Transportador de membrana / canal de iones
Los inhibidores de transportadores de membrana y canales iónicos son compuestos que bloquean la función de proteínas responsables del transporte de iones, nutrientes y otras moléculas a través de las membranas celulares. Estos inhibidores son cruciales para estudiar la regulación de la homeostasis celular, la transducción de señales y la neurotransmisión. Los inhibidores de transportadores de membrana y canales iónicos también son importantes para desarrollar tratamientos para trastornos como la epilepsia, las enfermedades cardiovasculares y los síndromes metabólicos. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de transportadores de membrana y canales iónicos para apoyar su investigación en fisiología, neurociencia y farmacología.
Subcategorías de "Transportador de membrana / canal de iones"
- ABC(3 productos)
- ATPasa(93 productos)
- Receptor de adiponectina(5 productos)
- CFTR(64 productos)
- Receptor CGRP(51 productos)
- Canal de calcio(493 productos)
- Canal de cloruro(49 productos)
- Receptor GABA(336 productos)
- Transportador de monoamina(23 productos)
- Transportador de monocarboxilato(17 productos)
- NKCC(2 productos)
- NPC1L1(3 productos)
- Cotransportador de Na-K-Cl(8 productos)
- OAT(27 productos)
- OCT(7 productos)
- P-gp(53 productos)
- Canal de potasio(276 productos)
- Bomba de protones(39 productos)
- SGLT(30 productos)
- Canal de sodio(202 productos)
- Canal TRP / TRPV(92 productos)
Mostrar 13 subcategorías más
Se han encontrado 2272 productos de "Transportador de membrana / canal de iones"
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AMPA-IN-1
CAS:<p>AMPA-IN-1: Potent AMPA receptor inhibitor; key in regulating brain excitatory transmission and plasticity.</p>Fórmula:C23H12F2N4O2Forma y color:SolidPeso molecular:414.36KCa1.1 channel activator-1
<p>A selective vascular KCa1.1 channel stimulator with CaV1.2 blocking ability and mild myorelaxant effects.</p>Fórmula:C25H16O10Forma y color:SolidPeso molecular:476.39L-822179
CAS:<p>L-822179 (α5IA) is a selective inverse agonist for the Α5 subtype of GABAA receptor with higher intrinsic activity at the A5 subtype than other drugs.</p>Fórmula:C17H14N8O2Pureza:98.5% - 99.61%Forma y color:SolidPeso molecular:362.35GABAA receptor agent 2 TFA
CAS:<p>Potent GABAA antagonist; IC50: 24 nM (α1β2γ2), Ki: 28 nM (rat); inactive on human GABA transporters.</p>Fórmula:C22H22F3N3O3Forma y color:SolidPeso molecular:433.426-Iodoamiloride
CAS:<p>6-Iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (ASIC1), exhibiting an IC50 value of 88 nM.</p>Fórmula:C6H8IN7OPureza:98%Forma y color:SolidPeso molecular:321.08A 425619
CAS:<p>A 425619 (1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA) is a potent TRPV1 antagonist</p>Fórmula:C18H14F3N3OPureza:99.75%Forma y color:SolidPeso molecular:345.32APS3
CAS:<p>APS3 is an inhibitor of GABA and nACh receptors, exhibiting an LC50 value of 7.2423 μg/mL against Plutella xylostella [1].</p>Fórmula:C18H7Cl2F6N5O5S2Forma y color:SolidPeso molecular:622.31Bupivacaine hydrochloride monohydrate
CAS:<p>Bupivacaine hydrochloride monohydrate is an NMDA receptor inhibitor that inhibits SCN5A channels and is commonly used in the study of chronic pain.</p>Fórmula:C18H31ClN2O2Pureza:99.91%Forma y color:SolidPeso molecular:342.9Funapide
CAS:<p>Funapide (TV 45070) is a potent Nav1.7 inhibitor, potentially treating inflammation and various pains.</p>Fórmula:C22H14F3NO5Pureza:99.91%Forma y color:SolidPeso molecular:429.35Maralixibat Chloride
