectively.</p>Forma y color:Odour SolidJYL-79
CAS:<p>JYL-79 is an agonist of the vanilloid receptor.</p>Fórmula:C26H36N2O4SForma y color:SolidPeso molecular:472.64Caloxin 2A1 acetate
<p>Caloxin 2A1 acetate is an inhibitor of extracellular plasma membrane Ca2+-ATPase (PMCA) peptide.</p>Fórmula:C66H95N19O24Pureza:98.2%Forma y color:SolidPeso molecular:1538.57PDZ1 Domain inhibitor peptide
CAS:<p>Novel cyclic peptide that disrupts interaction between GluR6 and PSD-95</p>Fórmula:C38H61N9O11Pureza:98%Forma y color:SolidPeso molecular:819.94Concanamycin B
CAS:<p>Concanamycin B, a macrolide, inhibits V-ATPases (IC50 = 5 nM), blocks vacuole acidification, affects bone resorption, CD8 T cells, and MHC II in B cells.</p>Fórmula:C45H73NO14Forma y color:SolidPeso molecular:852.072ORI-TRN-002
<p>ORI-TRN-002 is an AQP4 inhibitor with an IC50 value of 3 μM. It is applicable in the field of brain edema research.</p>Fórmula:C10H7N5OPeso molecular:213.06506P-gp inhibitor 23
<p>P-gp inhibitor 23 (compound 14F) is an effective inhibitor of both P-gp and CYP3A4, with an EC50 of 28 nM for P-gp and an IC50 of 223 nM for CYP3A4.</p>Fórmula:C40H37N5O6Peso molecular:683.27438KNa1.1-IN-2
CAS:<p>KNa1.1-IN-2 (Compound Z05) is a selective KNa1.1 channel inhibitor capable of penetrating the blood-brain barrier, and exhibits significant efficacy on hERG channels. It binds to KNa1.1 channels, effectively blocking channel activity caused by Gain-of-function (GOF) mutations, thus intervening in KCNT1-related seizures. Additionally, it inhibits the GOF mutant Y796H, making KNa1.1-IN-2 a promising candidate for research into KCNT1-associated epilepsy disorders.</p>Fórmula:C24H27NOForma y color:SolidPeso molecular:345.48Ampullosporin A
CAS:<p>Ampullosporin A is a peptaibol-type polypeptide isolated from the fungus Sepedonium ampullosporum (HKI-0053), exhibiting neuromodulatory activity. It inhibits hyperactivity induced by the NMDA receptor antagonist MK-801 and ameliorates social behavior abnormalities caused by subchronic ketamine treatment. Ampullosporin A modulates glutamate receptor activity without affecting dopamine D1 and D2 receptors.</p>Fórmula:C77H127N19O19Forma y color:SolidPeso molecular:1622.95MRS4596
<p>MRS4596: selective P2X4 blocker, IC50 1.38 μM, neuroprotective in stroke research.</p>Fórmula:C21H14N5NaO3SForma y color:SolidPeso molecular:439.42GsMTx4
CAS:<p>GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (CAS 1209500-46-8).</p>Fórmula:C185H273N49O45S6Pureza:98%Forma y color:SolidPeso molecular:4095.84Oleoyl-D-lysine
CAS:<p>Oleoyl-D-lysine: lipid-based GlyT2 inhibitor, eases neuropathic pain in mice, safe, non-sedative, no respiratory depression.</p>Fórmula:C24H46N2O3Forma y color:SolidPeso molecular:410.63APETx2 TFA
<p>APETx2 TFA from sea anemone is a selective ASIC3 inhibitor with a 63 nM IC50, reversing acid and inflammatory pain.</p>Fórmula:C198H281F3N54O62S6Forma y color:SolidPeso molecular:4675.02Ion Channel Targeted Library
<p>A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;</p>Forma y color:Odour Solid(1S,3R)-3-Aminocyclopentane carboxylic acid
CAS:<p>(1S,3R)-3-Aminocyclopentane carboxylic acid exhibits activity on GABAA receptors.</p>Fórmula:C6H11NO2Forma y color:SolidPeso molecular:129.16Chlorotoxin
CAS:<p>Chlorotoxin: 36-amino acid peptide from deathstalker scorpion venom; blocks small chloride channels.</p>Fórmula:C158H249N53O47S11Pureza:98%Forma y color:SolidPeso molecular:3995.71Nav1.7-IN-18
<p>Nav1.7-IN-18 (Compound 31) is a Nav1.7 inhibitor with a Ki value of 4.9 nM and an IC50 of 13 nM, demonstrating analgesic effects in transgenic mice with inherited erythromelalgia (IEM).</p>Fórmula:C30H33Cl2F2NO4Forma y color:SolidPeso molecular:580.49Fipronil sulfone
