Transportador de membrana / canal de iones
Los inhibidores de transportadores de membrana y canales iónicos son compuestos que bloquean la función de proteínas responsables del transporte de iones, nutrientes y otras moléculas a través de las membranas celulares. Estos inhibidores son cruciales para estudiar la regulación de la homeostasis celular, la transducción de señales y la neurotransmisión. Los inhibidores de transportadores de membrana y canales iónicos también son importantes para desarrollar tratamientos para trastornos como la epilepsia, las enfermedades cardiovasculares y los síndromes metabólicos. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de transportadores de membrana y canales iónicos para apoyar su investigación en fisiología, neurociencia y farmacología.
Subcategorías de "Transportador de membrana / canal de iones"
- ABC(3 productos)
- ATPasa(93 productos)
- Receptor de adiponectina(5 productos)
- CFTR(64 productos)
- Receptor CGRP(51 productos)
- Canal de calcio(493 productos)
- Canal de cloruro(49 productos)
- Receptor GABA(336 productos)
- Transportador de monoamina(23 productos)
- Transportador de monocarboxilato(17 productos)
- NKCC(2 productos)
- NPC1L1(3 productos)
- Cotransportador de Na-K-Cl(8 productos)
- OAT(27 productos)
- OCT(7 productos)
- P-gp(53 productos)
- Canal de potasio(276 productos)
- Bomba de protones(39 productos)
- SGLT(30 productos)
- Canal de sodio(202 productos)
- Canal TRP / TRPV(92 productos)
Mostrar 13 subcategorías más
Se han encontrado 2272 productos de "Transportador de membrana / canal de iones"
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DAD dichloride
<p>DAD dichloride is a 3rd-gen photoelectric switch, blocks K+ channels, and helps in visual function research.</p>Fórmula:C26H42Cl2N6OForma y color:SolidPeso molecular:525.56NSC73306
CAS:<p>NSC73306 is a thiosemicarbazone known for its role as a cell-permeable agent, exhibiting increased toxicity towards cells expressing p-glycoprotein.</p>Fórmula:C16H14N4O2SForma y color:SolidPeso molecular:326.373Unoprostone isopropyl
CAS:<p>Unoprostone isopropyl, a prostanoid and synthetic docosanoid, is approved for the treatment of ocular hypertension and open-angle glaucoma.</p>Fórmula:C25H44O5Pureza:98%Forma y color:SolidPeso molecular:424.618-Prenylchrysin
CAS:<p>8-Prenylchrysin is a C8-isopentenyl flavonoid compound. It acts as an inhibitor of P-glycoprotein (P-gp) and can be utilized in cancer research.</p>Fórmula:C20H18O4Forma y color:SolidPeso molecular:322.354(RS)-AMPA monohydrate
CAS:<p>(RS)-AMPA monohydrate, potent glutamate analogue, selectively activates L-glutamic acid without affecting kainic acid or NMDA receptors.</p>Fórmula:C7H12N2O5Forma y color:SolidPeso molecular:204.182Probenecid sodium
CAS:<p>Probenecid sodium is the sodium salt of Probenecid, a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Additionally, Probenecid acts as an inhibitor of pannexin 1 channels.</p>Fórmula:C13H18NNaO4SForma y color:SolidPeso molecular:307.341TRPC4/5-IN-1