CAS:<p>Maralixibat Chloride (LUM001 chloride), an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid recirculation.</p>Fórmula:C40H56ClN3O4SPureza:99.19% - 99.65%Forma y color:SolidPeso molecular:710.41C 101248
CAS:<p>C 101248 (KCNK13-IN-1) is a selective and potent tandem pore halogen inhibitor of K+ channel 1 (THIK-1) inhibitor and a human and mouse KCNK13 inhibitor.</p>Fórmula:C15H12N6OPureza:99.14% - 99.31%Forma y color:SolidPeso molecular:292.3VGSCs-IN-1
CAS:<p>VGSCs-IN-1, a VGSC inhibitor and Riluzole analog, exhibits good blocking activity on Nav1.4 and can be used to study cellular excitability disorders.</p>Fórmula:C12H12F3N3OSPureza:99.88%Forma y color:SolidPeso molecular:303.3CE-224535
CAS:<p>CE-224535 (PF-04905428) is a selective antagonist of P2X7 receptor. CE-224535 can be used in disease-modifying antirheumatic studies.</p>Fórmula:C22H29ClN4O6Pureza:99.68%Forma y color:SolidPeso molecular:480.94LE135
CAS:<p>LE135: RARα/RARβ antagonist (Ki: 1.4 μM/220 nM), favors RARβ, selective vs RARγ/RXRs; also activates TRPV1/TRPA1 (EC50s: 2.5/20 μM).</p>Fórmula:C29H30N2O2Pureza:97.94%Forma y color:SolidPeso molecular:438.56AMG-0347
CAS:<p>AMG-0347 inhibits TRPA1 ion channels in sensory neurons, blocking pain perception.</p>Fórmula:C24H26F3N3O2Pureza:99.93%Forma y color:SolidPeso molecular:445.48Kv3 modulator 1
CAS:<p>Kv3 modulator 1 is a voltage-gated potassium channel Kv3 modulator that can be used to study neurologic-level diseases.</p>Fórmula:C20H20N4O4Pureza:99.41%Forma y color:SolidPeso molecular:380.4CFTR corrector 4
CAS:<p>Potent, oral CFTR corrector 4 targets cystic fibrosis, increasing cell surface CFTR levels.</p>Fórmula:C29H27F2NO7Pureza:99.32%Forma y color:SolidPeso molecular:539.52MCT1-IN-3
CAS:<p>MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor.</p>Fórmula:C22H19N3O4Pureza:99.35%Forma y color:SoildPeso molecular:389.4Soraprazan
CAS:<p>BS3 Crosslinker (Bis(sulfosuccinimidyl)suberate) is an ADC linker that can be used to synthesize antibody-coupled active molecules.</p>Fórmula:C21H25N3O3Pureza:97.69% - 99.84%Forma y color:SolidPeso molecular:367.44L-DABA hydrobromide
CAS:<p>L-DABA hydrobromide (L-2,4-Diaminobutyric acid hydrobromide) , GABA transaminase inhibitor with antitumor and anticonvulsant activity.</p>Fórmula:C4H11BrN2O2Pureza:99.11%Forma y color:SolidPeso molecular:199.05Aneratrigine hydrochloride
CAS:<p>Aneratrigine hydrochloride is a Nav 1.9 blocker that may be used to prevent or treat sodium channel blocker-related disorders.</p>Fórmula:C19H21Cl2F2N5O2S2Pureza:98.37% - 99.16%Forma y color:SolidPeso molecular:524.43EMD57033
CAS:<p>EMD57033 activates cardiac troponin C, enhances Ca2+ sensitivity to boost heart contraction.</p>Fórmula:C22H23N3O4SPureza:99.72% - >99.99%Forma y color:SolidPeso molecular:425.5Reldesemtiv
CAS:<p>Reldesemtiv (CK-2127107) boosts exercise capacity, targeting fast muscle troponin, EC50 3.4 μM.</p>Fórmula:C19H18F2N6OPureza:97.27%Forma y color:SolidPeso molecular:384.38AMG2850
CAS:<p>AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).</p>Fórmula:C19H17F6N3OPureza:99.84%Forma y color:SolidPeso molecular:417.35(RS)-AMPA hydrobromide
CAS:<p>AMPAR agonist</p>Fórmula:C7H11BrN2O4Pureza:98%Forma y color:SolidPeso molecular:267.08Detajmium