CAS:<p>Fipronil sulfone is an insecticide fipronil. Its metabolite fipronil sulphone is an inhibitor of rat ɑ1β2γ2L GABA(A) receptor.</p>Fórmula:C12H4Cl2F6N4O2SPureza:98%Forma y color:SolidPeso molecular:453.14Chrodrimanin B
CAS:<p>Chrodrimanin B is a useful organic compound for research related to life sciences. The catalog number is T126052 and the CAS number is 132196-54-4.</p>Fórmula:C27H32O8Forma y color:SolidPeso molecular:484.545CW2158
<p>CW2158 (Compound 13) is a modulator of exportin1 (XPO1). It disrupts chromatin binding and inhibits the activation of NFAT transcription factors and T cells.</p>Fórmula:C14H8F4N4O2Peso molecular:340.05834Pyrazolam
CAS:<p>Pyrazolam is a psychoactive benzodiazepine compound serving as a central nervous system depressant. [Pyrazolam] can lead to psychomotor impairment.</p>Fórmula:C16H12BrN5Forma y color:SolidPeso molecular:354.2Amlenetug
<p>Amlenetug is a humanized IgG1κ antibody targeting SNCA, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.</p>Forma y color:Odour LiquidBCRP-IN-2
CAS:<p>BCRP-IN-2 is a compound with BCRP inhibitory activity, exhibiting enhanced inhibition of BCRP upon UV activation. It serves as a valuable probe for studying interactions between quinazoline amine derivatives and BCRP, and it stimulates ATP hydrolysis of the BCRP transporter, leading to increased mitoxantrone accumulation in BCRP-overexpressing H460/MX20 cells.</p>Fórmula:C19H13N7Forma y color:SolidPeso molecular:339.35EVT-401
<p>EVT-401 (P2X7 receptor antagonist-1), a purinergic P2X7 receptor antagonist, demonstrates efficacy in combating neuroinflammation [1].</p>Fórmula:C22H20F4N2O3Forma y color:SolidPeso molecular:436.4Sinapine hydroxide
CAS:<p>Sinapine hydroxide from crucifer seeds has anti-inflammatory, anti-oxidant, anti-tumor properties, and inhibits AChE, aiding neurodegenerative research.</p>Fórmula:C16H25NO6Forma y color:SolidPeso molecular:327.377Guangxitoxin 1E
CAS:<p>Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.</p>Fórmula:C178H248N44O45S7Pureza:98%Forma y color:SolidPeso molecular:3948.61Ebio3
<p>Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.</p>Fórmula:C19H23F2N3O2Forma y color:SolidPeso molecular:363.4Mepivacaine hydrochloride
CAS:<p>Mepivacaine hydrochloride (Mepivacaine HCl) is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.</p>Fórmula:C15H22N2O·HClPureza:98.76% - 99.94%Forma y color:White Or Off White Crystalline PowderPeso molecular:282.81Nitrazolam
CAS:<p>Nitrazolam is a benzodiazepine compound that may exhibit central nervous system depressant properties similar to traditional benzodiazepine drugs by acting on the GABA receptors (GABA receptor). These effects include sedation, hypnosis, anxiolytic, and anticonvulsant activities.</p>Fórmula:C17H13N5O2Forma y color:SolidPeso molecular:319.32Digoxigenin Monodigitoxoside
CAS:<p>Digoxigenin monodigitoxoside is a cardiac glycoside metabolite of digoxin and a Na+/K+ ATPase inhibitor.</p>Fórmula:C29H44O8Forma y color:SolidPeso molecular:520.663GeX-2
CAS:<p>GeX-2 is a truncated analogue of αO-conotoxin. It has the ability to activate GABAB receptors and inhibit α9α10nAChR as well as CaV2.2 channels. Additionally, GeX-2 is effective in alleviating pain in a rat model of chronic constriction injury.</p>Fórmula:C103H169N43O27Forma y color:SolidPeso molecular:2441.721-(1-Methyl-1h-pyrazol-4-yl)-ethanone
CAS:<p>1-(1-Methyl-1h-pyrazol-4-yl)-ethanone is a high purity biochemical reagent that can be used in research related to life sciences.</p>Fórmula:C6H8N2OPureza:99.92%Forma y color:SolidPeso molecular:124.14Albanin A
<p>Albanin A is a useful organic compound for research related to life sciences and the catalog number is T124310.</p>Fórmula:C20H18O6Forma y color:SolidPeso molecular:354.358c-Met-IN-23