<p>TRPC4/5-IN-1, a TRPC5/4 inhibitor with IC50s 0.54 μM/2.06 μM, targets skin inflammation and proteinuric kidney diseases.</p>Fórmula:C21H21N3OForma y color:SolidPeso molecular:331.41hURAT1 inhibitor 2
CAS:<p>hURAT1 inhibitor 2 (Compound 5) is an inhibitor of hURAT1 (uric acid transporter 1, SLC22A12) with an IC50 of 18 nM. It also exhibits some inhibitory activity against OATP1B1, with an IC50 of 0.73 μM. hURAT1 inhibitor 2 can be used in research related to hyperuricemia, gout, and other diseases associated with abnormal uric acid metabolism.</p>Fórmula:C17H11Br2FO3Forma y color:SolidPeso molecular:442.074P-gp modulator 2
<p>P-gp modulator 2 (Compound 27) is a potent competitive and metabotropic P-glycoprotein (P-gp) modulator.</p>Fórmula:C22H20BrN3O4Forma y color:SolidPeso molecular:470.32GABAA receptor agonist 2
<p>Compound 4c, a potent GABAA agonist with anti-depressive effects in mouse FST/TST, shows promise in depression research.</p>Fórmula:C22H36O5Forma y color:SolidPeso molecular:380.52Dehydelone
CAS:<p>Dehydelone(KOS-1584, R-1645, SK-10088) is a microtubule stabilizer that may be used in the treatment of non-small cell lung cancer.</p>Fórmula:C27H39NO5SForma y color:SolidPeso molecular:489.67P-gp inhibitor 2
CAS:<p>Potent P-gp inhibitor 2 reverses Doxorubicin resistance in colorectal carcinoma cells with IC50 of 0.22 µM.</p>Fórmula:C29H26N2O6Forma y color:SolidPeso molecular:498.53INCB-056868
CAS:<p>INCB-056868 is the metabolite M11 of Epacadostat. It serves as a substrate for BCRP and holds potential for use in the study of metabolic diseases.</p>Fórmula:C11H13BrFN7O3SForma y color:SolidPeso molecular:422.23NMDA receptor antagonist-3
<p>NMDA antagonist-3: recovery rate 40% at 100 μM, low toxicity in SH-SY5Y, human stem cells.</p>Fórmula:C13H19N3O6Forma y color:SolidPeso molecular:313.31BMS-986163
CAS:<p>BMS-986163, a prodrug, quickly becomes BMS-986169, a GluN2B inhibitor (Ki=4 nM, IC50=24 nM).</p>Fórmula:C23H28FN2O5PPureza:98%Forma y color:SolidPeso molecular:462.45Coleon-U-quinone
CAS:<p>Coleon-U-quinone, a P-gp inhibitor, reduces cancer cell viability and enhances Doxorubicin sensitivity in resistant cells.</p>Fórmula:C20H24O5Forma y color:SolidPeso molecular:344.4DFBTA
<p>DFBTA inhibits ANO1 with IC50 of 24 nM, effectively treating inflammatory pain orally.</p>Fórmula:C18H10ClF2NO3SForma y color:SolidPeso molecular:393.79KCa2 channel modulator 2
<p>Compound 2q is a potent, subtype-selective K/Ca 2 modulator, effective on human K Ca 2.3 and rat K Ca 2.2a with EC50s of 0.60 μM and 0.64 μM.</p>Fórmula:C16H15ClFN5Forma y color:SolidPeso molecular:331.78TRPV1 antagonist 3
<p>TRPV1 antagonist 3 (7q) strongly blocks TRPV1 at 2.66 nM IC50, is selective, 60% bioavailable, and crosses the blood-brain barrier.</p>Fórmula:C23H25N3OSForma y color:SolidPeso molecular:391.53Ro 0437626
CAS:<p>P2X1 purinergic receptor antagonist</p>Fórmula:C27H35N5O4SPureza:98%Forma y color:SolidPeso molecular:525.66NYX-2925
CAS:<p>NYX-2925, an oral NMDAR modulator, enhances Src in mPFC. No CAMKII impact or addictive/sedative effects. Useful for CNS disorder studies.</p>Fórmula:C14H23N3O4Forma y color:SolidPeso molecular:297.35(RS)-AMPA