CAS:<p>Detajmium is an anti-arrhythmia compound. It is an Na(+)-channel-blocking drug with an extremely long recovery from use-dependent sodium channel block.</p>Fórmula:C27H42N3O3Pureza:98%Forma y color:SolidPeso molecular:456.64Butein tetramethyl ether
CAS:<p>Butein tetramethyl ether (Compound 20) is a potent and selective inhibitor of breast cancer resistance protein / ATP-binding cassette sub-family G member 2 (BCRP/ABCG2). It inhibits MCF-7 MX and MDCKBCRP cells with IC50 values of 2.2 μM and 1.03 μM, respectively. Butein tetramethyl ether holds potential for cancer research.</p>Fórmula:C19H20O5Forma y color:SolidPeso molecular:328.359Leualacin
CAS:<p>Leualacin is a novel calcium blocker from Hapsidospora irregularis.</p>Fórmula:C31H47N3O7Pureza:98%Forma y color:SolidPeso molecular:573.72Tamitinol
CAS:<p>Tamitinol is a neurotropic drug. It has been found to help symptoms of obsessive rumination in conjunction with maprotiline.</p>Fórmula:C12H20N2OSPureza:98%Forma y color:SolidPeso molecular:240.37EF1502 free base
CAS:<p>EF1502 is a potent and selective GABA transporter inhibitor.</p>Fórmula:C22H26N2O2S2Pureza:98%Forma y color:SolidPeso molecular:414.58(R)-KMH-233
CAS:<p>(R)-KMH-233 is an isomer of KMH-233, which can serve as a reference compound in experiments. KMH-233 functions as a potent, reversible, and selective inhibitor of L-type amino acid transporter 1 (LAT1), effectively hindering the uptake of LAT1 substrate, l-leucine (IC50=18 μM), and also inhibiting cell growth. Even at a low concentration of 25 μM, KMH-233 significantly enhances the efficacy of Bestatin and cisplatin.</p>Fórmula:C32H25N7O5Peso molecular:587.58Caged MK801
CAS:<p>Caged MK801 (cMK801) is a selective, noncompetitive, and irreversible blocker of the NMDA receptor open channel. The NVOC cage is compatible in neuropharmacology and does not alter the intrinsic activity of the molecule.</p>Fórmula:C26H24N2O6Forma y color:SolidPeso molecular:460.48CFTR corrector 17
CAS:<p>CFTRcorrector 17 (example 17) is a regulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It is utilized in the study of diseases mediated by CFTR.</p>Fórmula:C18H15FN2O2Forma y color:SolidPeso molecular:310.32BGT1-IN-1
CAS:<p>BGT1-IN-1 (compound 9) is an effective inhibitor of BGT1, demonstrating IC50 values of 13.9 µM for hBGT1 and 58.3 µM for GAT3. It exhibits no cytotoxic effects and possesses neuroprotective activity.</p>Fórmula:C6H9NO2Forma y color:SolidPeso molecular:127.14S9-A13
CAS:<p>S9-A13 is a potent and selective inhibitor of SLC26A9, exhibiting an IC50 of 90.9 nM without inhibiting other members of the SLC26 family, such as SLC26A3, SLC26A4, and SLC26A6. It also inhibits the SLC26A9 Cl- current in cells lacking CFTR expression.</p>Fórmula:C20H18ClN3O2SForma y color:SolidPeso molecular:399.89H052
CAS:<p>H052 is a selective inhibitor of Staphylococcus aureus α-hemolysin (Hla). It binds to the Hla monomer, disrupting its interaction with the host cell membrane, thereby blocking pore formation and inhibiting calcium influx, cytotoxicity, and inflammatory response. H052 exhibits inhibitory activity against Hla-induced calcium influx (EC50 = 30 nM in U937 cells) and holds potential for research into lung infections caused by S. aureus.</p>Fórmula:C21H15ClFN3O4SForma y color:SolidPeso molecular:459.88EU 1622-240
CAS:<p>EU 1622-240 is an allosteric modulator with a preference for GluN2B, GluN2C, and GluN2D, exhibiting EC50 values of 0.57, 0.82, and 1.1 μM, respectively. It possesses favorable physicochemical properties, along with in vitro stability and permeability.</p>Fórmula:C20H14BrF2N3O2SForma y color:SolidPeso molecular:478.31Cyproflanilide