<p>c-Met-IN-23 (Compound 12g) functions as a c-Met inhibitor with an IC50 of 0.052 μM against c-Met. It also inhibits the MDR1 and MRP1/2 pumps in cancerous HepG2 and BxPC3 cells. As such, c-Met-IN-23 serves as an anticancer agent.</p>Fórmula:C16H13N7OPeso molecular:319.11816Leptomycin A
CAS:<p>Leptomycin A from Streptomyces inhibits CRM1, reducing HIV-1 replication, less potent than Leptomycin B, blocks protein nuclear export.</p>Fórmula:C32H46O6Pureza:98%Forma y color:SolidPeso molecular:526.7Linoleic Acid Amide
CAS:<p>Linoleic Acid Amide (Linoleamide) is derived from linoleic acid and regulates Ca2+ flux by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase.</p>Fórmula:C18H33NOPureza:98%Forma y color:SolidPeso molecular:279.46GaTx2
CAS:<p>High-affinity ClC-2 blocker (KD ~50 pM), selective over other ClCs/CFTR/GABAC/CaCC/KV1.2; slows activation, no effect on open channels.</p>Fórmula:C125H199N39O47S6Pureza:98%Forma y color:SolidPeso molecular:3192.54Fumitremorgin C
CAS:<p>Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP.</p>Fórmula:C22H25N3O3Pureza:98%Forma y color:SolidPeso molecular:379.45JTS-653
CAS:<p>JTS-653 is a potent TRPV1 antagonist, effective in reducing chronic pain unresponsive to NSAIDs.</p>Fórmula:C23H21F3N4O4Forma y color:SolidPeso molecular:474.44CBP-1008
<p>CBP-1008 is a dual-ligand peptide-drug conjugate (PDC) with MMAE, targeting folate receptor (FRα) and TRPV6. It exhibits high binding affinity to FRα and low affinity to TRPV6. CBP-1008 shows antitumor activity and can be utilized for research in advanced solid tumors such as colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma, and follicular dendritic cell sarcoma.</p>Forma y color:Odour SolidNF279
CAS:<p>P2X1 antagonist</p>Fórmula:C49H36N6Na6O23S6Pureza:98%Forma y color:SolidPeso molecular:1407.17AVLX-125
CAS:<p>AVLX-125 (UCCB01-125), a potent inhibitor of PSD-95 and PDZ domains, exhibits a dissociation constant (Kd) of 10 nM. It is utilized in researching inflammatory pain [1] [2].</p>Fórmula:C62H104N10O29Forma y color:SolidPeso molecular:1453.54NHE-1-IN-2
<p>NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC50 of 0.78 μM. It mitigates left ventricular systolic dysfunction in mouse models of heart failure.</p>Fórmula:C23H20ClN3O3Forma y color:SolidPeso molecular:421.11932Oleoyl Serotonin
CAS:<p>Oleoyl Serotonin is an antagonist of hTRPV1 with an IC50 of 2.57 μM.</p>Fórmula:C28H44N2O2Pureza:99.88%Forma y color:SolidPeso molecular:440.66Myomodulin
CAS:<p>Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A the</p>Fórmula:C36H67N11O8S2Pureza:98%Forma y color:SolidPeso molecular:846.123,4-Dihydroxypyrovalerone HCl
CAS:<p>3,4-Dihydroxypyrovalerone HCl is an analog of Pyrovalerone. Pyrovalerone inhibits the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET).</p>Fórmula:C15H22ClNO3Forma y color:SolidPeso molecular:299.79Rilmazolam
CAS:<p>Rilmazolam is a triazolobenzodiazepine compound and serves as the active metabolite of Rilmazafone.</p>Fórmula:C19H15Cl2N5OForma y color:SolidPeso molecular:400.26JC-229
CAS:<p>JC-229 is a potent and selective TbRPA1 inhibitor that can inhibit RPA1 in Trypanosoma brucei. JC-229 can be used to study human African Trypanosomiasis (HAT).</p>Fórmula:C20H14Cl4N2O3SPureza:97.14%Forma y color:SolidPeso molecular:504.21TPC2-A1-P
CAS:<p>TPC2-A1-P is a TPC2 agonist that can differentially activate two-pore channel 2 (TPC2) and mimic the activation of TPC2 with NAADP and PIP (2).</p>Fórmula:C20H21BrF3NO3Pureza:98.49%Forma y color:SolidPeso molecular:460.29(S)-ABT 102
CAS:<p>N-[(1S)-1H-inden-1-yl]-N'-indazol-4-ylurea is a strong TRPV1 blocker with a 123 nM IC50 against capsaicin.</p>Fórmula:C21H24N4OPureza:99.65% - 99.77%Forma y color:SoildPeso molecular:348.44Pinacidil monohydrate
CAS:<p>Pinacidil monohydrate is a potassium channel activator, antihypertensive drug.</p>Fórmula:C13H21N5OPureza:99.94% - 99.98%Forma y color:PowderPeso molecular:263.34Prilocaine acetate