CAS:<p>(RS)-AMPA ((±)-AMPA) is a glutamate analog. (RS)-AMPA is an agonist of effective and selective excitatory neurotransmitter L-glutamic acid.</p>Fórmula:C7H10N2O4Pureza:98%Forma y color:SolidPeso molecular:186.17Onfasprodil
CAS:<p>Onfasprodil, NR2B inhibitor & GABA regulator, potential for Alzheimer's research. (Patent CN111481543A)</p>Fórmula:C20H23FN2O3Forma y color:SolidPeso molecular:358.41Valbenazine tosylate
CAS:<p>Valbenazine tosylate, the tosylate salt of valbenazine, is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki value of 150 nM while displaying no</p>Fórmula:C38H54N2O10S2Pureza:98%Forma y color:SolidPeso molecular:762.974α-PDD
CAS:<p>4alpha-PDD activates transient receptor potential vanilloid 4 (TRPV4) channels and is inactive for signaling through PKC.</p>Fórmula:C40H64O8Forma y color:SolidPeso molecular:672.93DS88790512
CAS:<p>DS88790512, IC50 at 11 nM, is an effective, selective, oral bioeffective TRPC6 inhibitor.</p>Fórmula:C22H29N3O2Pureza:98%Forma y color:SolidPeso molecular:367.48KPH2f
CAS:<p>KPH2f: dual URAT1/GLUT9 inhibitor, orally active, IC50: 0.24μM (URAT1), 9.37μM (GLUT9), minimal OAT1/ABCG2 impact.</p>Fórmula:C24H16N3NaO2SForma y color:SolidPeso molecular:433.46Cav 3.2 inhibitor 3
<p>Cav 3.2 inhibitor 3 is a potent inhibitor of the Cav3.2 T-type Ca2+channel (IC50: 0.1534 μM) and has a low binding affinity for D2 receptors.</p>Fórmula:C32H37N3O2Forma y color:SolidPeso molecular:495.66P-gp modulator 1
CAS:<p>P-gp modulator 1 is a high affinity and orally available P-glycoprotein (Pgp) modulator</p>Fórmula:C41H72N2O6Pureza:98%Forma y color:SolidPeso molecular:689.02P-gp modulator 3
<p>P-gp modulator 3 (Compound 37) is a potent, competitive, metabotropic P-glycoprotein (P-gp) modulator.</p>Fórmula:C31H37N3O5Forma y color:SolidPeso molecular:531.64(R)-Duloxetine
CAS:<p>(R)-Duloxetine, an isomer of Duloxetine, induces tonic and use-dependent blockade of neuronal Na+ channels. This compound is utilized in pain research.</p>Fórmula:C18H19NOSForma y color:SolidPeso molecular:297.42Cav 3.2 inhibitor 1
<p>Cav 3.2 inhibitor 1 targets T-type calcium channels, weakly binds D2 receptors, and aids physical and visceral pain research.</p>Fórmula:C32H39N3OForma y color:SolidPeso molecular:481.67TP003
CAS:<p>TP003 is a novel non-selective GABAA receptor benzodiazepine site agonist with affinity for α1β2gam2, α2β3gam2, α3β3gam2, α5β2gam2, EC50 of 20.3, 10.6, 3.24, 5.</p>Fórmula:C23H16F3N3OPureza:99.17%Forma y color:SolidPeso molecular:407.39DAD
<p>DAD is an ion channel blocker (blocks voltage-gated potassium channels) and is a third generation photoelectric switch that responds to visible light.</p>Fórmula:C26H40N6OForma y color:SolidPeso molecular:452.64P-gp/BCRP-IN-1
CAS:<p>P-gp/BCRP-IN-1, safe and oral, inhibits P-gp/BCRP transporters, enhancing Paclitaxel bioavailability.</p>Fórmula:C27H25ClN4O3Forma y color:SolidPeso molecular:488.97TRPC5-IN-4
CAS:<p>TRPC5-IN-4: Potent, safe inhibitor; IC50 14.07 nM (TRPC5), 65 nM (TRPC4); non-toxic to liver/kidney cells; for CKD research.</p>Fórmula:C18H11ClF4N4O3Forma y color:SolidPeso molecular:442.75Suloctidil HCl