CAS:<p>Cyproflanilide is a GABAR antagonist that exhibits high activity against a variety of pests, including those from the Lepidoptera, Coleoptera, and Thysanoptera orders.</p>Fórmula:C28H17BrF12N2O2Forma y color:SolidPeso molecular:721.33Vormatrigine
CAS:<p>Vormatrigine effectively inhibits sodium channels (sodium channel).</p>Fórmula:C16H12F6N4O2Forma y color:SolidPeso molecular:406.28Kv7.2/Kv7.3 agonist 1
CAS:<p>Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.</p>Fórmula:C14H14FN3O2Forma y color:SolidPeso molecular:275.28NMD670
CAS:<p>NMD670 is an orally active, partial inhibitor of the skeletal muscle-specific chloride channel ClC-1. It enhances muscle excitability and neuromuscular transmission, restoring muscle function and mobility. NMD670 has a favorable safety profile and improves muscle function in rats, particularly in an MG rat model [1].</p>Fórmula:C12H10BrNO4Forma y color:SolidPeso molecular:312.12CRM1-IN-3
CAS:<p>CRM1-IN-3 (B28), a noncovalent inhibitor of CRM1, is utilized in the research of protein localization and tumor studies [1].</p>Fórmula:C26H26ClN3O3Forma y color:SolidPeso molecular:463.96Sp-8-Br-cGMPS
CAS:<p>Sp-8-Br-cGMPS, an analogue of cGMP, acts as an agonist for cGMP gated cation channels (CNG channels) with an EC50 of 106.5 μM. While Sp-8-Br-cGMPS can induce currents, it does not stabilize channel open states as effectively as a full agonist.</p>Fórmula:C10H11BrN5O6PSForma y color:SolidPeso molecular:440.17TRPV1 antagonist 10
CAS:<p>TRPV1 antagonist 10 is a potent, orally active TRPV1 antagonist with an IC50 of 33.06 nM and serves as a moderate to weak inhibitor of URAT1 (IC50 = 22.51 μM) and GLUT9 (inhibition of 60.25% at 50 μM). It exhibits analgesic and urate-lowering properties and is applicable for research in hyperuricemia and inflammatory pain.</p>Fórmula:C16H14N2O5Forma y color:SolidPeso molecular:314.293TRPA1 Antagonist 1
CAS:<p>TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.</p>Fórmula:C24H20F6N5Na2O7PSPureza:98%Forma y color:SolidPeso molecular:713.45pan-HCN-IN-1
CAS:<p>Pan-HCN-IN-1 (Compound J&J12e) is an inhibitor of the hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channel, with an IC50 of 58 nM. Pan-HCN-IN-1 reduces the voltage sag response and enhances EPSP summation in ex vivo rat brain slices [1].</p>Fórmula:C23H37N3O2Forma y color:SolidPeso molecular:387.56Sesamodil
CAS:<p>Sesamodil (SD 3211) is a novel calcium antagonist that can be used to study hypertension.</p>Fórmula:C29H32N2O6SPureza:98.58% - 99.01%Forma y color:SolidPeso molecular:536.64ABCA1 inducer 2
CAS:<p>ABCA1 inducer 2 is a non-lipogenic inducer of ABCA1. It increases the expression of ABCA1 by targeting the LXR pathway, thereby reducing lipid accumulation induced by ox-LDL and inhibiting foam cell formation. ABCA1 inducer 2 holds potential as an anti-atherosclerotic agent.</p>Fórmula:C16H11BrN2OForma y color:SolidPeso molecular:327.175MRS4738
<p>MRS4738 is a potent antagonist with high affinity for the P2Y14R receptor. It demonstrates in vivo anti-hyperallodynic and antiasthmatic activity [1].</p>Fórmula:C30H24F3NO2Forma y color:SolidPeso molecular:487.51GABAA receptor agonist 1
<p>Compound 3e, a potent GABAA agonist, targets GABA sites and has potential anti-depressive effects in mice.</p>Fórmula:C20H30O3Forma y color:SolidPeso molecular:318.45