<p>Prilocaine acetate, an amino amide compound, functions as a Na/K-ATPase inhibitor, exhibiting neurotoxic effects [1] [2].</p>Fórmula:C15H24N2O3Forma y color:SolidPeso molecular:280.36AR-C141990 hydrochloride
CAS:<p>AR-C141990 HCl inhibits MCT-1 (pKi 7.6) and MCT-2 (pKi 6.6), and has immunosuppressive effects.</p>Fórmula:C26H29ClN4O4SForma y color:SolidPeso molecular:529.05GSK2798745
CAS:<p>GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4).</p>Fórmula:C25H28N6O3Forma y color:SolidPeso molecular:460.53Dendrotoxin K
CAS:<p>Dendrotoxin K blocks Kv1.1 channels, modulating glutamate release in CA3 neurons by controlling presynaptic spike timing.</p>Fórmula:C294H462N84O75S6Forma y color:SolidPeso molecular:6559.66Milbemycin A4
CAS:<p>Milbemycin A4, a distinguished member of the macrocyclic lactones family featuring a unique spiroketal group, is derived from the fermentation of the soil bacterium Streptomyces hygroscopicus subsp. aureolacrimosus. It acts by enhancing the opening of glutamate and GABA-gated chloride channels, rendering it effective as both a nematocide and insecticide.</p>Fórmula:C32H46O7Forma y color:SolidPeso molecular:542.713Dalazatide HCl
<p>Dalazatide HCl is a peptide and specific Kv1.3 inhibitor that suppresses the activation and proliferation of memory effector T cells,</p>Forma y color:SolidPeso molecular:4317.53 (Free base)P2X3 antagonist 39
<p>P2X3 antagonist 39 (compound 26a) is a selective P2X3 receptor antagonist with an IC50 of 54.9 nM. It is utilized in the study of neuropathic pain models.</p>Forma y color:Odour SolidHuwentoxin I
CAS:<p>Huwentoxin I (HWTX-I) is a peptide toxin that targets and inhibits both voltage-gated sodium channels and N-type calcium channels.</p>Fórmula:C161H246N48O44S6Pureza:98%Forma y color:SolidPeso molecular:3750.36TRPV4 antagonist 4
CAS:<p>Potent TRPV4 blocker with 22.65 nM IC50; inhibits current and aids acute lung injury.</p>Fórmula:C28H32Cl2N6OForma y color:SolidPeso molecular:539.50TRPA1 Antagonist 3
CAS:<p>TRPA1 Antagonist 3 is a compound with photoswitchable properties that acts as an agonist on the TRPA1 channel, providing the ability for optical control.</p>Fórmula:C11H8ClN3Forma y color:SolidPeso molecular:217.66Anticonvulsant agent 8
<p>Anticonvulsant agent 8 (compound D4) is a chemical used in treating epilepsy by inhibiting GABAA currents. In mouse models, its ED50 values are 2.23 mg/kg for the maximal electroshock (MES) test and 24.60 mg/kg for the pentylenetetrazol (PTZ) test.</p>Fórmula:C15H11N5OForma y color:SolidPeso molecular:277.28CPI1
<p>CPI1 is an effective and highly specific inhibitor of multidrug resistance protein 1 (MRP1). It exhibits inhibitory activity against MRP1 at the nanomolar level (Ki: 100 nM) and has minimal effect on P-glycoprotein (Pgp). CPI1 competes with LTC4 for binding to the same site on MRP1, inhibiting ATP hydrolysis and substrate transport. It is useful in research related to drug delivery and addressing cancer chemotherapy resistance.</p>Fórmula:C111H131N23O30SForma y color:SolidPeso molecular:2299.43UCL 1684 dibromide
CAS:<p>apamin-sensitive Ca2+-activated K+ channel (KCa2.1) blocker</p>Fórmula:C34H30Br2N4Pureza:98%Forma y color:SolidPeso molecular:654.45Dofetilide N-oxide
CAS:<p>Dofetilide N-oxide (UK-116856) is a metabolite of dofetilide. Dofetilide can block potassium channels and is a tertiary antiarrhythmic drug.</p>Fórmula:C19H27N3O6S2Pureza:98%Forma y color:SolidPeso molecular:457.56BuChE-IN-9
<p>BuChE-IN-9 (compound 22a), an eqBuChE (equine serum-derived butyrylcholinesterase) inhibitor, exhibits potent activity with an IC50 of 173 nM.</p>Fórmula:C28H34N4O2Forma y color:SolidPeso molecular:458.6Rusfertide