CAS:<p>Suloctidil HCl is a peripheral vascular dilator.</p>Fórmula:C20H36ClNOSForma y color:SolidPeso molecular:374.02SC-435 mesylate
CAS:<p>SC-435 is an ileal apical sodium co-dependent bile acid transporter (ASBT). SC-435 inhibits plasma cholesterol.</p>Fórmula:C37H59N3O7S2Pureza:98%Forma y color:SolidPeso molecular:722.01Tuclazepam
CAS:<p>Tuclazepam (KC 1956) is a derivative of the benzodiazepine class of drugs, exhibiting anti-anxiety and sedative properties.</p>Fórmula:C17H16Cl2N2OForma y color:SolidPeso molecular:335.23KCC2 Modulator-2
CAS:<p>KCC2 Modulator-2 (example 53) is a regulator of KCC2 with an EC50 of 0.215 μM. It is used in the research of neurological diseases.</p>Fórmula:C35H45N5O3Forma y color:SolidPeso molecular:583.76N-Depropylpropafenone
CAS:<p>N-Depropylpropafenone, an active metabolite of Propafenone, is produced through the metabolism by the CYP450 enzyme system (primarily CYP2D6). It functions by blocking sodium ion channels, thereby delaying the depolarization process in myocardial cells and exhibiting antiarrhythmic properties.</p>Fórmula:C18H21NO3Forma y color:SolidPeso molecular:299.36Desmethylflunitrazepam
CAS:<p>Desmethylflunitrazepam (Norflunitrazepam) is a benzodiazepine derivative and an active metabolite of Flunitrazepam.</p>Fórmula:C15H10FN3O3Forma y color:SolidPeso molecular:299.26Tizolemide
CAS:<p>Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.</p>Fórmula:C11H14ClN3O3S2Forma y color:SolidPeso molecular:335.83cis-KV1.3-IN-1
CAS:<p>cis-KV1.3-IN-1, also known as Compound cis-18, is the cis-isomer of KV1.3-IN-1 and functions as an inhibitor of the KV1.3 channel. In Xenopus laevis oocytes expressing human hKV1.3, cis-KV1.3-IN-1 (10 μM) achieves an inhibition rate of 25.53% against KV1.3.</p>Fórmula:C23H30N2O4SForma y color:SolidPeso molecular:430.56Cyazofamid
CAS:<p>Cyazofamid functions as a fungicide by impairing the production of ATP. It inhibits Organic Cation Transporter 3 (OCT3) and OAT1 with IC50 values of 1.54 and 17.3 μM, respectively.</p>Fórmula:C13H13ClN4O2SForma y color:SolidPeso molecular:324.79Lu AF90103
CAS:<p>Lu AF90103 (Compound 42e) is the methyl ester prodrug of compound 42d, capable of crossing the blood-brain barrier. Compound 42d acts as a partial agonist of the GluN1/GluN2B complex, with an efficacy of 24% and an EC50 value of 78 nM. Lu AF90103 plays a significant role in neuropsychiatric disorder research.</p>Fórmula:C13H15N3O3SForma y color:SolidPeso molecular:293.342Cav 2.2/3.2 blocker 1
<p>Compound 9e is a Cav 2.2/3.2 blocker; IC50: 1.22 μM & 80 μM, respectively; penetrates CNS.</p>Fórmula:C28H30N2O3Forma y color:SolidPeso molecular:442.55Ro-51
CAS:<p>dual P2X3 and P2X2/3 antagonist</p>Fórmula:C17H23IN4O4Pureza:98%Forma y color:SolidPeso molecular:474.29Quinacainol dihydrochloride
CAS:<p>Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.</p>Fórmula:C21H32Cl2N2OForma y color:SolidPeso molecular:399.398IAB15
CAS:<p>IAB15 is a potent inhibitor of T-type calcium channel that can be used in the research of epilepsy [1].</p>Fórmula:C15H14F3NO2Forma y color:SolidPeso molecular:297.27
