Metabolismo

Sodium 2-mercaptoethanesulfonate (Uromitexan) is a sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from antineoplastic.

VU0359595 (ML-270) is a selective PLD1 inhibitor with 3.7 nM IC50; >1700x more selective over PLD2, for cancer/diabetes/neurodegenerative research.

(R)-Apremilast ((R)-CC-10004) is the enantiomer of Apremilast and one of the isoindoline derivatives.

Etofibrate is a combination of clofibrate and niacin, used to treat hyperlipemia.

Etofylline (Oxyphylline) is used for difficulty in breathing, asthma, breathing difficulty and other conditions.

Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.

Opevesostat (ODM-208) is an inhibitor of lyase (CYP11A1) (the enzyme cleavage cholesterol side chain).

Oxiconazole nitrate (Ro 13-8996) is an antifungal imidazole inhibiting fungal growth by blocking ergosterol synthesis, disrupting cell membranes.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse CT. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse CT. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse CT, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse CT in the samples is then determined by comparing the OD of the samples to the standard curve.

Actarit (4-acetylaminophenylacetic acid) is an anti-inflammatory drug.

Phenindione, an obsolete anticoagulant with warfarin-like effects, is rarely used due to severe side effects.

Chlorindione (chlophenadione) is a vitamin K antagonist, a potent anticoagulant compound.

5-Phenylhydantoin is a Mephenytoin metabolite with anti-epileptic effects, targeting NVSCs.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Pig PAI1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Pig PAI1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Pig PAI1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Pig PAI1 in the samples is then determined by comparing the OD of the samples to the standard curve.