CAS:<p>Rusfertide, a peptide mimetic of natural hepcidin, targets and degrades ferroportin, thereby reducing serum iron and transferrin saturation, which helps regulate red blood cell production. It ameliorates conditions such as polycythemia vera, β-thalassemia, and hereditary hemochromatosis [1] [2].</p>Fórmula:C114H181N27O28S2Forma y color:SolidPeso molecular:2441.95AQP4 (205-215)
CAS:<p>AQP4 (205-215) is a fragment of the water channel protein Aquaporin-4 (AQP4). This protein is an autoimmune antigen in optic neuromyelitis and, upon binding with CD40, is upregulated and presented in B cells. AQP4 is associated with neuromyelitis optica (NMO), an autoimmune inflammatory disease of the central nervous system (CNS).</p>Fórmula:C48H75N13O17SForma y color:SolidPeso molecular:1138.25Phe-Met-Arg-Phe amide trifluoroacetate
CAS:<p>Phe-met-arg-phe amide trifluoroacetate is an activator of K+ current with an ED50 of 23nm on the fundus nerve.</p>Fórmula:C33H44F6N8O8SPureza:98%Forma y color:SolidPeso molecular:826.81Lifastuzumab
CAS:<p>Sulfamethoxazole-NO (SMX-NO) is a SMX-NO derivative and is the primary immunogen for sulfonamide hypersensitivity reactions.</p>Pureza:97% (SDS-PAGE); 99.5% (SEC-HPLC) - 97% (SDS-PAGE); 99.5% (SEC-HPLC)Forma y color:LiquidPeso molecular:145.5 kDaCL-424032
CAS:<p>CL-424032 is an inhibitor of sodium channels (sodium channel).</p>Fórmula:C12H7F3N4O2Forma y color:SolidPeso molecular:296.21TNP-ATP triethylammonium salt
CAS:<p>P2X receptor antagonist</p>Fórmula:C40H77N12O19P3Pureza:98%Forma y color:SolidPeso molecular:1123.042GYKI-47261 dihydrochloride
CAS:<p>GYKI-47261 dihydrochloride is an AMPA receptor antagonist and CYP2E1 inducer, demonstrating broad-spectrum anticonvulsant and neuroprotective activities.</p>Fórmula:C18H17Cl3N4Pureza:98.32% - 99.14%Forma y color:SolidPeso molecular:395.71RN-1665
CAS:<p>RN-1665 is a potent and selective TRPV4 receptor antagonist.</p>Fórmula:C20H24F5N3O3S2Pureza:>99.99%Forma y color:SoildPeso molecular:513.54HG1 Toxin
<p>HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, known for its ability to inhibit the potassium channel Kv1.3 (potassium channel Kv1.3). Additionally, HG1 Toxin exhibits trypsin inhibitory activity (Ki=107 nM), making it useful for research into autoimmune diseases.</p>Fórmula:C337H503N103O97S6Peso molecular:7736.59176GDC-0334
CAS:<p>GDC-0334 is a TRPA1 antagonist useful in treatment TRPA1-mediated diseases, such as pain or asthma.</p>Fórmula:C24H19F8N5O3SForma y color:SolidPeso molecular:609.52,4,6-Tri-tert-butylphenol
CAS:<p>2,4,6-Tri-tert-butylphenol inhibits the Ca2+ ATPase activity of human red blood cell membranes and can be used in related research in the field of life sciences.</p>Fórmula:C18H30OPureza:99.55%Forma y color:SolidPeso molecular:262.43Urease-IN-19
<p>Urease-IN-19 (Compound 3c) is a potent inhibitor of urease, demonstrating an IC50 value of 2.7 µM. It shows potential for use in research related to kidney stones and gastric ulcers.</p>Fórmula:C17H16FN3SForma y color:SolidPeso molecular:313.39GABAA receptor modulator-3
<p>GABAA receptor modulator-3 (compound 3b) is a positive allosteric modulator (PAM). It inhibits the peak current and steady-state current of α1β3γ2 GABAAR with IC50 values of 671 μM and 64 μM, respectively.</p>Fórmula:C18H22O2Forma y color:SolidPeso molecular:270.37Cavα2δ-IN-1
CAS:<p>Cavα2δ-IN-1 demonstrates exceptional specificity for voltage-gated calcium channels Cavα2δ-1 (with a Ki value of 6 nM), in comparison to Cavα2δ-2 (with a Ki</p>Fórmula:C18H27N5OForma y color:SolidPeso molecular:329.448Margatoxin
CAS:<p>KV1.3 channel blocker, IC50 36 pM, no effect on calcium-activated channels, hinders VEGF-induced Ca++ influx & NO in endothelial cells.</p>Fórmula:C178H286N52O50S7Pureza:98%Forma y color:SolidPeso molecular:4178.96Lei-Dab7
CAS:<p>Selective KCa2.2 channel blocker with Kd 3.8 nM, >200-fold specificity, enhances LTP, convulsive in vivo.</p>Fórmula:C141H236N46O39S6Pureza:98%Forma y color:SolidPeso molecular:3392.06P2X4 antagonist-4
<p>P2X4 antagonist-4 (compound 64) is a potent P2X4R antagonist with an IC50 value of 8 µM. It can inhibit ATP-induced activation of the NLRP3 inflammasome and the subsequent release of IL-1β.</p>Fórmula:C27H22FN3O4SForma y color:SolidPeso molecular:503.545BKCa activator-1
<p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>Fórmula:C22H23F7N2O3Forma y color:SolidPeso molecular:496.418D-GsMTx4
<p>TRPC1/6 & Piezo2 inhibitor; mimics GsMTx4; blocks ~70% mechanosensitive currents; aids in mouse heart attack models; protease-resistant.</p>Forma y color:Soildω-Agatoxin IVA
CAS:<p>Selective blocker of P-type calcium channels (IC50 < 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations.</p>Fórmula:C217H360N68O60S10Pureza:98%Forma y color:SolidPeso molecular:5202.25GX 201
CAS:<p>GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.</p>Fórmula:C25H27ClF4N2O4SPureza:99.81%Forma y color:SolidPeso molecular:563ABCB1-IN-1
<p>ABCB1-IN-1 (compound 3) is a potent inhibitor of ABCB1 that promotes cell apoptosis.</p>Fórmula:C36H33F3FeN2O4PSForma y color:SolidPeso molecular:733.54α5-GABAA receptor modulator 1
<p>α5-GABAA receptor modulator 1 (Compound A-4) is a selective silent allosteric modulator (SAM) targeting the α5 subunit of GABAA receptors, useful for research into central nervous system (CNS) disorders.</p>Fórmula:C21H20FN3O4Forma y color:SolidPeso molecular:397.4Tacrine hydrochloride
CAS:<p>Tacrine: a cholinergic agonist, anticholinesterase; inhibits AChE/BChE with IC50s of 31/25.6 nM.</p>Fórmula:C13H15ClN2Pureza:98%Forma y color:SolidPeso molecular:234.73Agitoxin-2
CAS:<p>Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).</p>Fórmula:C169H278N54O48S8Pureza:98%Forma y color:SolidPeso molecular:4090.87Levamlodipine besylate Hemipentahydrate
CAS:<p>Levamlodipine besylate hemipentahydrate is the besylate hemipentahydrate salt form of Levamlodipine. It is an orally effective calcium channel blocker with antioxidative and vasodilatory properties. This compound can reduce serum malondialdehyde (MDA) levels, enhance the activity of superoxide dismutase (SOD), and alleviate oxidative stress. Levamlodipine besylate hemipentahydrate is relevant for research in vascular dementia, hypertension, and cerebrovascular diseases.</p>Fórmula:C20H25ClN2O5·C6H6O3SH2OForma y color:SolidPeso molecular:1224.18Ouabagenin
CAS:<p>Ouabagenin, a naturally occurring LXR ligand with selective agonist activity, functions as an EC 3.6.3.9 (Na(+)/K(+)-transport ATPase) inhibitor [1] [2].</p>Fórmula:C23H34O8Forma y color:SolidPeso molecular:438.51GS-9191 PM
<p>GS-9191 PM: novel antitumorviral bis-amide prodrug, inhibits MDR1/BCRP, has antiproliferative activity.</p>Fórmula:C11H16N6OPureza:99.79%Forma y color:SoildPeso molecular:248.28AQP3-IN-1
CAS:<p>AQP3-IN-1 (compounds 3), an AQP3 inhibitor, exhibits an IC 50 of 8.91 μM and effectively inhibits melanoma cell proliferation [1].</p>Fórmula:C11H9AuCl2N2Forma y color:SolidPeso molecular:437.08Anticonvulsant agent 9
<p>Anticonvulsant agent 9 (compound 4f) is an activator of the α1β2γ2GABA_A receptor, with an EC50 value of 1.24 μM. It inhibits the inactivation of Nav1.2 channels and exhibits significant anticonvulsant activity.</p>Fórmula:C22H24N4O2Forma y color:SolidPeso molecular:376.45PptT-IN-4
<p>PptT-IN-4 (Compound 3a) is a PptT inhibitor exhibiting an IC50 of 0.71 μM.</p>Fórmula:C17H23N3Pureza:98%Forma y color:SolidPeso molecular:269.38Elgodipine
CAS:<p>Elgodipine decreases angina severity, inhibits muscle growth, and is voltage-sensitive, showing promise for angina treatment.</p>Fórmula:C29H33FN2O6Pureza:98.95% - 99.50%Forma y color:SolidPeso molecular:524.585-Tridecanol
CAS:<p>5-Tridecanol blocks ion flux in sodium channels.</p>Fórmula:C13H28OPureza:97.87%Forma y color:SolidPeso molecular:200.3617(R)-Resolvin D1
CAS:<p>Resolvins are anti-inflammatory lipids from EPA and DHA. Resolvin D1, made from DHA, and its aspirin-triggered epimer 17(R)-RvD1, inhibit acute inflammation.</p>Fórmula:C22H32O5Forma y color:SolidPeso molecular:376.493P-gp inhibitor 15
<p>P-gp Inhibitor 15 (compound 7a), a nonsubstrate inhibitor of P-glycoprotein (Pgp), inhibits Pgp-ATPase activity and interferes with Pgp-mediated Rhodamine123</p>Fórmula:C35H60N2O4Forma y color:SolidPeso molecular:572.86Crofelemer
CAS:<p>Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.</p>Forma y color:SolidAnalgesic/antidepressant agent-1
<p>Analgesic/antidepressant agent-1 (Compound k1) is an orally active N-acetylamino chloro ketone derivative capable of crossing the blood-brain barrier. It exhibits high affinity for NMDA receptors and demonstrates analgesic, anti-inflammatory, and antidepressant properties, with low psychotomimetic activity.</p>Fórmula:C22H25ClN2O2Forma y color:SolidPeso molecular:384.9AQP4 (201-220) TFA
<p>AQP4 (201-220) TFA is an encephalitogenic epitope of AQP-4. This compound can induce experimental autoimmune encephalomyelitis (EAE), characterized by midline brain lesions, retinal abnormalities, and lesions at the grey/white matter boundary of the spinal cord. AQP-4 is the target antigen in neuromyelitis optica.</p>Forma y color:Odour SolidCalcium Ionophore I
CAS:<p>Calcium Ionophore I has a wide range of applications in life science related research.</p>Fórmula:C38H72N2O8Forma y color:SolidPeso molecular:685.0Charybdotoxin
CAS:<p>Specific inhibitor of the big conductance Ca2+-activated K+ channel.</p>Fórmula:C176H277N57O55S7Pureza:98%Forma y color:SolidPeso molecular:4295.95ATP synthase inhibitor 2 TFA
<p>ATP Synthase Inhibitor 2 (Compound 22) TFA is a potent inhibitor of Pseudomonas aeruginosa ATP synthase with an IC50 value of 10 μg/mL.</p>Fórmula:C23H23F3N2O5SForma y color:SolidPeso molecular:496.5JAMI1001A
CAS:<p>JAMI1001A enhances AMPA receptor signaling, slows deactivation/desensitization for flip/flop isoforms.</p>Fórmula:C16H17F3N4O3SForma y color:SolidPeso molecular:402.39Phe-Met-Arg-Phe, amide
CAS:<p>Phe-Met-Arg-Phe amide activates K+ current in neurons (ED50=23 nM), co-localizes with neuropeptide Y in brain regions.</p>Fórmula:C29H42N8O4SPureza:98%Forma y color:SolidPeso molecular:598.76Tariquidar dimesylate
CAS:<p>Tariquidar, a non-competitive P-glycoprotein inhibitor, may help combat cancer drug resistance.</p>Fórmula:C80H94N8O25S4Pureza:98%Forma y color:SolidPeso molecular:1695.9L-Palmitoylcarnitine TFA
<p>L-Palmitoylcarnitine TFA: long-chain fat metabolite that disrupts membranes in ischaemia & inhibits KATP channels via Kir6.2 interaction.</p>Fórmula:C25H46F3NO6Forma y color:SolidPeso molecular:513.63Apamin acetate
<p>Apamin acetate: Selective Ca2+-activated K+ channel blocker, 18-amino acid bee venom peptide, promotes synapse repair, anti-inflammatory.</p>Pureza:96.97%Forma y color:SolidRoquefortine C
CAS:<p>Roquefortine C is a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins</p>Fórmula:C22H23N5O2Pureza:98%Forma y color:SolidPeso molecular:389.45SLC26A3-IN-2
CAS:<p>Vilobelimab (CaCP-29) is a human-mouse chimeric IgG antibody targeting human complement component 5a, a C5a inhibitor that inhibits neutrophil activation.</p>Fórmula:C19H13ClN2O2SPureza:99.86%Forma y color:SolidPeso molecular:368.84P-gp inhibitor 14
CAS:<p>Compound 8a, also known as P-gp inhibitor 14, demonstrates high affinity as a P-gp inhibitor and effectively reverses P-gp-mediated multidrug resistance (EC 50 = 48.74 nM). Additionally, this compound exhibits a weak inhibitory effect on CYP3A4 activity [1].</p>Fórmula:C37H38N2O8Forma y color:SolidPeso molecular:638.71MS7710
<p>MS7710 is a brain-penetrant inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. It reduces Ih current by inhibiting HCN channels, thereby decreasing the activity of dopamine neurons in the ventral tegmental area (VTA). MS7710 effectively improves social interaction deficits and reward-related cognitive flexibility in mouse models of chronic social defeat stress (CSDS) and shows promise for depression research.</p>Forma y color:Odour SolidATP Synthesis-IN-2
<p>ATP Synthesis-IN-2 (Compound 5) serves as a potent inhibitor of ATP synthesis activity, displaying significant antibacterial properties with an IC50 value of 0.</p>Forma y color:Odour SolidWay 125971
CAS:<p>Way 125971 is a bioactive chemcial.</p>Fórmula:C22H28N4O5S2Forma y color:SolidPeso molecular:492.61Chlorotoxin TFA
<p>Chlorotoxin TFA, a scorpion venom peptide, blocks chloride channels and has anti-cancer properties.</p>Fórmula:C160H250F3N53O49S11Forma y color:SolidPeso molecular:4109.74AQP4 (205-215) TFA
<p>AQP4 (205-215) TFA is a fragment of the water channel protein-4 (AQP4). AQP4 acts as an autoimmune antigen in neuromyelitis optica, upregulating and presenting in B cells upon binding with CD40. AQP4 is associated with neuromyelitis optica (NMO), an autoimmune inflammatory disease of the central nervous system (CNS).</p>Forma y color:Odour SolidHomocarnosine
CAS:<p>Homocarnosine is an endogenous dipeptide in cerebral regions and cerebrospinal fluid.</p>Fórmula:C10H16N4O3Forma y color:SolidPeso molecular:240.26Quinine hemisulfate hydrate
CAS:<p>Quinine hemisulfate hydrate: anti-malaria, derived from cinchona bark, inhibits mouse Slo3 channels with IC50 169 μM.</p>Fórmula:C20H26N2O3H2O4S·H2OForma y color:SolidPeso molecular:391.47S-Sulfo-L-cysteine sodium salt
CAS:<p>S-Sulfo-L-cysteine sodium salt shows a weak affinity for mGluR1α and mGluR5a at high concentrations and has potential antioxidant activity.</p>Fórmula:C3H6NNaO5S2Pureza:99.88%Forma y color:SolidPeso molecular:223.217(S)-HETE
CAS:<p>Arachidonic acid and its CYP450 metabolite, 17(S)-HETE, regulate kidney electrolytes; 17(S)-HETE reduces proximal tubule ATPase activity by 70% at 2 μM.</p>Fórmula:C20H32O3Forma y color:SolidPeso molecular:320.473Trans (2,3)-Dihydrotetrabenazine
CAS:<p>Trans (2,3)-Dihydrotetrabenazine is a Tetrabenazine metabolite, shows inhibition activity on vesicular monoamine transporter (VMAT2).</p>Fórmula:C19H29NO3Pureza:98%Forma y color:SolidPeso molecular:319.44MMK 1
CAS:<p>Potent hFPR2 agonist; EC50: 1 nM (mFPR2), 2 nM (hFPR2), >10,000 nM (hFPR1). Induces monocyte/neutrophil migration, boosts IL-1β/IL-6, activates NADPH-oxidase.</p>Fórmula:C75H123N19O18SPureza:98%Forma y color:SolidPeso molecular:1610.97TP-050
CAS:<p>TP-050: potent, selective NMDAR agonist, EC50 0.51 µM (GluN2A), 9.6 µM (GluN2D), BBB permeable, boosts hippocampal LTP.</p>Fórmula:C16H15ClF2N6OForma y color:SolidPeso molecular:380.78RuBi-GABA
CAS:<p>Ruthenium-bipyridine-triphenylphosphine caged GABA</p>Fórmula:C42H39F6N5O2P2RuPureza:98%Forma y color:SolidPeso molecular:922.8AHN-683
CAS:<p>AHN-683 is a fluorescent ligand. It was used for peripheral-type benzodiazepine receptors.</p>Fórmula:C42H32FN3O7Pureza:98%Forma y color:SolidPeso molecular:709.72NF864
CAS:<p>NF864, a suramin analog, is a P2X1 receptor inhibitor.</p>Fórmula:C57H28N6Na12O41S12Pureza:98%Forma y color:SolidPeso molecular:2113.5LY-466195
CAS:<p>LY-466195 is a competitive antagonist of GLUK5 receptor.</p>Fórmula:C16H24F2N2O4Forma y color:SolidPeso molecular:346.37Spongionellol A
<p>Spongionellol A inhibits MDR1, selectively kills prostate cancer through caspase-induced apoptosis, and aids cancer research.</p>Fórmula:C27H40O9Forma y color:SolidPeso molecular:508.6
